447 research outputs found
Pathways to early retirement: structure and agency in decision-making among British civil servants
TREATMENT OF PARKINSON'S DISEASE USING THE CAYCE WET CELL BATTERY
Parkinson's disease, a condition involving progressive deterioration of the nervous system, is at present incurable by conventional medicine. Here we report on a study in which we have evidence of clinical improvement from using a treatment modality recommended by Edgar Cayce, a subtle energy device known as the wet cell battery. Cayce said that the wet cell would transfer vibratory energy into the body, and specifically recommended it for neurological disorders, but there have been no previous clinical studies of this modality. T en participants with Parkinson's disease used the wet cell, a chemical battery, with gold and silver solutions, for a four-month treatment period at home. Nine of the ten people followed the protocol consistently (but none completely or perfectly). They averaged slight to moderate improvement in Parkinson's disease symptoms over four months, based on observations by researchers and subjective questionnaires. Over the long term (three years), one participant obtained almost complete remission of his Parkinson's disease symptoms. Since there was no control group the placebo effect cannot be ruled out. However, many minor symptoms showed interesting improvement in several individuals. For example, two people reported regaining their sense of smell, and one had improved color vision. Several people had more facial emotional expressiveness, and reported reduced tremors
IMPROVEMENT OF CIRCUlATION USING THE RADIAL APPLIANCE
The purpose of this study was to determine if a subtle energy device, the Cayce Radial Appliance, could improve circulation in the extremities. There were two aspects to the study: a doubleblind, placebo-controlled experiment and a small clinical investigation. In the experiment, 30 subjects were selected for cold extremities, with the criterion that either the hands or the feet had to be below 800 F during the initial measurement session. To measure improvement of circulation, we used digital thermometers to record the temperatures of the thumbs and big toes on both hands and feet. Subjects were instructed to use the appliance 16 times; laboratory measurements were taken during the 1st, 4th and 16th sessions. Skin temperature turned our to be a difficult variable to work with, due to the wide variability in temperature apparently unrelated to the experimental siruation. The strongest results were observed in the 4th session. During session baseline, differences between hand and foot temperatures of the experimental group were significantly greater than those of the control group (t [13,11] 2.49, p '" .02). The 16th session did not yield significant differences between the experimental and control groups. However, in the experimental group, there was a correlation of r (9) -.56 (p '" .07) of hand temperarure increase with the number of days it took to complete the 16 sessions. That is, those subjects who were more consistent in using the appliance may have obtained better results, though statistically the result is only suggestive due to the small sample size. In contrast, in a clinical follow-up study with five subjects and no control group, we found that all subjects had a substantial increase in hand temperature following three sessions on the appliance (Mean increase'" 8.40 F, SO = 3.3). This increase was well in excess of that seen in either the experimental or control groups in the previous study. One important difference was that in the clinical study, use of the appliance was closely supervised, whereas in the blind study most of the appliance sessions were conducted by the subjects alone in their homes
The solar chromosphere at high resolution with IBIS. I. New insights from the Ca II 854.2 nm line
(Abridged)
Aims: In this paper, we seek to establish the suitability of imaging
spectroscopy performed in the Ca II 854.2 nm line as a means to investigate the
solar chromosphere at high resolution.
Methods: We utilize monochromatic images obtained with the Interferometric
BIdimensional Spectrometer (IBIS) at multiple wavelengths within the Ca II
854.2 nm line and over several quiet areas. We analyze both the morphological
properties derived from narrow-band monochromatic images and the average
spectral properties of distinct solar features such as network points,
internetwork areas and fibrils.
Results: The spectral properties derived over quiet-Sun targets are in full
agreement with earlier results obtained with fixed-slit spectrographic
observations, highlighting the reliability of the spectral information obtained
with IBIS. Furthermore, the very narrowband IBIS imaging reveals with much
clarity the dual nature of the Ca II 854.2 nm line: its outer wings gradually
sample the solar photosphere, while the core is a purely chromospheric
indicator. The latter displays a wealth of fine structures including bright
points, akin to the Ca II H2V and K2V grains, as well as fibrils originating
from even the smallest magnetic elements. The fibrils occupy a large fraction
of the observed field of view even in the quiet regions, and clearly outline
atmospheric volumes with different dynamical properties, strongly dependent on
the local magnetic topology. This highlights the fact that 1-D models
stratified along the vertical direction can provide only a very limited
representation of the actual chromospheric physics.Comment: 13 pages, 8 figures. Accepted in A&A. Revised version after referee's
comments. New Fig. 1 and 7. Higher quality figures in
http://www.arcetri.astro.it/~gcauzzi/papers/ibis.caii.pd
Estimation of solar prominence magnetic fields based on the reconstructed 3D trajectories of prominence knots
We present an estimation of the lower limits of local magnetic fields in
quiescent, activated, and active (surges) promineces, based on reconstructed
3-dimensional (3D) trajectories of individual prominence knots. The 3D
trajectories, velocities, tangential and centripetal accelerations of the knots
were reconstructed using observational data collected with a single
ground-based telescope equipped with a Multi-channel Subtractive Double Pass
imaging spectrograph. Lower limits of magnetic fields channeling observed
plasma flows were estimated under assumption of the equipartition principle.
Assuming approximate electron densities of the plasma n_e = 5*10^{11} cm^{-3}
in surges and n_e = 5*10^{10} cm^{-3} in quiescent/activated prominences, we
found that the magnetic fields channeling two observed surges range from 16 to
40 Gauss, while in quiescent and activated prominences they were less than 10
Gauss. Our results are consistent with previous detections of weak local
magnetic fields in the solar prominences.Comment: 14 pages, 12 figures, 1 tabl
A DNA methylation signature in the stress driver gene Fkbp5 indicates a neuropathic component in chronic pain
BACKGROUND: Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to epigenetic regulation that contribute to the maintenance of chronic pain and with an epigenetic landscape indicative of the susceptibility to persistent pain. Such genes would provide a novel opportunity for better pain management, as their epigenetic profile could be targeted for the treatment of chronic pain or used as an indication of vulnerability for prevention strategies. Here, we investigated the epigenetic profile of the gene Fkbp5 for this potential, using targeted bisulphite sequencing in rodent pre-clinical models of chronic and latent hypersensitive states. RESULTS: The Fkbp5 promoter DNA methylation (DNAm) signature in the CNS was significantly different between models of persistent pain, and there was a significant correlation between CNS and peripheral blood Fkbp5 DNAm, indicating that further exploration of Fkbp5 promoter DNAm as an indicator of chronic pain pathogenic origin is warranted. We also found that maternal separation, which promotes the persistency of inflammatory pain in adulthood, was accompanied by long-lasting reduction in Fkbp5 DNAm, suggesting that Fkbp5 DNAm profile may indicate the increased vulnerability to chronic pain in individuals exposed to trauma in early life. CONCLUSIONS: Overall, our data demonstrate that the Fkbp5 promoter DNAm landscape brings novel insight into the differing pathogenic origins of chronic pain, may be able to stratify patients and predict the susceptibility to chronic pain
3D evolution of a filament disappearance event observed by STEREO
A filament disappearance event was observed on 22 May 2008 during our recent
campaign JOP 178. The filament, situated in the southern hemisphere, showed
sinistral chirality consistent with the hemispheric rule. The event was well
observed by several observatories in particular by THEMIS. One day before the
disappearance, H observations showed up and down flows in adjacent
locations along the filament, which suggest plasma motions along twisted flux
rope. THEMIS and GONG observations show shearing photospheric motions leading
to magnetic flux canceling around barbs. STEREO A, B spacecraft with separation
angle 52.4 degrees, showed quite different views of this untwisting flux rope
in He II 304 \AA\ images. Here, we reconstruct the 3D geometry of the filament
during its eruption phase using STEREO EUV He II 304 \AA\ images and find that
the filament was highly inclined to the solar normal. The He II 304 \AA\ movies
show individual threads, which oscillate and rise to an altitude of about 120
Mm with apparent velocities of about 100 km s, during the rapid
evolution phase. Finally, as the flux rope expands into the corona, the
filament disappears by becoming optically thin to undetectable levels. No CME
was detected by STEREO, only a faint CME was recorded by LASCO at the beginning
of the disappearance phase at 02:00 UT, which could be due to partial filament
eruption. Further, STEREO Fe XII 195 \AA\ images showed bright loops beneath
the filament prior to the disappearance phase, suggesting magnetic reconnection
below the flux rope
Prevention and management of chronic disease in Aboriginal and Islander Community Controlled Health Services in Queensland: a quality improvement study assessing change in selected clinical performance indicators over time in a cohort of services
OBJECTIVE To evaluate clinical healthcare performance in Aboriginal Medical Services in Queensland and to consider future directions in supporting improvement through measurement, target setting and standards development. DESIGN Longitudinal study assessing baseline performance and improvements in service delivery, clinical care and selected outcomes against key performance indicators 2009-2010. SETTING 27 Aboriginal and Islander Community Controlled Health Services (AICCHSs) in Queensland, who are members of the Queensland Aboriginal and Islander Health Council (QAIHC). PARTICIPANTS 22 AICCHS with medical clinics. INTERVENTION Implementation and use of an electronic clinical information system that integrates with electronic health records supported by the QAIHC quality improvement programme-the Close the Gap Collaborative. MAIN OUTCOME MEASURES Proportion of patients with current recording of key healthcare activities and the prevalence of risk factors and chronic disease. RESULTS Aggregated performance was high on a number of key risk factors and healthcare activities including assessment of tobacco use and management of hypertension but low for others. Performance between services showed greatest variation for care planning and health check activity. CONCLUSIONS Data collected by the QAIHC health information system highlight the risk factor workload facing the AICCHS in Queensland, demonstrating the need for ongoing support and workforce planning. Development of targets and weighting models is necessary to enable robust between-service comparisons of performance, which has implications for health reform initiatives in Australia. The limited information available suggests that although performance on key activities in the AICCHS sector has potential for improvement in some areas, it is nonetheless at a higher level than for mainstream providers. IMPLICATIONS The work demonstrates the role that the Community Controlled sector can play in closing the gap in Aboriginal and Torres Strait Islander health outcomes by leading the use of clinical data to record and assess the quality of services and health outcome.Office of Aboriginal and Torres Strait Islander Health, Department of
Health and Ageing, Canberra, ACT, Australia
Lighthouse Parenting Programme: Description and pilot evaluation of mentalization-based treatment (MBT) to address child maltreatment
This paper introduces an innovative Mentalization-Based Treatment (MBT) parenting intervention for families where children are at risk of maltreatment. The Lighthouse MBT Parenting Programme (MBT-P LH) aims to prevent child maltreatment by promoting sensitive caregiving in parents. The programme is designed to enhance parents’ capacity for curiosity about their child’s inner world, to help parents ‘see’ (understand) their children clearly, to make sense of misunderstandings in their relationship with their child, and to help parents inhibit harmful responses in those moments of misunderstanding and to repair the relationship when harmed. The programme is an adaptation of MBT for borderline and antisocial personality disorders, with a particular focus on attachment and child development. Its strength is in engaging hard to reach parents, who typically do not benefit from parenting programmes. The findings of the pilot evaluation suggest that the programme may be effective in improving parenting confidence and sensitivity and that parents valued the programme and the changes it had helped them to bring about
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