Differenzanalyse bei LP-Modellen

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Vogelconcentraties en vogelbewegingen in Zeeland

The paper presents the results of a detailed study of the annual rainfall of India in relation to the sunspot cycle for the period 1871 to 1978. Rainfall time series of individual stations as well as of meteorological subdivisions have been examined for the full period (108 years) and for two half periods.The correlation coefficients (CC) of 306 stations for the full period lie between 4-0-29 and -0-14 with a preponderance of positive over negative values in the ratio 4:1. Twenty-six CC values are significant at the 5 per cent level. The CC values for the two subseries reveal appreciable temporal variations, the correlations being higher for the first half. Lag correlations between the rainfall and sunspot series indicate that the CC values tend to increase when the rainfall is correlated with sunspot numbers 1 to 3 years later and to decrease when correlated with sunspot numbers 1 to 3 years earlier.Examination of the all-India rainfall series and the sunspot series for the full period shows that excess rainfall years were significantly more during the ascending phase of alternate cycles. Superposed epoch analysis and the Student t test show that the rainfall around the maximum of even cycles characterized by high sunspot activity is significantly higher than the corresponding rainfall in the odd cycles with lesser spot activity. Correlation study with a 15-year sliding window reveals large temporal variations in the CC values.Although most of the variance in the rainfall time series is due to causes unconnected with the sunspot cycle, the present study suggests the existence of a weak positive association between Indian rainfall and sunspots on the 22-year time scale, although the causal connection is unknown

Kit receptor tyrosine kinase dysregulations in feline splenic mast cell tumours

This study investigated Ki t receptor dysregulations (cytoplasmic immunohistochemical expression and/or c-KIT mutations) in cats a\ufb00ected with splenic mast cell tumours. Twenty-two cats were included. Median survival time was 780 days (range: 1\u20131219). An exclusive splenic involvement was signi\ufb01cantly (P = 0.042) associated with longer survival (807 versus 120 days). Eighteen tumours (85.7%) showed Kit cytoplasmic expression (Kit pattern 2, 3). Mutation analysis was successful in 20 cases. Fourteen missense mutations were detected in 13 out of 20 tumours (65%). Eleven (78.6%) were located in exon 8, and three (21.6%) in exon 9. No mutations were detected in exons 11 and 17. Seven mutations corresponded to the same internal tandem duplication in exon 8 (c.1245_1256dup). Although the association between Kit cytoplasmic expression and mutations was signi\ufb01cant, immunohistochemistry cannot be considered a surrogate marker for mutation analysis. No correlation was observed between c-Kit mutations and tumour di\ufb00erentiation, mitotic activity or survival

Identification of Six Novel SOD1 Gene Mutations in Familial Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the premature death of motor neurons. In approximately 10% of the cases the disease is inherited as autosomal dominant trait (FALS). It has been found that mutations in the Cu/Zn superoxide dismutase gene (SODl) are responsible for approximately 15% of FALS kindreds. We screened affected individuals from 70 unrelated FALS kindreds and identified 10 mutations, 6 of which are novel. Surprisingly, we have found a mutation in exon 3, which includes most of the active site loop and Zn2+ binding sites, a region where no previous SOD1 mutations have been found. Our data increase the number of different SODl mutations causing FALS to 55, a significant fraction of the 154 amino acids of this relatively small protei

WDPH 2017 Summer Internship Report

In the spring of 2014, the Worcester Division of Public Health, UMass Memorial Health Care, and Clark University’s Mosakowski Institute for Public Enterprise joined forces to begin developing a partnership that would combine academic resources, student input, and public health needs in the City of Worcester. Founders of this program were motivated to seek and implement innovative interventions for public health issues while simultaneously inspiring a new generation of public health professionals. Each year, the Academic Health Collaborative of Worcester (AHCW) brings in student interns to work on the pressing public health issues of the moment. Interns work alongside epidemiologists, researchers, and public health professionals to understand and address a wide assortment of health problems facing Worcester residents of all ages. The goal of the initiative is to train students in the field of public health, and to support the development of public health research in the City of Worcester

The Effect of Rejection of a Copyright License on a Non-Debtor Licensee

(Excerpt) In general, a trustee may assume, reject, or assign an executory contract of the debtor under title 11 of the United States Code (the “Bankruptcy Code”). Courts have generally held that intellectual property license agreements are executory contracts. If the license is an exclusive copyright license, it is a transfer of ownership under title 17 of the United States Code (the “Copyright Act”). Thus, some courts treat a copyright license as transfer of ownership, not an executory contract. This article explores the rights and obligations of a non-debtor licensee when a debtor-licensor rejects a copyright license under the Bankruptcy Code. Part I analyzes the legal standard and differing approaches that courts have adopted to determine whether a copyright license is an executory contract. Part II examines the effect of section 365(n) on a licensee’s rights and obligations after a copyright license is rejected