3,459 research outputs found
Cranial nerve outcomes in regionally recurrent head & neck melanoma after sentinel lymph node biopsy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/156007/1/lary28243.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/156007/2/lary28243_am.pd
The AllWISE Motion Survey, Part 2
We use the AllWISE Data Release to continue our search for WISE-detected
motions. In this paper, we publish another 27,846 motion objects, bringing the
total number to 48,000 when objects found during our original AllWISE motion
survey are included. We use this list, along with the lists of confirmed
WISE-based motion objects from the recent papers by Luhman and by Schneider et
al. and candidate motion objects from the recent paper by Gagne et al. to
search for widely separated, common-proper-motion systems. We identify 1,039
such candidate systems. All 48,000 objects are further analyzed using
color-color and color-mag plots to provide possible characterizations prior to
spectroscopic follow-up. We present spectra of 172 of these, supplemented with
new spectra of 23 comparison objects from the literature, and provide
classifications and physical interpretations of interesting sources. Highlights
include: (1) the identification of three G/K dwarfs that can be used as
standard candles to study clumpiness and grain size in nearby molecular clouds
because these objects are currently moving behind the clouds, (2) the
confirmation/discovery of several M, L, and T dwarfs and one white dwarf whose
spectrophotometric distance estimates place them 5-20 pc from the Sun, (3) the
suggestion that the Na 'D' line be used as a diagnostic tool for interpreting
and classifying metal-poor late-M and L dwarfs, (4) the recognition of a triple
system including a carbon dwarf and late-M subdwarf, for which model fits of
the late-M subdwarf (giving [Fe/H] ~ -1.0) provide a measured metallicity for
the carbon star, and (5) a possible 24-pc-distant K5 dwarf + peculiar red L5
system with an apparent physical separation of 0.1 pc.Comment: 62 pages with 80 figures, accepted for publication in The
Astrophysical Journal Supplement Series, 23 Mar 2016; second version fixes a
few small typos and corrects the footnotes for Table
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Mutations in epigenetic regulators including SETD2 are gained during relapse in pediatric acute lymphoblastic leukemia
Relapsed pediatric acute lymphoblastic leukemia (ALL) has high rates of treatment failure. Epigenetic regulators have been proposed as modulators of chemoresistance, here we sequence genes encoding epigenetic regulators in matched diagnosis-remission-relapse ALL samples. We find significant enrichment of mutations in epigenetic regulators at relapse with recurrent somatic mutations in SETD2, CREBBP, MSH6, KDM6A and MLL2, mutations in signaling factors are not enriched. Somatic alterations in SETD2, including frameshift and nonsense mutations, are present at 12% in a large de novo ALL patient cohort. We conclude that the enrichment of mutations in epigenetic regulators at relapse is consistent with a role in mediating therapy resistance
A new conceptual framework for revenge firesetting
Revenge has frequently been acknowledged to account for a relatively large proportion of motives in deliberate firesetting. However, very little is actually known about the aetiology of revenge firesetting. Theoretical approaches to revenge-seeking behaviour are discussed. A brief review of how revenge is accounted for in existing theoretical explanations of deliberate firesetting and the known characteristics of revenge firesetters are provided. On this basis, the authors suggest, as a motive, revenge firesetting has to date been misconceptualised. A new conceptual framework is thus proposed, paying particular attention to the contextual, affective, cognitive, volitional and behavioural factors which may influence and generate a single episode of revenge firesetting. Treatment implications and suggestions for future research are also provided
Searching for Exoplanets Using a Microresonator Astrocomb
Detection of weak radial velocity shifts of host stars induced by orbiting
planets is an important technique for discovering and characterizing planets
beyond our solar system. Optical frequency combs enable calibration of stellar
radial velocity shifts at levels required for detection of Earth analogs. A new
chip-based device, the Kerr soliton microcomb, has properties ideal for
ubiquitous application outside the lab and even in future space-borne
instruments. Moreover, microcomb spectra are ideally suited for astronomical
spectrograph calibration and eliminate filtering steps required by conventional
mode-locked-laser frequency combs. Here, for the calibration of astronomical
spectrographs, we demonstrate an atomic/molecular line-referenced,
near-infrared soliton microcomb. Efforts to search for the known exoplanet HD
187123b were conducted at the Keck-II telescope as a first in-the-field
demonstration of microcombs
Negotiating professional and social voices in research principles and practice
This paper draws on work conducted for a qualitative interview based study which explores the gendered racialised and professional identifications of health and social care professionals. Participants for the project were drawn from the professional executive committees of recently formed Primary Care Trusts. The paper discusses how the feminist psychosocial methodological approach developed for the project is theoretically, practically and ethically useful in exploring the voices of those in positions of relative power in relation to both health and social care services and the social relations of gender and ethnicity. The approach draws on psychodynamic accounts of (defended) subjectivity and the feminist work of Carol Gilligan on a voice-centred relational methodology. Coupling the feminist with the psychosocial facilitates an emphasis on voice and dialogic communication between participant and researcher not always captured in psychosocial approaches which tend towards favouring the interviewer as ‘good listener’. This emphasis on dialogue is important in research contexts where prior and ongoing relationships with professional participants make it difficult and indeed undesirable for researchers to maintain silence
The natural history of thin melanoma and the utility of sentinel lymph node biopsy
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141184/1/jso24765_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141184/2/jso24765.pd
Communicating Phylogeny: Evolutionary Tree Diagrams in Museums
Tree of life diagrams are graphic representations of phylogeny—the evolutionary history and
relationships of lineages—and as such these graphics have the potential to convey key evolutionary
ideas and principles to a variety of audiences. Museums play a significant role in teaching about
evolution to the public, and tree graphics form a common element in many exhibits even though
little is known about their impact on visitor understanding. How phylogenies are depicted and used
in informal science settings impacts their accessibility and effectiveness in communicating about
evolution to visitors. In this paper, we summarize the analysis of 185 tree of life graphics collected
from museum exhibits at 52 institutions and highlight some potential implications of how trees are
presented that may support or hinder visitors’ understanding about evolution. While further work is
needed, existing learning research suggests that common elements among the diversity of museum
trees such as the inclusion of anagenesis and absence of time and shared characters might
represent potential barriers to visitor understanding
The Revised TESS Input Catalog and Candidate Target List
We describe the catalogs assembled and the algorithms used to populate the
revised TESS Input Catalog (TIC), based on the incorporation of the Gaia second
data release. We also describe a revised ranking system for prioritizing stars
for 2-minute cadence observations, and assemble a revised Candidate Target List
(CTL) using that ranking. The TIC is available on the Mikulski Archive for
Space Telescopes (MAST) server, and an enhanced CTL is available through the
Filtergraph data visualization portal system at the URL
http://filtergraph.vanderbilt.edu/tess_ctl.Comment: 30 pages, 16 figures, submitted to AAS Journals; provided to the
community in advance of publication in conjunction with public release of the
TIC/CTL on 28 May 201
DHODH modulates transcriptional elongation in the neural crest and melanoma
Melanoma is a tumour of transformed melanocytes, which are originally derived from the embryonic neural crest. It is unknown to what extent the programs that regulate neural crest development interact with mutations in the BRAF oncogene, which is the most commonly mutated gene in human melanoma1. We have used zebrafish embryos to identify the initiating transcriptional events that occur on activation of human BRAF(V600E) (which encodes an amino acid substitution mutant of BRAF) in the neural crest lineage. Zebrafish embryos that are transgenic for mitfa:BRAF(V600E) and lack p53 (also known as tp53) have a gene signature that is enriched for markers of multipotent neural crest cells, and neural crest progenitors from these embryos fail to terminally differentiate. To determine whether these early transcriptional events are important for melanoma pathogenesis, we performed a chemical genetic screen to identify small-molecule suppressors of the neural crest lineage, which were then tested for their effects on melanoma. One class of compound, inhibitors of dihydroorotate dehydrogenase (DHODH), for example leflunomide, led to an almost complete abrogation of neural crest development in zebrafish and to a reduction in the self-renewal of mammalian neural crest stem cells. Leflunomide exerts these effects by inhibiting the transcriptional elongation of genes that are required for neural crest development and melanoma growth. When used alone or in combination with a specific inhibitor of the BRAF(V600E) oncogene, DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in mouse xenograft studies. Taken together, these studies highlight developmental pathways in neural crest cells that have a direct bearing on melanoma formation
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