Placental glucocorticoid receptor isoforms in a sheep model of maternal allergic asthma

Maternal asthma increases the risk of adverse pregnancy outcomes and may affect fetal growth and placental function by differential effects on the expression of glucocorticoid receptor (GR) isoforms, leading to altered glucocorticoid signalling. Our aim was to examine the effect of maternal asthma on placental GR profiles using a pregnant sheep model of asthma. Nine known GR isoforms were detected. There was a significant increase in the expression of placental GR isoforms that are known to have low trans-activational activity in other species including GR A, GR P and GRγ which may result in a pro-inflammatory environment in the presence of allergic asthma

Solar abundance of manganese: a case for near Chandrasekhar-mass Type Ia supernova progenitors

Context: Manganese is predominantly synthesised in Type Ia supernova (SN Ia) explosions. Owing to the entropy dependence of the Mn yield in explosive thermonuclear burning, SNe Ia involving near Chandrasekhar-mass white dwarfs (WDs) are predicted to produce Mn to Fe ratios significantly exceeding those of SN Ia explosions involving sub-Chandrasekhar mass primary WDs. Of all current supernova explosion models, only SN Ia models involving near-Chandrasekhar mass WDs produce [Mn/Fe] > 0.0. Aims: Using the specific yields for competing SN Ia scenarios, we aim to constrain the relative fractions of exploding near-Chandrasekhar mass to sub-Chandrasekhar mass primary WDs in the Galaxy. Methods: We extract the Mn yields from three-dimensional thermonuclear supernova simulations referring to different initial setups and progenitor channels. We then compute the chemical evolution of Mn in the Solar neighborhood, assuming SNe Ia are made up of different relative fractions of the considered explosion models. Results: We find that due to the entropy dependence of freeze-out yields from nuclear statistical equilibrium, [Mn/Fe] strongly depends on the mass of the exploding WD, with near-Chandraskher mass WDs producing substantially higher [Mn/Fe] than sub-Chandrasekhar mass WDs. Of all nucleosynthetic sources potentially influencing the chemical evolution of Mn, only explosion models involving the thermonuclear incineration of near-Chandrasekhar mass WDs predict solar or super-solar [Mn/Fe]. Consequently, we find in our chemical evolution calculations that the observed [Mn/Fe] in the Solar neighborhood at [Fe/H] > 0.0 cannot be reproduced without near-Chandrasekhar mass SN Ia primaries. Assuming that 50 per cent of all SNe Ia stem from explosive thermonuclear burning in near-Chandrasekhar mass WDs results in a good match to data.Comment: Added author R. Pakmor, who mistakenly was forgotten in the first version. Sorry Ruediger! 5 pages, 1 figure, 1 table, submitted as a letter to Astronomy & Astrophysic

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Data for Effect of HCl cleaning on InSb–Al2O3 MOS capacitors

In this work, the role of HCl treatments on InSb surfaces and InSb–Al2O3 dielectric interfaces is characterised. X-ray photoelectron spectroscopy measurements indicate that HCl diluted in and rinsed with isopropanol (IPA) results in a surface layer of InCl3 which is not present for similar HCl-water processes. Furthermore, this InCl3 layer desorbs from the surface between 200 °C and 250 °C. Metal–oxide–semiconductor capacitors were fabricated using atomic layer deposition of Al2O3 at 200 °C and 250 °C and the presence of InCl3 was associated with a +0.79 V flatband voltage shift. The desorption of the InCl3 layer at 250 °C reversed this shift but the increased process temperature resulted in increased interface-trapped charge (D it) and hysteresis voltage (V H ). This shift in flatband voltage, which does not affect other figures of merit, offers a promising route to manipulate the threshold voltage of MOS transistors, allowing enhancement-mode and depletion-mode devices to be fabricated in parallel