Consistencia y latecoming en aplicaciones colaborativas

A pesar de la existencia de una gran variedad de aplicaciones groupware, que soportan muchas tareas cooperativas, varios estudios de la CSCW encontraron que tales aplicaciones no soportan adecuadamente la variabilidad del trabajo cooperativo en las organizaciones. Sin embargo desarrollar esta clase de aplicaciones es una tarea compleja, dado que involucran diversas áreas de trabajo, tales como sistemas distribuidos, comunicaciones, interfaces humano-computador, bases de datos, y algunas otras áreas más. En aplicaciones groupware que desempeñan funciones en un espacio de trabajo compartido, tales como las aplicaciones colaborativas sincrónicas, es imprescindible mantener alguna clase de consistencia entre dos o más representaciones del mismo espacio de trabajo compartido, a pesar de las actividades concurrentes de los usuarios en el mismo instante de tiempo. Así es que uno de los problemas con los que deben enfrentarse los desarrolladores de tales aplicaciones, es que muchas veces las actividades concurrentes de los usuarios conducen a acciones concurrentes sobre el mismo espacio de trabajo compartido, lo cual puede causar representaciones inconsistentes de la misma información.Tesis digitalizada en SEDICI gracias a la colaboración de la Biblioteca de la Facultad de Informática.Facultad de Informátic

Food Patterns According to Sociodemographics, Physical Activity, Sleeping and Obesity in Portuguese Children

Our study aimed to describe the association between food patterns and gender, parental education, physical activity, sleeping and obesity in 1976 children aged 5−10 years old. Dietary intake was measured by a semi quantitative food frequency questionnaire; body mass index was calculated and categorized according to the IOTF classification. Factor analysis and generalized linear models were applied to identify food patterns and their associations. TV viewing and male gender were significant positive predictors for fast-food, sugar sweetened beverages and pastry pattern, while a higher level of maternal education and longer sleeping duration were positively associated with a dietary patterns that included fruit and vegetables

The effect of fluoride on the structure, function, and proteome of intestinal epithelia.

Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we examined the effects of fluoride on the transepithelial ion transport and resistance of three intestinal epithelia. We used the Caco-2 cell line as a model of human intestinal epithelium, and rat and mouse colonic epithelia for purposes of comparison. Fluoride caused a concentration-dependent decline in forskolin-induced Cl- secretion and transepithelial resistance of Caco-2 cell monolayers, with an IC50 for fluoride of about 3 mM for both parameters. In the presence of 5 mM fluoride, transepithelial resistance fell exponentially with time, with a t1/2 of about 7 hours. Subsequent imaging by immunofluorescence and scanning electron microscopy showed structural abnormalities in Caco-2 cell monolayers exposed to fluoride. The Young's modulus of the epithelium was not affected by fluoride, although proteomic analysis revealed changes in expression of a number of proteins, particularly those involved in cell-cell adhesion. In line with its effects on Caco-2 cell monolayers, fluoride, at 5 mM, also had profound effects on Cl- secretion and transepithelial resistance of both rat and mouse colonic epithelia. Our results show that treatment with fluoride has major effects on the structure, function, and proteome of intestinal epithelia, but only at concentrations considerably higher than those likely to be encountered in vivo, when much lower fluoride doses are normally ingested on a chronic basis

In-depth characterization of NK cell markers from CML patients who discontinued tyrosine kinase inhibitor therapy

IntroductionTreatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase is considered a safe option if suitable molecular monitoring is available. However, the question arises as to which factors can contribute to the maintenance of TFR, and immunologic surveillance of the remaining leukemic cells is believed to be one of them. Argentina Stop Trial is an open-label, single-arm, multicenter trial assessing TFR after tyrosine kinase inhibitors interruption, that after more than 4 years showed a successful TFR rate of 63%.MethodsIn this context, we set up an immunological study by flow cytometry in order to analyze specific NK cell subsets from peripheral blood patient samples both at the time of discontinuation as well as during the subsequent months.ResultsAt the time of discontinuation, patients show a mature NK cell phenotype, probably associated to TKI treatment. However, 3 months after discontinuation, significant changes in several NK cell receptors occurred. Patients with a higher proportion of CD56dim NK and PD-1+ NK cells showed better chances of survival. More interestingly, non-relapsing patients also presented a subpopulation of NK cells with features associated with the expansion after cytomegalovirus infection (expression of CD57+NKG2C+), and higher proportion of NKp30 and NKp46 natural cytotoxicity receptors, which resulted in greater degranulation and associated with better survival (p<0.0001).DiscussionThis NK cell subset could have a protective role in patients who do not relapse, thus further characterization could be useful for patients in sustained deep molecular response

Implementasi Keterampilan Abad 21 Dalam Pembelajaran Sejarah Kebudayaan Islam di Madrasah Tsanawiyah Negeri 1 Kota Malang

مستخلص البحث إن القرن الحادي والعشرين قرن مليء بالتحديات. إن عالم التعليم له دور ومسؤولية أكبر ليتمكن من التغلب على هذه التحديات والاستجابة لها. من بين مهارات القرن الحادي والعشرين التي يجب أن يمتلكها الطلاب هي مهارات 4ج ، وهي التفكير النقدي والتواصل والتعاون والإبداع. اليوم ، تستند مؤشرات النجاح بشكل أكبر على القدرة على التواصل وتبادل واستخدام المعلومات لحل المشكلات المعقدة ، والقدرة على التكيف والابتكار في الاستجابة للطلبات الجديدة والظروف المتغيرة ، وتوسيع قوة التكنولوجيا لخلق معرفة جديدة. ثم يجب أن يكون على دراية بأنشطة التعلم التي تمارس مهارات 4ج نفسها. وكذلك في دراسة التربية الإسلامية خاصة في موضوعات تاريخ الثقافة الإسلامية. يمتلك المعلمون أدوارًا ومسؤوليات مهمة في تطبيق مهارات القرن الحادي والعشرين ، خاصةً 4ج في كل عملية تعلم. أهداف هذه الدراسة هي: (1) لمعرفة تخطيط تعلم التاريخ الثقافي الإسلامي في تطبيق مهارات القرن الحادي والعشرين في المدرسة المتؤسطة الإسلامية الحكومية 1 ، مدينة مالانج. (2) لمعرفة عملية التعلم التاريخ الثقافي الإسلامي في تطبيق مهارات القرن 21 في المدرسة المتؤسطة الإسلامية الحكومية 1 ، مدينة مالانج. (3) لمعرفة تقييم تعلم التاريخ الثقافي الإسلامي في تطبيق مهارات القرن الحادي والعشرين في المدرسة المتؤسطة الإسلامية الحكومية 1 ، مدينة مالانج. طريقة البحث المستخدمة في هذا البحث هي طريقة وصفية وصفية لتحليل البيانات في شكل جمل أو كلمات. هذا النوع من البحث هو دراسة حالة ، لأن الباحثين ينظرون مباشرة إلى المشاكل الموجودة في الموقع ويهتمون بالظروف قيد الدراسة. تقنيات جمع البيانات في شكل الملاحظة والمقابلات والتوثيق. تم تحليل البيانات عن طريق جمع البيانات ، وتقليل البيانات ، وتقديم البيانات وتقديم الاستنتاجات. في هذه الدراسة ، وجد الباحثة العديد من النتائج المتعلقة بتنفيذ مهارات القرن الحادي والعشرين في تعلم التاريخ الثقافي الإسلامي في طلاب الصف السابع في المدرسة المتؤسطة الإسلامية الحكومية 1 ، مدينة مالانج: (1) تخطيط تعلم التاريخ الثقافي الإسلامي في تطبيق مهارات القرن 21 من خلال RPP ووحدة نشاط التعلم المستقل (UKBM) ، كل لدى UKBM نموذج تعليمي واحد وطرق تدريس مختلفة (2) تنفيذ تعلم SKI في تطبيق مهارات القرن الحادي والعشرين من خلال UKBM باستخدام نموذج التعلم النشط مع طريقة الجيوب الودية (3) تقييم تعلم التاريخ الثقافي الإسلامي في تطبيق مهارات القرن الحادي والعشرين لا يتم فقط في نهاية التعلم. بالإضافة إلى اجتياز اختبارات منتصف الفصل الدراسي ، ونهاية امتحانات نهاية الفصل الدراسي والاختبارات اليومية ، يتم إجراء التقييم أيضًا من خلال نتائج أنشطة التعلم في UKBM من خلال الممارسة والاختبارات المكتوبة وغير المكتوبة والشفوية وغير الشفوية. ABSTRACT The 21st century is a century full of challenges. the education world has a greater role and responsibility to be able to overcome and respond to these challenges. Among the 21st century skills that must be possessed by students are the 4C Skills, namely critical thinking, communication, collaboration and creativity. Today, indicators of success are based more on the ability to communicate, share and use information to solve complex problems, be able to adapt and innovate in responding to new demands and changing circumstances, and expanding the power of technology to create new knowledge. Then it needs to be familiarized with learning activities that practice the 4C Skills themselves. Likewise in the study of Islamic Religious Education, especially on SKI subjects. Teachers have important roles and responsibilities in applying 21st century skills, especially 4C in every learning process. The objectives of this study are: (1) To find out the planning of SKI learning in applying 21st century skills in MTsN 1 Malang City (2) To find out the SKI learning process in applying 21st century skills in MTsN 1 Malang City (3) To find out the evaluation of SKI learning in applying 21st century skills in MTsN 1 Malang City. The research method used in this research is descriptive qualitative research method to analyze data in the form of sentences or words. This type of research is a case study, because researchers look directly at the problems found in the location and pay attention to the circumstances under study. Data collection techniques in the form of observation, interviews, and documentation. Data were analyzed by collecting data, reducing data, presenting data and presenting conclusions. In this study, researchers found several findings regarding the implementation of 21st century skills in learning SKI in grade VII students in MTsN 1 Malang City: UKBM has one learning model and various teaching methods (2) the implementation of SKI learning in applying 21st Century skills through UKBM using active learning model with friendly pockets method (3) evaluating SKI learning in applying 21st Century skills is not only done at the end of learning. In addition to going through midterms, end of semester exams and daily tests, assessment is also carried out through the results of learning activities in UKBM through practice, written and non-written tests, oral and non-verbal. ABSTRAK Abad 21 merupakan abad yang penuh dengan berbagai tantangan . dunia pendidikan memiliki peran dan tanggung jawab yang lebih besar untuk dapat mengatasi dan menjawab tantangan tersebut. Diantara keterampilan abad 21 yang harus dimiliki oleh peserta didik ialah Keterampilan 4C, yaitu berpikir kritis, komunikasi, kolaborasi dan kreativitas. Saat ini, indikator keberhasilan lebih didasarkan pada kemampuan untuk berkomunikasi, berbagi, dan menggunakan informasi untuk memecahkan masalah yang kompleks, dapat beradaptasi dan berinovasi dalam menanggapi tuntutan baru dan mengubah keadaan, dan memperluas kekuatan teknologi untuk menciptakan pengetahuan baru. Maka perlu dibiasakan dengan aktivitas pembelajaran yang melatih Keterampilan 4C itu sendiri. Begitupun dalam pembelajaran Pendidikan Agama Islam khususnya pada mata pelajaran SKI. Guru memiliki peranan dan tanggung jawab penting dalam menerapkan keterampilan abad 21 khususnya 4C dalam setiap proses pembelajaran. Tujuan Penelitian ini adalah: (1) Untuk mengetahui perencanaan pembelajaran SKI dalam menerapkan keterampilan abad 21 di MTsN 1 Kota Malang (2) Untuk mengetahui proses pembelajaran SKI dalam menerapkan keterampilan abad 21 di MTsN 1 Kota Malang (3) Untuk mengetahui evaluasi pembelajaran SKI dalam menerapkan keterampilan abad 21 di MTsN 1 Kota Malang. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif untuk menganalisa data-data berupa kalimat atau kata. Jenis penelitian yang digunakan adalah bersifat studi kasus, karena peneliti melihat langsung masalah yang terdapat dalam lokasi dan memperhatikan keadaan yang diteliti. Teknik pengumpulan data berupa observasi, wawancara, dan dokumentasi. Data dianalisis dengan pengumpulan data, mereduksi data, penyajian data dan penyajian kesimpulan. Dalam penelitian ini, peneliti menemukan beberapa temuan mengenai implementasi keterampilan abad 21 dalam pembelajaran SKI pada siswa kelas VII di MTsN 1 Kota Malang adalah: (1) perencanaan pembelajaran SKI dalam menerapkan keterampilan abad 21 melalui RPP dan Unit Kegiatan Belajar Mandiri (UKBM), setiap UKBM terdapat satu model pembelajaran dan berbagai metode pengajaran (2) pelaksanaan pembelajaran SKI dalam menerapkan keterampilan abad 21 melalui UKBM menggunakan model active learning dengan metode kantong bersahabat (3) evaluasi pembelajaran SKI dalam menerapkan keterampilan abad 21 tidak hanya dilakukan di akhir pembelajaran. Selain memalui ujian tengah semester , ujian akhir semester dan ulangan harian , penilaian juga dilakukan melalui hasil kegiatan-kegiatan pembelajaran yang ada dalam UKBM baik memalui praktek, tes tulis maupun non tulis, lisan mamupun non lisan

Impact of Ibrutinib in Quality of Life (QoL) in Patients with Chronic Lymphocytic Leukemia (CLL): Preliminary Results of Real-World Experience

Context: Clinical data from controlled trials report an improvement in QoL in patients with CLL in ibrutinib monotherapy. Reallife evidence is necessary to confirm this data. Objective: The disease control when treatment is initiated could lead to decreasedfatigue. It is likely that treatment with ibrutinib could result in animprovement in QoL in our real-world population. Primaryobjective: evaluate impact of ibrutinib treatment in QoL. Wedefined a clinically meaningful improvement 3 points in FACITfatigue score. Secondary Endpoints: Detect a 10% improvement byEQ5D VAS. Correlate baseline and follow-up hemoglobin levels(meaningful improvement 1g/dL). Design: This is a prospective,longitudinal, single arm study enrolling consecutive CLL patientsunder ibrutinib monotherapy either as first or further line oftreatment. Median follow-up was 7 months (range 1-28). Setting:Patients are recruited in an academic referral center in BuenosAires. Interventions: QoL was explored with FACIT-fatigue andEQ5D visual-analogue-scale (VAS) questionnaires (with copyrightpermission). Assessment by results reported by patient questionnaires are completed on months 0-1-3-6 and 12 since the beginningof treatment. Main Outcomes Measures: We are reporting preliminary results after 3 months of treatment compared to baseline.Statistical Analysis: data was analyzed with the Sign Test (BinomialTest). Results: A total of 21 CLL patients who started ibrutinibbetween 2016 and 2018 were included. Median age was 75 years(range 57-84); 12 patients (57%) were males. Ibrutinib was first-linetherapy in 7 patients (33%), second-line in 7 patients (33%) and 7patients (33%) received 3 previous lines. After 3 months oftreatment, the median change in FACIT-fatigue score 3 pointswas reached in 13 patients (62%) as compared to baseline(p=0.024). After 3 months of treatment there was no evidence of amedian change >10% on the EQ5D VAS (p=0.593) nor a significant improvement on hemoglobin level (p=0.105).Conclusions: These results suggest an early improvement of fatiguewithin the first 3 months of treatment with ibrutinib. Longerfollow-up and larger number of patient are necessary to confirm thisdata and determine the further improvements of QoL withcontinuous treatment and correlation with hemoglobin changes.Fil: Mela Osorio, Maria Jose. Fundación Para Combatir la Leucemia; ArgentinaFil: Pavlovsky, Carolina. Fundación Para Combatir la Leucemia; ArgentinaFil: Pavlovsky, Astrid. Fundación Para Combatir la Leucemia; ArgentinaFil: Fernandez, Isolda. Fundación Para Combatir la Leucemia; ArgentinaFil: Massa, Federico Sackmann. Fundación Para Combatir la Leucemia; ArgentinaFil: Ferrari, Luciana. Fundación Para Combatir la Leucemia; ArgentinaFil: Juni, Mariana. Fundación Para Combatir la Leucemia; ArgentinaFil: Riddick, Maximiliano Luis. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Matemáticas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Cálculo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pavlovsky, Miguel A.. Fundación Para Combatir la Leucemia; Argentin

Elevated plasma levels of IL-6 and MCP-1 selectively identify CML patients who better sustain molecular remission after TKI withdrawal

Abstract Treatment-free remission (TFR) in chronic myeloid leukemia (CML) is safe under adequate molecular monitoring, but questions remain regarding which factors may be considered predictive for TFR. Argentina Stop Trial (AST) is a multicenter TFR trial showing that 65% of patients sustain molecular remission, and the prior time in deep molecular response (DMR) was associated with successful TFR. Luminex technology was used to characterize cytokines in plasma samples. Using machine learning algorithms, MCP-1 and IL-6 were identified as novel biomarkers and MCP-1low/IL-6low patients showed eightfold higher risk of relapse. These findings support the feasibility of TFR for patients in DMR and MCP-1/IL-6 plasma levels are strong predictive biomarkers

DataSheet_1_In-depth characterization of NK cell markers from CML patients who discontinued tyrosine kinase inhibitor therapy.docx

IntroductionTreatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase is considered a safe option if suitable molecular monitoring is available. However, the question arises as to which factors can contribute to the maintenance of TFR, and immunologic surveillance of the remaining leukemic cells is believed to be one of them. Argentina Stop Trial is an open-label, single-arm, multicenter trial assessing TFR after tyrosine kinase inhibitors interruption, that after more than 4 years showed a successful TFR rate of 63%.MethodsIn this context, we set up an immunological study by flow cytometry in order to analyze specific NK cell subsets from peripheral blood patient samples both at the time of discontinuation as well as during the subsequent months.ResultsAt the time of discontinuation, patients show a mature NK cell phenotype, probably associated to TKI treatment. However, 3 months after discontinuation, significant changes in several NK cell receptors occurred. Patients with a higher proportion of CD56dim NK and PD-1+ NK cells showed better chances of survival. More interestingly, non-relapsing patients also presented a subpopulation of NK cells with features associated with the expansion after cytomegalovirus infection (expression of CD57+NKG2C+), and higher proportion of NKp30 and NKp46 natural cytotoxicity receptors, which resulted in greater degranulation and associated with better survival (pDiscussionThis NK cell subset could have a protective role in patients who do not relapse, thus further characterization could be useful for patients in sustained deep molecular response.</p