Exploring the value of Scotland's environment

Protection of the environment can be regarded as representing a substantial cost to business. However, it is typically considered from the point of view of effect on company profitability, rather than its relative importance to human kind. This paper estimates the value of Scotland's natural environment by applying the methodology developed by Costanza et al (1997a and b) for estimation of the value of the earth's ecosystem services. Ecosystem services provide the vital functions to support life on Earth, such as flows of materials and energy. Since the study's publication, further research has sought to apply this global methodology to a regional and national level (for example Loomis et al, 2000, Farber and Griner, 2000 and Stevens et al, 2000). The value derived for Scotland provides a useful context for understanding the scale and importance of Scotland's natural habitats and it helps to reinforce the message that the environment is central to human welfare (Williams et al, 2003). The valuation of ecosystem services in monetary terms provokes theoretical, practical and philosophical arguments. This paper does not seek to revisit in depth these debates; rather the valuation should be taken as a starting point for setting the importance of Scotland's ecosystems in an interesting perspective. A recent edition of the journal Ecological Economics (Costanza and Farber, 2002) was devoted to considering some of these issues and providing many avenues for further exploration

Press and social media reaction to ideologically inspired murder:The case of Lee Rigby

This article analyses reaction to the ideologically inspired murder of a soldier, Lee Rigby, in central London by two converts to Islam, Michael Adebowale and Michael Adebolajo. The focus of the analysis is upon the contrast between how the event was reacted to by the UK National Press and on social media. To explore this contrast, we undertook a corpus-assisted discourse analysis to look at three periods during the event: the initial attack, the verdict of the subsequent trial and the sentencing of the murderers. To do this, we constructed and analysed corpora of press and Twitter coverage of the attack, the conviction of the suspects and the sentencing of them. The analysis shows that social media and the press are intertwined, with the press exerting a notable influence through social media, but social media not always being led by the press. When looking at social media reaction to such an event as this, analysts should always consider the role that the press are playing in forming that discourse

SURGICAL VERSUS NON-SURGICAL INTERVENTIONS FOR VOCAL CORD NODULES

ABSTRACT Background Vocal cord nodules are bilateral swellings of the mid-portion of the membranous vocal folds. They are of variable size and are characterised histologically by thickening of the epithelium with a variable degree of inflammatory action in the underlying superficial lamina propria. They characteristically produce hoarseness. Treatment of vocal cord nodules aims to eliminate or reduce this hoarseness

Feasibility of a randomized controlled trial of functional strength training for people between six months and five years after stroke: FeSTivaLS trial

Background: Functional Strength Training (FST) could enhance recovery late after stroke. The aim of this study was to evaluate the feasibility of a subsequent fully powered, randomized controlled trial. Methods: The study was designed as a randomized, observer-blind trial. Both interventions were provided for up to one hour a day, four days a week, for six weeks. Evaluation points were before randomization (baseline), after six weeks intervention (outcome), and six weeks thereafter (follow-up). The study took place in participants’ own homes. Participants (n = 52) were a mean of 24.4 months after stroke with a mean age of 68.3 years with 67.3% male. All had difficulty using their paretic upper (UL) and lower limb (LL). Participants were allocated to FST-UL or FST-LL by an independent randomization service. The outcome measures were recruitment rate, attrition rate, practicality of recruitment strategies, occurrence of adverse reactions, acceptability of FST, and estimation of sample size for a subsequent trial. Primary clinical efficacy outcomes were the Action Research Arm Test (ARAT) and the Functional Ambulation Categories (FAC). Analysis was conducted using descriptive statistics and thematic analysis of participants’ views of FST. A power calculation used estimates of clinical efficacy variance to estimate sample size for a subsequent trial. Results: The screening process identified 1,127 stroke survivors of whom 52 (4.6%) were recruited. The recruitment rate was higher for referral from community therapists than for systematic identification of people discharged from an acute stroke unit. The attrition rate was 15.5% at the outcome and follow-up time-points. None of the participants experienced an adverse reaction. The participants who remained in the study at outcome had received 68% of the total possible amount of therapy. Participants reported that their experience of FST provided a sense of purpose and involvement and increased their confidence in performing activities. The power calculation provides estimation that 150 participants in each group will be required for a subsequent clinical trial. Conclusions: This study found that a subsequent clinical trial was feasible with modifications to the recruitment strategy to be used

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate cilia function, governed in part by the activity of intraflagellar transport (IFT). In articular cartilage, primary cilia length is increased and hedgehog signaling activated in osteoarthritis (OA). Here, we examine primary cilia length with exposure to the quintessential inflammatory cytokine interleukin-1 (IL-1), which is up-regulated in OA. We then test the hypothesis that the cilium is involved in mediating the downstream inflammatory response. Primary chondrocytes treated with IL-1 exhibited a 50 % increase in cilia length after 3 h exposure. IL-1-induced cilia elongation was also observed in human fibroblasts. In chondrocytes, this elongation occurred via a protein kinase A (PKA)-dependent mechanism. G-protein coupled adenylate cyclase also regulated the length of chondrocyte primary cilia but not downstream of IL-1. Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2. However, in cells with a mutation in IFT88 whereby the cilia structure is lost, this response to IL-1 was significantly attenuated and, in the case of nitric oxide, completely abolished. Inhibition of IL-1-induced cilia elongation by PKA inhibition also attenuated the chemokine response. These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA

The mechanical hybrid vehicle: an investigation of a flywheel-based vehicular regenerative energy capture system

Capturing braking energy by regeneration into an onboard energy storage unit offers the potential to reduce significantly the fuel consumption of vehicles. A common technique is to generate electricity in the motors of a hybrid electric vehicle when braking, and to use this to charge an onboard electrochemical battery. However, such batteries are costly, bulky, and generally not amenable to fast charging as this affects battery life and capacity. In order to overcome these problems, a mechanical energy storage system capable of accepting and delivering surges of power is proposed and investigated. A scale physical model of the system, based around a flywheel, a planetary gear set, and a brake, was built and operated in a laboratory. Tests showed that the proposed system could be used to store and provide braking energy between a flywheel and a vehicle, the latter emulated by an air-drag dynamometer. This validated the operating principle of the system and its computational model. Further, a computational analysis of a full-size vehicle incorporating the mechanical energy storage system was conducted. The results showed that the utilization of this system in a vehicle, when compared with a conventional vehicle, led to reductions in emissions and fuel consumption

Prescription of antipsychotic medication to patients at ultra high risk of developing psychosis

Little is known about medication prescription in a naturalistic setting to patients at ultra high risk (UHR) of developing psychosis. Antipsychotic medication prescription to UHR patients is not recommended in clinical practice guidelines based on the current evidence. The aim of this study is to investigate medication prescription to UHR patients in the Netherlands. The frequency of antipsychotic medication prescription to UHR patients (n=72) was compared with the frequency of antipsychotic medication prescription to patients who were diagnosed with a Diagnostic and Statistical Manual of Mental Disorders, fourth edition psychotic disorder at first diagnostic evaluation (n=90). Within the UHR group, frequency of antipsychotic medication prescription at baseline was compared between UHR patients who did make the transition to psychosis (n=18) and UHR patients who did not (n=54). No significant differences were found in antipsychotic medication prescription to UHR patients and to patients who turned out to have a florid psychosis: 51% in the psychotic group and 58% in the UHR group used no medication. Thirty-four percent in the psychotic group and 21% in the UHR group used antipsychotic medication. There was also no difference in medication prescription between UHR patients who did and did not make the transition to psychosis. More research should be aimed at developing and implementing clinical practice guidelines for the treatment of UHR patients