1,190 research outputs found
Theory of pixel lensing towards M31 I: the density contribution and mass of MACHOs
POINT-AGAPE is an Anglo-French collaboration which is employing the Isaac
Newton Telescope (INT) to conduct a pixel-lensing survey towards M31. In this
paper we investigate what we can learn from pixel-lensing observables about the
MACHO mass and fractional contribution in M31 and the Galaxy for the case of
spherically-symmetric near-isothermal haloes. We employ detailed pixel-lensing
simulations which include many of the factors which affect the observables. For
a maximum MACHO halo we predict an event rate in V of up to 100 per season for
M31 and 40 per season for the Galaxy. However, the Einstein radius crossing
time is generally not measurable and the observed full-width half-maximum
duration provides only a weak tracer of lens mass. Nonetheless, we find that
the near-far asymmetry in the spatial distribution of M31 MACHOs provides
significant information on their mass and density contribution. We present a
likelihood estimator for measuring the fractional contribution and mass of both
M31 and Galaxy MACHOs which permits an unbiased determination to be made of
MACHO parameters, even from data-sets strongly contaminated by variable stars.
If M31 does not have a significant population of MACHOs in the mass range
0.001-1 Solar masses strong limits will result from the first season of INT
observations. Simulations based on currently favoured density and mass values
indicate that, after three seasons, the M31 MACHO parameters should be
constrained to within a factor four uncertainty in halo fraction and an order
of magnitude uncertainty in mass (90% confidence). Interesting constraints on
Galaxy MACHOs may also be possible. For a campaign lasting ten years,
comparable to the lifetime of current LMC surveys, reliable estimates of MACHO
parameters in both galaxies should be possible. (Abridged)Comment: 21 pages, 14 figures. Submitted to MNRA
Characterization of a POROS\u3csup\u3eTM\u3c/sup\u3e-fumonisin B1 Affinity Column for Isolating Ceramide Synthase from Rat Liver
Fumonisin B1 is a mycotoxin produced by fungi of the genus Fusarium, common pathogens of corn and other grain plants. Toxic effects associated with fumonisin B1 include equine leukoencephalomacia, porcine pulmonary edema, rat renal carcinoma, and murine hepatocellular carcinoma. Increased risk for esophageal cancer in humans has been epidemiologically associated with consumption of corn contaminated with Fusarium, suggesting that fumonisin B1 may be involved. The biological effects of fumonisin B1 exposure result primarily from disruption of de novo sphingolipid biosynthesis via inhibition of ceramide synthase. Exposure of animals or cultured cells to fumonisin B1 results in the characteristic accumulation of sphinganine, a toxic sphingolipid intermediate, concomitant with depletion of essential complex sphingolipids. Ceramide synthase has not been purified to homogeniety and characterized. We prepared crude ceramide synthase from detergent-extracted rat liver homogenates using PEG-precipitation and cation exchange chromatography. Ceramide synthase activity was then sequestered, using fumonisin B1 covalently coupled to POROS-NH particles, and eluted selectively. The observed 119-fold enrichment in specific activity demonstrates the utility of fumonisin-POROS affinity chromatography in the purification of ceramide synthase
Signals for Lorentz Violation in Post-Newtonian Gravity
The pure-gravity sector of the minimal Standard-Model Extension is studied in
the limit of Riemann spacetime. A method is developed to extract the modified
Einstein field equations in the limit of small metric fluctuations about the
Minkowski vacuum, while allowing for the dynamics of the 20 independent
coefficients for Lorentz violation. The linearized effective equations are
solved to obtain the post-newtonian metric. The corresponding post-newtonian
behavior of a perfect fluid is studied and applied to the gravitating many-body
system. Illustrative examples of the methodology are provided using bumblebee
models. The implications of the general theoretical results are studied for a
variety of existing and proposed gravitational experiments, including lunar and
satellite laser ranging, laboratory experiments with gravimeters and torsion
pendula, measurements of the spin precession of orbiting gyroscopes, timing
studies of signals from binary pulsars, and the classic tests involving the
perihelion precession and the time delay of light. For each type of experiment
considered, estimates of the attainable sensitivities are provided. Numerous
effects of local Lorentz violation can be studied in existing or near-future
experiments at sensitivities ranging from parts in 10^4 down to parts in
10^{15}.Comment: 46 pages two-column REVTeX, accepted in Physical Review
Individual scatterers as microscopic origin of equilibration between spin- polarized edge channels in the quantum Hall regime
The equilibration length between spin-polarized edge states in the Quantum
Hall regime is measured as a function of a gate voltage applied to an electrode
on top of the edge channels. Reproducible fluctuations in the coupling are
observed and interpreted as a mesoscopic fingerprint of single spin-flip
scatterers which are turned on and off. A model to analyze macroscopic edge
state coupling in terms of individual scatterers is developed, and
characteristic values for these scatterers in our samples are extracted. For
all samples investigated, the distance between spin-flip scatterers lies
between the Drude and the quantum scattering length.Comment: 4 pages, 2 figure
CLASH-VLT: A Highly Precise Strong Lensing Model of the Galaxy Cluster RXC J2248.7-4431 (Abell S1063) and Prospects for Cosmography
We perform a comprehensive study of the total mass distribution of the galaxy
cluster RXCJ2248 () with a set of high-precision strong lensing
models, which take advantage of extensive spectroscopic information on many
multiply lensed systems. In the effort to understand and quantify inherent
systematics in parametric strong lensing modelling, we explore a collection of
22 models where we use different samples of multiple image families,
parametrizations of the mass distribution and cosmological parameters. As input
information for the strong lensing models, we use the CLASH HST imaging data
and spectroscopic follow-up observations, carried out with the VIMOS and MUSE
spectrographs, to identify bona-fide multiple images. A total of 16 background
sources, over the redshift range , are multiply lensed into 47 images,
24 of which are spectroscopically confirmed and belong to 10 individual
sources. The cluster total mass distribution and underlying cosmology in the
models are optimized by matching the observed positions of the multiple images
on the lens plane. We show that with a careful selection of a sample of
spectroscopically confirmed multiple images, the best-fit model reproduces
their observed positions with a rms of in a fixed flat CDM
cosmology, whereas the lack of spectroscopic information lead to biases in the
values of the model parameters. Allowing cosmological parameters to vary
together with the cluster parameters, we find (at confidence level)
and for a flat
CDM model, and and
for a universe with and free
curvature. Using toy models mimicking the overall configuration of RXCJ2248, we
estimate the impact of the line of sight mass structure on the positional rms
to be .(ABRIDGED)Comment: 23 pages, 13 figures, accepted for publication in A&
Lines, Circles, Planes and Spheres
Let be a set of points in , no three collinear and not
all coplanar. If at most are coplanar and is sufficiently large, the
total number of planes determined is at least . For similar conditions and
sufficiently large , (inspired by the work of P. D. T. A. Elliott in
\cite{Ell67}) we also show that the number of spheres determined by points
is at least , and this bound is best
possible under its hypothesis. (By , we are denoting the
maximum number of three-point lines attainable by a configuration of
points, no four collinear, in the plane, i.e., the classic Orchard Problem.)
New lower bounds are also given for both lines and circles.Comment: 37 page
The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes
In the proximity of melting transitions of artificial and biological
membranes fluctuations in enthalpy, area, volume and concentration are
enhanced. This results in domain formation, changes of the elastic constants,
changes in permeability and slowing down of relaxation processes. In this study
we used pressure perturbation calorimetry to investigate the relaxation time
scale after a jump into the melting transition regime of artificial lipid
membranes. This time corresponds to the characteristic rate of domain growth.
The studies were performed on single-component large unilamellar and
multilamellar vesicle systems with and without the addition of small molecules
such as general anesthetics, neurotransmitters and antibiotics. These drugs
interact with membranes and affect melting points and profiles. In all systems
we found that heat capacity and relaxation times are related to each other in a
simple manner. The maximum relaxation time depends on the cooperativity of the
heat capacity profile and decreases with a broadening of the transition. For
this reason the influence of a drug on the time scale of domain formation
processes can be understood on the basis of their influence on the heat
capacity profile. This allows estimations of the time scale of domain formation
processes in biological membranes.Comment: 12 pages, 6 figure
Difference Image Analysis of Galactic Microlensing I. Data Analysis
This is a preliminary report on the application of Difference Image Analysis
(DIA) to galactic bulge images. The aim of this analysis is to increase the
sensitivity to the detection of gravitational microlensing. We discuss how the
DIA technique simplifies the process of discovering microlensing events by
detecting only objects which have variable flux. We illustrate how the DIA
technique is not limited to detection of so called ``pixel lensing'' events,
but can also be used to improve photometry for classical microlensing events by
removing the effects of blending. We will present a method whereby DIA can be
used to reveal the true unblended colours, positions and light curves of
microlensing events. We discuss the need for a technique to obtain the accurate
microlensing time scales from blended sources, and present a possible solution
to this problem using the existing HST colour magnitude diagrams of the
galactic bulge and LMC. The use of such a solution with both classical and
pixel microlensing searches is discussed. We show that one of the major causes
of systematic noise in DIA is differential refraction. A technique for removing
this systematic by effectively registering images to a common airmass is
presented. Improvements to commonly used image differencing techniques are
discussed.Comment: 18 pages, 8 figures, uses AAS LaTEX 4.0, To appear in Astrophysical
Journa
CLASH-VLT: The mass, velocity-anisotropy, and pseudo-phase-space density profiles of the z=0.44 galaxy cluster MACS 1206.2-0847
We use an unprecedented data-set of about 600 redshifts for cluster members,
obtained as part of a VLT/VIMOS large programme, to constrain the mass profile
of the z=0.44 cluster MACS J1206.2-0847 over the radial range 0-5 Mpc (0-2.5
virial radii) using the MAMPOSSt and Caustic methods. We then add external
constraints from our previous gravitational lensing analysis. We invert the
Jeans equation to obtain the velocity-anisotropy profiles of cluster members.
With the mass-density and velocity-anisotropy profiles we then obtain the first
determination of a cluster pseudo-phase-space density profile. The kinematics
and lensing determinations of the cluster mass profile are in excellent
agreement. This is very well fitted by a NFW model with mass M200=(1.4 +- 0.2)
10^15 Msun and concentration c200=6 +- 1, only slightly higher than theoretical
expectations. Other mass profile models also provide acceptable fits to our
data, of (slightly) lower (Burkert, Hernquist, and Softened Isothermal Sphere)
or comparable (Einasto) quality than NFW. The velocity anisotropy profiles of
the passive and star-forming cluster members are similar, close to isotropic
near the center and increasingly radial outside. Passive cluster members follow
extremely well the theoretical expectations for the pseudo-phase-space density
profile and the relation between the slope of the mass-density profile and the
velocity anisotropy. Star-forming cluster members show marginal deviations from
theoretical expectations. This is the most accurate determination of a cluster
mass profile out to a radius of 5 Mpc, and the only determination of the
velocity-anisotropy and pseudo-phase-space density profiles of both passive and
star-forming galaxies for an individual cluster [abridged]Comment: A&A in press; 22 pages, 19 figure
Neuroactive steroids in depression and anxiety disorders: Clinical studies
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor. During major depression, there is a disequilibrium of 3 alpha-reduced neuroactive steroids, which is corrected by clinically effective pharmacological treatment. To investigate whether these alterations are a general principle of successful antidepressant treatment, we studied the impact of nonpharmacological treatment options on neuroactive steroid concentrations during major depression. Neither partial sleep deprivation, transcranial magnetic stimulation, nor electroconvulsive therapy affected neuroactive steroid levels irrespectively of the response to these treatments. These studies suggest that the changes in neuroactive steroid concentrations observed after antidepressant pharmacotherapy more likely reflect distinct pharmacological properties of antidepressants rather than the clinical response. In patients with panic disorder, changes in neuroactive steroid composition have been observed opposite to those seen in depression. However, during experimentally induced panic induction either with cholecystokinine-tetrapeptide or sodium lactate, there was a pronounced decline in the concentrations of 3 alpha-reduced neuroactive steroids in patients with panic disorder, which might result in a decreased GABAergic tone. In contrast, no changes in neuroactive steroid concentrations could be observed in healthy controls with the exception of 3 alpha,5 alpha-tetrahydrodeoxycorticosterone. The modulation of GABA(A) receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds. Copyright (c) 2006 S. Karger AG, Basel
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