2,268 research outputs found
Assessment of maximum inspiratory pressure: Prior submaximal respiratory muscle activity (‘warm-up’) enhances maximum inspiratory activity and attenuates the learning effect of repeated measurement
The official published version can be obtained from the link belowBackground: The variability of maximal inspiratory pressure (PImax) in response to repeated measurement affects its reliability; published studies have used between three and twenty PImax measurements on a single occasion. Objective: This study investigated the influence of a specific respiratory ‘warm-up’ upon the repeated measurement of inspiratory muscle strength and attempts to establish a procedure by which PImax can be assessed with maximum reliability using the smallest number of manoeuvres. Methods: Fourteen healthy subjects, familiar with the Mueller manoeuvre, were studied. The influence of repeated testing on a single occasion was assessed using an 18-measurement protocol. Using a randomised cross-over design, subjects performed the protocol, preceded by a specific respiratory warm-up (RWU) and on another occasion, without any preliminary activity (control). Comparisons were made amongst ‘baseline’ (best of the first 3 measurements), ‘short’ series (best of 7th to 9th measurement) and ‘long’ series (best of the last 3 measurements). Results: Under control conditions, the mean increase (‘baseline’ vs. ‘long’ series) was 11.4 (5.8)%; following the RWU, the increase (post RWU ‘baseline’ vs. ‘long’ series) was 3.2 (10.0)%. There were statistically significant differences between measurements made at all 3 protocol stages (‘baseline’, ‘short’ and ‘long’ series) under control conditions, but none following the RWU. Conclusions: The present data suggest that a specific RWU may attenuate the ‘learning effect’ during repeated PImax measurements, which is one of the main contributors of the test variability. The use of a RWU may provide a means of obtaining reliable values of PImax following just 3 measurements.This work was partially supported by a grant from the University of Wolverhampton, UK
Polarisation measurements with a CdTe pixel array detector for Laue hard X-ray focusing telescopes
Polarimetry is an area of high energy astrophysics which is still relatively
unexplored, even though it is recognized that this type of measurement could
drastically increase our knowledge of the physics and geometry of high energy
sources. For this reason, in the context of the design of a Gamma-Ray Imager
based on new hard-X and soft gamma ray focusing optics for the next ESA Cosmic
Vision call for proposals (Cosmic Vision 2015-2025), it is important that this
capability should be implemented in the principal on-board instrumentation. For
the particular case of wide band-pass Laue optics we propose a focal plane
based on a thick pixelated CdTe detector operating with high efficiency between
60-600 keV. The high segmentation of this type of detector (1-2 mm pixel size)
and the good energy resolution (a few keV FWHM at 500 keV) will allow high
sensitivity polarisation measurements (a few % for a 10 mCrab source in 106s)
to be performed. We have evaluated the modulation Q factors and minimum
detectable polarisation through the use of Monte Carlo simulations (based on
the GEANT 4 toolkit) for on and off-axis sources with power law emission
spectra using the point spread function of a Laue lens in a feasible
configuration.Comment: 10 pages, 6 pages. Accepted for publication in Experimental Astronom
Gamma-ray Burst UV/optical afterglow polarimetry as a probe of Quantum Gravity
A possible birefringence effect that arises in quantum gravity leads to a
frequency-dependent rotation of the polarization angle of linearly polarized
emission from distant sources. Here we use the UV/optical polarization data of
the afterglows of GRB 020813 and GRB 021004 to constrain this effect. We find
an upper limit on the Gambini & Pulin birefringence parameter . This limit is of 3 orders better than the previous limits
from observations of AGNs and of the Crab pulsar. Much stronger limits may be
obtained by the future observation of polarization of the prompt -rays.Comment: typos correcte
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An ASKAP Search for a Radio Counterpart to the First High-significance Neutron Star-Black Hole Merger LIGO/Virgo S190814bv
We present results from a search for a radio transient associated with the LIGO/Virgo source S190814bv, a likely neutron star-black hole (NSBH) merger, with the Australian Square Kilometre Array Pathfinder. We imaged a 30 deg2 field at ΔT = 2, 9, and 33 days post-merger at a frequency of 944 MHz, comparing them to reference images from the Rapid ASKAP Continuum Survey observed 110 days prior to the event. Each epoch of our observations covers 89% of the LIGO/Virgo localization region. We conducted an untargeted search for radio transients in this field, resulting in 21 candidates. For one of these, AT2019osy, we performed multiwavelength follow-up and ultimately ruled out the association with S190814bv. All other candidates are likely unrelated variables, but we cannot conclusively rule them out. We discuss our results in the context of model predictions for radio emission from NSBH mergers and place constrains on the circum-merger density and inclination angle of the merger. This survey is simultaneously the first large-scale radio follow-up of an NSBH merger, and the most sensitive widefield radio transients search to-date
A naturalistic study of treatment outcomes with aripiprazole in young people with first episode psychosis
Objective: Adequate treatment of a first psychotic episode in young people is a difficult challenge but may be of critical importance for changing the course of psychotic illness. Pharmacotherapy is the standard treatment of psychosis, however there is a paucity of data specific to first-episode psychosis.Methods: In this study 12 young people who presented with a psychotic episode at a specialised early intervention service were commenced on treatment with aripiprazole. They were assessed at baseline and weeks 4, 6, 24 and 48 using a broad battery of outcome measures. Case notes were also examined.Results: Data was available for 6 participants at week 48, and of those, one remained on treatment with Aripiprazole at endpoint. Case histories were typified by presentations that included illicit substance use and treatments characterised by several changes in medications. No single treatment choice predominated. Most participants tolerated treatment and showed symptomatic improvement with individualised therapy.Conclusion: Most participants showed improvement during the treatment period. Aripiprazole was one of many medications used in this study and may have been useful for the treatment of some individuals with first episode psychosis.<br /
A focal plane detector design for a wide-band Laue-lens telescope
The energy range above 60 keV is important for the study of many open
problems in high energy astrophysics such as the role of Inverse Compton with
respect to synchrotron or thermal processes in GRBs, non thermal mechanisms in
SNR, the study of the high energy cut-offs in AGN spectra, and the detection of
nuclear and annihilation lines. Recently the development of high energy Laue
lenses with broad energy bandpasses from 60 to 600 keV have been proposed for a
Hard X ray focusing Telescope (HAXTEL) in order to study the X-ray continuum of
celestial sources. The required focal plane detector should have high detection
efficiency over the entire operative range, a spatial resolution of about 1 mm,
an energy resolution of a few keV at 500 keV and a sensitivity to linear
polarization. We describe a possible configuration of the focal plane detector
based on several CdTe/CZT pixelated layers stacked together to achieve the
required detection efficiency at high energy. Each layer can operate both as a
separate position sensitive detector and polarimeter or work with other layers
to increase the overall photopeak efficiency. Each layer has a hexagonal shape
in order to minimize the detector surface required to cover the lens field of
view. The pixels would have the same geometry so as to provide the best
coupling with the lens point spread function and to increase the symmetry for
polarimetric studies.Comment: 10 pages, 9 figure
Expected performance of a hard X-ray polarimeter (POLAR) by Monte Carlo Simulation
Polarization measurements of the prompt emission in Gamma-ray Bursts (GRBs)
can provide diagnostic information for understanding the nature of the central
engine. POLAR is a compact polarimeter dedicated to the polarization
measurement of GRBs between 50-300 keV and is scheduled to be launched aboard
the Chinese Space Laboratory about year 2012. A preliminary Monte Carlo
simulation has been accomplished to attain the expected performance of POLAR,
while a prototype of POLAR is being constructed at the Institute of High Energy
Physics, Chinese Academy of Sciences. The modulation factor, efficiency and
effective area, background rates and Minimum Detectable Polarization (MDP) were
calculated for different detector configurations and trigger strategies. With
the optimized detector configuration and trigger strategy and the constraint of
total weight less than 30 kg, the primary science goal to determine whether
most GRBs are strongly polarized can be achieved, and about 9 GRBs/yr can be
detected with MDP < 10% for the conservative detector configurationComment: 15pages, 15 figures, accepted by Nuclear Instruments and Methods in
Physics Research A 200
Long optical plateau in the afterglow of the short GRB 150424A with extended emission
Context. Short-duration gamma-ray bursts (GRBs) with extended emission form a subclass of short GRBs, comprising about 15% of the short-duration sample. Afterglow detections of short GRBs are also rare (about 30%) because of their lower luminosity.
Aims. We present a multiband data set of the short burst with extended emission, GRB 150424A, comprising of GROND observations, complemented with data from Swift/UVOT, Swift/XRT, HST, Keck/LRIS, and data points from the literature. The GRB 150424A afterglow shows an extended plateau phase, lasting about 8 h. The analysis of this unique GRB afterglow might shed light on the understanding of afterglow plateau emission, the nature of which is still under debate.
Methods. We present a phenomenological analysis made by applying fireball closure relations and interpret the findings in the context of the fireball model. We discuss the plausibility of a magnetar as a central engine, which would be responsible for additional and prolonged energy injection into the fireball.
Results. We find convincing evidence for energy injection into the afterglow of GRB 150424A. We find that a magnetar spin-down as the source for a prolonged energy injection requires that at least 4% of the spin-down energy is converted into radiation
Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling.
N-myristoylation on glycine is an irreversible modification that has long been recognized to govern protein localization and function. In contrast, the biological roles of lysine myristoylation remain ill-defined. We demonstrate that the cytoplasmic scaffolding protein, gravin-α/A kinase–anchoring protein 12, is myristoylated on two lysine residues embedded in its carboxyl-terminal protein kinase A (PKA) binding domain. Histone deacetylase 11 (HDAC11) docks to an adjacent region of gravin-α and demyristoylates these sites. In brown and white adipocytes, lysine myristoylation of gravin-α is required for signaling via β(2)- and β(3)-adrenergic receptors (β-ARs), which are G protein–coupled receptors (GPCRs). Lysine myristoylation of gravin-α drives β-ARs to lipid raft membrane microdomains, which results in PKA activation and downstream signaling that culminates in protective thermogenic gene expression. These findings define reversible lysine myristoylation as a mechanism for controlling GPCR signaling and highlight the potential of inhibiting HDAC11 to manipulate adipocyte phenotypes for therapeutic purposes
High energy emission from microquasars
The microquasar phenomenon is associated with the production of jets by X-ray
binaries and, as such, may be associated with the majority of such systems. In
this chapter we briefly outline the associations, definite, probable, possible,
and speculative, between such jets and X-ray, gamma-ray and particle emission.Comment: Contributing chapter to the book Cosmic Gamma-Ray Sources, K.S. Cheng
and G.E. Romero (eds.), to be published by Kluwer Academic Publishers,
Dordrecht, 2004. (19 pages
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