A hydrodynamical halo model for weak-lensing cross correlations

On the scale of galactic haloes, the distribution of matter in the cosmos is affected by energetic, non-gravitational processes; so-called baryonic feedback. A lack of knowledge about the details of how feedback processes redistribute matter is a source of uncertainty for weak-lensing surveys, which accurately probe the clustering of matter in the Universe over a wide range of scales. We develop a cosmology-dependent model for the matter distribution that simultaneously accounts for the clustering of dark matter, gas and stars. We inform our model by comparing it to power spectra measured from the BAHAMAS suite of hydrodynamical simulations. As well as considering matter power spectra, we also consider spectra involving the electron-pressure field, which directly relates to the thermal Sunyaev-Zel'dovich (tSZ) effect. We fit parameters in our model so that it can simultaneously model both matter and pressure data and such that the distribution of gas as inferred from tSZ has influence on the matter spectrum predicted by our model. We present two variants; one that matches the feedback-induced suppression seen in the matter-matter power spectrum at the per-cent level and a second that matches the matter-matter data slightly less well (~2 per cent), but that is able to simultaneously model the matter-electron pressure spectrum at the ~15 per-cent level. We envisage our models being used to simultaneously learn about cosmological parameters and the strength of baryonic feedback using a combination of tSZ and lensing auto- and cross-correlation data

Neurofilament light chain and tau concentrations are markedly increased in the serum of patients with sporadic Creutzfeldt-Jakob disease, and tau correlates with rate of disease progression

OBJECTIVES: A blood-based biomarker of neuronal damage in sporadic Creutzfeldt-Jakob disease (sCJD) will be extremely valuable for both clinical practice and research aiming to develop effective therapies. METHODS: We used an ultrasensitive immunoassay to measure two candidate biomarkers, tau and neurofilament light (NfL), in serum from patients with sCJD and healthy controls. We tested longitudinal sample sets from six patients to investigate changes over time, and examined correlations with rate of disease progression and associations with known phenotype modifiers. RESULTS: Serum concentrations of both tau and NfL were increased in patients with sCJD. NfL distinguished patients from controls with 100% sensitivity and 100% specificity. Tau did so with 91% sensitivity and 83% specificity. Both tau and NfL appeared to increase over time in individual patients, particularly in those with several samples tested late in their disease. Tau, but not NfL, was positively correlated with rate of disease progression, and was particularly increased in patients homozygous for methionine at codon 129 ofPRNP. CONCLUSIONS: These findings independently replicate other recent studies using similar methods and offer novel insights. They show clear promise for these blood-based biomarkers in prion disease. Future work should aim to fully establish their potential roles for monitoring disease progression and response to therapies

An analysis of galaxy cluster mis-centring using cosmological hydrodynamic simulations

The location of a galaxy cluster’s centroid is typically derived from observations of the galactic and/or gas component of the cluster, but these typically deviate from the true centre. This can produce bias when observations are combined to study average cluster properties. Using data from the BAryons and HAloes of MAssive Systems (BAHAMAS) cosmological hydrodynamic simulations, we study this bias in both two and three dimensions for 2000 clusters over the 1013–1015 M⊙ mass range. We quantify and model the offset distributions between observationally motivated centres and the ‘true’ centre of the cluster, which is taken to be the most gravitationally bound particle measured in the simulation. We fit the cumulative distribution function of offsets with an exponential distribution and a Gamma distribution fit well with most of the centroid definitions. The galaxy-based centres can be seen to be divided into a mis-centred group and a well-centred group, with the well-centred group making up about 60 per cent of all the clusters. Gas-based centres are overall less scattered than galaxy-based centres. We also find a cluster-mass dependence of the offset distribution of gas-based centres, with generally larger offsets for smaller mass clusters. We then measure cluster density profiles centred at each choice of the centres and fit them with empirical models. Stacked, mis-centred density profiles fit to the Navarro–Frenk–White dark matter profile and Komatsu–Seljak gas profile show that recovered shape and size parameters can significantly deviate from the true values. For the galaxy-based centres, this can lead to cluster masses being underestimated by up to 10 per cent⁠

Outer zone electrons

Spatial and temporal behavior of high energy trapped electrons in outer zone of magnetospher

Joint constraints on cosmology and the impact of baryon feedback: Combining KiDS-1000 lensing with the thermal Sunyaeva- Zeldovich effect from Planck and ACT

We conduct a pseudo-analysis of the tomographic cross-correlation between 1000 deg2 of weak-lensing data from the Kilo-Degree Survey (KiDS-1000) and the thermal Sunyaeva- Zeldovich (tSZ) effect measured by Planck and the Atacama Cosmology Telescope (ACT). Using HMX, a halo-model-based approach that consistently models the gas, star, and dark matter components, we are able to derive constraints on both cosmology and baryon feedback for the first time from these data, marginalising over redshift uncertainties, intrinsic alignment of galaxies, and contamination by the cosmic infrared background (CIB). We find our results to be insensitive to the CIB, while intrinsic alignment provides a small but significant contribution to the lensinga- tSZ cross-correlation. The cosmological constraints are consistent with those of other low-redshift probes and prefer strong baryon feedback. The inferred amplitude of the lensinga- tSZ cross-correlation signal, which scales as I8(Om/0.3)0.2, is low by compared to the primary cosmic microwave background constraints by Planck. The lensinga- tSZ measurements are then combined with pseudo-CAmeasurements of KiDS-1000 cosmic shear into a novel joint analysis, accounting for the full cross-covariance between the probes, providing tight cosmological constraints by breaking parameter degeneracies inherent to both probes. The joint analysis gives an improvement of 40% on the constraint of S8 = I8Om/0.3 over cosmic shear alone, while providing constraints on baryon feedback consistent with hydrodynamical simulations, demonstrating the potential of such joint analyses with baryonic tracers such as the tSZ effect. We discuss remaining modelling challenges that need to be addressed if these baryonic probes are to be included in future precision-cosmology analyses

Prioritising surveillance for alien organisms transported as stowaways on ships travelling to South Africa

The global shipping network facilitates the transportation and introduction of marine and terrestrial organisms to regions where they are not native, and some of these organisms become invasive. South Africa was used as a case study to evaluate the potential for shipping to contribute to the introduction and establishment of marine and terrestrial alien species (i.e. establishment debt) and to assess how this varies across shipping routes and seasons. As a proxy for the number of species introduced (i.e. 'colonisation pressure') shipping movement data were used to determine, for each season, the number of ships that visited South African ports from foreign ports and the number of days travelled between ports. Seasonal marine and terrestrial environmental similarity between South African and foreign ports was then used to estimate the likelihood that introduced species would establish. These data were used to determine the seasonal relative contribution of shipping routes to South Africa's marine and terrestrial establishment debt. Additionally, distribution data were used to identify marine and terrestrial species that are known to be invasive elsewhere and which might be introduced to each South African port through shipping routes that have a high relative contribution to establishment debt. Shipping routes from Asian ports, especially Singapore, have a particularly high relative contribution to South Africa's establishment debt, while among South African ports, Durban has the highest risk of being invaded. There was seasonal variation in the shipping routes that have a high relative contribution to the establishment debt of the South African ports. The presented method provides a simple way to prioritise surveillance effort and our results indicate that, for South Africa, port-specific prevention strategies should be developed, a large portion of the available resources should be allocated to Durban, and seasonal variations and their consequences for prevention strategies should be explored further. (Résumé d'auteur

Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Recent advances in single-cell transcriptomics are ideally placed to unravel intratumoral heterogeneity and selective resistance of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies. However, current single-cell RNA-sequencing approaches lack the sensitivity required to reliably detect somatic mutations. We developed a method that combines high-sensitivity mutation detection with whole-transcriptome analysis of the same single cell. We applied this technique to analyze more than 2,000 SCs from patients with chronic myeloid leukemia (CML) throughout the disease course, revealing heterogeneity of CML-SCs, including the identification of a subgroup of CML-SCs with a distinct molecular signature that selectively persisted during prolonged therapy. Analysis of nonleukemic SCs from patients with CML also provided new insights into cell-extrinsic disruption of hematopoiesis in CML associated with clinical outcome. Furthermore, we used this single-cell approach to identify a blast-crisis-specific SC population, which was also present in a subclone of CML-SCs during the chronic phase in a patient who subsequently developed blast crisis. This approach, which might be broadly applied to any malignancy, illustrates how single-cell analysis can identify subpopulations of therapy-resistant SCs that are not apparent through cell-population analysis

Paracrine-mediated neuroprotection and neuritogenesis of axotomised retinal ganglion cells by human dental pulp stem cells:Comparison with human bone marrow and adipose-derived mesenchymal stem cells

We have investigated and compared the neurotrophic activity of human dental pulp stem cells (hDPSC), human bone marrow-derived mesenchymal stem cells (hBMSC) and human adipose-derived stem cells (hAMSC) on axotomised adult rat retinal ganglion cells (RGC) in vitro in order to evaluate their therapeutic potential for neurodegenerative conditions of RGC. Using the transwell system, RGC survival and length/number of neurites were quantified in coculture with stem cells in the presence or absence of specific Fc-receptor inhibitors to determine the role of NGF, BDNF, NT-3, VEGF, GDNF, PDGF-AA and PDGF-AB/BB in stem cell-mediated RGC neuroprotection and neuritogenesis. Conditioned media, collected from cultured hDPSC/hBMSC/hAMSC, were assayed for the secreted growth factors detailed above using ELISA. PCR array determined the hDPSC, hBMSC and hAMSC expression of genes encoding 84 growth factors and receptors. The results demonstrated that hDPSC promoted significantly more neuroprotection and neuritogenesis of axotomised RGC than either hBMSC or hAMSC, an effect that was neutralized after the addition of specific Fc-receptor inhibitors. hDPSC secreted greater levels of various growth factors including NGF, BDNF and VEGF compared with hBMSC/hAMSC. The PCR array confirmed these findings and identified VGF as a novel potentially therapeutic hDPSC-derived neurotrophic factor (NTF) with significant RGC neuroprotective properties after coculture with axotomised RGC. In conclusion, hDPSC promoted significant multi-factorial paracrine-mediated RGC survival and neurite outgrowth and may be considered a potent and advantageous cell therapy for retinal nerve repair