Enzyme production from food wastes using a biorefinery concept

According to Food and Agricultural Organization (FAO), one-third of food produced globally for human consumption (nearly 1.3 billion tonnes) is lost along the food supply chain. In many countries food waste is currently landfilled or incinerated together with other combustible municipal wastes for possible recovery of energy. However, these two options are facing more and more economic and environmental stresses. Due to its organic- and nutrient-rich nature, theoretically food waste can be converted to valuable products (e.g. bio-products such as methane, hydrogen, ethanol, enzymes, organic acids, chemicals and fuels) through various fermentation processes. Such conversion of food waste is potentially more profitable than its conversion to animal feed or transportation fuel. Food waste valorisation has therefore gained interest, with value added bio-products such as methane, hydrogen, ethanol, enzymes, organic acids, chemicals, and fuels. Therefore, the aim of this review is to provide information on the food waste situation with emphasis on Asia–Pacific countries and the state of the art food waste processing technologies to produce enzymes

Turkish League Against Rheumatism (Tlar) Recommendations For The Pharmacological Management Of Rheumatoid Arthritis: 2018 Update Under Guidance Of Current Recommendations

Objectives: This study aims to report the assessment of the Turkish League Against Rheumatism (TLAR) expert panel on the compliance and adaptation of the European League Against Rheumatism (EULAR) 2016 recommendations for the management of rheumatoid arthritis (RA) in Turkey. Patients and methods: The EULAR 2016 recommendations for the treatment of RA were voted by 27 specialists experienced in this field with regard to participation rate for each recommendation and significance of items. Afterwards, each recommendation was brought forward for discussion and any alteration gaining >= 70% approval was accepted. Also, Turkish version of each item was rearranged. Last version of the recommendations was then revoted to determine the level of agreement. Levels of agreement of the two voting rounds were compared with Wilcoxon signed-rank test. In case of significant difference, the item with higher level of agreement was accepted. In case of no difference, the changed item was selected. Results: Four overarching principles and 12 recommendations were assessed among which three overarching principles and one recommendation were changed. The changed overarching principles emphasized the importance of physical medicine and rehabilitation specialists as well as rheumatologists for the care of RA patients in Turkey. An alteration was made in the eighth recommendation on treatment of active RA patients with unfavorable prognostic indicators after failure of three conventional disease modifying anti-rheumatic drugs. Remaining principles were accepted as the same although some alterations were suggested but could not find adequate support to reach significance. Conclusion: Expert opinion of the TLAR for the treatment of RA was composed for practices in Turkish rheumatology and/or physical medicine and rehabilitation clinics.WoSScopu

Turkish League Against Rheumatism (Tlar) Recommendations For The Pharmacological Management Of Rheumatoid Arthritis: 2018 Update Under Guidance Of Current Recommendations

Objectives: This study aims to report the assessment of the Turkish League Against Rheumatism (TLAR) expert panel on the compliance and adaptation of the European League Against Rheumatism (EULAR) 2016 recommendations for the management of rheumatoid arthritis (RA) in Turkey. Patients and methods: The EULAR 2016 recommendations for the treatment of RA were voted by 27 specialists experienced in this field with regard to participation rate for each recommendation and significance of items. Afterwards, each recommendation was brought forward for discussion and any alteration gaining >= 70% approval was accepted. Also, Turkish version of each item was rearranged. Last version of the recommendations was then revoted to determine the level of agreement. Levels of agreement of the two voting rounds were compared with Wilcoxon signed-rank test. In case of significant difference, the item with higher level of agreement was accepted. In case of no difference, the changed item was selected. Results: Four overarching principles and 12 recommendations were assessed among which three overarching principles and one recommendation were changed. The changed overarching principles emphasized the importance of physical medicine and rehabilitation specialists as well as rheumatologists for the care of RA patients in Turkey. An alteration was made in the eighth recommendation on treatment of active RA patients with unfavorable prognostic indicators after failure of three conventional disease modifying anti-rheumatic drugs. Remaining principles were accepted as the same although some alterations were suggested but could not find adequate support to reach significance. Conclusion: Expert opinion of the TLAR for the treatment of RA was composed for practices in Turkish rheumatology and/or physical medicine and rehabilitation clinics.WoSScopu

patients with axial psoriatic arthritis

Objectives In this study, we aimed to evaluate the effect of gender on clinical findings, disease activity, functional status and quality of life in patients with axial involvement in Turkey. Methods Patients with PsA who met the CASPAR classification criteria were enrolled consequently in this cohort. Turkish League Against Rheumatism (TLAR)-Network was formed with the participation of 25 centres. The demographic variables, fatigue, diagnostic delay, the beginning of peripheral arthritis, enthesitis, dactylitis and spine involvement, inflammatory low back pain, BASFI, HAQ, HAQ-s, visual analogue scale-pain (VAS-pain), anxiety, depression and disease activity parameters (ESR, DAS28, BASDAI) were recorded. Axial involvement was assessed according to clinical and radiological data according to modified New York (MNYC) or Assessment of SpondyloArthritis international Society (ASAS) criteria. Results A total of 1018 patients with PsA were included in this study. Of the 373 patients with axial involvement, 150 were male (40.2%) and 223 (59.8%) were female. Spondylitis was detected in 14,7% of men and 21,9% of women in all patients. Pain score (VAS) (p < .002), fatigue (p < .001), ESR (p < .001), DAS28 (p < .001), BASDAI score (p < .001), PsAQoL (p < .001), HAQ score (p < ,01), HAQ-S score (p < .001), anxiety (p < .001), depression (p < .024), FACIT (p < .001) and FiRST (p < .001) scores were statistically significantly worse in women than males with axial PsA. However, quality of life was better (p < .001) and PASI score (p < .005) were statistically worse in male patients than in female patients with axial involvement. Conclusion This study has shown that the burden of disease in axial PsA has significant difference between genders. Disease activity, physical disability, functional limitation, depression and anxiety scores were higher in female patients, while quality of life were better and PASI score were higher in male patients. Therefore, we suggest that new strategies should be developed for more effective treatment of axial PsA in female patients.C1 [Nas, Kemal; Tekeoglu, Ibrahim; Baykul, Merve; Kamanli, Ayhan] Sakarya Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol & Immunol, Sakarya, Turkey.[Kilic, Erkan] Kanuni Training & Res Hosp, Rheumatol Clin, Trabzon, Turkey.[Keskin, Yasar; Kucukakkas, Okan; Yurdakul, Ozan Volkan] Bezmialem Fdn Univ, Dept Phys Med & Rehabil, Istanbul, Turkey.[cevik, Remzi] Dicle Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Diyarbakir, Turkey.[Sargin, Betul; Sendur, Omer Faruk] Adnan Menderes Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Aydin, Turkey.[Acer Kasman, Sevtap; Duruoz, Mehmet Tuncay] Marmara Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Istanbul, Turkey.[Alkan, Hakan] Pamukkale Univ, Sch Med, Dept Phys Med & Rehabil, Denizli, Turkey.[Sahin, Nilay] Balikesir Univ, Sch Med, Dept Phys Med & Rehabil, Balikesir, Turkey.[Cengiz, Gizem] Univ Hlth Sci, Van Training & Res Hosp, Rheumatol Clin, Van, Turkey.[Cuzdan, Nihan] Balikesir Ataturk City Hosp, Rheumatol Clin, Balikesir, Turkey.[Albayrak Gezer, Ilknur] Selcuk Univ, Sch Med, Dept Phys Med & Rehabil, Konya, Turkey.[Keskin, Dilek] Kirikkale Univ, Sch Med, Dept Phys Med & Rehabil, Kirikkale, Turkey.[Mulkoglu, Cevriye] Ankara Numune Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.[Resorlu, Hatice] Canakkale Onsekiz Mart Univ, Sch Med, Dept Phys Med & Rehabil, Canakkale, Turkey.[Ataman, Sebnem] Ankara Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Ankara, Turkey.[Bal, Ajda] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Ho, Dept Phys Med & Rehabil, Ankara, Turkey.[Alkan Melikoglu, Meltem] Ataturk Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Erzurum, Turkey.[Ayhan, Fikriye Figen] Atilim Univ, Med Sch, Dept Phys Med & Rehabil, Ankara, Turkey.[Bodur, Hatice] Yildirim Beyazit Univ, Sch Med, Dept Phys Med & Rehabil, Ankara, Turkey.[Calis, Mustafa] Erciyes Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Kayseri, Turkey.[Capkin, Erhan] Karadeniz Tech Univ, Sch Med, Dept Phys Med & Rehabil, Trabzon, Turkey.[Devrimsel, Gul] Recep Tayyip Erdogan Univ, Sch Med, Dept Phys Med & Rehabil, Rize, Turkey.[Gok, Kevser] Ankara City Hosp, Rheumatol Clin, Ankara, Turkey.[Hizmetli, Sami] Cumhuriyet Univ Sivas, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Sivas, Turkey.[Kocabas, Hilal] Necmettin Erbakan Univ, Meram Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Konya, Turkey.[Kutluk, Oznur; Tuncer, Tiraje] Akdeniz Univ, Sch Med, Dept Phys Med & Rehabil, Div Rheumatol, Antalya, Turkey.[Sen, Nesrin] Kartal Dr Lutfi Kirdar Training & Res Hosp, Dept Rheumatol, Istanbul, Turkey.[Toprak, Murat] Yuzuncu Yil Univ, Sch Med, Dept Phys Med & Rehabil, Van, Turkey.[Tolu, Sena] Medipol Univ, Sch Med, Dept Phys Med & Rehabil, Istanbul, Turkey

The impact of fatigue on patients with psoriatic arthritis: a multi-center study of the TLAR-network

PMID = 3256415

Enthesitis and its relationship with disease activity, functional status, and quality of life in psoriatic arthritis: a multi-center study

Psoriatic arthritis (PsA) is an inflammatory arthritis with distinct phenotypic subtypes. Enthesitis is assigned as a hallmark of the disease, given its significant relations to disease activity and quality of life. Our objective is to evaluate the prevalence of enthesitis and its association with some clinical parameters, particularly quality of life, using data from a national registry. Patients with PsA meeting ClASsification criteria for Psoriatic Arthritis (CASPAR) were enrolled by means of a multi-centre Turkish League Against Rheumatism (TLAR) Network Project. The following information was recorded in web-based case report forms: demographic, clinical and radiographic data; physical examination findings, including tender and swollen joint counts (TJC and SJC); nail and skin involvement; Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate (DAS 28-ESR); Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES); Psoriasis Area Severity Index (PASI); Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s); Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire for the spondyloarthropathies (HAQ-s); Psoriatic arthritis quality of Life scale (PsAQoL); Short Form 36 (SF-36); Hospital Anxiety Depression Scale (HADS); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and Fibromyalgia Rapid Screening Tool (FiRST) scores. The patients were divided into two groups, namely with and without enthesitis, based on the triple Likert-type physician-reported statement of ‘active enthesitis’, ‘history of enthesitis’ or ‘none’ in the case report forms. Patients with active enthesitis were compared to others in terms of these clinical parameters. A total of 1130 patients were enrolled in this observational study. Of these patients, 251 (22.2%) had active enthesitis according to the clinical assessment. TJC, HAQ-s, BASDAI, FiRST and PsAQoL were significantly higher whereas the SF-36 scores were lower in patients with enthesitis (p < 0.05). Chronic back pain, dactylitis, and tenosynovitis were more frequent in the enthesopathy group (59.4%/39%, 13.1%/6.5% and 24.7%/3.4%, respectively). Significant positive correlations between the MASES score and the TJC, HAQ, DAS 28-ESR, BASDAI, FiRST and PsAQoL scores, and a negative correlation with the SF-36 score were found. When linear regression analysis was performed, the SF-36 MCS and PCS scores decreased by − 9.740 and − 11.795 units, and the FiRST scores increased by 1.223 units in patients with enthesitis. Enthesitis is an important involvement of PsA with significant relations to quality of life determined with PsAQoL and SF-36 scores. Our study found higher frequency of dactylitis and chronic back pain, and worse quality of life determined with SF-36 and PsAQoL scores in patients with enthesitis. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature

Enthesitis and its relationship with disease activity, functional status, and quality of life in psoriatic arthritis: a multi-center study

PMID = 3177339