Digital interaction: where are we going?

In the framework of the AVI 2018 Conference, the interuniversity center ECONA has organized a thematic workshop on "Digital Interaction: where are we going?". Six contributions from the ECONA members investigate different perspectives around this thematic

A Holocene tephra layer within coastal aeolian deposits north of Caleta Olivia (Santa Cruz Province, Argentina)

In this paper we illustrate the stratigraphy, geochronology, and geochemistry (major, minor, trace elements and Sr-isotopes) of a Holocene tephra layer found within coastal sedimentary deposits north of Caleta Olivia (Santa Cruz Province, Argentina). The stratigraphic succession comprises beach deposits with basal erosive surface resting on the local substrate (“Formación Patagonia”) followed by a poorly developed paleosoil. The paleosoil is covered by a lenticular fine grained (Mdφ: 5.2, 0.027 mm), well sorted (σφ: 1.2) volcanic ash layer and aeolian sands. The geochemical composition of shard fragments points to an origin from the Hudson volcano, located in the southern Andes, ca. 400 km to the west. The geochemistry, Sr-isotopes and the radiometric constraints (younger than the age of the underlying marine layer dated at ca. 4,100 a cal BP) further allow correlating this tephra with the so-called H2 eruption (ca. 3,900 a cal BP). This finding is of interest owing to the poor preservation potential of tephra within the Late Holocene sedimentary deposits of the Atlantic coast of Patagonia and represents the first finding of H2 eruption in this area, improving our knowledge of the dispersion of the fine-grained distal deposit of the Hudson volcanic explosive activity, thus allowing a better estimate of the eruptive dynamics and the risks associated with the Hudson volcano

Evidence-based tailored nutrition educational intervention improves adherence to dietary guidelines, anthropometric measures and serum metabolic biomarkers in early-stage breast cancer patients: A prospective interventional study

Purpose: The impact of the adherence to dietary guidelines of early-stage breast cancer (EBC) patients on body composition changes during treatment is not entirely defined. This study aimed to evaluate the role of an evidence-based nutrition educational intervention, according to adherence to dietary guidelines, in EBC patients. Methods: This prospective study included EBC patients, candidates for neoadjuvant/adjuvant therapy. Patients received an evidence-based tailored nutrition educational intervention. The adherence to dietary guidelines, anthropometric and dietary assessments, and blood glucose and lipid profile tests were evaluated at baseline and after a 12-months nutritional intervention. Results: Two hundred and forty-three patients were enrolled. At baseline, 38.3% and 23.9% of patients were overweight and obese, weight gain ≥5% (compared to 6-months before enrollment) and central obesity were observed in 47.3% and 52.7% of patients, respectively. Adherence to dietary guidelines was low (median Med-Diet score: 6 [IQR 4-8]). After the nutritional intervention (median follow-up: 22 months [range 12-45]), adherence to dietary guidelines significantly increased (median Med-Diet score: 12 [IQR 8-13]), p < 0.0001). High adherence to dietary guidelines (defines as Med-Diet score ≥10) significantly correlated with: 1) overall weight loss ≥5% (21.8% vs. 2.5%, p = 0.003); 2) median BMI drop (from 25.6 kg/m2 to 24.4 kg/m2, p = 0.003); 3) lower prevalence of central obesity (38.2% vs. 7.2%, p = 0.01); 4) improvement in blood glucose levels and lipid profile. Conclusion: This study suggests that an evidence-based tailored nutrition educational intervention during treatment for EBC significantly increases overall adherence to dietary guidelines, and it improves both anthropometric measures and serum metabolic biomarkers in patients with high adherence

Una capa de tefra holocena intercalada en los depósitos eólicos costeros ubicados al norte de Caleta Olivia (Provincia de Santa Cruz, Argentina)

In this paper we illustrate the stratigraphy, geochronology, and geochemistry (major, minor, trace elements and Sr-isotopes) of a Holocene tephra layer found within coastal sedimentary deposits north of Caleta Olivia (Santa Cruz Province, Argentina). The stratigraphic succession comprises beach deposits with basal erosive surface resting on the local substrate (“Formacion Patagonia”) followed by a poorly developed paleosoil. The paleosoil is covered by a lenticular fine-grained (Mdφ: 5.2, 0.027 mm), well sorted (σφ: 1.2) volcanic ash layer and aeolian sands. The geochemical composition of shard fragments points to an origin from the Hudson volcano, located in the southern Andes, ca. 400 km to the west. The geochemistry, Sr-isotopes and the radiometric constraints (younger than the age of the underlying marine layer dated at ca. 4,100 a cal BP) further allow correlating this tephra with the so-called H2 eruption (ca. 3,900 a cal BP). This finding is of interest owing to the poor preservation potential of tephra within the Late Holocene sedimentary deposits of the Atlantic coast of Patagonia and represents the first finding of H2 eruption in this area, improving our knowledge of the dispersion of the fine-grained distal deposit of the Hudson volcanic explosive activity, thus allowing a better estimate of the eruptive dynamics and the risks associated with the Hudson volcano.Este artículo aborda la estratigrafía, geocronología y geoquímica (elementos mayoritarios, minoritarios, trazas e isótopos de Sr) de un nivel de tefra holocena que forma parte de una secuencia de sedimentos costeros ubicados al norte de Caleta Olivia (provincia de Santa Cruz, Argentina). La secuencia comprende depósitos sedimentarios que se disponen sobre una superficie basal erosiva que suprayace al sustrato local (“Formación Patagonia”), y continúa esta secuencia con un paleosuelo de escaso desarrollo. El paleosuelo está cubierto por una capa lenticular de cenizas volcánicas de grano fino (Mdφ: 5,2, 0,027 mm), bien seleccionada (σφ: 1,2) y arenas eólicas. La composición geoquímica de los shards indica que esta tefra se originó en el volcán Hudson, ubicado en los Andes del sur, a aproximadamente 400 km hacia el oeste. La geoquímica, los isótopos de Sr y las restricciones radiométricas (más joven que la edad de la capa marina que la subyace, fechada en aproximadamente 4.100 a cal AP) permiten correlacionar esta tefra con la denominada erupción H2 de dicho volcán (ocurrida aproximadamente 3.900 a cal AP). Este hallazgo es de interés debido al escaso potencial de preservación de los depósitos de tefra dentro de las secuencias sedimentarias costeras del Holoceno Tardío, en la costa atlántica de Patagonia y representa el primer hallazgo del evento eruptivo H2 en esta área, lo cual contribuye a mejorar el conocimiento sobre la dispersión de la tefra generada por la actividad volcánica explosiva del volcán Hudson, lo que permite una mejor estimación de la dinámica eruptiva y los riesgos asociados con este volcán.Centro de Estudios Integrales de la Dinámica Exógen

In vivo migration of labeled autologous natural killer cells to liver metastases in patients with colon carcinoma

BACKGROUND: Besides being the effectors of native anti-tumor cytotoxicity, NK cells participate in T-lymphocyte responses by promoting the maturation of dendritic cells (DC). Adherent NK (A-NK) cells constitute a subset of IL-2-stimulated NK cells which show increased expression of integrins and the ability to adhere to solid surface and to migrate, infiltrate, and destroy cancer. A critical issue in therapy of metastatic disease is the optimization of NK cell migration to tumor tissues and their persistence therein. This study compares localization to liver metastases of autologous A-NK cells administered via the systemic (intravenous, i.v.) versus locoregional (intraarterial, i.a.) routes. PATIENTS AND METHODS: A-NK cells expanded ex-vivo with IL-2 and labeled with (111)In-oxine were injected i.a. in the liver of three colon carcinoma patients. After 30 days, each patient had a new preparation of (111)In-A-NK cells injected i.v. Migration of these cells to various organs was evaluated by SPET and their differential localization to normal and neoplastic liver was demonstrated after i.v. injection of (99m)Tc-phytate. RESULTS: A-NK cells expressed a donor-dependent CD56(+)CD16(+)CD3(- )(NK) or CD56(+)CD16(+)CD3(+ )(NKT) phenotype. When injected i.v., these cells localized to the lung before being visible in the spleen and liver. By contrast, localization of i.a. injected A-NK cells was virtually confined to the spleen and liver. Binding of A-NK cells to liver neoplastic tissues was observed only after i.a. injections. CONCLUSION: This unique study design demonstrates that A-NK cells adoptively transferred to the liver via the intraarterial route have preferential access and substantial accumulation to the tumor site

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

The double sustainability: The link between government debt and renewable energy

This paper innovatively explores the relationship between a country's government debt and the use of renewable energy. Incorporating key socio-economic and financial variables, critical to the United Nations SDG-7, we build a panel dataset for G7 countries from 1990-2021. Using cointegrating regression methods (FMOLS and DOLS), Quantile Regressions (QR) and pairwise panel causality tests, we find bidirectional causality between government debt and renewable energy consumption (REC). The empirical findings emphasize the important policy implications for sustainable economic development. Escalating government debt can hinder investment in renewable energy infrastructure, while increased renewable energy has a positive impact on government debt dynamics. Policymakers are encouraged to prioritize fiscal responsibility to secure resources for renewable energy investments. Moreover, incentivizing renewable energy deployment promotes long-term fiscal benefits and creates a positive feedback loop. In fact, a comprehensive understanding of the relationship between government finances and environmental sustainability is crucial for an optimal balance

Poteri, relazioni, guerra nel regno di Ferrante d’Aragona. Studi sulle corrispondenze diplomatiche.

Il volume raccoglie una serie di studi nati attorno all’impresa di edizione delle corrispondenze diplomatiche milanesi e fiorentine da Napoli in età aragonese, in particolare negli anni di Ferrante d’Aragona (1458-’94). Essi spaziano dalla storia della guerra e del territorio alla prosopografia, dalla ricostruzione delle reti di relazione negli ambienti cortigiani alla politica internazionale, dalla geografia feudale ai conflitti tra la monarchia e l’aristocrazia. Ne risulta un importante incremento delle nostre conoscenze sul regno di Napoli, reso possibile dallo studio ampio e sistematico della fonte diplomatica, che viene valutata nei suoi differenti gradi di attendibilità con il concorso delle altre fonti disponibili, regnicole e non, e utilizzata nella varietà delle sue potenzialità informative

Ocean acidification, warming and feeding impacts on biomineralization pathways and shell material properties of Magallana gigas and Mytilus spp.

Molluscs are among the organisms affected by ocean acidification (OA), relying on carbon for shell biomineralization. Metabolic and environmental sourcing are two pathways potentially affected by OA, but the circumstances and patterns by which they are altered are poorly understood. From previous studies, mollusc shells grown under OA appear smaller in size, brittle and thinner, suggesting an important alteration in carbon sequestration. However, supplementary feeding experiments have shown promising results in offsetting the negative consequences of OA on shell growth. Our study compared carbon uptake by δ13C tracing and deposition into mantle tissue and shell layers in Magallana gigas and Mytilus species, two economically valuable and common species. After subjecting the species to 7.7 pH, +2 °C seawater, and enhanced feeding, both species maintain shell growth and metabolic pathways under OA without benefitting from extra feeding, thus, showing effective acclimation to rapid and short-term environmental change. Mytilus spp. increases metabolic carbon into the calcite and environmental sourcing of carbon into the shell aragonite in low pH and high temperature conditions. Low pH affects M. gigas mantle nitrogen isotopes maintaining growth. Calcite biomineralization pathway differs between the two species and suggests species-specific response to OA