Cow, farm, and herd management factors in the dry period associated with raised somatic cell counts in early lactation

This study investigated cow characteristics, farm facilities, and herd management strategies during the dry period to examine their joint influence on somatic cell counts (SCC) in early lactation. Data from 52 commercial dairy farms throughout England and Wales were collected over a 2-yr period. For the purpose of analysis, cows were separated into those housed for the dry period (6,419 cow-dry periods) and those at pasture (7,425 cow-dry periods). Bayesian multilevel models were specified with 2 response variables: ln SCC (continuous) and SCC >199,000 cells/mL (binary), both within 30 d of calving. Cow factors associated with an increased SCC after calving were parity, an SCC >199,000 cells/mL in the 60 d before drying off, increasing milk yield 0 to 30 d before drying off, and reduced DIM after calving at the time of SCC estimation. Herd management factors associated with an increased SCC after calving included procedures at drying off, aspects of bedding management, stocking density, and method of pasture grazing. Posterior predictions were used for model assessment, and these indicated that model fit was generally good. The research demonstrated that specific dry-period management strategies have an important influence on SCC in early lactation

"I always know what's going on." Assessing the Relationship between Perceived and Actual Situation Awareness across Different Scenarios

Effective performance in a situation relies on having a good awareness of that situation or at least, if SA is poor, being aware that this is the case. This study examined the bias (tendency to accept or reject available information) and actual and perceived SA of firefighters across two different situations The data suggested that, although actual SA and bia varied across the situations, perceived SA remained relatively constant. This raises the possibility that individuals may have a ‘resting level’ of perceived SA and that the tasks used in this study were effective in manipulating actual SA while perceived SA remained at the resting level

"I always know what's going on." Assessing the Relationship between Perceived and Actual Situation Awareness across Different Scenarios

Effective performance in a situation relies on having a good awareness of that situation or at least, if SA is poor, being aware that this is the case. This study examined the bias (tendency to accept or reject available information) and actual and perceived SA of firefighters across two different situations The data suggested that, although actual SA and bia varied across the situations, perceived SA remained relatively constant. This raises the possibility that individuals may have a ‘resting level’ of perceived SA and that the tasks used in this study were effective in manipulating actual SA while perceived SA remained at the resting level

A Fair Exchange: The Reciprocal Relationship Between Universities and Clinical Placement Supervisors

Clinical psychology training in the UK relies heavily upon supervised clinical practice placements. Placement supervisors have a significant responsibility for providing trainees with the learning experiences required for qualification. The role is demanding and whilst the university benefits greatly, it is less clear what supervisors receive in return. This is important when one considers how positive relationships and social action are influenced by reciprocity and a sense of belongingness. Despite its importance, no research has directly explored the relationship between supervisors and the university in a clinical psychology training context. This novel study sought to explore how supervisors perceive their role and their connectedness / belongingness to the university, and whether technology utilized by other areas of pedagogy led to improvements. Access to electronic resources was sent to clinical placement supervisors (n=100). A subset of these (n=7) signed up to complete a semi-structured interview. The interviews were analysed using template analysis. Common themes emerged, including perceived benefits of the supervisor role, such as feeling connected to the training course, despite significant challenges and demands. The provision of electronic resources was found to have the potential to enhance connectedness for all stakeholders. The implications of these findings are discussed

The human brain in fireground decision-making: trustworthy firefighting equipment?

The research programme to date has involved studies of the response of Fire and Rescue (FRS) crew and commanders in fireground training situations and simulations (tabletop, BA and incident command exercises). The studies have revealed patterns and tendencies with potentially serious consequences for real FRS situations. The main conclusion from these studies is that the fire personnel involved were well-trained professionals with good “Situation Awareness” (SA) or knowledge of the incident under study, but there was also evidence of “bias” in decision-making leading to either a tunneling or broadening of focus that may respectively produce “miss” or “false alarm” errors. This tendency is linked to the limits of the human brain under pressure and could explain tragic errors of decision-making such as may have occurred in real-life fire incidents

Identification of Cyclically Symmetric Resonance in Experimental Data for Engine Failure Analysis

Many structural components are rotationally symmetric. For a perfectly manufactured structure, the modal wave shapes are exactly sinusoidal. These structures can be excited by similarly-shaped forcing functions such as those found frequently in or near turbomachinery. Due to orthogonality, resonance occurs only when the integer wave number of the structure equals the integer wave number of the excitation as well as when the excitation frequency is close to the natural frequency of the mode. This resonance can lead to high-cycle fatigue (HCF) cracking of the structure. To help understand this phenomenon, it is desirable to determine the modal composition of the response and excitation. Once the modal composition is known, either the excitation or the structure can be modified to reduce the response and therefore prevent HCF cracking

Physiological Changes as a Measure of Crustacean Welfare under Different Standardized Stunning Techniques: Cooling and Electroshock

Stunning of edible crustaceans to reduce sensory perception prior and during slaughter is an important topic in animal welfare. The purpose of this project was to determine how neural circuits were affected during stunning by examining the physiological function of neural circuits. The central nervous system circuit to a cardiac or skeletal muscle response was examined. Three commercially important crustacean species were utilized for stunning by immersion in an ice slurry below 4 °C and by electrocution; both practices are used in the seafood industry. The blue crab (Callinectes sapidus), the red swamp crayfish (Procambarus clarkii), and the whiteleg shrimp (Litopenaeus vannamei) responded differently to stunning by cold and electric shock. Immersion in ice slurry induced sedation within seconds in crayfish and shrimp but not crabs and cardiac function was reduced fastest in shrimp. However, crabs could retain a functional neural circuit over the same time when shrimp and crayfish were nonresponsive. An electroshock of 10 s paralyzed all three species and subsequently decreased heart rate within 1 min and then heart rate increased but resulted in irregularity over time. Further research is needed to study a state of responsiveness by these methods

A missing dimension in measures of vaccination impacts

Immunological protection, acquired from either natural infection or vaccination, varies among hosts, reflecting underlying biological variation and affecting population-level protection. Owing to the nature of resistance mechanisms, distributions of susceptibility and protection entangle with pathogen dose in a way that can be decoupled by adequately representing the dose dimension. Any infectious processes must depend in some fashion on dose, and empirical evidence exists for an effect of exposure dose on the probability of transmission to mumps-vaccinated hosts [1], the case-fatality ratio of measles [2], and the probability of infection and, given infection, of symptoms in cholera [3]. Extreme distributions of vaccine protection have been termed leaky (partially protects all hosts) and all-or-nothing (totally protects a proportion of hosts) [4]. These distributions can be distinguished in vaccine field trials from the time dependence of infections [5]. Frailty mixing models have also been proposed to estimate the distribution of protection from time to event data [6], [7], although the results are not comparable across regions unless there is explicit control for baseline transmission [8]. Distributions of host susceptibility and acquired protection can be estimated from dose-response data generated under controlled experimental conditions [9]–[11] and natural settings [12], [13]. These distributions can guide research on mechanisms of protection, as well as enable model validity across the entire range of transmission intensities. We argue for a shift to a dose-dimension paradigm in infectious disease science and community health

Observationally constrained surface mass balance of Larsen C IceShelf, Antarctica

Abstract. Combining several geophysical techniques, we reconstruct spatial and temporal patterns of surface mass balance (SMB) over Larsen C Ice Shelf (LCIS), Antarctic Peninsula. Continuous time series of snow height at five locations allow for multi-year estimates of seasonal and annual SMB over LCIS. There is high interannual variability, with an SMB of 395 ± 61 to 413 ± 42 mm w.e. y−1 in the north and a larger SMB of up to 496 ± 50 mm w.e. y−1 farther south. This difference between north and south is corroborated by winter snow accumulation derived from an airborne radar survey from 2009, which showed an average snow thickness of 0.95 m north of 76° S, and 1.12 m south of 78°. Analysis of ground-penetrating radar from several field campaigns allows for a longer-term perspective of spatial SMB: a particularly strong and coherent reflection horizon below 25–44 m w.e. of ice and firn is observed in radargrams collected across the shelf. We propose that this horizon was formed in a single melt season over the ice shelf. Combining ground and airborne radar with SMB output from a regional climate model confirms that SMB increases from north to south, overprinted by a gradient of increasing SMB to the west. Previous observations show a strong decrease in firn air content toward the west, which we attribute to spatial patterns of melt, refreezing, and densification, rather than SMB. </jats:p

Estimating health care costs at scale in low- and middle-income countries: Mathematical notations and frameworks for the application of cost functions

Appropriate costing and economic modeling are major factors for the successful scale-up of health interventions. Various cost functions are currently being used to estimate costs of health interventions at scale in low- and middle-income countries (LMICs) potentially resulting in disparate cost projections. The aim of this study is to gain understanding of current methods used and provide guidance to inform the use of cost functions that is fit for purpose. We reviewed seven databases covering the economic and global health literature to identify studies reporting a quantitative analysis of costs informing the projected scale-up of a health intervention in LMICs between 2003 and 2019. Of the 8725 articles identified, 40 met the inclusion criteria. We classified studies according to the type of cost functions applied-accounting or econometric-and described the intended use of cost projections. Based on these findings, we developed new mathematical notations and cost function frameworks for the analysis of healthcare costs at scale in LMICs setting. These notations estimate variable returns to scale in cost projection methods, which is currently ignored in most studies. The frameworks help to balance simplicity versus accuracy and increase the overall transparency in reporting of methods