A review on the role of inositol in aquaculture

Inositol is usually classified as an essential vitamin for most animals, and is recognised as a part of the B-complex vitamins. Among all other inositol isomer forms, myo-inositol possesses biological activity. It is found in the brain, skeletal, heart, and main reproductive tissues and exists as a structural component of phosphatidylinositol in biological cell membranes. Myo-inositol, also acts as a growth factor and affects the antioxidant capacity and oxidative status of cells. It is a major intracellular osmolyte that can be accumulated to protect cells from a variety of stresses and can also participate in transmembrane signal transfer. Myo-inositol is synthesised by various animal tissues and microorganisms in gut and fulfills the requirement for a few fish species. However, the supply of inositol by exogenous source (the diet) is required in most fish and shrimp for preventing deficiency signs such as inefficiency in digestion and food utilization, poor growth, fin erosion, dark skin colouration, and high accumulation of lipid in liver and muscle. The current paper aimed to provide a review on the published studies on the role of inositol in aquaculture

Prevalence and Antibiotic Susceptibility Pattern of E. coli Isolated from Urinary Tract Infection in Patients with Renal Failure Disease and Renal Transplant Recipients

Purpose: To determine the common uropathogens found in patients with urinary tract infections and to assess their antibiotic susceptibility patterns.Methods: The prevalence and antibiotic susceptibility pattern of E. coli in urinary tract infection inpatients with renal failure disease and renal transplant recipients (group 1) and in outpatients (group 2), admitted in/attending Imam Reza Hospital in Tabriz, Iran, were determined. Isolates were analyzed by standard methods, and antimicrobial susceptibility testing was performed by Kirby-Bauer disc diffusion method.Results: A total of 136 E. coli strains from 81 females and 55 males were examined. The high level of antibiotic susceptibility for group 1 was cefuroxime/ceftazidime (100 %) and nitrofurantoin (81.63 %), respectively; and for group 2, it was ampicillin (95.83 %) and nitrofurantoin (93.75 %), respectively.Conclusion: The most important finding of this study is that a considerable proportion of the studied E. coli isolates are resistant to the antibiotics tested, except nitrofurantoin. This finding is useful for clinicians to determine appropriate empirical antimicrobial treatment in similar cases and would also help health authorities to formulate antibiotic prescription policies.Keywords: Urinary tract infection, Antibiotic susceptibility pattern, Uropathogens, Renal failure, Renal transplant, Escherichia col

Trends, determinants and the implications of population aging in Iran

Fertility and mortality decline are major drivers of Iran's population aging. A rapid and sharp fall in fertility rates over the past three decades as well as a substantial rise in life expectancy are causing rapid aging of Iran’s population. The present paper uses the 2015 United Nations Population Division data to discuss the trends, determinants and the implications of population aging in Iran. According to the medium fertility variant, people age 60 and older will represent 31 percent (almost 29 million people) of Iran’s population by 2050. The population age 65 and older is projected to be 22 percent (more than 20 million) and that of aged 80 and older 3.8 percent (around 3.5 million) in 2050, that are almost four-times the corresponding figures in 2015. Data on the speed of population aging show that Iran is the second fastest aging cou

Research paper: Comparing the diadochokinetic rate in farsi-speaking young and older adults

Objectives: Speech Diadochokinesis (DDK) is defined as the ability to produce repetitive and fast speech movements. This study aimed at comparing the DDK rate between Farsi-speaking young and older adults. Methods: In this study, 244 normal adults (122 males and 122 females) were divided into two groups of young people (20-49 years) and elderly (50-69 years). DDK tasks was performed based on two ways: the participant was asked to produce /pa/,/ta/,/ka/,/pata/,/paka/,/taka/, and /pataka/ sounds in 5 s; and to repeat single syllable sounds (/pa/,/ta/,/ka/) 20 times, two syllables sounds (/pata/,/paka/,/taka/) 15 times, and a three syllables sound (/pataka/) ten times, separately and quickly. The independent T-test, one-way ANOVA, and Pearson correlation were used for data analysis. Results: The results indicated a significant negative and weak correlation between age and all syllables in the specified time (range:-0.139 to-0.254), and a positive and weak correlation between age and time with respect to the repetition of all syllables (range: 0.121 to 0.245). There was no significant difference between genders in both ways (P>0.05). Discussion: The results indicated different DDK rate between the young and elderly subjects that can be used as a benchmark for the diagnosis of disabled individuals in producing repetitive and fast oral movements and also as a basis for clinical assessments. © 2020 University of Social Welfare and Rehabilitation Sciences

Application of Pseudo-Hermitian Quantum Mechanics to a Complex Scattering Potential with Point Interactions

We present a generalization of the perturbative construction of the metric operator for non-Hermitian Hamiltonians with more than one perturbation parameter. We use this method to study the non-Hermitian scattering Hamiltonian: H=p^2/2m+\zeta_-\delta(x+a)+\zeta_+\delta(x-a), where \zeta_\pm and a are respectively complex and real parameters and \delta(x) is the Dirac delta function. For regions in the space of coupling constants \zeta_\pm where H is quasi-Hermitian and there are no complex bound states or spectral singularities, we construct a (positive-definite) metric operator \eta and the corresponding equivalent Hermitian Hamiltonian h. \eta turns out to be a (perturbatively) bounded operator for the cases that the imaginary part of the coupling constants have opposite sign, \Im(\zeta_+) = -\Im(\zeta_-). This in particular contains the PT-symmetric case: \zeta_+ = \zeta_-^*. We also calculate the energy expectation values for certain Gaussian wave packets to study the nonlocal nature of \rh or equivalently the non-Hermitian nature of \rH. We show that these physical quantities are not directly sensitive to the presence of PT-symmetry.Comment: 22 pages, 4 figure

An exactly solvable quantum-lattice model with a tunable degree of nonlocality

An array of N subsequent Laguerre polynomials is interpreted as an eigenvector of a non-Hermitian tridiagonal Hamiltonian $H$ with real spectrum or, better said, of an exactly solvable N-site-lattice cryptohermitian Hamiltonian whose spectrum is known as equal to the set of zeros of the N-th Laguerre polynomial. The two key problems (viz., the one of the ambiguity and the one of the closed-form construction of all of the eligible inner products which make $H$ Hermitian in the respective {\em ad hoc} Hilbert spaces) are discussed. Then, for illustration, the first four simplest, $k-$parametric definitions of inner products with $k=0,k=1,k=2$ and $k=3$ are explicitly displayed. In mathematical terms these alternative inner products may be perceived as alternative Hermitian conjugations of the initial N-plet of Laguerre polynomials. In physical terms the parameter $k$ may be interpreted as a measure of the "smearing of the lattice coordinates" in the model.Comment: 35 p

Characterization of the Humoral Immune Response during Staphylococcus aureus Bacteremia and Global Gene Expression by Staphylococcus aureus in Human Blood

Attempts to develop an efficient anti-staphylococcal vaccine in humans have so far been unsuccessful. Therefore, more knowledge of the antigens that are expressed by Staphylococcus aureus in human blood and induce an immune response in patients is required. In this study we further characterize the serial levels of IgG and IgA antibodies against 56 staphylococcal antigens in multiple serum samples of 21 patients with a S. aureus bacteremia, compare peak IgG levels between patients and 30 non-infected controls, and analyze the expression of 3626 genes by two genetically distinct isolates in human blood. The serum antibody levels were measured using a bead-based flow cytometry technique (xMAP®, Luminex corporation). Gene expression levels were analyzed using a microarray (BμG@s microarray). The initial levels and time taken to reach peak IgG and IgA antibody levels were heterogeneous in bacteremia patients. The antigen SA0688 was associated with the highest median initial-to-peak antibody fold-increase for IgG (5.05-fold) and the second highest increase for IgA (2.07-fold). Peak IgG levels against 27 antigens, including the antigen SA0688, were significantly elevated in bacteremia patients versus controls (P≤0.05). Expression of diverse genes, including SA0688, was ubiquitously high in both isolates at all time points during incubation in blood. However, only a limited number of genes were specifically up- or downregulated in both isolates when cultured in blood, compared to the start of incubation in blood or during incubation in BHI broth. In conclusion, most staphylococcal antigens tested in this study, including many known virulence factors, do not induce uniform increases in the antibody levels in bacteremia patients. In addition, the expression of these antigens by S. aureus is not significantly altered by incubation in human blood over time. One immunogenic and ubiquitously expressed antigen is the putative iron-regulated ABC transporter SA0688

A survey of South Carolina pharmacists\u27 readiness to prescribe human immunodeficiency virus pre-exposure prophylaxis

Introduction: Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is largely underutilized in the Southern United States. Given their community presence, pharmacists are well positioned to provide PrEP within rural, Southern regions. However, pharmacists\u27 readiness to prescribe PrEP in these communities remains unknown. Objective: To determine the perceived feasibility and acceptability of prescribing PrEP by pharmacists in South Carolina (SC). Methods: We distributed a 43-question online descriptive survey through the University of South Carolina Kennedy Pharmacy Innovation Center\u27s listserv of licensed SC pharmacists. We assessed pharmacists\u27 comfort, knowledge, and readiness to provide PrEP. Results: A total of 150 pharmacists responded to the survey. The majority were White (73%, n = 110), female (62%, n = 93), and non-Hispanic (83%, n = 125). Pharmacists practiced in retail (25%, n = 37), hospital (22%, n = 33), independent (17%, n = 25), community (13%, n = 19), specialty (6%, n = 9), and academic settings (3%, n = 4); 11% (n = 17) practiced in rural locales. Pharmacists viewed PrEP as both effective (97%, n = 122/125) and beneficial (74% n = 97/131) for their clients. Many pharmacists reported being ready (60% n = 79/130) and willing (86% n = 111/129) to prescribe PrEP, although over half (62% n = 73/118) cited lack of PrEP knowledge as a barrier. Pharmacists described pharmacies as an appropriate location to prescribe PrEP (72% n = 97/134). Conclusions: Most SC pharmacists surveyed considered PrEP to be effective and beneficial for individuals who frequent their pharmacy and are willing to prescribe this therapy if statewide statutes allow. Many felt that pharmacies are an appropriate location to prescribe PrEP but lack a complete understanding of required protocols to manage these patients. Further investigation into facilitators and barriers of pharmacy-driven PrEP is needed to enhance utilization within communities

Galaxy Zoo: the dependence of morphology and colour on environment

We analyse the relationships between galaxy morphology, colour, environment and stellar mass using data for over 100,000 objects from Galaxy Zoo, the largest sample of visually classified morphologies yet compiled. We conclusively show that colour and morphology fractions are very different functions of environment. Both are sensitive to stellar mass; however, at fixed stellar mass, while colour is also highly sensitive to environment, morphology displays much weaker environmental trends. Only a small part of both relations can be attributed to variation in the stellar mass function with environment. Galaxies with high stellar masses are mostly red, in all environments and irrespective of their morphology. Low stellar-mass galaxies are mostly blue in low-density environments, but mostly red in high-density environments, again irrespective of their morphology. The colour-density relation is primarily driven by variations in colour fractions at fixed morphology, in particular the fraction of spiral galaxies that have red colours, and especially at low stellar masses. We demonstrate that our red spirals primarily include galaxies with true spiral morphology. We clearly show there is an environmental dependence for colour beyond that for morphology. Before using the Galaxy Zoo morphologies to produce the above results, we first quantify a luminosity-, size- and redshift-dependent classification bias that affects this dataset, and probably most other studies of galaxy population morphology. A correction for this bias is derived and applied to produce a sample of galaxies with reliable morphological type likelihoods, on which we base our analysis.Comment: 25 pages, 20 figures (+ 6 pages, 11 figures in appendices); moderately revised following referee's comments; accepted by MNRA