A Birthday Poem for Christ

Nature of the Universe commentary in vers

Windows on the World: The Literary Revolutions of Adam King’s Genethliacon Iesu Christi

The first detailed assessment of the use made by Parisian professors of mathematics of the didactic tradition of sphere poetry in the late 16th century

The Roman elite and the power of the past: continuity and change in Ostrogothic Italy

This thesis examines the changes forced upon the Roman elite in the evolving political climate of Ostrogothic Italy. It examines what mechanisms the Roman elite employed to renegotiate their position of influence within the state. The relationship the elite had with the past provides evidence for wider changes in society. I assert that, using the language and landscape of the past, the elite formed discourses which responded to, and which attempted to facilitate a realignment in, a changing environment. The education system still provided the Roman elite with a mechanism through which they could define themselves and prepare for what they considered to be the important aspects of the world outside the classroom. Religious discussions and debate in the post-imperial Italy of Late Antiquity were increasingly directed toward attempts to reunite the fractured Roman Empire through a unified empire of Orthodox faith. Having such a close relationship with the Roman Empire and its political and philosophical culture, education and religion are particularly suitable fields to reflect the changes to the political map of the Roman Empire. Focusing on the elite’s relationship with education and religion, this thesis will uncover examples of continuity and change which are implied by the construction of, and interaction with, discourses designed to facilitate the elite’s renegotiation strategies. Reconstructing the education of prominent members of the elite from their writings provides the evidence for such discourses. The emphasis on this part of the thesis is on discovering how the discourses circulating in relation to education responded to the political and philosophical problems through the language of the past and what these responses tell us about changes in the present. The religious discussion focuses on the attempts of the opinion formers in Italy to create and direct narratives designed to establish the superiority of one religious world-view over another. An examination of the language of tradition in the construction of these narratives provides evidence for the potency of the past in the decision-making process and ideology- forming strategies of the Roman elite. It also provides evidence for the changes in society to which the strategies were responding. A final-chapter case study provides an opportunity to see evidence of the effectiveness of these discourse-forming strategies. In this chapter we see a contemporary historical source interacting with those narratives and discourses we witnessed the elite employing in the education and religion chapters. It also provides an opportunity to see how the past is used to justify the actions of the Roman elite in Ostrogothic Italy to a post-Gothic audience (as the work was composed in the immediate aftermath of the fall of Ostrogothic Italy). This final consideration provides an instructive contrast which brings into sharp focus the extent and nature of continuity and change brought about by the Ostrogothic state

The Nature of the Universe

First critical assessment of the background to a Spherical instructional text of educational significance, which was used at Universities in Paris and Edinburgh across the 16th and 17th centuries

Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV):use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3

The effect of sequence variability between different types of hepatitis C virus (HCV) on the antigenicity of the NS-4 protein was investigated by epitope mapping and by enzyme-linked immunosorbent assay with branched oligopeptides. Epitope mapping of the region between amino acid residues 1679 and 1768 in the HCV polyprotein revealed two major antigenic regions (1961 to 1708 and 1710 to 1728) that were recognized by antibody elicited upon natural infection of HCV. The antigenic regions were highly variable between variants of HCV, with only 50 to 60% amino acid sequence similarity between types 1, 2, and 3. Although limited serological cross-reactivity between HCV types was detected between peptides, particularly in the first antigenic region of NS-4, type-specific reactivity formed the principal component of the natural humoral immune response to NS-4. Type-specific antibody to particular HCV types was detected in 89% of the samples from anti-HCV-positive blood donors and correlated almost exactly with genotypic analysis of HCV sequences amplified from the samples by polymerase chain reaction. Whereas almost all blood donors appeared to be infected with a single virus type (97%), a higher proportion of samples (40%) from hemophiliacs infected from transfusion of non-heat-inactivated clotting factor contained antibody to two or even all three HCV types, providing evidence that long-term exposure may lead to multiple infection with different variants of HCV

Nosocomial hepatitis C virus infection in a renal transplantation center

AbstractNosocomial hepatitis C virus (HCV) infections were recorded in the renal transplantation unit of the university hospital. There were cases of acute HCV infection with aggressive clinical courses diagnosed from a positive HCV RNA test in the early post-transplantation period and which remained anti-HCV negative. Their anti-HCV seronegativity was attributed to them having acquired HCV under intense immunosuppressive therapy and suggested that the aggressive clinical course could be due to the deficient immune response resulting in an inability to limit viral replication. There were also donors diagnosed as having acute HCV infection in the early post-operative period. Genotyping and sequence analysis for HCV were performed on the isolates of eight of these patients who were consecutively transplanted and of three donors whose recipients were infected with HCV prior to transplantation, and who acquired acute HCV infection after transplantation. Of the eight recipients in the first group three were genotype 1a, three were genotype 1b, one wasgenotype 3a, and the last one was genotype 4 according to Simmond's classification. Of the three donor-recipient couples both the HCV isolates from one couple were genotyped as 1b and the phylogenetic analysis indicated that the patients were infected with a common variant of HCV, but the genotypesof HCV isolates from the other couples were different. Recipients were genotype 1b and the donors were genotype 1a in these couples. Genotype results of the first group and donor-recipient couples, and sequence analysis of genotype 1b and 1a isolates, showed that the source of infection was not a unique strain and there were multiple breaks in universal precautions while managing these patients

Hepatitis C virus genotype frequency in Isfahan province of Iran: a descriptive cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Hepatitis C is an infectious disease affecting the liver, caused by the hepatitis C virus (HCV). The hepatitis C virus is a small, enveloped, single-stranded, positive sense RNA virus with a large genetic heterogeneity. Isolates have been classified into at least eleven major genotypes, based on a nucleotide sequence divergence of 30-35%. Genotypes 1, 2 and 3 circulate around the world, while other genotypes are mainly restricted to determined geographical areas. Genotype determination of HCV is clinically valuable as it provides important information which can be used to determine the type and duration of therapy and to predict the outcome of the disease.</p> <p>Results</p> <p>Plasma samples were collected from ninety seven HCV RNA positive patients admitted to two large medical laboratory centers in Isfahan province (Iran) from the years 2007 to 2009. Samples from patients were subjected to HCV genotype determination using a PCR based genotyping kit. The frequency of HCV genotypes was determined as follows: genotype 3a (61.2%), genotype 1a (29.5%), genotype 1b (5.1%), genotype 2 (2%) and mixed genotypes of 1a+3a (2%).</p> <p>Conclusion</p> <p>Genotype 3a is the most frequent followed by the genotype 1a, genotype 1b and genotype 2 in Isfahan province, Iran.</p

Dividing the land: time and land division in the English North Midlands and Yorkshire

Land divisions are ubiquitous features of the British countryside. Field boundaries, enclosures, pit alignments, and other forms of land division have been used to shape and delineate the landscape over thousands of years. While these divisions are critical for understanding economies and subsistence, the organization of tenure and property, social structure and identity, and their histories of use have remained unclear. Here, the authors present the first robust, Bayesian statistical chronology for land division over three millennia within a study region in England. Their innovative approach to investigating long-term change demonstrates the unexpected scale of later ‘prehistoric’ land demarcation, which may correspond to the beginnings of increasing social hierarchy