Sneddon's syndrome: clinical and laboratory analysis of 10 cases.

Sneddon's syndrome is characterized by livedo reticularis and cerebrovascular lesions. We report the cases of women (mean age, 36.2 +/- 8.1 years) diagnosed with Sneddon's syndrome based on the presence of livedo reticularis and characteristic cerebrovascular findings. Seven of these patients had cerebral infarcts on cranial computed tomography scan. Antiphospholipid antibodies were positive in 6 of these cases. Three cases had abnormal levels of antithrombin III. Analyses of chromosome 6 revealed no abnormalities. In 3 of the cases, investigation of the pedigrees revealed autosomal dominant traits. Two cases had epilepsy, and 3 had migraine. One case with migraine also had myasthenia gravis. In addition, we detected inferior altudinal hemianopia in 2 cases, cognitive functional disorder in 3 and depression in 2. Based on these findings, the entire vascular, haematologic, neurologic, and dermatologic systems should be evaluated in patients diagnosed with Sneddon's syndrome.</p

New Alien Mediterranean Biodiversity Records (August 2022)

In this Collective Article on alien and cryptogenic diversity in the Mediterranean Sea we report a total of 19 species belonging to nine Phyla and coming from nine countries. Several of these records concern fish species, and of particular interest are the first records of: Terapon puta for Italian waters; Pteragopus trispilus from Malta; Plotosus lineatus from Cyprus; and the northernmost Mediterranean record of Lagocephalus sceleratus. The northernmost Mediterranean record was also reported for the sea urchin Diadema setosum. The portunid crab Thalamita poissonii was recorded for the first time in Libya. The copepod Pseudodiaptomus marinus was recorded for the first time in the Marmara Sea. The polychaete Branchiomma luctuosum was recorded for the first time from the Mediterranean coast of France. The alien anemone Diadumene lineata was recorded for the first time from Slovenia. The macroalgae Sargassum furcatum was recorded for the first time from Italy. The new Mediterranean records here reported help tracing abundance and distribution of alien and cryptic species in the Mediterranean Sea

Epidemiology of pemphigus in Turkey: One-year prospective study of 220 cases

Pemphigus is a group of rare and life-threatening autoimmune blistering diseases of the skin and mucous membranes. Although they occur worldwide, their incidence shows wide geographical variation, and prospective data on the epidemiology of pemphigus are very limited. Objective of this work is to evaluate the incidence and epidemiological and clinical features of patients with pemphigus in Turkey. All patients newly diagnosed with pemphigus between June 2013 and June 2014 were prospectively enrolled in 33 dermatology departments in 20 different provinces from all seven regions of Turkey. Disease parameters including demography and clinical findings were recorded. A total of 220 patients were diagnosed with pemphigus during the 1-year period, with an annual incidence of 4.7 per million people in Turkey. Patients were predominantly women, with a male to female ratio of 1:1.41. The mean age at onset was 48.9 years. Pemphigus vulgaris (PV) was the commonest clinical subtype (n=192; 87.3%), followed by pemphigus foliaceus (n=21; 9.6%). The most common clinical subtype of PV was the mucocutaneous type (n=83; 43.2%). The mean Pemphigus Disease Area Index was 28.14±22.21 (mean ± Standard Deviation).  The incidence rate of pemphigus in Turkey is similar to the countries of South-East Europe, higher than those reported for the Central and Northern European countries and lower than the countries around the Mediterranean Sea and Iran. Pemphigus is more frequent in middle-aged people and is more common in women. The most frequent subtype was PV, with a 9-fold higher incidence than pemphigus foliaceus.   </p

Investigating thermal comfort in an automobile compartment at different enviromental conditions

Isıl konforu etkileyen çevresel parametreler iç ortam sıcaklığı, bağıl nemi, ortalama ışınım sıcaklığı ve kişi üzerindeki hava hızlarıdır. Bu çalışmada otomobillerin ısıtma ve soğutma süreçlerinde sürekli değişen ve kabin içinde düzensiz bir dağılım gösteren ısıl konfor parametrelerinin sürücünün fizyolojik tepkilerine ve ısıl konforuna olan etkileri deneysel ve teorik yöntemlerle incelenmiştir.Yaz ve kış şartlarında yürütülen deneysel çalışmalarda, kabin içinde yolcuların diz ve baş hizalarına gelecek 8 noktadan ve sürücü vücut bölmeleri etrafından ise 11 farklı noktadan hava sıcaklığı, sürücü etrafında 17 noktadan hava hızı, sürücü baş hizasından ise bağıl nem ve karbondioksit miktarı ölçümleri alınmıştır. Ortalama ışınım sıcaklığı ise tabandan 0.6 metre yüksekliğe konumlandırılan bir siyah küresel termometre ölçümlerinin aynı noktadan alınan hava sıcaklığı ve hava hızı ölçümleri ile düzeltilmesi sonucunda hesaplanmıştır. Belirlenen ortam şartlarının sürücünün fizyolojik tepkileri ve ısıl konforu üzerindeki etkilerinin belirlenmesi amacıyla sürücünün deri yüzey sıcaklıkları 12 ayrı vücut bölmesi üzerinden ölçülmüş ve deneyler süresince deneklere ısıl konfor algılarının sorgulandığı anketler uygulanmıştır. Deneysel çalışmalar 2 faklı menfez çalışma konumu (yalnız orta konsol üzerindeki 4 adet hareketli menfezin açık tutulması, ayak ve ön cam altındaki buğu veya buz giderici menfezlerinin birlikte açık tutulması) ve menfez çıkış havasının 3 farklı hız kademesi (yavaş, orta, hızlı) için tekrarlanmış ve elde edilen sonuçlar karşılaştırılmıştır.Teorik çalışmalar 2 kısımda yürütülmüştür. 1. kısımda anlık enerji dengesi modeli kullanılarak sürücünün çevresi ile olan ısıl etkileşimini, vücut sıcaklıklarını ve denetim mekanizmalarının etkilerini çözümleyen dinamik, sürekli ve kapalı döngülü modelin matematiksel denklemi kurulmuş ve bağ grafiği yöntemi ile Matlab-Simulink ortamına aktarılmıştır. Yerel konforsuzlukların da hesaplanabilmesi için insan vücudu 16 bölmeye ayrılarak modellenmiştir. 2. kısımda ise dış ortam sıcaklığı, rüzgar veya taşıt hızı, güneş ışınımı gibi dış ortam parametrelerinin etkisinde kabin iç ortam sıcaklığı ve ortalama ışınım sıcaklığı gibi ısıl konfor parametrelerini kütle ve enerjinin korunumu yasalarından yola çıkarak tahmin edebilen model hazırlanmıştır. Kabini oluşturan malzemelerin optiksel ve termofiziksel özelliklerinin iç ortam şartlarına ve sürücünün ısıl konforuna olan etkisi simülasyon sonuçları karşılaştırılarak incelenmiştir.Otomobillerde ısıtma süreçlerinde ayak ve ön cam menfezlerinin birlikte açık tutulması ile sürücü üzerinde daha homojen sıcaklık dağılımları elde edilmiştir. Orta konsol menfezlerinden çıkan hava sürücünün elleri ve kolları ile direk temas halinde olması bu vücut bölmeleri üzerinde yüksek hızlarda hava hareketleri oluşturmaktadır. Bu vücut bölmeleri üzerinde hava hızlarının yüksek olması ısı kayıplarını arttırmış ve deri yüzey sıcaklıklarını düşürerek yerel konforsuzlara neden olmuştur. Otomobillerde ısıtma sürecinde yüzey sıcaklıklarının hava sıcaklığından daha geç ısınması nedeniyle ısı kayıpları büyük miktarda ışınım yoluyla olmaktadır.Hazırlanan simülasyonda, otomobil camlarının güneş ışınımı yutma katsayısı ve güneş ışınımı geçirme katsayısının, taşıt boyasında güneş ışınımı yutma katsayının düşük tutulması ve kabin yüzeylerindeki yalıtım malzemesi kalınlığının arttırılması ile kabin içinde ısıl konfor şartlarının sağlanabilmesi için soğutma ünitesinden çekilen güç önemli oranda azaltılmıştır.Parameters affecting the thermal comfort are; air temperature, relative humidity, mean radiant temperature and air velocities on human body segments. At this study, the effects of nonuniform and highly transient thermal comfort parameters on physiological reactions and thermal sensation of a driver during the heating and cooling periods in an automobile were investigated both experimentally and theoretically. Experiments were performed both summer and winter conditions. In order to determined temperature distribution in automobile, data were taken from knee and head levels of four seats. In addition to that, temperatures and velocities around the human body segments were measured at 11 and 17 different points respectively. Relative humidity and measurements were performed from the head region of the driver. To obtain mean radiant temperature, globe thermometer was placed 0.6 m height from the floor level and the data were taken from globe thermometer were corrected with air temperature and velocity measurements around the globe thermometer. Two different ventilation modes (instrumental panel vents, foot and windshield vents) and three velocity step of HVAC system were tested in the experiments.Theoretical studies were executed as two steps. In the first step, dynamic and close loop Matlab-Simulink model of the human body was developed to simulate thermal interactions between the driver and environment, driver body temperatures and behaviour of the thermoregulatory control mechanism. In the simulation, the human body separated to 16 body segments to predict local dissatisfactions.In the second step, thermal behaviour simulation of the passenger compartment was prepared to benefit from thermodynamic's basic laws. With the model interior air temperature and mean radiant temperature can be calculated for different states of sun radiation, car speed, and ambient temperature. The effects of optical and thermophysical properties of the compartment metarials to interior thermal conditions and driver thermal comfort were investigated. Experimental studies revealed that for the same conditions foot and windshield vents mode was more efficient to obtain homogeneous temperature distribution on the driver during the heating periods. For panel vents mode high air velocities affect driver body segments especially arms and hands owing to exposed vent air directly. This couses considerable temperature decline and low thermal sensations at skin surfaces.Simulation results were conclused that cooling loads, can be reduced after a vehicle parked inthe sun with increasing insulation thickness and using solar reflective glass and paint.FIAT TOFA

An approach to adnexal masses in pregnancy: Presentation of three operated cases and review of the literature

Gebelikte saptanan adneksiyel kitlelerin yönetimi kitlenin saptandığı gebelik haftası, semptomatolojisi, ultrasonografi ve muayene bulguları doğrultusunda düşü- nülen ön tanıya göre, ailenin de görüşü alınarak şekillendirilir. Makalede, gebelikte saptanan adneksiyel kitle nedeniyle opere ettiğimiz üç olguda (endometrioma, dermoid kist, müsinöz kistadenom) sergilenen klinik yaklaşım tarzı, histopatolojik bulgular, anne ve fetus açısından gebelik prognozları sunularak, konu güncel literatürün ışığında tartışıldı.Management of adnexal masses detected during pregnancy is modeled in consideration of the initial diagnosis based upon gestational week when the mass is found, symptomatology, ultrasonography and examination findings, as well as the opinion of the family. In the present article clinical approach, histopathological findings, pregnancy prognosis for the mother and the fetus in three cases we operated (endometrioma, dermoid cyst, mucinous cystadenoma) for adnexal mass found during pregnancy are presented, and the subject is discussed in the light of contemporary literature

An approach to adnexal masses in pregnancy: Presentation of three operated cases and review of the literature

Gebelikte saptanan adneksiyel kitlelerin yönetimi kitlenin saptandığı gebelik haftası, semptomatolojisi, ultrasonografi ve muayene bulguları doğrultusunda düşü- nülen ön tanıya göre, ailenin de görüşü alınarak şekillendirilir. Makalede, gebelikte saptanan adneksiyel kitle nedeniyle opere ettiğimiz üç olguda (endometrioma, dermoid kist, müsinöz kistadenom) sergilenen klinik yaklaşım tarzı, histopatolojik bulgular, anne ve fetus açısından gebelik prognozları sunularak, konu güncel literatürün ışığında tartışıldı.Management of adnexal masses detected during pregnancy is modeled in consideration of the initial diagnosis based upon gestational week when the mass is found, symptomatology, ultrasonography and examination findings, as well as the opinion of the family. In the present article clinical approach, histopathological findings, pregnancy prognosis for the mother and the fetus in three cases we operated (endometrioma, dermoid cyst, mucinous cystadenoma) for adnexal mass found during pregnancy are presented, and the subject is discussed in the light of contemporary literature

Habituation of auditory event-related potentials in patients with Behcet's disease

kavak, ayse/0000-0002-4679-1181WOS: 000225978500003PubMed: 15624083Behcet's disease is a progressive and/or relapsing-remitting multisystem inflammatory disorder. Involvement of the central nervous system occurs in 10%-29% of cases with Behcet's disease. The aim of the present study was to assess the effect of repetitive auditory stimulations on event-related potentials (ERP) in patients with Behcet's without neurologic manifestations. The study was performed in 14 patients with Behcet's disease and 14 healthy volunteers. ERPs were recorded from Fz, Cz and Pz. The auditory ERPs test was continued until 20 artefact-free rare tones were averaged, which was accepted as one trial block. After six blocks were obtained in a sequential manner, the test was completed. According to the results of the present study, P300 latency changed in different manners over trial blocks in the two groups. P300 latency values showed a progressive increase in the controls; however this was not determined in the Behcet's group. Thus, habituation was not observed in the patient group. Because of the lack of habituation related to P300 latency, it may be thought that there is an insidious pathologic process in Behcet's disease without neurologic manifestation