Castlemans Disease- A Case Report

Castlemans disease(CD) is a heterogeneous group of lymphoproliferative disorders of uncertain cause presenting with lymphadenopathy. It is histologically and prognostically distinct from malignant lymph-node hyperplasia. It was first described in a group of patientswith benign localised hyperplastic lymph-nodes in 1956 by Castleman et al. We report a case of a 70 year old gentleman who was clinically suspected to have lymphoma , but later histologically confirmed to have Castlemans disease.DOI: http://dx.doi.org/10.3329/bsmmuj.v5i1.11031 BSMMU J 2012; 5(1):79-80

Did national holidays accelerate COVID-19 diffusion during the first phase of the pandemic in Bangladesh?

Bangladesh registered 20,117,32 confirmed cases of COVID-19 and the death toll crossed the grim milestone of 29,323 across the country as of August 31st, 2022. Despite the enforcement of stringent COVID-19 measures, the country witnessed an accelerated diffusion of coronavirus cases during the national events, inclusive of short festivals, in 2020. The present study aims to examine the association between these national holidays and the COVID-19 trasmission rate in Bangladesh. We employed a mathematical model and calculated the instantaneous reproduction number, Rt, of the 64 districts in Bangladesh to check the dynamics of COVID-19 diffusion. The comprehensive analysis shows a notable escalation of Rt value and thus the enhanced transmission rate in Dhaka and in all industrialized cities during the major events such as, garments reopening and religious holidays in Bangladesh. We further showcase the COVID-19 diffusion explicitly in Dhaka Division at the first phase of the pandemic in Bangladesh. Based on our analysis, a set of measures, including restricted public mobility and the celebration of festivals, alongside improving the public’s awareness of the situation, has been recommended to evade the future pandemic risks while running the national festival activities in Bangladesh

A 30-day follow-up study on the prevalence of SARS-COV-2 genetic markers in wastewater from the residence of COVID-19 patient and comparison with clinical positivity

Wastewater based epidemiology (WBE) is an important tool to fight against COVID-19 as it provides insights into the health status of the targeted population from a small single house to a large municipality in a cost-effective, rapid, and non-invasive way. The implementation of wastewater based surveillance (WBS) could reduce the burden on the public health system, management of pandemics, help to make informed decisions, and protect public health. In this study, a house with COVID-19 patients was targeted for monitoring the prevalence of SARS-CoV-2 genetic markers in wastewa-ter samples (WS) with clinical specimens (CS) for a period of 30 days. RT-qPCR technique was employed to target non-structural (ORF1ab) and structural-nucleocapsid (N) protein genes of SARS-CoV-2, according to a validated experimental protocol. Physiological, environmental, and biological parameters were also measured following the American Public Health Association (APHA) standard protocols. SARS-CoV-2 viral shedding in wastewater peaked when the highest number of COVID-19 cases were clinically diagnosed. Throughout the study period, 7450 to 23,000 gene copies/1000 mL were detected, where we identified 47 % (57/120) positive samples from WS and 35 % (128/360) from CS. When the COVID-19 patient number was the lowest (2), the highest CT value (39.4; i.e., lowest copy number) was identified from WS. On the other hand, when the COVID-19 patients were the highest (6), the lowest CT value (25.2 i.e., highest copy numbers) was obtained from WS. An advance signal of increased SARS-CoV-2 viral load from the COVID-19 patient was found in WS earlier than in the CS. Using customized primer sets in a traditional PCR approach, we confirmed that all SARS-CoV-2 variants identified in both CS and WS were Delta variants (B.1.617.2). To our knowledge, this is the first follow-up study to determine a temporal relationship be-tween COVID-19 patients and their discharge of SARS-CoV-2 RNA genetic markers in wastewater from a single house including all family members for clinical sampling from a developing country (Bangladesh), where a proper sewage system is lacking. The salient findings of the study indicate that monitoring the genetic markers of the SARS-CoV-2 virus in wastewater could identify COVID-19 cases, which reduces the burden on the public health system during COVID-19 pandemics.Peer reviewe

Provision of renal-specific nutrition knowledge for changing dietary practice in bangladeshi hemodialysis patients

Studies show that provision of nutrition knowledge help renal patients make informed food choices. This study aimed to evaluate the impact of nutrition knowledge for changing dietary practice among Bangladeshi dialysis Following development of a renal-specific nutrition booklet, a pilot study was conducted among 50 hemodialysis patients from a single dialysis setting. Demographic, anthropometric, clinical, biochemical, dietary data, and a 10-item MCQ on renal-specific nutrition information were collected before and 3 months after the provision of the booklet. 52%of the participants were male, 54% had twice weekly dialysis, age 53±12 years, and dialysis vintage was 46 ± 25 months. Serum potassium and phosphorous, dietary potassium, phosphorous, and phosphorous to protein ratio were significantly reduced after the provision of the booklet. Additionally, patients consuming >3 meals/day increased to 66% while adherence to renal-specific cooking method and vegetable preference were significantly increased to 70% and 62%, respectively. Provision of knowledge via renal-specific nutrition booklet was able to improve patients' dietary practice and enhance their dietary adherence to renal specific recommendations. Innovation: The booklet was developed using locally available food items in local language and was found beneficial in low-resource settings where overall health care facilities, including nutrition support are limited

How do traditional media access and mobile phone use affect maternal healthcare service use in Bangladesh? Moderated mediation effects of socioeconomic factors.

BackgroundExposure to traditional media (TV, radio, and newspapers) and the use of mobile as an interpersonal communication tool allow for a variety of information provision. The purpose of this study is to investigate how women's media and mobile access affect maternal health service (MHS) utilization. The study also aims to look into the moderated mediation effects of socioeconomic variables on the association mentioned above.MethodsThe study analyzed reproductive and media data of 5,011 ever-married women extracted from the latest nationally representative Bangladesh Demographic and Health Survey. Hierarchical logistic regression and moderated mediation analysis are performed to determine the association.ResultsOnly 26.9% of women used mobile for health service use, while more than 55% had media access. Media access is significantly associated with all three types of MHS use; mobile usage also has a significant association with antenatal and delivery care. When women have both access to media and mobile, the likelihood of delivering in a health facility increased by 1.82 times (AOR: 1.82, 95%CI: 1.51, 2.20) which is slightly better than having access to only one type of media channel. Women's education, household wealth, place of residence, religion, and current working status are among the socioeconomic factors associated with access to media and mobile. Women's education mediates the relationship of media and MHS; however, the mediation effect of women (β: .45; LLCI: .21, ULCI: .68) on the association of media and place of delivery is seen to be moderated by household wealth. Women who belong to well-off families moderates positively (Effect: .33, 95%CI: .27, .40) the education effect of media and where to deliver. Place of residence, another moderator, significantly moderates (Effect: .09, BootLLCI: .02, BootULCI: .16) the mediation effect of women's education on the association of media and antenatal care visits; women living in urban areas seems to have positively moderated the education effects on the mentioned association.ConclusionsProvision of media access and mobile use indicate better utilization of MHS in Bangladesh, and women's education mediates these relationships via the influence of household wealth and area of residence. Therefore, while planning interventions to increase MHS use, its relationships with the media and mobile use should be extrapolated. The collective use of these channels could be a catalyst for the success of health promotion initiatives to improve women's health behaviors, build community capacity, and create mass awareness that supports the optimal use of MHS in Bangladesh

Menopausal experiences of women of Chinese ethnicity: A meta-ethnography.

ObjectiveMenopause and the changes it brings to a woman's life necessitate a comprehensive approach to face and experience the transition. This paper aims at synthesizing results from qualitative studies of menopausal experiences among Chinese and other women of similar ethnicity and culture.Design and methodA comprehensive search strategy of multiple databases along with bibliographic hand searches was employed to identify qualitative studies published in English peer-reviewed journals between 2008 and 2022 focused on the menopausal experiences (peri and post-menopause) of Chinese and other women of similar ethnic backgrounds. Twelve studies met the inclusion criteria. The final sample consisted of 238 women aged between 40 to 60 years who had experienced menopausal symptoms. This qualitative systematic literature review adopted Noblit and Hare's seven-stage theoretical meta-ethnographic approach to construct an inductive and interpretive form of synthesis and subsequent analysis.Syntheses of findingsThe synthesis of primary data identified four key concepts that entitle women's menopausal experiences: being menopausal, ramifications on well-being, family and social support around menopause, and healthcare throughout menopause. The subsequent second-order interpretation revealed that women accepted the inevitability of the natural aging process in the decline of sexual drive, reinvented relationships with partners, and expressed the significance of a supportive environment in order to successfully navigate the transition. Third-order interpretations sought to establish a link between physiological complications, loss of femininity, patriarchal-dominated societal norms, and a support system that spans the entire menopause experience. Healthcare's contribution has also been deemed to be insufficient due to a lack of information and empathy from health experts. Negligence or reluctance to seek healthcare and skepticism toward hormone replacement therapy (HRT) had also been a source of concern, as they have had the potential to exacerbate medical difficulties and emotional turmoil.Conclusions and implications for practiceA comprehensive approach that considers women's physiological and psychological well-being and major attempts to change cultural beliefs and norms about women's sexual health may be effective in aiding menopausal women during their transition. Additionally, appropriate guidelines and management should be in place to enable women to address menopause difficulties effectively with the assistance of healthcare experts and the support of their families and community

Genotypic screening of wheat and their physiological responses under lead toxicity

Lead (Pb) is the second most harmful heavy metal contaminant in the environment and toxic for plant growth and development. Therefore, the identification and selection of plant genotypes tolerant to Pb stress are of great significance. In this study, twenty-six wheat lines (Triticum aestivum) were screened for Pb tolerance based on their morpho-physiological variations at the seedling stage with a rapid hydroponic technique using lead nitrate (Pb(NO3)2) at two concentrations (500 ?M and 1 mM) along with control. Wheat genotypes showed distinct variations in plant height, plant biomass and chlorophyll concentration in response to different concentrations of Pb. Considering all parameters, Akbar was found most tolerant (T) with minimum RS (2.97) to Pb stress, followed by BARI Gom-31 (3.45), Barkat (3.54) and Sufi (3.65), while BARI Gom-26 (10.14) was most sensitive (S) followed by Khude Gom (9.69), BARI Gom-30 (8.79), LalGom (8.76) and BARI Gom-32 respectively. More scores were seen in the remaining genotypes and were graded as moderately tolerant/resistant (MT) to Pb stress. Results showed that the resistant line had less damage to root and shoot characteristics along with chlorophyll score, thereby providing a hint about the Pb tolerance capacity of wheat genotypes at the seedling stage. Furthermore, findings indicate that Pb susceptibility in wheat is predominantly associated with a decrease in the Pb components of the root and shoot. We suggest Akbar as an elite genotype to cultivate or use in downstream studies on the basis of our findings to ensure an improved crop production relative to other varieties evaluated. These findings provide the necessary background for Pb cleansing and Pb-free wheat development for environment and health safety