Nuptial Rape: Rape Within Marriage

Section 375 of the Indian Penal Code, 1860 Criminalizes ’Rape’ under Offences Affecting the Human Body, where prevails an oddly fitted exception to this Section, which states: Sexual intercourse by a man with his wife who is not less than 15 years of age does not amount to the offence of rape. Marital Rape, a non-criminalized crime in India is where the victim herself does not know she is a victim of Marital Rape. It is one of the most under-reported crimes with 77% of women never seeking any aid regarding the violence they ever experienced. The section clearly states that rape within marriage cannot be treated as a criminal offence unless the wife is below 15 years of age. Considering the repercussions, the adverse effect on mental health highly caused by marital rape due to its non-criminalization, especially in India is reviewed legally and psychologically in this paper. The data for the above piece of research has been taken from Secondary sources: law sites, search engines, research articles, Google Scholar etc.Lattice Science Publication (LSP) © Copyright: All rights reserved

Vision - based self - guided Quadcopter landing on moving platform during fault detection

Fault occurrence in the quadcopter is very common during operation in the air. This paper presents a real-time implementation to detect the fault and then the system is guaranteeing to safely land on the surface, even the moving landing platform. Primarily, PixHawk auto-pilot was used to verify in real-time, with platform detection and various environmental conditions. The method is ensuring the quadcopter operates in the landing area zone with the help of a GPS feature. Then the precise landing on the astable-landing platform is calibrated automatically using the vision-based learning feedback technique. The proposed objective is developed using reconfigurable Raspberry Pi-3 with a Pi camera. The full decision on an efficient landing algorithm is deployed into the quadcopter. The system is self-guided and automatically returns to home-based whenever the fault detects. The study is conducted with the situation of low battery operation and the trigger of auto-pilot helps to land the device safely before any mal-function. The system is featured with predetermined speed and altitude while navigating the home base, thus improves the detection process. Finally, the experiment study provided successful trials to track usable platform, landing on a restricted area, and disarm the motors autonomously

Multiagent Simulators for Social Networks

Multiagent social network simulations are an avenue that can bridge the communication gap between the public and private platforms in order to develop solutions to a complex array of issues relating to online safety. While there are significant challenges relating to the scale of multiagent simulations, efficient learning from observational and interventional data to accurately model micro and macro-level emergent effects, there are equally promising opportunities not least with the advent of large language models that provide an expressive approximation of user behavior. In this position paper, we review prior art relating to social network simulation, highlighting challenges and opportunities for future work exploring multiagent security using agent-based models of social network

The Future of Flu: A Review of the Human Challenge Model and Systems Biology for Advancement of Influenza Vaccinology

Objectives: Novel approaches to advance the field of vaccinology must be investigated, and are particularly of importance for influenza in order to produce a more effective vaccine. A systematic review of human challenge studies for influenza was performed, with the goal of assessing safety and ethics and determining how these studies have led to therapeutic and vaccine development. A systematic review of systems biology approaches for the study of influenza was also performed, with a focus on how this technology has been utilized for influenza vaccine development.Methods: The PubMed database was searched for influenza human challenge studies, and for systems biology studies that have addressed both influenza infection and immunological effects of vaccination.Results: Influenza human challenge studies have led to important advancements in therapeutics and influenza immunization, and can be performed safely and ethically if certain criteria are met. Many studies have investigated the use of systems biology for evaluating immune response to influenza vaccine, and several promising molecular signatures may help advance our understanding of pathogenesis and be used as targets for influenza interventions. Combining these methodologies has the potential to lead to significant advances in the field of influenza vaccinology and therapeutics.Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations

Design and analysis of photovoltaic powered battery - operated computer vision - based multi - purpose smart farming robot

Farm machinery like water sprinklers (WS) and pesticide sprayers (PS) are becoming quite popular in the agricultural sector. The WS and PS are two distinct types of machinery, mostly powered using conventional energy sources. In recent times, the battery and solar-powered WS and PS have also emerged. With the current WS and PS, the main drawback is the lack of intelligence on water and pesticide use decisions and autonomous control. This paper proposes a novel multi-purpose smart farming robot (MpSFR) that handles both water sprinkling and pesticide spraying. The MpSFR is a photovoltaic (PV) powered battery-operated internet of things (IoT) and computer vision (CV) based robot that helps in automating the watering and spraying process. Firstly, the PV-powered battery-operated autonomous MpSFR equipped with a storage tank for water and pesticide drove with a programmed pumping device is engineered. The sprinkling and spraying mechanisms are made fully automatic with a programmed pattern that utilizes IoT sensors and CV to continuously monitor the soil moisture and the plant’s health based on pests. Two servo motors accomplish the horizontal and vertical orientation of the spraying nozzle. We provided an option to remotely switch the sprayer to spray either water or pesticide using an infrared device, i.e., within a 5-m range. Secondly, the operation of the developed MpSFR is experimentally verified in the test farm. The field test’s observed results include the solar power profile, battery charging, and discharging conditions. The results show that the MpSFR operates effectively, and decisions on water use and pesticide are automated

Ebola Virus Persistence in Semen of Male Survivors

We investigated the duration of Ebola virus (EBOV) RNA and infectious EBOV in semen specimens of 5 Ebola virus disease (EVD) survivors. EBOV RNA and infectious EBOV was detected by real-time RT-PCR and virus culture out to 290 days and 70 days, respectively, after EVD onset

In Vivo T Cell Costimulation Blockade with Abatacept for Acute Graft-versus-Host Disease Prevention: A First-in-Disease Trial

AbstractWe performed a first-in-disease trial of in vivo CD28:CD80/86 costimulation blockade with abatacept for acute graft-versus-host disease (aGVHD) prevention during unrelated-donor hematopoietic cell transplantation (HCT). All patients received cyclosporine/methotrexate plus 4 doses of abatacept (10 mg/kg/dose) on days −1, +5, +14, +28 post-HCT. The feasibility of adding abatacept, its pharmacokinetics, pharmacodynamics, and its impact on aGVHD, infection, relapse, and transplantation-related mortality (TRM) were assessed. All patients received the planned abatacept doses, and no infusion reactions were noted. Compared with a cohort of patients not receiving abatacept (the StdRx cohort), patients enrolled in the study (the ABA cohort) demonstrated significant inhibition of early CD4+ T cell proliferation and activation, affecting predominantly the effector memory (Tem) subpopulation, with 7- and 10-fold fewer proliferating and activated CD4+ Tem cells, respectively, at day+28 in the ABA cohort compared with the StdRx cohort (P < .01). The ABA patients demonstrated a low rate of aGVHD, despite robust immune reconstitution, with 2 of 10 patients diagnosed with grade II-IV aGVHD before day +100, no deaths from infection, no day +100 TRM, and with 7 of 10 evaluable patients surviving (median follow-up, 16 months). These results suggest that costimulation blockade with abatacept can significantly affect CD4+ T cell proliferation and activation post-transplantation, and may be an important adjunct to standard immunoprophylaxis for aGVHD in patients undergoing unrelated-donor HCT

Persistence of Ebola virus in ocular fluid during convalescence

Please note: A correction to the original article has been published. “From New England Journal of Medicine, Jay B. Varkey, Jessica G. Shantha, Ian Crozier, Colleen S. Kraft, G. Marshall Lyon, Aneesh K. Mehta, Gokul Kumar, Justine R. Smith, Markus H. Kainulainen, Shannon Whitmer, Ute Ströher, Timothy M. Uyeki, Bruce S. Ribner, and Steven Yeh, Persistence of Ebola Virus in Ocular Fluid during Convalescence, 2015; 372:2423-2427. Copyright © (2015) Massachusetts Medical Society. Reprinted with permission.Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.Supported by a grant from the National Center for Advancing Translational Sciences of the National Institutes of Health (UL1TR000454, to the Atlanta Clinical and Translational Science Institute), an unrestricted grant from Research to Prevent Blindness and a grant from the National Eye Institute (P30-EY06360, to the Department of Ophthalmology, Emory University School of Medicine), and a fellowship grant from the Australian Research Council (FT130101648, to Dr. Smith). Favipiravir was provided by the Department of Defense Joint Project Manager Medical Countermeasure Systems

Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

Although scarce after annual influenza vaccination, B cells producing antibodies capable of neutralizing multiple influenza strains are abundant in humans infected with pandemic 2009 H1N1 influenza

Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV

Human herpesviruses are important causes of potentially severe chronic infections for which T cells are believed to be necessary for control. In order to examine the role of virus-specific CD8 T cells against Varicella Zoster Virus (VZV), we generated a comprehensive panel of potential epitopes predicted in silico and screened for T cell responses in healthy VZV seropositive donors. We identified a dominant HLA-A*0201-restricted epitope in the VZV ribonucleotide reductase subunit 2 and used a tetramer to analyze the phenotype and function of epitope-specific CD8 T cells. Interestingly, CD8 T cells responding to this VZV epitope also recognized homologous epitopes, not only in the other α-herpesviruses, HSV-1 and HSV-2, but also the γ-herpesvirus, EBV. Responses against these epitopes did not depend on previous infection with the originating virus, thus indicating the cross-reactive nature of this T cell population. Between individuals, the cells demonstrated marked phenotypic heterogeneity. This was associated with differences in functional capacity related to increased inhibitory receptor expression (including PD-1) along with decreased expression of co-stimulatory molecules that potentially reflected their stimulation history. Vaccination with the live attenuated Zostavax vaccine did not efficiently stimulate a proliferative response in this epitope-specific population. Thus, we identified a human CD8 T cell epitope that is conserved in four clinically important herpesviruses but that was poorly boosted by the current adult VZV vaccine. We discuss the concept of a “pan-herpesvirus” vaccine that this discovery raises and the hurdles that may need to be overcome in order to achieve this