COINING PHRASES FOR DOLLARS: JAY-Z, ECONOMIC LITERACY, AND THE EDUCATIONAL IMPLICATIONS OF HIP-HOP’S ENTREPRENEURIAL ETHOS

Previous research examining Hip-Hop and education has almost exclusively examined Hip-Hop’s connection to literacy and literary education, Morrell, 2002; Hill, 2009; Fisher, 2007 Lee & Majors, 2003). The paper examines the educational implications of Hip-Hip’s entrepreneurial ethos. This paper examines data collected over a five year period from 8th grade through four years of high school looking at the Hip-Hop practices of 12 youths in the group, “Bassline Entertainment.” Using the lyrics of Jay-Z as a thematic frame, this paper delineates the manner in which the entrepreneurial ethos of Hip-Hop helped convince these young artists of the relevance of a college education.  This paper found that the educational relevance of Hip-Hop culture emerged from the fact that the youth were engaged in an entrepreneurial endeavor. In contrast to previous research on Hip-Hop and education which viewed the students’ texts as literary documents, the students of Bassline Entertainment perceived their Hip-Hop texts as commodities or commodified texts. Thus, the Hip-Hop lyrical and musical composition for the Bassline students was inherently incomplete. It was only complete once it was marketed or sold in the manner in which it gained access to an audience. Consequently, an additional and extended array of skills and competencies became relevant to the Bassline Students, persuasive letter-writing skills to intellectual property attorneys in order to get the samples on their CD’s cleared, web design and digital graphics to promote their music, event planning and promotion to create performance opportunities, as well as videography and film to create videos for their work. Within this framework, the extended skill development afforded by a college education became personally relevant to the Bassline artists. In the end, each of the members of the Bassline Entertainment group applied for and was accepted into a four-year post-secondary college or University

Effect of Meter Orientation Downstream of a Short Radius Elbow on Electromagnetic Flow Meters

Electromagnetic flow meters (known as magnetic flow meters) are a widely used type of flow meter. This study examines the performance of magnetic flow meters when the electrodes in the meter are positioned at two different orientations: electrodes parallel with the plane of an upstream 90° short radius elbow and electrodes perpendicular to the plane of an upstream 90° short radius elbow. Four different meters from four different manufacturers were included in the study in which a baseline straight pipe test was first performed using more than 50 diameters of straight pipe upstream of each meter. The four meters were then installed at five different locations downstream from a 90° short-radius elbow. At each location, the meters were tested in two orientations at five different flow rates. From this study, shifts in the flow rate were observed with the electrodes located at two different orientations. These shifts in flow rate ranged from 0.01% to 4.40% of the total flow measurement, and the average shifts in flow rate ranged from 0.07% to 2.78%. For the purposes of this study, the shift in flow rate is the percentage relative to the baseline test. The results from this study illustrated that there is a significant difference in measurement accuracy when the meter electrodes are installed at different orientations relative to the plane of the bend

BCL-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response

The Bcl-2 family encompasses a diverse set of apoptotic regulators that are dynamically activated in response to various cell-intrinsic and -extrinsic stimuli. An extensive variety of cell culture experiments have identified effects of growth factors, cytokines, and drugs on Bcl-2 family functions, but in vivo studies have tended to focus on the role of one or two particular members in development and organ homeostasis. Thus, the ability of physiologically relevant contexts to modulate canonical dependencies that are likely to be more complex has yet to be investigated systematically. In this study, we report findings derived from a pool-based shRNA assay that systematically and comprehensively interrogated the functional dependence of leukemia and lymphoma cells upon various Bcl-2 family members across many diverse in vitro and in vivo settings. This approach permitted us to report the first in vivo loss of function screen for modifiers of the response to a front-line chemotherapeutic agent. Notably, our results reveal an unexpected role for the extrinsic death pathway as a tissue-specific modifier of therapeutic response. In particular, our findings show that particular tissue sites of tumor dissemination play critical roles in demarcating the nature and extent of cancer cell vulnerabilities and mechanisms of chemoresistance. Cancer Res; 71(17); 5850–8. ©2011 AACR.National Institutes of Health (U.S.) (NIH RO1 CA128803)National Cancer Institute (U.S.) (Integrated Cancer Biology Program grant NCI 1-U54-CA112967)David H. Koch Institute for Integrative Cancer Research at MIT (Ludwig Fellowship)Massachusetts Institute of Technology. Dept. of Biology (training grant

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in culture versus in their native microenvironment. Specifically, we identified many “context-specific” regulators of leukemia development. These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in human myeloid and T-cell malignancies, we found that Phf6 suppression in B-cell malignancies impairs tumor progression. Thus, Phf6 is a “lineage-specific” cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.Massachusetts Institute of Technology. Department of Biology (Training Grant)National Cancer Institute (U.S.). Integrative Cancer Biology Program (U54-CA112967-06)National Institutes of Health (U.S.) (RO1-CA128803-05

Climate dynamics and fluid mechanics: Natural variability and related uncertainties

The purpose of this review-and-research paper is twofold: (i) to review the role played in climate dynamics by fluid-dynamical models; and (ii) to contribute to the understanding and reduction of the uncertainties in future climate-change projections. To illustrate the first point, we focus on the large-scale, wind-driven flow of the mid-latitude oceans which contribute in a crucial way to Earth's climate, and to changes therein. We study the low-frequency variability (LFV) of the wind-driven, double-gyre circulation in mid-latitude ocean basins, via the bifurcation sequence that leads from steady states through periodic solutions and on to the chaotic, irregular flows documented in the observations. This sequence involves local, pitchfork and Hopf bifurcations, as well as global, homoclinic ones. The natural climate variability induced by the LFV of the ocean circulation is but one of the causes of uncertainties in climate projections. Another major cause of such uncertainties could reside in the structural instability in the topological sense, of the equations governing climate dynamics, including but not restricted to those of atmospheric and ocean dynamics. We propose a novel approach to understand, and possibly reduce, these uncertainties, based on the concepts and methods of random dynamical systems theory. As a very first step, we study the effect of noise on the topological classes of the Arnol'd family of circle maps, a paradigmatic model of frequency locking as occurring in the nonlinear interactions between the El Nino-Southern Oscillations (ENSO) and the seasonal cycle. It is shown that the maps' fine-grained resonant landscape is smoothed by the noise, thus permitting their coarse-grained classification. This result is consistent with stabilizing effects of stochastic parametrization obtained in modeling of ENSO phenomenon via some general circulation models.Comment: Invited survey paper for Special Issue on The Euler Equations: 250 Years On, in Physica D: Nonlinear phenomen

Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O2-mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O2-mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.Center for Bio-Integrated Electronics at Northwestern University; Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF) [ECCS-1542205]; Materials Research Science and Engineering Center [DMR-1720139]; State of Illinois; Northwestern University; Developmental Therapeutics Core at Northwestern University; Robert H. Lurie Comprehensive Cancer Center [NCI CA060553]Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Preliminary Characterization and Analysis of the Designs and Research-Manufacturing Approaches

This report summarizes the results of Phase I of a study entitled, Low-Cost Manufacturing Of Multilayer Ceramic Fuel Cells. The work was carried out by a group called the Multilayer Fuel Cell Alliance (MLFCA) led by NexTech Materials and including Adaptive Materials, Advanced Materials Technologies (AMT), Cobb & Co., Edison Materials Technology Center, Iowa State University, Gas Technology Institute (GTI), Northwestern University, Oak Ridge National Laboratory (ORNL), Ohio State University, University of Missouri-Rolla (UMR), and Wright-Patterson Air Force Base. The objective of the program is to develop advanced manufacturing technologies for making solid oxide fuel cell components that are more economical and reliable for a variety of applications. In the Phase I effort, five approaches were considered: two based on NexTech's planar approach using anode and cathode supported variations, one based on UMR's ultra-thin electrolyte approach, and two based on AMI's co-extrusion technology. Based on a detailed manufacturing cost analysis, all of the approaches are projected to result in a significantly reduced production cost. Projected costs range from $139/kW to$179/kW for planar designs. Development risks were assessed for each approach and it was determined that the NexTech and UMR approaches carried the least risk for successful development. Using advanced manufacturing methods and a proprietary high power density design, the team estimated that production costs could be reduced to $94/kW

Estimate of Hanford Waste Rheology and Settling Behavior

The U.S. Department of Energy (DOE) Office of River Protection’s Waste Treatment and Immobilization Plant (WTP) will process and treat radioactive waste that is stored in tanks at the Hanford Site. Piping, pumps, and mixing vessels have been selected to transport, store, and mix the high-level waste slurries in the WTP. This report addresses the analyses performed by the Rheology Working Group (RWG) and Risk Assessment Working Group composed of Pacific Northwest National Laboratory (PNNL), Bechtel National Inc. (BNI), CH2M HILL, DOE Office of River Protection (ORP) and Yasuo Onishi Consulting, LLC staff on data obtained from documented Hanford waste analyses to determine a best-estimate of the rheology of the Hanford tank wastes and their settling behavior. The actual testing activities were performed and reported separately in referenced documentation. Because of this, many of the required topics below do not apply and are so noted