Voluntary Disclosures by Activist Shareholders

Using hand-collected data, we find that activist shareholders often publicly disclose open letters that demand various changes in corporate operating decisions at their target firms. These letters are associated with significant stock price movements, decreased bid-ask spreads, and key activism outcomes such as directorship wins, corporate strategy shifts, and proxy advisor recommendations. Managers commonly respond to activists' open letters with their own voluntary disclosures. We conclude that activists use voluntary disclosure to mitigate investor information asymmetry and that managers' voluntary disclosures can be induced by activists

Rocuronium vs Succinylcholine: Emergency Airway Management of the COVID-19 Patient

Tracheal Intubation is routinely performed in many settings.  Anesthesia providers are experts in this procedure.  Determination for the best possible approach for tracheal intubation include patient and provider specific considerations.  Severe acute respiratory syndrome-coronavirus-2 (SARS CoV-2) infection has led to the COVID-19 pandemic.  SARS CoV-2 is a highly contagious RNA virus that has caused widespread infections, severe respiratory disease, and deaths.  The purpose of this article is to describe the airway management currently recommended in Germany as well as the United States, the multi-systems pathophysiologic complications of these patients, and review the need for minimum airway manipulation prior to intubation of the trachea.  Further, this article discusses the pharmacologic options that are available for muscle relaxation during rapid sequence induction.  A review of the literature was performed.  Further, some authors of this article have actively participated in airway management of COVID-19 patients.  Available literature and guidelines suggest that rapid sequence induction with minimal airway manipulation is superior to standard induction. The article suggests that appropriate doses of rocuronium with an option of sugammadex reversal is a safer and superior choice to succinylcholine

Youth experience matters: participation in physical activity by young people with physical disability. A protocol for a national participation snapshot and Delphi consensus study

Data availability: Underlying data: No underlying data are associated with this article. Extended data: Figshare: Youth Experience Matters: Parent Information Leaflet https://doi.org/10.6084/m9.figshare.23278283.v1 This project contains the following extended data: AD6791_YEM_Parent_A5Booklet_V6.pdf Figshare: Youth Experience Matters: Young Person Information Leaflet https://doi.org/10.6084/m9.figshare.23278316.v1 This project contains the following extended data: AD6791_YEM_YoungPerson_A5Booklet_V3.pdf Figshare: Youth Experience Matters: Promotional material https://doi.org/10.6084/m9.figshare.23278370.v1 This project contains the following extended data: AD6791_YEM_Pull-Up-V1.pdf Figshare: Youth Experience Matters: Round 1 survey (Parts 1 and 2) - for information only (not for completion by participants.) https://doi.org/10.6084/m9.figshare.23280209.v1 This project contains the following extended data: YEM_SurveyR1_reproduced.pdf Figshare: Youth Experience Matters Data Management Plan 02 May 2023 https://doi.org/10.6084/m9.figshare.23277638.v1 This project contains the following extended data: HRCI-HRB-2022-006_Youth_Experience_Matters-DMP_v1.2_02May2023.pdf Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).Copyright: © 2023 Brady K et al. Young people with physical disability experience challenges to being physically active. To attain the health benefits of physical activity (PA) and sustain engagement, it is essential that participation is meaningful and enjoyable. This study aims to understand “what really matters” for participating in PA, from the perspectives of adolescents with physical disability. A parallel convergent mixed methods study will be undertaken, comprising a national cross-sectional quantitative assessment of PA participation (“Participation Snapshot”) and Delphi consensus study (“Delphi”). Young people (n=100) aged 13-17 years with a primary physical disability diagnosis will be invited to take part. The Participation Snapshot primary outcome is the Children’s Assessment of Participation and Enjoyment (CAPE). Contextual factors including disability diagnosis, demographics, mobility (Functional Mobility Scale), hand function (Manual Ability Classification System) and health related quality of life (Child Health Utility 9D) will also be collected. The Delphi will comprise two to four survey rounds, until consensus is reached. Round 1 (“Your Experience”) consists of a bespoke survey, designed and piloted with a public and patient involvement (PPI) panel, with open-ended questions and Likert scales inviting contributions from young people on their prior experience, barriers and facilitators, and ideas on participation in PA. Responses will be analysed using reflexive thematic analysis to construct the key themes, conceptualized under the “F-words” framework of the International Classification of Functioning, Disability and Health (ICF). These themes will be presented back to participants in subsequent rounds for selection and ranking, until consensus is achieved on the “top 10 priorities”. The project team and PPI panel will then co-design dissemination material and identify targets for dissemination to relevant stakeholder or policy groups. The findings will provide a basis for developing interventions aiming to empower, encourage and sustain future physical activity participation in a meaningful way by young people with physical disability.Health Research Board Ireland (HRCI-JFS-2022-006) via the Health Research Charities Ireland / Health Research Board Joint Funding Scheme 2022

Airway microbiota-host interactions regulate secretory leukocyte protease inhibitor levels and influence allergic airway inflammation

Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights into human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts mucosal immunity and the development of allergic airway inflammation (AAI). Colonization with Bph induces the differentiation of interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. Bph colonization protects from AAI and is associated with increased production of secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide with anti-inflammatory properties. These findings are additionally supported by clinical data showing that higher levels of upper respiratory SLPI correlate both with greater asthma control and the presence of Haemophilus, a bacterial genus associated with AAI. We propose that SLPI could be used as a biomarker of beneficial host-commensal relationships in the airway

Isolated right ventricular failure in hyperthyroidism: a clinical dilemma

We present a unique case of a 42-year-old gentleman with newly diagnosed Graves’ disease and isolated right ventricular failure. Extensive evaluation to include echocardiogram and cardiac catheterization were negative for significant pulmonary hypertension or coronary artery disease as potential etiologies. Hyperthyroid induced vasospasm is a rare but reported clinical entity that serves to be a clinical and diagnostic dilemma

The gut microbiota of people with asthma influences lung inflammation in gnotobiotic mice

The gut microbiota in early childhood is linked to asthma risk, but may continue to affect older patients with asthma. Here, we profile the gut microbiota of 38 children (19 asthma, median age 8) and 57 adults (17 asthma, median age 28) by 16S rRNA sequencing and find individuals with asthma harbored compositional differences from healthy controls in both adults and children. We develop a model to aid the design of mechanistic experiments in gnotobiotic mice and show enterotoxigeni

Exile Vol. XL No. 1

38th Year Title Page by Carrie Horner \u2797 i Epigraph by Ezra Pound ii Table of Contents iii-iv Vertigo by Lisa Stillman \u2795 1 Departing Flight by Morgan Roper \u2794 2 Untitled by Lizzie Loud \u2795 3 Marietta by Craig McDonough \u2794 4 Interlaken by Kira A . Pollack \u2794 5 Why Nature Surprises Us by Josh Endicott \u2796 6-7 Untitled by Colin Mack \u2794 7 My Father by Matt Wanat \u2795 8 Legs In The Dust by Alison Stevens \u2795 9-11 Untitled by Lilly Streett \u2794 12 of cigarettes, saltwater and death... by Tricia B. Swearingen \u2794 13 Serendipity by Lizzie Lout \u2795 14 Untitled by Lilly Streett \u2794 15 Summer by Allison Lemieux \u2795 16 And the Rain Fell by Jeremy Aufrance \u2795 17-18 Main Street by Elise Gargarella \u2795 19 Füssen by Morgan Roper \u2794 20 Lightning on the Snow by Matt Wanat \u2795 21 A discussion of 12 year-old murders, of course by Jeremy Aufrance \u2795 22 Get your hands off my hat by Jamie Oliver \u2794 23 The Hero by Sara Sterling Ely \u2796 24-26 Punker Dave by Trevett Allen \u2795 27 still looking for the perfect line by ryan shafer \u2794 28-29 Untitled by Lizzie Loud \u2795 30 Civil War by Katherine Anne Campo \u2794 31 Disposable belief by ryan shafer \u2794 32-33 Schizophrenic Sylvia by Maria Mohiuddin \u2795 34 Excerpts from Revolutions, a novel by Marcu McLaughlin \u2794 35-36 Untitled by Keith Chapman \u2795 37 The Survivors by Kira A. Pollack \u2794 38 Days of Prophecy by Trey Dunham \u2794 39 Untitled by Carrie Horner \u2797 40 What to do by Christopher Harnish \u2794 41 Familiar Stranger by Lisa Stillman \u2795 42-46 Untitled by John Salter \u2797 47 On Meeting Emma by Allison Lemieux \u2795 48 Nude Figure by James Oliver \u2794 49 Tathagata by Leslie Dana Wells \u2794 50 On Fences and My Dogs by Christopher Harnish \u2794 51 Editorial Board 52 Cover, Kira Pollack \u2794 -iv Editorial decision is shared equally among the Editorial Board. -5