Using the Fermilab Proton Source for a Muon to Electron Conversion Experiment

The Fermilab proton source is capable of providing 8 GeV protons for both the future long-baseline neutrino program (NuMI), and for a new program of low energy muon experiments. In particular, if the 8 GeV protons are rebunched and then slowly extracted into an external beamline, the resulting proton beam would be suitable for a muon-to-electron conversion experiment designed to improve on the existing sensitivity by three orders of magnitude. We describe a scheme for the required beam manipulations. The scheme uses the Accumulator for momentum stacking, and the Debuncher for bunching and slow extraction. This would permit simultaneous operation of the muon program with the future NuMI program, delivering 10^20 protons per year at 8 GeV for the muon program at the cost of a modest (~10%) reduction in the protons available to the neutrino program.Comment: 18 pages, 7 figure

Pressure ulcer related pain in community populations: a prevalence survey.

BACKGROUND: Pressure ulcers are costly to the healthcare provider and can have a major impact on patient's quality of life. One of the most distressing symptoms reported is pain. There is very little published data on the prevalence and details of pain experienced by patients with pressure ulcers, particularly in community populations. The study was conducted in two community NHS sites in the North of England. METHODS: The aim was to estimate the prevalence of pressure area related pain within a community population. We also explored the type and severity of the pain and its association with pressure ulcer classification. A cross-sectional survey was performed of community nurses caseloads to identify adult patients with pressure ulcers and associated pain. Consenting patients then had a full pain assessment and verification of pressure ulcer grade. RESULTS: A total of 287 patients were identified with pressure ulcers (0.51 per 1000 adult population). Of the 176 patients who were asked, 133 (75.6%) reported pain. 37 patients consented to a detailed pain assessment. Painful pressure ulcers of all grades and on nearly all body sites were identified. Pain intensity was not related to number or severity of pressure ulcer. Both inflammatory and neuropathic pain were reported at all body sites however the proportion of neuropathic pain was greater in pressure ulcers on lower limbs. CONCLUSIONS: This study has identified the extent and type of pain suffered by community patients with pressure ulcers and indicates the need for systematic and regular pain assessment and treatment

Preliminary Experiments and Modelling of the Fate of CO2 Bubbles in the Water Column Near Panarea Island (Italy)

Although CO2 capture and storage in deep, offshore reservoirs is a proven technology, as illustrated by over 15 years of operation of the Sleipner site in the Norwegian North Sea, potential leakage from such sites into the overlying water column remains a concern for some stakeholders. Therefore, we are obliged to carefully assess our ability to predict and monitor the migration, fate, and potential ecosystem impact of any leaked CO2. The release of bubbles from the sea floor, their upward movement, and their dissolution into the surrounding water controls the initial boundary conditions, and thus an understanding of the behavior of CO2 bubbles is critical to address such issues related to monitoring and risk assessment. The present study describes results from an in situ experiment conducted in 12 m deep marine water near the extinct volcanic island of Panarea (Italy). Bubbles of a controlled size were created using natural CO2 released from the sea floor, and their evolution during ascent in the water column was monitored via both video and chemical measurements. The obtained results were modelled and a good fit was obtained, showing the potential of the model as a predictive tool. These preliminary results and an assessment of the difficulties encountered are examined and will be used to improve experimental design for the subsequent phase of this research

Statistical Communication Theory

Contains reports on seven research projects

Managing Quality and Safety in Real Time? Evidence from an Interview Study.

Health systems around the world are investing increasing effort in monitoring care quality and safety. Dashboards can support this process, providing summary data on processes and outcomes of care, making use of data visualization techniques such as graphs. As part of a study exploring development and use of dashboards in English hospitals, we interviewed senior managers across 15 healthcare providers. Findings revealed substantial variation in sophistication of the dashboards in place, largely presenting retrospective data items determined by national bodies and dependent on manual collation from a number of systems. Where real time systems were in place, they supported staff in proactively managing quality and safety

The Panarea natural CO2 seeps: fate and impact of the leaking gas (PaCO2) ; R/V URANIA, Cruise No. U10/2011, 27 July – 01 August 2011, Naples (Italy) – Naples (Italy)

Carbon capture and storage (CCS), both on- and offshore, is expected to be an important technique to mitigate anthropogenic effects on global climate by isolating man-made carbon dioxide (CO2) in deep geological formations. In marine environments, however, the potential impacts of CO2 leakage, appropriate detection methods, and risk and pathways of atmospheric emissions are poorly defined. The natural CO2 gas seeps that occur in the relatively shallow waters off the coast of Panarea Island (Aeolian Islands, Italy) can be studied as a large-scale, real-world analogue of what might occur at a leaking offshore CCS site and what tools can be used to study it. The oceanographic survey PaCO2 was performed aboard R/V Urania from 27 July – 01 August 2011 (Naples – Naples). The project’s ship-time was funded by Eurofleets, with work being performed as a sub-project of the Seventh Framework Programme projects “ECO2” and “RISCS”, which provided subsidiary funding. Large amounts of data and samples were collected during the cruise which will be interpreted in the coming months, with preliminary results detailed here. Of particular importance was the discovery of much larger areas showing gas seepage than previously reported. Interdisciplinary measurements were performed at the Panarea seepage site. The international team of scientists onboard R/V Urania performed complementary sampling and measurements for biological, chemical, and physical parameters throughout the area. Together with the dedication of R/V Urania’s Captain and crew, and the eagerness and cooperation of the scientific crew, we were able to obtain excellent scientific results during this six-day cruise

Stratification strength and light climate explain variation in chlorophyll a at the continental scale in a European multilake survey in a heatwave summer.

To determine the drivers of phytoplankton biomass, we collected standardized morphometric, physical, and biological data in 230 lakes across the Mediterranean, Continental, and Boreal climatic zones of the European continent. Multilinear regression models tested on this snapshot of mostly eutrophic lakes (median total phosphorus [TP] = 0.06 and total nitrogen [TN] = 0.7 mg L 1), and its subsets (2 depth types and 3 climatic zones), show that light climate and stratification strength were the most significant explanatory variables for chlorophyll a (Chl a) variance. TN was a significant predictor for phytoplankton biomass for shallow and continental lakes, while TP never appeared as an explanatory variable, suggesting that under high TP, light, which partially controls stratification strength, becomes limiting for phytoplankton development. Mediterranean lakes were the warmest yet most weakly stratified and had significantly less Chl a than Boreal lakes, where the temperature anomaly from the long-term average, during a summer heatwave was the highest (+4 C) and showed a significant, exponential relationship with stratification strength. This European survey represents a summer snapshot of phytoplankton biomass and its drivers, and lends support that light and stratification metrics, which are both affected by climate change, are better predictors for phytoplankton biomass in nutrient-rich lakes than nutrient concentrations and surface temperature

The Impact of Financial Interest in Intensity-Modulated Radiation Therapy on the Utilization of Radiation Therapy for Treatment of Newly Diagnosed Prostate Cancer: A Single Center Experience

Objective. As recent participants in an integrated prostate cancer (PCa) care center, we sought to evaluate whether financial investment in an intensity-modulated radiation therapy (IMRT) center resulted in an increased utilization of radiation therapy in our patients with newly diagnosed PCa. Materials & Methods. Following institutional review board approval, we retrospectively reviewed the records of all consecutive patients who were diagnosed with prostate cancer in the 12 months prior to and after investment in IMRT. Primary treatment modalities included active surveillance (AS), brachytherapy (BT), radiation therapy (XRT), radical prostatectomy (RP), and androgen deprivation therapy (ADT). Treatment data were available for all patients and were compared between the two groups. Results. A total of 344 patients with newly diagnosed PCa were evaluated over the designated time period. The pre-investment group totaled 198 patients, while 146 patients constituted the post-investment group. Among all patients evaluated, there was a similar rate in the use of XRT (20.71% versus 20.55%, P = 1.000) pre- and post-investment in IMRT. Conclusions. Financial interest in IMRT by urologists does not impact overall utilization rates among patients with newly diagnosed PCa at our center

Pilot feasibility randomized clinical trial of negative-pressure wound therapy versus usual care in patients with surgical wounds healing by secondary intention

Background Surgical wounds healing by secondary intention (SWHSI) are increasingly being treated with negative‐pressure wound therapy (NPWT) despite a lack of high‐quality research evidence regarding its clinical and cost‐effectiveness. This pilot feasibility RCT aimed to assess the methods for and feasibility of conducting a future definitive RCT of NPWT for the treatment of SWHSI. Methods Eligible consenting adult patients receiving care at the study sites (2 acute and 1 community) and with a SWHSI appropriate for NPWT or wound dressing treatment were randomized 1 : 1 centrally to receive NPWT or usual care (no NPWT). Participants were followed up every 1–2 weeks for 3 months. Feasibility (recruitment rate, time to intervention delivery) and clinical (time to wound healing) outcomes were assessed. Results A total of 248 participants were screened for eligibility; 40 (16·1 per cent) were randomized, 19 to NPWT and 21 to usual care. Twenty‐four of the 40 wounds were located on the foot. Participants received NPWT for a median of 18 (range 0–72) days. Two participants in the NPWT group never received the intervention and 14 received NPWT within 48 h of randomization. Five participants in the usual care group received NPWT during the study. Ten of the 40 wounds were deemed to have healed during the study. Conclusion A full‐scale RCT to investigate the clinical and cost‐effectiveness of NPWT for SWHSI is feasible. This study identified crucial information on recruitment rates and data collection methods to consider during the design of a definitive RCT. Registration number: ISRCTN12761776 (www.iscrtn.com

Surface Temperature Probability Distributions in the NARCCAP Hindcast Experiment: Evaluation Methodology, Metrics, and Results

Methodology is developed and applied to evaluate the characteristics of daily surface temperature distributions in a six-member regional climate model (RCM) hindcast experiment conducted as part of the North American Regional Climate Change Assessment Program (NARCCAP). A surface temperature dataset combining gridded station observations and reanalysis is employed as the primary reference. Temperature biases are documented across the distribution, focusing on the median and tails. Temperature variance is generally higher in the RCMs than reference, while skewness is reasonably simulated in winter over the entire domain and over the western United States and Canada in summer. Substantial differences in skewness exist over the southern and eastern portions of the domain in summer. Four examples with observed long-tailed probability distribution functions (PDFs) are selected for model comparison. Long cold tails in the winter are simulated with high fidelity for Seattle, Washington, and Chicago, Illinois. In summer, theRCMs are unable to capture the distribution width and long warm tails for the coastal location of Los Angeles, California, while long cold tails are poorly realized for Houston, Texas. The evaluation results are repeated using two additional reanalysis products adjusted by station observations and two standard reanalysis products to assess the impact of observational uncertainty. Results are robust when compared with those obtained using the adjusted reanalysis products as reference, while larger uncertainties are introduced when standard reanalysis is employed as reference. Model biases identified in this work will allow for further investigation into associated mechanisms and implications for future simulations of temperature extremes