Acute Myeloid Leukemia in a Patient with Ovarian Carcinoma

The occurrence of myelodysplastic syndrome or acute myeloid leukemia has been reported after treatment with cytotoxic alkylating agent-based chemotherapy for solid tumors. We report a 50-year-old woman presented with abdominal distension, vomiting, and fatique. The abdominal tomography showed bilaterally ovarian masses and ascite. Surgery was performed and histopathology of the ovarian mass revealed moderately differentiated papillary adenocarcinoma of ovarian. The patient was treated with chemotherapy combination including paclitaxel and carboplatin for six cycles. At 4 years after chemotherapy, recurrence of the primary disease developed. She received carboplatin and paclitaxel. Two years later, complete blood count showed leukocyte count 15.700 /mm3 (15% myeloblasts), hemoglobin 8.7 g/dL, and platelet count 88.000 /mm3. Bone marrow examination and flow cytometry analysis were consistent with acute myeloid leukemia. Standard induction chemotherapy with idarubicin and cytosine arabinoside was administered with failure to achieve complete remission. At the follow-up, the patient died due to prolonged febrile neutropenia. In conclusion, patients who were treated with high dose or long term alkylating agents should particularly follow-up for secondary tumors

In Vivo Intraocular Pressure Measurements Using A Miniaturized Nano-Photonic Sensor Implant

Purpose : We have been developing a nanophotonic pressure sensor whose optical resonance is directly related to intraocular pressure (IOP). Bench testing has demonstrated sensor near-infrared (NIR) reflectance to accurately track pressures from 0-50 mmHg. The current study examined sensor performance following implantation into rabbit eyes for up to one month

Assessment of subjective sleep quality in iron deficiency anaemia

Objectives: We aimed to assess the effect of anemia on subjective sleep quality in patients with iron deficiency anemia (IDA). Methods: One hundred and four patients diagnosed with IDA and 80 healthy individuals, who are gender and age matched, were included in the study. All participants were requested to fill 3 forms: a socio-demographic form (age, gender, marital status, income level and educational status), hospital anxiety and depression (HAD) scale and pittsburgh sleep quality index (PSQI). Results: According to the HAD scale, the average anxiety score was found 9.24\ub14.37 in patients and 7.58\ub1 4.07 in controls. And, the average depression score was 7.53\ub14.10 in patients and 6.41\ub12.74 in controls. The total sleep quality score was 6.71\ub13.02 in patients and 4.11\ub11.64 in controls. There was a statistically significant difference in terms of anxiety, depression and sleep quality scores. Linear regression analysis showed no association between anxiety and depression with poor sleeping. Conclusion: IDA affects sleep quality irrespective of psychological symptoms such as depression and anxiety

Effect of Thickness-to-Chord Ratio on Flow Structure of a Low Swept Delta Wing

The effect of thickness-to-chord (t/C) ratio on flow structure of a delta wing with sweep angle of 35 deg is characterized in a low-speed wind tunnel using laser-illuminated smoke visualization, particle image velocimetry, and surface pressure measurements. Four different t/C ratios varying from 4.75 to 19% are tested at angles of attack, 4, 6, 8, and 10 deg, for Reynolds numbers Re =1 x 10(4) and 3.5 x 10(4). The results indicate that the effect of thicknessto-chord ratio on flow structure is quite substantial, such that, as the wing thickness increases, the flow structure transforms from leading edge vortex to three-dimensional separated flow regime. The wing with lowest t/C ratio of 4.75% has pronounced surface separation at significantly higher angle of attack compared with the wing with highest t/C ratio, which indicates that lowest t/C ratio wing might be more resistive to the stall condition. However, considering the low angles of attack where all wings experience leading edge vortex structure, the strength of the vortex structure increases as the t/C ratio increases, which might suggest a better vortex-induced lift performance with high t/C ratio wing at low angles of attack

Self-esteem and quality of life in bariatric surgery candidates

WOS: 000455891800003Objective: The basic aim of this study was to explore the differences between bariatric surgery candidates (BSC) and control group in self-esteem and quality of life. In addition, our secondary aim is to find out the relationship between self-esteem and quality of life in bariatric surgery candidates. Methods: The study involves a group of BSCs screened at Haydarpasa Numune Training and Research Hospital. Sixty-one consecutive BSCs and control group assessed by Short Form-36 (SF-36), Rosenberg Self-Esteem Scale and Beck Depression Inventory (BDI). Control group was constituted from 61 normal-weight employees from the same hospital. Results: BSCs group consisted from 50 women and 11 men. BSCs scored statistically lower on all the SF-36 subscales, BDI and self-esteem scale compared with controls. The rates of having a lifetime psychiatric disorder and having any comorbid medical condition in the BSCs were statistically significantly higher than the control group. Because of regression analysis, mental health subscale score of SF-36 and BDI score were found to have the most effect on self-esteem in BSCs group. Conclusion: Self-esteem and quality of life are interrelated concepts in BSCs. Self-esteem is most commonly associated with mental health and depression levels as expected. Psychiatric follow-up has a great importance in evaluation and treatment of these patients

Micro/Nano Patterened Integrated Electrochemical Sensors for Implantable Applications

Electrochemical sensors are important candidates for autonomous integrated sensing applications. Such sensors can provide accurate and long-term measurements of multiple analyte for applications in complex environments e.g. in body fluids. As such sensors are made smaller and need to be fully integrated, special approaches need to be taken in order to achieve functional sensitivity, stability, and longevity. Here, we provide details of CMOS compatible, integrated design and fabrication of these sensors on very small scales using micro/nano scale fabrication and surface modification techniques. We also present in situ functionalization and novel interface design techniques. We also provide a comparison between integrated reference electrodes fabricated using CMOS compatible fabrication techniques. Finally, we show examples of sensing Glucose and DNA concentration in biological samples

Is there a link between mean platelet volume and thrombotic events in antiphospholipid syndrome?

The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the production of antiphospholipid antibodies (aPL) that promote vascular thrombosis and pregnancy loss. APS can occur in the absence of underlying or associated disease (primary APS) or in combination with other diseases (secondary APS). Mean platelet volume (MPV) is largely regarded as a useful surrogate marker of platelet activation. We aimed to investigate if there is a relationship between MPV and thrombotic events in APS. The study consisted of 22 patients and 22 healthy controls. Group 1 is defined as all the patients in the first day of thrombotic event. Group 2 is defined as the same patient population three months after the thrombotic event. The erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Statistical analyses showed that MPV was significantly higher in group 1 than group 2 (pThe antiphospholipid syndrome (APS) is an autoimmune disease characterized by the production of antiphospholipid antibodies (aPL) that promote vascular thrombosis and pregnancy loss. APS can occur in the absence of underlying or associated disease (primary APS) or in combination with other diseases (secondary APS). Mean platelet volume (MPV) is largely regarded as a useful surrogate marker of platelet activation. We aimed to investigate if there is a relationship between MPV and thrombotic events in APS. The study consisted of 22 patients and 22 healthy controls. Group 1 is defined as all the patients in the first day of thrombotic event. Group 2 is defined as the same patient population three months after the thrombotic event. The erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Statistical analyses showed that MPV was significantly higher in group 1 than group 2 (p&thinsp;&lt;&thinsp;0.0001) and healthy controls (p&thinsp;&lt;&thinsp;0.05). However, there was no difference between group 2 and healthy controls (p&thinsp;=&thinsp;0.888). WBC, hemoglobin and other platelet indices such as platelet distribution width and platecrit did not differ in groups. In conclusion, MPV was increased at initial thrombotic event of APS, and then it was normalized three months later by therapeutic interventions. To our knowledge, this is the first study demonstrating a correlation between MPV and thrombotic events in APS.KEYWORDS:Antiphospholipid syndrome; mean platelet volume; thrombosis</p