10 research outputs found
Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Background</p> <p>Although the incidence of melanoma in the U.S. is rising faster than any other cancer, the FDA-approved chemotherapies lack efficacy for advanced disease, which results in poor overall survival. Lysophosphatidic acid (LPA), autotaxin (ATX), the enzyme that produces LPA, and the LPA receptors represent an emerging group of therapeutic targets in cancer, although it is not known which of these is most effective.</p> <p>Results</p> <p>Herein we demonstrate that thio-ccPA 18:1, a stabilized phosphonothionate analogue of carba cyclic phosphatidic acid, ATX inhibitor and LPA1/3 receptor antagonist, induced a marked reduction in the viability of B16F10 metastatic melanoma cells compared with PBS-treated control by 80-100%. Exogenous LPA 18:1 or D-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothioate did not reverse the effect of thio-ccPA 18:1. The reduction in viability mediated by thio-ccPA 18:1 was also observed in A375 and MeWo melanoma cell lines, suggesting that the effects are generalizable. Interestingly, siRNA to LPA3 (siLPA3) but not other LPA receptors recapitulated the effects of thio-ccPA 18:1 on viability, suggesting that inhibition of the LPA3 receptor is an important dualistic function of the compound. In addition, siLPA3 reduced proliferation, plasma membrane integrity and altered morphology of A375 cells. Another experimental compound designed to antagonize the LPA1/3 receptors significantly reduced viability in MeWo cells, which predominantly express the LPA3 receptor.</p> <p>Conclusions</p> <p>Thus the ability of thio-ccPA 18:1 to inhibit the LPA3 receptor and ATX are key to its molecular mechanism, particularly in melanoma cells that predominantly express the LPA3 receptor. These observations necessitate further exploration and exploitation of these targets in melanoma.</p
Relationships of preservice early childhood teachers’ cultural values, ethical and cognitive developmental levels, and Views of Nature of Science
- Author
- A. Woolfolk
- American Association for the Advancement of Science (AAAS)
- B. L. Shapiro
- C. A. Buzzelli
- Cary A. Buzzelli
- D. Pomeroy
- F. S. Abd-El-Khalick
- G. E. DeBoer
- J. Kelton
- J. L. Lemke
- J. P. Barufaldi
- J. R. McGinnis
- J. Slay
- M. Fleer
- N. G. Lederman
- N. G. Lederman
- S. H. Schwartz
- V. L. Akerson
- V. L. Akerson
- V. L. Akerson
- Valarie L Akerson
- W. G. Perry
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Watershed Partnerships in California and Washington: Final Report for the Watershed Partnerships Project
- Author
- Allan Curtis
- Arthur Stinchcombe
- Betsy K Landre
- Betsy Rieke
- Bruce Mitchell
- Bruce P Hooper
- Bruce P Hooper
- C A Oakland
- Carl Mr
- Carole B Griffin
- Carole B Griffin
- Cary Coglianese
- Charles W Huntington
- Chris M Weible
- Chris M Weible
- Connie Ozawa
- Craig W Thomas
- Cynthia Ms
- Daniel A Mazmanian
- David Marshall
- Davis
- Davis Ms Martha
- Deborah S Carr
- Diane Ms
- Douglas S Kenney
- Douglas S Kenney
- Dr
- Edella Dr
- Elizabeth M Cook
- G Kondolf
- Geoff Mcdonald
- Graham Allison
- J P Connell
- J S Coleman
- Janine Ms
- Jesse A Gordon
- Jim Appendix C Advisory Committee Mr
- John Platt
- John T Woolley
- Judith E Innes
- Judith E Innes
- Julia M Wondolleck
- L Festinger
- M L Miranda
- Margaret A Moote
- Maria Ms
- Marjorie M Holland
- Mark Cantwell
- Mark Lubell
- Mark Lubell
- Mark Rickenbach
- Melissa Dr
- Michael A Schuett
- Michael Mccloskey
- Michael V Mcginnis
- Michael V Mcginnis
- Michael W Mullen
- Mr
- Mr
- Mr
- Mr
- Mr
- Ms
- Nancy J Manring
- Nancy Manring
- Paul A Sabatier
- R G Farrow
- Rachel A Nugent
- Rainer Dr
- Ray L Wallis
- Rebecca S Toupal
- Richard D Margerum
- Richard D Margerum
- Robert D Putnam
- Robert D Putnam
- Robert W Penrose
- Sam Mr
- Sarah A Ewing
- Sonya Salamon
- Stefan Mr
- Stephen M Born
- Steven L Yafeee
- Susan Dr
- Susan H Mackenzie
- Thomas C Beierle
- Thomas H Wakeman
- William D Leach
- William D Leach
- William D Leach
- William D. Leach
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2002
- Field of study
Chromatographic methods for the determination of therapeutic oligonucleotides
- Author
- A. Cary McGinnis
- Amarzguioui
- Apffel
- Apffel
- Arora
- Arora
- Bahr
- Bahr
- Bartel
- Bartlett
- Bellon
- Bernstein
- Beverly
- Beverly
- Beverly
- Bigelow
- Bothner
- Bourque
- Braasch
- Brazolot
- Buncek
- Buncek
- Buyun Chen
- Castleberry
- Chen
- Chen
- Chiu
- Clercq
- Crain
- Crooke
- Crooke
- Crooke
- Crooke
- Dai
- Davis
- de la Mora
- De Paula
- Deng
- Devi
- Dickman
- Dickman
- Distler
- Doench
- Doggrell
- Easter
- Eckstein
- Elbashir
- Emmerechts
- Ewan Birney
- Fabris
- Farand
- Farand
- Fire
- Fountain
- Fritz
- Gaus
- Gilar
- Gilar
- Gilar
- Gilar
- Griffey
- Haddad
- Hammond
- Holzl
- Hossain
- Huang
- Huber
- Huber
- Huber
- Huber
- Huber
- Huber
- Ivleva
- Jackson
- Johnson
- Jorgensen
- Kamel
- Kasai
- Kebarle
- Kenski
- Khvorova
- Kirpekar
- Lecchi
- Leuschner
- Lin
- Little
- Mack
- MacRae
- Matranga
- Mayr
- McCarthy
- McLuckey
- McLuckey
- Meister
- Michael G. Bartlett
- Morris
- Muddiman
- Murugaiah
- Nguyen
- Ni
- Nikcevic
- Oberacher
- Oberacher
- Pheasant
- Pomerantz
- Pomerantz
- Pomerantz
- Prakash
- Rand
- Raynaud
- Rodgers
- Rozenski
- Schwarz
- Stein
- Strapps
- Sudha
- Thayer
- Thayer
- Wang
- Wang
- Waters
- Watson
- Watts
- Weitzer
- Wincott
- Yu
- Zamecnik
- Zhang
- Zou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
The law in computation: What machine learning, artificial intelligence, and big data mean for law and society scholarship
- Author
- Adams‐Prassl Jeremia
- Ajunwa Ifeoma
- Ajunwa Ifeoma
- American Civil Liberties Union (ACLU)
- Barocas Solon
- Barocas Solon
- Bodie Matthew T.
- Boellstorff Tom
- Boyd Danah
- Boyd Danah
- Brennan‐Marquez Kiel
- Brinkley Ian
- Buolamwini Joy
- Buolamwini Joy
- Caplan Robyn
- Citron Danielle Keats
- Coglianese Cary
- Cohen Julie
- Costello Cathryn
- Crawford Neta.
- De Filippi Primavera
- De Stefano Valerio
- Desai Deven R.
- Dubal Veena B.
- Dumbrava Costica
- Eubanks Virginia
- Felstiner Andrew
- Fisk Catherine L.
- Fuster Andreas
- Hassan Samer
- Hu Margaret
- Hurley Mikella
- Jaeger Paul T.
- Katz Daniel Martin
- Kluttz Daniel N.
- Kroll Joshua A.
- Lessig Lawrence
- Lodinova Anna
- Marx Gary T.
- McGinnis John O.
- Nelson Michael R.
- Pardo‐Guerra Juan Pablo
- Pound Roscoe
- Pugliese Joseph
- Raval Noopur
- Reed Chris
- Remus Dana
- Richardson Rashida
- Schneider Nathan
- Selbst Andrew D.
- Semmler Sean
- Sinnreich Aram
- Solow‐Niederman Alicia
- Starr Sonja B.
- Stop LAPD Spying Coalition
- Surden Harry
- Trubek David M.
- UNHCR
- Vladeck David C.
- Wachter Sandra
- Zureik Elia
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Hormone interactions at the root apical meristem
- Author
- A Cano-Delgado
- A Dill
- A Hewelt
- A Izhaki
- A Kutz
- A Nakamura
- A Nordstrom
- A Rahman
- A Rahman
- A Rosado
- A Sasaki
- A Tsuchisaka
- AB Bleecker
- AC Smigocki
- AJ Cary
- AJ Paquette
- AK Wilson
- AM Rashotte
- AN Stepanova
- AN Stepanova
- AN Stepanova
- AP Mahonen
- AP Mahonen
- B Scheres
- C Berg van den
- C Camilleri
- C Galinha
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- C Luschnig
- C Mussig
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- CE Hutchison
- CF Mouchel
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- CK Wen
- CS Hardtke
- D Eapen
- D Weijers
- D Weijers
- D Welch
- E Benkova
- E Truernit
- Eva Benková
- FB Pickett
- FJ Ferreira
- FM Watt
- G Ephritikhine
- G Roman
- GT Beemster
- GT Kim
- H Cui
- H Fukaki
- H Guo
- HC Yi
- HM Leyser
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- I Barlier
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- J Petrášek
- Jan Hejátko
- JI Medford
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- JM Alonso
- JM Arteca
- JP To
- JR Dinneny
- K Knox
- K Miyawaki
- K Nakajima
- K Ruzicka
- KM McGinnis
- L Di Laurenzio
- L Dolan
- L Galweiler
- L Laplaze
- LMS Palni
- LS Tran
- M Aida
- M Frigerio
- M Ghassemian
- M Higuchi
- M Riefler
- MJ Bennett
- MP Levesque
- N Beaudoin
- N Dharmasiri
- O Ortega-Martinez
- O Son
- O Yanai
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- Q Tian
- R Benjamins
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- S Yang
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- SF Yang
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- T Hamann
- T Sieberer
- T Ulmasov
- T Werner
- WH Vriezen
- X Fu
- X Fu
- X Li
- X Liang
- Y Greenboim-Wainberg
- Y Helariutta
- Y Liang
- Y Okushima
- Y Shimada
- Y Tao
- Y Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of river damming on biogenic silica turnover: implications for biogeochemical carbon and nutrient cycles
- Author
- A Cociasu
- AC Redfield
- AH Beusen
- AJ Bennekom Van
- AR Norris
- AS Ahluwalia
- B Müller
- B Sherman
- C Ge
- C Humborg
- C Humborg
- C Humborg
- C Humborg
- C Nilsson
- C Teodoru
- CEJ Ronde De
- CL Schelske
- CQ Liu
- CY Bernard
- D Cabanes
- D Rickert
- D Rickert
- D Uhlmann
- D Unzué-Belmonte
- DF McGinnis
- DJ Conley
- DJ Conley
- DJ Conley
- DJ Conley
- DJ Conley
- DJ Conley
- DJ DeMaster
- DM Nelson
- DM Nelson
- DM Soballe
- EO Okuku
- F Bartoli
- F Fraysse
- F Guo
- F Runge
- F Wang
- G Friedl
- G Friedl
- G Josette
- G Klaver
- G Olivié-Lauquet
- GG Laruelle
- I Fantin-Cruz
- J Kameník
- J Molozzi
- J Parr
- J Zang
- JD Milliman
- JF Parr
- JF Parr
- JH Ryther
- JI Parker
- JJ Hudson
- JPM Syvitski
- JT Cornelis
- KH Wedepohl
- L Cary
- L Rahm
- LA Derry
- LD Meyer
- LD Triplett
- LM Mayer
- LM Mosley
- LM Rangel
- LMB Ver
- M Hildebrand
- M Ngoc Nguyen
- MA Brzezinski
- MA Burford
- MC Geddes
- NV Madhu
- O Aumont
- O Kawara
- P Cappellen Van
- P Koszelnik
- P Regnier
- P Shi
- P Treguer
- PL Cook
- PV Brady
- R Anala
- R Shanthi
- RA Wüst
- RB Domingues
- RC Aller
- RE Turner
- RE Turner
- RE Turner
- RW Battarbee
- RW Howarth
- S Bergström
- S Capellacci
- S Loucaides
- SC Mulholland
- SD Wahby
- SI Belikov
- SW Blecker
- T Dejenie
- T Maavara
- TC Malone
- V Ittekkot
- V Thieu
- VJ Kelly
- W Admiraal
- W Dodds
- WH Schlesinger
- X Ran
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- X Sun
- X Zuo
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- XB Ran
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- Z Huang
- Z Li
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- Z Song
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- AE Axelrod
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- AE Schaefer
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- AE Sobel
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- CA Elvehjem
- CA Elvehjem
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- M Boas
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- M Gompel
- M Hindhede
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- M Hindhede
- M Hochberg
- M Kleiber
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- M Kochmann
- M Kunitz
- M Kunitz
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- MA Stetten
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- N Jollife
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- O Bergeim
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- P Aschkenasy-Lelu
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- PS Salej
- R Angier
- R Berg
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- R Braude
- R Elman
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- R Emmrich
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- R Hoagland
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- R Jacksch
- R Klement
- R Kuhn
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- R Lecoq
- R McCarrison
- R Okey
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- R Rosemann
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- RE Spitzer
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- RF Loeb
- RH Chittenden
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- RH Common
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- RJ Block
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- RL Potter
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- RT Conner
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- RW McKee
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- S Ansbacher
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- S Black
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- S Lepkovsky
- S Lepkovsky
- S Ochoa
- S Sherlock
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- SA Harris
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- SC Werner
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- SD Rubbo
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- SE Smith
- SG Smith
- SK Kon
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- SS Zilva
- SW Klatzein
- SZ Levine
- T Hamada
- T Li
- T Moore
- T Pfeiffer
- T Pfeiffer
- TB Osborne
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- TB Osborne
- TB Osborne
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- TD Ltjckey
- TD Spies
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- TD Spies
- TD Spies
- TD Spies
- TJ Haley
- TM Carpenter
- Tobbin Jr
- TR Riggs
- TW Birch
- V Augur
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- V Vigneaud du
- VA Najjar
- VA Najjar
- VA Najjar
- VB Reader
- VG Heller
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- VN Patwardhan
- VP Sydenstricker
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- VR Potter
- W Bachmann
- W Caspari
- W Heupke
- W Heupke
- W Keil
- W Keil
- W Kempner
- W Lintzel
- W Menschick
- W Neuweiler
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- W Shive
- W Stepp
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- WC Rose
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- WC Rose
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- WD Salmon
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- WH Adolph
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- WH Jansen
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- WH Riessen
- WH Sebrell
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- WJ Dann
- WJ Darby
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- WJ Linghorne
- WJ Nungester
- WK Hall
- WM Cox Jr
- WM Cox Jr
- WM Sperry
- WM Sperry
- WM Towler
- WO Atwater
- WR Brown
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- WT Pommerenke
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- WW Campbell
- Y Armand
- Y Kotake
- Y Saho
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1950
- Field of study