Beyond the Economy: Internal Factors Affecting theFuture of the Russian Military

Since the breakup of The Soviet Union, many factors have been reshaping the new Russian military. The economy is of course the dominant factor in that process. Financial difficulties have been so severe that, according to a Russian deputy defense minister, as of early August 1993 more than 60% of servicemen [had] not received their pay for July ...[and] many units and subunits {had] not received it for June. People {were) refusing to carry out their duties, including alert duty

The Impact of Scientific Creationism in the Soviet Union and the Soviet Response

Increasing references to scientific creationism in Soviet atheistic publications indicate that it is having an impact. Attacks on creationism in Soviet publications have not ended with glasnost\u27, but concurrently, this policy-- which allows greater press freedoms and more importation of material published in the West--may eventually expose more persons in the Soviet Union than ever before to the concepts of scientific creationism

K-band Properties of Well-Sampled Groups of Galaxies

We use a sample of 55 groups and 6 clusters of galaxies ranging in mass from 7 x 10^11 Msun to 1.5 x 10^15 Msun to examine the correlation of the Ks-band luminosity with mass discovered by Lin et al. (2003). We use the 2MASS catalog and published redshifts to construct complete magnitude limited redshift surveys of the groups. From these surveys we explore the IR photometric properties of groups members including their IR color distribution and luminosity function. Although we find no significant difference between the group Ks luminosity function and the general field, there is a difference between the color distribution of luminous group members and their counterparts (generally background) in the field. There is a significant population of luminous galaxies with H-Ks > 0.35 which are rarely, if ever, members of the groups in our sample. The most luminous galaxies which populate the groups have a very narrow range of IR color. Over the entire mass range covered by our sample, the Ks luminosity increases with mass as L ~ M^(0.64 +/- 0.06) implying that the mass-to-light ratio in the Ks-band increases with mass. The agreement between this result and earlier investigations of essentially non-overlapping sets of systems shows that this window in galaxy formation and evolution is insensitive to the selection of the systems and to the details of the mass and luminosity computations.Comment: 38 pages, 9 figures, 2 tables. Accepted for publication on Astronomical Journa

Fundamental Flaws of Hormesis for Public Health Decisions

Hormesis (defined operationally as low-dose stimulation, high-dose inhibition) is often used to promote the notion that while high-level exposures to toxic chemicals could be detrimental to human health, low-level exposures would be beneficial. Some proponents claim hormesis is an adaptive, generalizable phenomenon and argue that the default assumption for risk assessments should be that toxic chemicals induce stimulatory (i.e., “beneficial”) effects at low exposures. In many cases, nonmonotonic dose–response curves are called hormetic responses even in the absence of any mechanistic characterization of that response. Use of the term “hormesis,” with its associated descriptors, distracts from the broader and more important questions regarding the frequency and interpretation of nonmonotonic dose responses in biological systems. A better understanding of the biological basis and consequences of nonmonotonic dose–response curves is warranted for evaluating human health risks. The assumption that hormesis is generally adaptive is an oversimplification of complex biological processes. Even if certain low-dose effects were sometimes considered beneficial, this should not influence regulatory decisions to allow increased environmental exposures to toxic and carcinogenic agents, given factors such as interindividual differences in susceptibility and multiplicity in exposures. In this commentary we evaluate the hormesis hypothesis and potential adverse consequences of incorporating low-dose beneficial effects into public health decisions

Piecing together the puzzle of NGC 5253: abundances, kinematics and WR stars

We present Gemini-S/GMOS-IFU optical spectroscopy of four regions near the centre of the nearby (3.8 Mpc) dwarf starburst galaxy NGC 5253. This galaxy is famous for hosting a radio supernebula containing two deeply embedded massive super star clusters, surrounded by a region of enhanced nitrogen abundance that has been linked to the presence of WR stars. We detected 11 distinct sources of red WR bump (CIV) emission over a 20" (~350 pc) area, each consistent with the presence of ~1 WCE-type star. WC stars are not found coincident with the supernebula, although WN stars have previously been detected here. We performed a multi-component decomposition of the H\alpha\ line across all four fields and mapped the kinematics of the narrow and broad (FWHM = 100-250 km/s) components. These maps paint a picture of localised gas flows, as part of multiple overlapping bubbles and filaments driven by the star clusters throughout the starburst. We confirm the presence of a strong H\alpha\ velocity gradient over ~4.5" (~80 pc) coincident with the region of N/O enhancement, and high gas density known from previous study, and interpret this as an accelerating ionized gas outflow from the supernebula clusters. We measure the ionized gas abundances in a number of regions in the outer IFU positions and combine these with measurements from the literature to assess the radial abundance distribution. We find that the O/H and N/H profiles are consistent with being flat. Only the central 50 pc exhibits the well-known N/O enhancement, and we propose that the unusually high densities/pressures in the supernebula region have acted to impede the escape of metal-enriched hot winds from the star clusters and allow them to mix with the cooler phases, thus allowing these freshly processed chemicals to be seen in the optical.Comment: 16 pages, accepted to A&

Shredded Galaxies as the Source of Diffuse Intrahalo Light On Varying Scales

We make predictions for diffuse stellar mass fractions in dark matter halos from the scales of small spiral galaxies to those of large galaxy clusters. We use an extensively-tested analytic model for subhalo infall and evolution and empirical constraints from galaxy survey data to set the stellar mass in each accreted subhalo to model diffuse light. We add stellar mass to the diffuse light as subhalos become disrupted due to interactions within their host halos. We predict that the stellar mass fraction in diffuse, intrahalo light should rise on average from ~0.5% to approximately 20% from small galaxy halos to poor groups. The trend with mass flattens considerably beyond the group scale, increasing weakly from a fraction of ~20% in poor galaxy clusters (~10^14 M_sun) to roughly ~30% in massive clusters (~10^15 M_sun). The mass-dependent diffuse light fraction is governed primarily by the empirical fact that the mass-to-light ratio in galaxy halos must vary as a function of halo mass. Galaxy halos have little diffuse light because they accrete most of their mass in small subhalos that themselves have high mass-to-light ratios; stellar halos around galaxies are built primarily from disrupted dwarf-irregular-type galaxies with M*~10^8.5 M_sun. The diffuse light in group and cluster halos is built from satellite galaxies that form stars efficiently and have correspondingly low mass-to-light ratios; intracluster light is dominated by material liberated from massive galaxies with M*~10^11 M_sun. Our results are consistent with existing observations spanning the galaxy, group, and cluster scale; however, they can be tested more rigorously in future deep surveys for faint diffuse light.Comment: version accepted for publication in ApJ; details clarified and robustness discussion expanded, with results and conclusions unchanged; 15 pages, 10 figure

SDSSJ103913.70+533029.7: A Super Star Cluster in the Outskirts of a Galaxy Merger

We describe the serendipitous discovery in the spectroscopic data of the Sloan Digital Sky Survey of a star-like object, SDSSJ103913.70+533029.7, at a heliocentric radial velocity of +1012 km/s. Its proximity in position and velocity to the spiral galaxy NGC 3310 suggests an association with the galaxy. At this distance, SDSSJ103913.70+533029.7 has the luminosity of a super star cluster and a projected distance of 17 kpc from NGC 3310. Its spectroscopic and photometric properties imply a mass of > 10^6 solar masses and an age close to that of the tidal shells seen around NGC 3310, suggesting that it formed in the event which formed the shells.Comment: Accepted by AJ: 4 figures (1 color

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition

PTPN11 encodes the Shp2 non-receptor protein-tyrosine phosphatase implicated in several signaling pathways. Activating mutations in Shp2 are commonly associated with juvenile myelomonocytic leukemia but are not as well defined in other neoplasms. Here we report that Shp2 mutations occur in human acute myeloid leukemia (AML) at a rate of 6.6% (6/91) in the ECOG E1900 data set. We examined the role of mutated Shp2 in leukemias harboring MLL translocations, which co-occur in human AML. The hyperactive Shp2E76K mutant, commonly observed in leukemia patients, significantly accelerated MLL-AF9-mediated leukemogenesis in vivo. Shp2E76K increased leukemic stem cell frequency and affords MLL-AF9 leukemic cells IL3 cytokine hypersensitivity. As Shp2 is reported to regulate anti-apoptotic genes, we investigated Bcl2, Bcl-xL and Mcl1 expression in MLL-AF9 leukemic cells with and without Shp2E76K. Although the Bcl2 family of genes was upregulated in Shp2E76K cells, Mcl1 showed the highest upregulation in MLL-AF9 cells in response to Shp2E76K. Indeed, expression of Mcl1 in MLL-AF9 cells phenocopies expression of Shp2E76K, suggesting Shp2 mutations cooperate through activation of anti-apoptotic genes. Finally, we show Shp2E76K mutations reduce sensitivity of AML cells to small-molecule-mediated Mcl1 inhibition, suggesting reduced efficacy of drugs targeting MCL1 in patients with hyperactive Shp2

Science Impacts of the SPHEREx All-Sky Optical to Near-Infrared Spectral Survey: Report of a Community Workshop Examining Extragalactic, Galactic, Stellar and Planetary Science

SPHEREx is a proposed SMEX mission selected for Phase A. SPHEREx will carry out the first all-sky spectral survey and provide for every 6.2" pixel a spectra between 0.75 and 4.18 $\mu$m [with R$\sim$41.4] and 4.18 and 5.00 $\mu$m [with R$\sim$135]. The SPHEREx team has proposed three specific science investigations to be carried out with this unique data set: cosmic inflation, interstellar and circumstellar ices, and the extra-galactic background light. It is readily apparent, however, that many other questions in astrophysics and planetary sciences could be addressed with the SPHEREx data. The SPHEREx team convened a community workshop in February 2016, with the intent of enlisting the aid of a larger group of scientists in defining these questions. This paper summarizes the rich and varied menu of investigations that was laid out. It includes studies of the composition of main belt and Trojan/Greek asteroids; mapping the zodiacal light with unprecedented spatial and spectral resolution; identifying and studying very low-metallicity stars; improving stellar parameters in order to better characterize transiting exoplanets; studying aliphatic and aromatic carbon-bearing molecules in the interstellar medium; mapping star formation rates in nearby galaxies; determining the redshift of clusters of galaxies; identifying high redshift quasars over the full sky; and providing a NIR spectrum for most eROSITA X-ray sources. All of these investigations, and others not listed here, can be carried out with the nominal all-sky spectra to be produced by SPHEREx. In addition, the workshop defined enhanced data products and user tools which would facilitate some of these scientific studies. Finally, the workshop noted the high degrees of synergy between SPHEREx and a number of other current or forthcoming programs, including JWST, WFIRST, Euclid, GAIA, K2/Kepler, TESS, eROSITA and LSST.Comment: Report of the First SPHEREx Community Workshop, http://spherex.caltech.edu/Workshop.html , 84 pages, 28 figure