2,148 research outputs found
Phylogenetic differences in content and intensity of periodic proteins
Many proteins exhibit sequence periodicity, often correlated with a visible structural periodicity. The statistical significance of such periodicity can be assessed by means of a chi-square-based test, with significance thresholds being calculated from shuffled sequences. Comparison of the complete proteomes of 45 species reveals striking differences in the proportion of periodic proteins and the intensity of the most significant periodicities. Eukaryotes tend to have a higher proportion of periodic proteins than eubacteria, which in turn tend to have more than archaea. The intensity of periodicity in the most periodic proteins is also greatest in eukaryotes. By contrast, the relatively small group of periodic proteins in archaea also tend to be weakly periodic compared to those of eukaryotes and eubacteria. Exceptions to this general rule are found in those prokaryotes with multicellular life-cycle phases, e.g. Methanosarcina sps. or Anabaena sps., which have more periodicities than prokaryotes in general, and in unicellular eukaryotes, which have fewer than multicellular eukaryotes. The distribution of significantly periodic proteins in eukaryotes is over a wide range of period lengths, whereas prokaryotic proteins typically have a more limited set of period lengths. This is further investigated by repeating the analysis on the NRL-3D database of proteins of solved structure. Some short range periodicities are explicable in terms of basic secondary structure, e.g. alpha helices, while middle range periodicities are frequently found to consist of known short Pfam domains, e.g. leucine-rich repeats, tetratricopeptides or armadillo domains. However, not all can be explained in this way
Research in the design of high-performance reconfigurable systems
An initial design for the Bit Processor (BP) referred to in prior reports as the Processing Element or PE has been completed. Eight BP's, together with their supporting random-access memory, a 64 k x 9 ROM to perform addition, routing logic, and some additional logic, constitute the components of a single stage. An initial stage design is given. Stages may be combined to perform high-speed fixed or floating point arithmetic. Stages can be configured into a range of arithmetic modules that includes bit-serial one or two-dimensional arrays; one or two dimensional arrays fixed or floating point processors; and specialized uniprocessors, such as long-word arithmetic units. One to eight BP's represent a likely initial chip level. The Stage would then correspond to a first-level pluggable module. As both this project and VLSI CAD/CAM progress, however, it is expected that the chip level would migrate upward to the stage and, perhaps, ultimately the box level. The BP RAM, consisting of two banks, holds only operands and indices. Programs are at the box (high-level function) and system level. At the system level initial effort has been concentrated on specifying the tools needed to evaluate design alternatives
Peculiar mean velocity profiles within a porous bed of an open channel
Peer reviewedPublisher PD
Learning Experiences Contributing to Service-Delivery Competence in Applied Psychologists: Lessons for Sport Psychologists
The purpose of the present study was to compare learning experiences perceived to contribute to service-delivery competence in sport, clinical, and counseling psychologists. Twenty psychologists (11 female, 9 male; 28–70 years of age) participated in semistructured interviews. All participants emphasized the role of client interactions in learning service-delivery processes. In addition, clinical and counseling participants reported personal therapy and supervision as influential experiences. Applied implications for training include (a) regional supervision networks comprising peers and elders, (b) university-based sport psychology clinics, and (c) personal and professional development groups
The effectiveness of teamwork training on teamwork behaviors and team performance : A systematic review and meta-analysis of controlled interventions
The objective of this study was to conduct a systematic review and meta-analysis of teamwork interventions that were carried out with the purpose of improving teamwork and team performance, using controlled experimental designs. A literature search returned 16,849 unique articles. The meta-analysis was ultimately conducted on 51 articles, comprising 72 (k) unique interventions, 194 effect sizes, and 8439 participants, using a random effects model. Positive and significant medium-sized effects were found for teamwork interventions on both teamwork and team performance. Moderator analyses were also conducted, which generally revealed positive and significant effects with respect to several sample, intervention, and measurement characteristics. Implications for effective teamwork interventions as well as considerations for future research are discussed
Verifying timestamps of occultation observation systems
We describe an image timestamp verification system to determine the exposure
timing characteristics and continuity of images made by an imaging camera and
recorder, with reference to Coordinated Universal Time (UTC). The original use
was to verify the timestamps of stellar occultation recording systems, but the
system is applicable to lunar flashes, planetary transits, sprite recording, or
any area where reliable timestamps are required. The system offers good
temporal resolution (down to 2 msec, referred to UTC) and provides exposure
duration and interframe dead time information. The system uses inexpensive,
off-the- shelf components, requires minimal assembly and requires no
high-voltage components or connections. We also describe an application to load
FITS (and other format) image files, which can decode the verification image
timestamp. Source code, wiring diagrams and built applications are provided to
aid the construction and use of the device.Comment: 10 pages, 7 figures, accepted to Publications of the Astronomical
Society of Australia (PASA
Fairtrade, place and moral economy: between abstract ethical discourse and the moral experience of Northern Cape farmers
This paper explores the significance of the relationships and disjunctures between the global moral discourses of Fairtrade that are articulated through ethics of fairness in supply chains and the everyday moral experiences, discourses and practices of producers that shape moral economies in specific localities. Due to increased governance through universal codes, standards and certification, Fairtrade risks becoming an abstract ethical and regulatory tool, disconnected from the moral economies of those poor farmers it is intended to benefit. In response, the paper makes a case for a deeper understanding of the moral economies of farmers involved in Fairtrade networks and the ways in which these emerge out of moral experiences that are deeply embedded in local social and cultural relations. Through a case study of Eksteenskuil Agricultural Cooperative in South Africa’s Northern Cape, it seeks to demonstrate the importance of understanding the moral experiences of producers to better consider what is at stake for them, focusing on notions of cooperation, fairness and the ‘good farmer’, perceptions of community, and concerns with survival and self-sufficiency. The paper concludes that working in culturally-sensitive ways with producer communities and understanding how their local moral worlds are structured is vital in bridging the gap between abstract ethical discourses and the place-based moral experiences of producers, and to ensuring the effectiveness of Fairtrade initiatives
Ethical trading and socioeconomic transformation: critical reflections on the South African wine industry
Newly emerging ethical trade practices in the South African wine industry are examined as a way of engaging with debates about the ability of alternative trade approaches to facilitate meaningful opportunities for socioeconomic development in the global South. The South African wine industry has undergone rapid restructuring since the end of apartheid in order to meet the demands of international markets. However, transforming racially skewed ownership and skill patterns is proving a particular challenge. In this paper we outline some of the initiatives that have been introduced to stimulate socioeconomic change within the industry. By utilising analytical tools such as commodity chains, networks, and cultural approaches we demonstrate that a complex array of forces is driving change on the ground. Such forces include national imperatives derived from the legacy of apartheid and the concerns of consumers in the global North. We conclude by considering the types of local and global constraints that need to be challenged if these initiatives are to be successful in facilitating meaningful socioeconomic transformation within the wine industry
PDB81 Validating the ukpds 82 risk equations to contemporary outcomes studies in type 2 diabetes
Stability of Ca-montmorillonite hydrates: A computer simulation study
Classic simulations are used to study interlayer structure, swelling curves,
and stability of Ca-montmorillonite hydrates. For this purpose, NPzzT$ and
MuPzzT ensembles are sampled for ground level and given burial conditions. For
ground level conditions, a double layer hydrate having 15.0 A of basal spacing
is the predominant state for relative vapor pressures (p/po) ranging in
0.6-1.0. A triple hydrate counting on 17.9 A of interlaminar distance was also
found stable for p/po=1.0. For low vapor pressures, the system may produce a
less hydrated but still double layer state with 13.5 A or even a single layer
hydrate with 12.2 A of interlaminar distance. This depends on the established
initial conditions. On the other hand, the effect of burial conditions is two
sided. It was found that it enhances dehydration for all vapor pressures except
for saturation, where swelling is promoted.Comment: 8 pages, 9 figure
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