An Introduction To Bach Studies

This volume is a guide to the resources and materials of Bach scholarship, both for the nonspecialist wondering where to begin in the enormous literature on J. S. Bach, and for the Bach specialist looking for a convenient and up-to-date survey of the field. It describes the tools of Bach research and how to use them, and suggests how to get started in Bach research by describing the principal areas of research and citing the essential literature on each piece and topic. The authors emphasize the issues that have engaged Bach scholars for generations, focusing on particularly important writings on recent literature on overviews, collections of essays and handbooks and on writings in English. Subjects covered include bibliographic tools of Bach research and sources of literature Bach\u27s family Bach biographies places Bach lived and worked Bach\u27s teaching the liturgy Bach source studies and the transmission of his music repertory and editions genres and individual vocal and instrumental works performance practice the reception and analysis of Bach\u27s music and many others. The book also offers explanations of important and potentially confusing topics in Bach research, such as the organization of the annual cantata cycles, pitch standards, the history of the Berlin libraries, the structure of the critical commentary volumes in the Neue Bach-Ausgabe, and so on. This book opens up the rich world of Bach scholarship to students, teachers, performers, and listener

Bach\u27s Christmas Oratorio, BWV 248, and the Jews

It has been recognized since the nineteenth century that most of the poetic arias and choruses in J. S. Bach’s Christmas Oratorio BWV 248 are parodies of music composed to other texts. In the early twentieth century it was claimed that at least one gospel narrative chorus was also derived from extant music, a hypothesis subsequently expanded to include several such movements said to be parodies as well. The claims are flimsily argued and are unlikely on source-critical grounds, but they have stuck, persisting in scholarly writings, reference works, and popular literature. The origin of this idea is a 1916 article by one Gerhard Freiesleben, a Leipzig lawyer, Thomasschule graduate, and Wagnerite who asserted that the wise men in Part 5 of Bach’s oratorio sounded not like kings but like cacophonous Jews, and that the setting of their words, unbecoming royalty or Bach, must therefore be parody. He proposed that the origin of this music was one of the “Jew choruses” from the lost St. Mark Passion BWV 247. Later authors took up Freiesleben’s results while sidestepping his crazy argument. In fact the persistence of this theory owes a great deal to an inherited view of the Christmas Oratorio that approaches it primarily in relation to Bach’s passion settings. It is entwined with a scholarly and practical obsession with the St. Mark Passion and to the futile search for its recovery. And it is tied disturbingly to stereotypes of Jews and their musical depiction, even in literature that does not explicitly invoke Jewishness. The claim—the supposed origins of gospel choruses from the Christmas Oratorio in the St. Mark Passion—can safely be set aside as wrong. But its perpetuation calls attention to an unsettling legacy of interpretation of the Christmas Oratorio and other narrative works that we ought to confront, and tainted research that we need to step away from

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide.

Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are deregulated in GBM, including Hedgehog (Hh) signaling. Here, we investigate suppression of Hh signaling as an adjuvant to TMZ using U87-MG and T98G cell lines as in vitro models of GBM. We found that silencing GLI1 with siRNA reduces cell metabolic activity by up to 30% in combination with TMZ and reduces multidrug efflux activity by 2.5-fold. Additionally, pharmacological GLI inhibition modulates nuclear p53 levels and decreases MGMT expression in combination with TMZ. While we surprisingly found that silencing GLI1 does not induce apoptosis in the absence of TMZ co-treatment, we discovered silencing GLI1 without TMZ co-treatment induces senescence as evidenced by a significant 2.3-fold increase in senescence associated β-galactosidase staining, and this occurs in a loss of PTEN-dependent manner. Finally, we show that GLI inhibition increases apoptosis in glioma stem-like cells by up to 6.8-fold in combination with TMZ, and this reduces the size and number of neurospheres grown from glioma stem-like cells. In aggregate, our data warrant the continued investigation of Hh pathway inhibitors as adjuvants to TMZ chemotherapy and highlight the importance of identifying signaling pathways that determine whether co-treatment will be successful

Detection of pollution transport events southeast of Mexico City using ground-based visible spectroscopy measurements of nitrogen dioxide

This work presents ground based differential optical absorption spectroscopy (DOAS) measurements of nitrogen dioxide (NO<sub>2</sub>) during the MILAGRO field campaign in March 2006 at the Tenango del Aire research site located to the southeast of Mexico City. The DOAS NO<sub>2</sub> column density measurements are used in conjunction with ceilometer, meteorological and surface nitric oxide (NO), nitrogen oxides (NO<sub>x</sub>) and total reactive nitrogen (NO<sub>y</sub>) measurements to analyze pollution transport events to the southeast of Mexico City during the MILARGO field campaign. The study divides the data set into three case study pollution transport events that occurred at the Tenango del Aire research site. The unique data set is then used to provide an in depth analysis of example days of each of the pollution transport events. An in depth analysis of 13 March 2006, a Case One day, shows the transport of several air pollution plumes during the morning through the Tenango del Aire research site when southerly winds are present and demonstrates how DOAS tropospheric NO<sub>2</sub> vertical column densities (VCD), surface NO<sub>2</sub> mixing ratios and ceilometer data are used to determine the vertical homogeneity of the pollution layer. The analysis of 18 March 2006, a Case Two day, shows that when northerly winds are present for the entire day, the air at the Tenango del Aire research site is relatively clean and no major pollution plumes are detected. Case 3 days are characterized by relatively clean air throughout the morning with large DOAS NO<sub>2</sub> enhancements detected in the afternoon. The analysis of 28 March 2006 show the DOAS NO<sub>2</sub> enhancements are likely due to lightning activity and demonstrate how suitable ground-based DOAS measruements are for monitoring anthropogenic and natural pollution sources that reside above the mixing layer

Ternary Nitride Semiconductors in the Rocksalt Crystal Structure

Inorganic nitrides with wurtzite crystal structures are well-known semiconductors used in optoelectronic devices. In contrast, rocksalt-based nitrides are known for their metallic and refractory properties. Breaking this dichotomy, here we report on ternary nitride semiconductors with rocksalt crystal structures, remarkable optoelectronic properties, and the general chemical formula Mg$_{x}$TM$_{1-x}$N (TM=Ti, Zr, Hf, Nb). These compounds form over a broad metal composition range and our experiments show that Mg-rich compositions are nondegenerate semiconductors with visible-range optical absorption onsets (1.8-2.1 eV). Lattice parameters are compatible with growth on a variety of substrates, and epitaxially grown MgZrN$_{2}$ exhibits remarkable electron mobilities approaching 100 cm$^{2}$V$^{-1}$s$^{-1}$. Ab initio calculations reveal that these compounds have disorder-tunable optical properties, large dielectric constants and low carrier effective masses that are insensitive to disorder. Overall, these experimental and theoretical results highlight Mg$_{G-3}$TMN$_{G-2}$ rocksalts as a new class of semiconductor materials with promising properties for optoelectronic applications

T-DNA-Genome junctions form early after infection and are influenced by the chromatin state of the host genome

Agrobacterium tumefaciens mediated T-DNA integration is a common tool for plant genome manipulation. However, there is controversy regarding whether T-DNA integration is biased towards genes or randomly distributed throughout the genome. In order to address this question, we performed high-throughput mapping of T-DNA-genome junctions obtained in the absence of selection at several time points after infection. T-DNA-genome junctions were detected as early as 6 hours post-infection. T-DNA distribution was apparently uniform throughout the chromosomes, yet local biases toward AT-rich motifs and T-DNA border sequence micro-homology were detected. Analysis of the epigenetic landscape of previously isolated sites of T-DNA integration in Kanamycin-selected transgenic plants showed an association with extremely low methylation and nucleosome occupancy. Conversely, non-selected junctions from this study showed no correlation with methylation and had chromatin marks, such as high nucleosome occupancy and high H3K27me3, that correspond to three-dimensional-interacting heterochromatin islands embedded within euchromatin. Such structures may play a role in capturing and silencing invading T-DNA