Formulation and Evaluation of Ritonavir Immediate Release Tablets by Hot Melt Extrusion Method

In the present work, an attempt has been made to develop immediate release coated tablets of Ritonavir by hot met extrusion method using 16 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as bulk density, tapped density. The prepared IR coated tablets of ritonavir shown good post compression parameters. They passed all the quality control evaluation parameters as per USP limits. Among all the formulations, F5 formulation showed maximum % drug release i.e., 99 % in 120 mins hence it is considered as optimized formulation. The optimized formulation was compared to innovator tablets. Keywords: Ritonavir, HPMC, Ethyl cellulose, Copovidone immediate release tablets

Prevalence and risk factors of text neck syndrome among medical students

Background: Mobile phone and other similar gadget use are now part of our life and it has acquired as an essential position in our life. It cannot be avoided. But judicious use is possible only after the severity of the problem is understood and risk factors are identified. Objective: To study the prevalence and risk factors of text neck syndrome among medical students of MRIMS Methods: This was a cross sectional study carried out among 306 medical students of one medical college. Data was collected in the pre designed, pre tested, and semi-structured study questionnaire developed based on the extensive review of literature. The questionnaire was given to the medical students and they were asked to submit after half an hour. Attempt was made to ensure that all questions were answered. Chi square test and Students t test was used for statistical analysis. Results: Almost 85% of students agreed that their virtual life orientation was affected. About 1/3rd complained of stiffness sometimes, 57% of users suffered from headaches sometimes. 1/4th suffered from numbness and weakness sometimes. The prevalence of pain in males was more i.e. 76.4% compared to 37.3% among females. The pain was significantly more in standing position (60%). The pain was found to be significantly more (68.9%) when the gadget was held at abdomen level. Conclusion: Almost all students used some or the other gadgets. But the use was actually misuse as it has affected majority. Disorientation of virtual life, stiffness, headache, pain was very common. Pain was associated with position and level at which the gadget was held