HF-rTMS treatment decreases psychomotor retardation in medication-resistant melancholic depression

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A qualitative study exploring effective timing and methods for physiotherapy-led pelvic health education during the childbearing year

Physiotherapy-led pelvic health education (PPHE) may help to address some of the potentially adverse health outcomes that are associated with pregnancy and child- birth. However, there is wide variation in the provision of this education during the childbearing year, and limited evidence for when and how it may be effective. Five studies with different methodologies have previously investigated the effectiveness of PPHE during the childbearing year. However, no consensus can be found be- cause of the variety of timings and methods that were investigated. Five women were purposively recruited to participate in semi-structured video interviews about their experience of PPHE during the childbearing year. These sessions were audio- recorded and then transcribed verbatim. The transcripts were analysed using the- matic analysis. This revealed three themes with three emergent factors that were identified as influencing the effectiveness of PPHE: assimilation, timing and deliv- ery of the message. It is hoped that these findings will: add to the evidence base in the field; help health professionals to understand the factors that may influence women’s engagement with education during the childbearing year; be considered in local service development plans; and direct further researc

Understanding The Hobbit: the cross-national and cross-linguistic reception of a global media product in Belgium, France and the Netherlands

The Hobbit franchise, as many global media products, reaches audiences worldwide. Audience members apparently consume a uniform media product. But do they? The World Hobbit Project offers a new and exciting opportunity to explore differences and similarities, for it provides us with audiences' understandings of the trilogy across languages and nationalities. In this paper we conduct a statistical analysis on differences and similarities in understandings of The Hobbit trilogy between Belgium, the Netherlands, and France – both in what audiences do and do not feel The Hobbit films to be. Analyzing this particular region in Europe provides an extraordinary opportunity, for The World Hobbit project allows us to compare on the language level (the Dutch and French-speaking Belgian regions with respectively the Netherlands and France), as well as on the level of national identities (comparing the three countries amongst each other). In doing so, we are able to further understand what informs geographical and linguistic differences in the consumption of a uniform media product. As such, this paper touches upon cultural hegemony, cross-border flows of fiction, language and cultural proximity

New Photodetection Method Using Unbalanced Sidebands for Squeezed Quantum Noise in Gravitational Wave Interferometer

Homodyne detection is one of the ways to circumvent the standard quantum limit for a gravitational wave detector. In this paper it will be shown that the same quantum-non-demolition effect using homodyne detection can be realized by heterodyne detection with unbalanced RF sidebands. Furthermore, a broadband quantum-non-demolition readout scheme can also be realized by the unbalanced sideband detection.Comment: 9 pages, 5 figure

Observing binary inspiral in gravitational radiation: One interferometer

We investigate the sensitivity of individual LIGO/VIRGO-like interferometers and the precision with which they can determine the characteristics of an inspiralling binary system. Since the two interferometers of the LIGO detector share nearly the same orientation, their joint sensitivity is similar to that of a single, more sensitive interferometer. We express our results for a single interferometer of both initial and advanced LIGO design, and also for the LIGO detector in the limit that its two interferometers share exactly the same orientation. We approximate the evolution of a binary system as driven exclusively by leading order quadrupole gravitational radiation. To assess the sensitivity, we calculate the rate at which sources are expected to be observed, the range to which they are observable, and the precision with which characteristic quantities describing the observed binary system can be determined. Assuming a conservative rate density for coalescing neutron star binary systems we expect that the advanced LIGO detector will observe approximately 69~yr${}^{-1}$ with an amplitude SNR greater than 8. Of these, approximately 7~yr${}^{-1}$ will be from binaries at distances greater than 950~Mpc. We explore the sensitivity of these results to a tunable parameter in the interferometer design (the recycling frequency). The optimum choice of the parameter is dependent on the goal of the observations, e.g., maximizing the rate of detections or maximizing the precision of measurement. We determine the optimum parameter values for these two cases.Comment: 40 pages (plus 7 figures), LaTeX/REVTEX3.0, NU-GR-

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity

Histone H3 lysine 36 methylation (H3K36me) is thought to participate in a host of co-transcriptional regulatory events. To study the function of this residue independent from the enzymes that modify it, we used a ‘histone replacement’ system in Drosophila to generate a non-modifiable H3K36 lysine-to-arginine (H3K36R) mutant. We observed global dysregulation of mRNA levels in H3K36R animals that correlates with the incidence of H3K36me3. Similar to previous studies, we found that mutation of H3K36 also resulted in H4 hyperacetylation. However, neither cryptic transcription initiation, nor alternative pre-mRNA splicing, contributed to the observed changes in expression, in contrast with previously reported roles for H3K36me. Interestingly, knockdown of the RNA surveillance nuclease, Xrn1, and members of the CCR4-Not deadenylase complex, restored mRNA levels for a class of downregulated, H3K36me3-rich genes. We propose a post-transcriptional role for modification of replication-dependent H3K36 in the control of metazoan gene expression

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion

Endogenous retroviruses (ERVs) are proviral sequences that result from colonization of the host germ line by exogenous retroviruses. The majority of ERVs represent defective retroviral copies. However, for most ERVs, endogenization occurred millions of years ago, obscuring the stages by which ERVs become defective and the changes in both virus and host important to the process. The koala retrovirus, KoRV, only recently began invading the germ line of the koala (Phascolarctos cinereus), permitting analysis of retroviral endogenization on a prospective basis. Here, we report that recombination with host genomic elements disrupts retroviruses during the earliest stages of germ-line invasion. One type of recombinant, designated recKoRV1, was formed by recombination of KoRV with an older degraded retroelement. Many genomic copies of recKoRV1 were detected across koalas. The prevalence of recKoRV1 was higher in northern than in southern Australian koalas, as is the case for KoRV, with differences in recKoRV1 prevalence, but not KoRV prevalence, between inland and coastal New South Wales. At least 15 additional different recombination events between KoRV and the older endogenous retroelement generated distinct recKoRVs with different geographic distributions. All of the identified recombinant viruses appear to have arisen independently and have highly disrupted ORFs, which suggests that recombination with existing degraded endogenous retroelements may be a means by which replication-competent ERVs that enter the germ line are degraded

Results of the First Coincident Observations by Two Laser-Interferometric Gravitational Wave Detectors

We report an upper bound on the strain amplitude of gravitational wave bursts in a waveband from around 800Hz to 1.25kHz. In an effective coincident observing period of 62 hours, the prototype laser interferometric gravitational wave detectors of the University of Glasgow and Max Planck Institute for Quantum Optics, have set a limit of 4.9E-16, averaging over wave polarizations and incident directions. This is roughly a factor of 2 worse than the theoretical best limit that the detectors could have set, the excess being due to unmodelled non-Gaussian noise. The experiment has demonstrated the viability of the kind of observations planned for the large-scale interferometers that should be on-line in a few years time.Comment: 11 pages, 2 postscript figure