Making a difference - the appropriate use of web technology

Much has been written elsewhere about how, different Information Technology tools, can in principle be used by groups or communities to make their web sites more effective for Continued Professional Development. In practice, complex use is not often the case. In particular, three sites were studied in Scotland, which provided web facilities for the over 60s. The sites, and the communities they served, used only simple Information Technology. Nevertheless, they enabled their communities to participate effectively, on the 'right side', of the European population's 'digital divide'

Exploring Supply Chains from a Technical Debt Perspective

Software development has evolved from software development organizations building custom solutions for every need and creating a backlog of applications needed by users to specialized organizations producing components that are supplied to other software development organizations to speed the development of their software products. Our objective is to illustrate how a manager might use supply chain information to evaluate software being considered for inclusion in a product. We investigated the Eclipse platform code to illustrate analysis methods that produce information of use to decision makers. The technical debt of the software pieces was measured using the Technical Debt plug-in to SONAR as one input into the evaluation of supply chain quality. The dependency graphs of uses relationships among files were analyzed using graph metrics such as betweenness centrality. There was a statistically significant moderate correlation between the technical debt for a file and the betweenness centrality for that file. This relationship is used as the basis for a heuristic approach to forming advice to a development manager regarding which assets to acquire

Longitudinal Analysis of Technical Debt for Strategic Platform Adoption

Increasingly, software producing organizations utilize a common software platform, joining an ecosystem; however, little expertise exists on selecting which platform to use when presented a number of different platforms. While technical debt can be used to examine the quality of a software platform by the organization that produces the software, a single discrete data point does not provide sufficient context for analysis. In this paper, we seek to resolve this difficulty by applying linear regression analysis to technical debt data collected by the SonarQube static analyzer. We apply this method to a case study on Cytoscape network analysis platform to perform a pedagogical investigation on the longitudinal technical debt found in that platform. We present our case study on the longitudinal technical debt in the form of arguments for and against the adoption of the Cytoscape network analysis platform, utilizing the data and analysis generated from our method

Recent trends in primary-care antidepressant prescribing to children and young people: an e-cohort study

Concerns relating to increased use of psychotropic medication contrast with those of under-treatment and under-recognition of common mental disorders in children and young people (CYP) across developed countries. Little is known about the indications recorded for antidepressant prescribing in primary care in CYP.This was an electronic cohort study of routinely collected primary-care data from a population of 1.9 million, Wales, UK. Poisson regression was undertaken to model adjusted counts of recorded depression symptoms, diagnoses and antidepressant prescriptions. Associated indications were explored.3 58 383 registered patients aged 6-18 years between 1 January 2003 and 31 December 2013 provided a total of 19 20 338 person-years of follow-up. The adjusted incidence of antidepressant prescribing increased significantly [incidence rate ratio (IRR) for 2013 = 1.28], mainly in older adolescents. The majority of new antidepressant prescriptions were for citalopram. Recorded depression diagnoses showed a steady decline (IRR = 0.72) while depression symptoms (IRR = 2.41) increased. Just over half of new antidepressant prescriptions were associated with depression (diagnosis or symptoms). Other antidepressant prescribing, largely unlicensed, was associated with diagnoses such as anxiety and pain.Antidepressant prescribing is increasing in CYP while recorded depression diagnoses decline. Unlicensed citalopram prescribing occurs outside current guidelines, despite its known toxicity in overdose. Unlicensed antidepressant prescribing is associated with a wide range of diagnoses, and while accepted practice, is often not supported by safety and efficacy studies. New strategies to implement current guidance for the management of depression in CYP are required

Structure and dynamics of aqueous 2-propanol: a THz-TDS, NMR and neutron diffraction study.

Aqueous liquid mixtures, in particular, those involving amphiphilic species, play an important role in many physical, chemical and biological processes. Of particular interest are alcohol/water mixtures; however, the structural dynamics of such systems are still not fully understood. Herein, a combination of terahertz time-domain spectroscopy (THz-TDS) and NMR relaxation time analysis has been applied to investigate 2-propanol/water mixtures across the entire composition range; while neutron diffraction studies have been carried out at two specific concentrations. Excellent agreement is seen between the techniques with a maximum in both the relative absorption coefficient and the activation energy to molecular motion occurring at ∼90 mol% H2O. Furthermore, this is the same value at which well-established excess thermodynamic functions exhibit a maximum/minimum. Additionally, both neutron diffraction and THz-TDS have been used to provide estimates of the size of the hydration shell around 2-propanol in solution. Both methods determine that between 4 and 5 H2O molecules per 2-propanol are found in the 2-propanol/water clusters at 90 mol% H2O. Based on the acquired data, a description of the structure of 2-propanol/water across the composition range is presented.The authors would like to acknowledge CASTech (EPSRC grant EP/G011397/1), RCUK Basic Technology Grant (EP/E048811/1), STFC for beamtime allocation (RB910286) and Jon Mitchell (Cambridge) for valuable discussions.This is the final version of the article. It was first available from RSC via http://dx.doi.org/10.1039/C5CP01132

Coronary CT Angiography and 5-Year Risk of Myocardial Infarction.

BACKGROUND: Although coronary computed tomographic angiography (CTA) improves diagnostic certainty in the assessment of patients with stable chest pain, its effect on 5-year clinical outcomes is unknown. METHODS: In an open-label, multicenter, parallel-group trial, we randomly assigned 4146 patients with stable chest pain who had been referred to a cardiology clinic for evaluation to standard care plus CTA (2073 patients) or to standard care alone (2073 patients). Investigations, treatments, and clinical outcomes were assessed over 3 to 7 years of follow-up. The primary end point was death from coronary heart disease or nonfatal myocardial infarction at 5 years. RESULTS: The median duration of follow-up was 4.8 years, which yielded 20,254 patient-years of follow-up. The 5-year rate of the primary end point was lower in the CTA group than in the standard-care group (2.3% [48 patients] vs. 3.9% [81 patients]; hazard ratio, 0.59; 95% confidence interval [CI], 0.41 to 0.84; P=0.004). Although the rates of invasive coronary angiography and coronary revascularization were higher in the CTA group than in the standard-care group in the first few months of follow-up, overall rates were similar at 5 years: invasive coronary angiography was performed in 491 patients in the CTA group and in 502 patients in the standard-care group (hazard ratio, 1.00; 95% CI, 0.88 to 1.13), and coronary revascularization was performed in 279 patients in the CTA group and in 267 in the standard-care group (hazard ratio, 1.07; 95% CI, 0.91 to 1.27). However, more preventive therapies were initiated in patients in the CTA group (odds ratio, 1.40; 95% CI, 1.19 to 1.65), as were more antianginal therapies (odds ratio, 1.27; 95% CI, 1.05 to 1.54). There were no significant between-group differences in the rates of cardiovascular or noncardiovascular deaths or deaths from any cause. CONCLUSIONS: In this trial, the use of CTA in addition to standard care in patients with stable chest pain resulted in a significantly lower rate of death from coronary heart disease or nonfatal myocardial infarction at 5 years than standard care alone, without resulting in a significantly higher rate of coronary angiography or coronary revascularization. (Funded by the Scottish Government Chief Scientist Office and others; SCOT-HEART ClinicalTrials.gov number, NCT01149590 .)

Discovery of an Extraordinarily Massive Cluster of Red Supergiants

We report the discovery of an extraordinarily massive young cluster of stars in the Galaxy, having an inferred total initial cluster mass comparable to the most massive young clusters in the Galaxy. Using {\it IRMOS}, {\it 2MASS}, and {\it Spitzer} observations, we conclude that there are 14 red supergiants in the cluster, compared with five, in what was previously thought to be the richest Galactic cluster of such stars. We infer spectral types from near-infrared spectra that reveal deep CO bandhead absorption that can only be fit by red supergiants. We identify a gap of $\Delta${\it K}$_s$$\sim$4 magnitudes between the stars and the bulk of the other stars in the region that can only be fit by models if the brightest stars in the cluster are red supergiants. We estimate a distance of 5.8~\kpc to the cluster by associating an OH maser with the envelope of one of the stars. We also identify a ``yellow'' supergiant of G6~I type in the cluster. Assuming a Salpeter IMF, we infer an initial cluster mass of 20,000 to 40,000~\Msun for cluster ages of 7-12~\Myr. Continuing with these assumptions, we find 80% of the intial mass and 99% of the number of stars remain at the present time. We associate the cluster with an x-ray source (detected by {\it ASCA} and {\it Einstein}), a recently discovered very high energy $\gamma$-ray source (detected by {\it INTEGRAL} and {\it HESS}), and several non-thermal radio sources, finding that these objects are likely related to recent supernovae in the cluster. In particular, we claim that the cluster has produced at least one recent supernova remnant with properties similar to the Crab nebula. It is not unlikely to find such a source in this cluster, given our estimated supernova rate of one per 40,000 to 80,000~{\it yr}.Comment: ApJ, accepte