Paleotectonic Investigation by Successive 3D Seismic Horizon Flattening in the Pennsylvanian Interval of Western Osage County, Oklahoma

3D seismic and well log data in Western Osage County, Oklahoma, are utilized to evaluate possible intracratonic tectonic signals present in the subsurface stratigraphy of the Cherokee Platform as a result of the regional tectonic events of Pennsylvanian age. These events include: the Wichita, Ouachita, and Arbuckle orogenies, the Nemaha and Ozark Uplifts, and the Southeast Oklahoma Aulacogen. Horizon flattening within 3D seismic volumes allows for identification of paleotectonic structures and syntectonic depositional features, which may be related to the collateral effects of these orogenies on the Cherokee Platform. Identified structures were assigned geologic ages using precision synthetic seismograms tuned to the Pennsylvanian interval in a 45 square mile 3D seismic data volume. Paleostructure maps and isochron, or time-thickness, maps created in conjunction with the flattened horizons highlight contemporaneous structural features that may be related to regional orogenic events. Paleostructure maps also help determine the sedimentological processes occurring at the time of deposition. This investigation will add knowledge to the tectonic and depositional evolution of the Cherokee Platform and the surrounding basins, which have been prolific hydrocarbon-producing regions for over a century

Feasibility Testing of the Alert for AFib Intervention.

Improving early detection and treatment of atrial fibrillation (AF) is critical because untreated AF is a major contributor to stroke and heart failure. We sought to generate knowledge about the feasibility of conducting a randomized controlled trial to test the effect of the Alert for AFib intervention on knowledge, attitudes, and beliefs about treatment-seeking for signs and symptoms of AF. Adults ≥65 years old (96% White) at risk for developing AF were randomized to receive the Alert for AFib intervention ( n = 40) or an attention control session ( n = 40). Feasibility goals for recruitment, participant retention, adherence, perceived satisfaction and burden, and intervention fidelity were met. From baseline to study completion, knowledge ( p = .005) and attitudes ( p < .001) about treatment-seeking improved more in the intervention group compared with the control group. Results support testing the effectiveness of the Alert for AFib intervention in a large trial

Developing a method for quantifying hip joint angles and moments during walking using neural networks and wearables

Quantifying hip angles/moments during gait is critical for improving hip pathology diagnostic and treatment methods. Recent work has validated approaches combining wearables with artificial neural networks (ANNs) for cheaper, portable hip joint angle/moment computation. This study developed a Wearable-ANN approach for calculating hip joint angles/moments during walking in the sagittal/frontal planes with data from 17 healthy subjects, leveraging one shin-mounted inertial measurement unit (IMU) and a force-measuring insole for data capture. Compared to the benchmark approach, a two hidden layer ANN (n = 5 nodes per layer) achieved an average rRMSE = 15% and R2=0.85 across outputs, subjects and training rounds

Hip Joint Angles and Moments during Stair Ascent Using Neural Networks and Wearable Sensors

End-stage hip joint osteoarthritis treatment, known as total hip arthroplasty (THA), improves satisfaction, life quality, and activities of daily living (ADL) function. Postoperatively, evaluating how patients move (i.e., their kinematics/kinetics) during ADL often requires visits to clinics or specialized biomechanics laboratories. Prior work in our lab and others have leveraged wearables and machine learning approaches such as artificial neural networks (ANNs) to quantify hip angles/moments during simple ADL such as walking. Although level-ground ambulation is necessary for patient satisfaction and post-THA function, other tasks such as stair ascent may be more critical for improvement. This study utilized wearable sensors/ANNs to quantify sagittal/frontal plane angles and moments of the hip joint during stair ascent from 17 healthy subjects. Shin/thigh-mounted inertial measurement units and force insole data were inputted to an ANN (2 hidden layers, 10 total nodes). These results were compared to gold-standard optical motion capture and force-measuring insoles. The wearable-ANN approach performed well, achieving rRMSE = 17.7% and R2 = 0.77 (sagittal angle/moment: rRMSE = 17.7 ± 1.2%/14.1 ± 0.80%, R2 = 0.80 ± 0.02/0.77 ± 0.02; frontal angle/moment: rRMSE = 26.4 ± 1.4%/12.7 ± 1.1%, R2 = 0.59 ± 0.02/0.93 ± 0.01). While we only evaluated healthy subjects herein, this approach is simple and human-centered and could provide portable technology for quantifying patient hip biomechanics in future investigations

Using technology to promote social connectedness: Insights from the T&Scon project

Loneliness and social isolation can affect anyone, with policymakers recognising the impact of isolation on individual wellbeing and public health. In 2018 the Scottish Government set out its approach to tackling social isolation in A Connected Scotland, a national strategy to achieve a Scotland “where individuals and communities are more connected, and everyone has the opportunity to develop meaningful relationships regardless of age, stage, circumstances, or identity.” A priority of the strategy is to create opportunities for people to connect, with a specific commitment to work with older age groups to “understand how digital technology can add value to their lives in a way that is meaningful”, informing wider work to deliver the Scottish Government’s Digital Strategy for Scotland. The Technology and Social Connectedness (T&Scon) project explored the potential of technology to support social connectedness for adults living in Scotland, producing a toolkit to provide guidance for individuals and organisations on the use of digital technology in building and maintaining social connections. This briefing paper, drawing on the project’s key findings and recommendations, provides a summary of key information for policymakers and practitioners in Scotland, and further afield. Its findings will be of particular interest to those who are developing new ways of keeping in touch, as the risk of social isolation becomes more pronounced in the wake of the global coronavirus pandemic. Key findings A wide range of UK and international technology-based and technology-enabled services exist, designed to support social connectedness, targeted at different adult age user groups. Most technologies used in this way are intended for people living at home although there are technologies in use and in development for the care home sector. Data from the Healthy Ageing in Scotland (HAGIS) study revealed patterns of social connectedness among people over the age of 50 living across Scotland. Patterns of technology use across different groups suggest that those who are least socially connected may also be those least likely to utilise technology to connect with others. Careful evaluation of the target user group is an important factor in the successful adoption of technology-based solutions, breaking down assumptions about who uses technology and who doesn’t, and understanding the risks and opportunities of using technology for this purpose.Briefing based on: T&SCon: Technology and Social Connectedness, Final Report, available online at http://www.tec.sco

The social, health and economic impact of COVID-19 – Healthy Ageing In Scotland (HAGIS):a protocol for a mixed-methods study

Introduction Public health responses to the COVID-19 pandemic have reaped adverse physical, psychological, social and economic effects, with older adults disproportionally affected. Psychological consequences of the pandemic include fear, worry and anxiety. COVID-19 fear may impact individuals’ mitigation behaviours, influencing their willingness to (re)engage in health, social and economic behaviours. This study seeks (1) to develop a robust and evidence-based questionnaire to measure the prevalence of COVID-19 fear among older adults (aged ≥50) in Scotland and (2) to examine the impact of COVID-19 fear on the willingness of older adults to (re)engage across health, social and economic domains as society adjusts to the ‘new normal’ and inform policy and practice. Methods and analysis This mixed-method study includes a large-scale multimodal survey, focus groups and interviews with older adults (aged ≥50) living in Scotland, and an email-based ‘e-Delphi’ consultation with professionals working with older adults. The COVID-19 fear scale was developed and validated using exploratory and confirmatory factor analyses. Survey data will be analysed using descriptive and inferential statistics. Thematic analysis will be used to analyse qualitative data. Survey and qualitative findings will be triangulated and used as the starting point for an ‘e-Delphi’ consensus consultation with expert stakeholders. Ethics and dissemination Ethical approval has been obtained from the University of Stirling for multimodal survey development, fieldwork methodology and data management. Anonymised survey data will be deposited with the UK Data Service, with a link provided via the Gateway to Global Ageing. Qualitative data will be deposited with the University of Stirling online digital repository—DataSTORRE. A dedicated work package will oversee dissemination via a coproduced project website, conference presentations, rapid reports and national and international peer-reviewed journal articles. There is planned engagement with Scottish and UK policy makers to contribute to the UK government’s COVID-19 recovery strategy

Ophthalmic manifestations of Cryptococcus gattii species complex: a case series and review of the literature

AIM: To report 4 cases of Cryptococcus gattii (C. gattii) species complex infection with diverse ophthalmic manifestations, and to review the literature to examine pathobiology of disease, classical ophthalmic presentations and outcomes, and treatment modalities for this emerging pathogen. METHODS: Cases of C. gattii meningoencephalitis with ophthalmic manifestations were identified via chart review at two institutions in Australia and one institution in the mid-west region of the United States and are reported as a case series. Additionally, a MEDLINE literature review was conducted to identify all reported cases of C. gattii with ophthalmic manifestations from 1990-2020. Cases were reviewed and tabulated, together with our series of patients, in this report. RESULTS: Four cases of C. gattii with ophthalmic manifestations are presented; three from Australia and one from the USA. A literature review identified a total of 331 cases of C. gattii with visual sequelae. The majority of cases occurred in immunocompetent individuals. Blurred vision and diplopia were the most common presenting symptoms, with papilloedema the most common sign, reported in 10%-50% of cases. Visual loss was reported in 10%-53% of cases, as compared to rates of visual loss of 1%-9% in C. neoformans infection. Elevated intracranial pressure, cerebrospinal fluid (CSF) fungal burden, and abnormal neurological exam at presentation correlated with poor visual outcomes. The mainstays of treatment are anti-fungal agents and aggressive management of intracranial hypertension with serial lumbar punctures. CSF diversion procedures should be considered for refractory cases. Acetazolamide and mannitol are associated with high complication rates, and adjuvant corticosteroids have demonstrated higher mortality rates; these treatments should be avoided. CONCLUSION: Permanent visual loss represents a devastating yet potentially preventable sequelae of C. gattii infection. Intracranial hypertension needs to be recognised early and aggressively managed. Referral to an ophthalmologist/neuro-ophthalmologist in all cases of cryptococcal infection independent of visual symptoms at time of diagnosis is recommended

Using Technology the Right Way to Support Social Connectedness for Older People in the Era of COVID-19

The restrictions imposed in response to the COVID-19 pandemic pose significant risks to the human rights of older people from limitations in how people are able to engage with their social lives and from increased risk of discrimination linked to conceptualization of COVID-19 as a disease of the old. Further, COVID-19 increases risks of social isolation through public health and societal responses such as lockdowns. These responses have resulted in significant shifts in how citizens and service providers think about technology as a tool to allow people to stay socially connected. However, there are risks to the rights of older people inherent in the use of technology related to their ability to access technology and ageist assumptions that may limit engagement. The ‘Technology and Social Connectedness’ project was a pre-pandemic mixed-methods study involving evidence review, secondary analyses, and qualitative methods. Cross-dataset analyses led to evidence-based guidance to inform a rights-based approach to using technology. This paper provides analysis from the project that foregrounds a rights-based approach demonstrating how we developed the guidance within this framework and, contextualized within the pandemic response in Scotland, how that guidance can help others to protect and uphold the human rights of older people

Evaluation of Potential Protective Factors Against Metabolic Syndrome in Bottlenose Dolphins: Feeding and Activity Patterns of Dolphins in Sarasota Bay, Florida

Free-ranging bottlenose dolphins (Tursiops truncatus) living in Sarasota Bay, Florida appear to have a lower risk of developing insulin resistance and metabolic syndrome compared to a group of dolphins managed under human care. Similar to humans, differences in diet and activity cycles between these groups may explain why Sarasota dolphins have lower insulin, glucose, and lipids. To identify potential protective factors against metabolic syndrome, existing and new data were incorporated to describe feeding and activity patterns of the Sarasota Bay wild dolphin community. Sarasota dolphins eat a wide variety of live fish and spend 10–20% of daylight hours foraging and feeding. Feeding occurs throughout the day, with the dolphins eating small proportions of their total daily intake in brief bouts. The natural pattern of wild dolphins is to feed as necessary and possible at any time of the day or night. Wild dolphins rarely eat dead fish or consume large amounts of prey in concentrated time periods. Wild dolphins are active throughout the day and night; they may engage in bouts of each key activity category at any time during daytime. Dive patterns of radio-tagged dolphins varied only slightly with time of day. Travel rates may be slightly lower at night, suggesting a diurnal rhythm, albeit not one involving complete, extended rest. In comparison, the managed dolphins are older; often fed a smaller variety of frozen-thawed fish types; fed fish species not in their natural diet; feedings and engaged activities are often during the day; and they are fed larger but fewer meals. In summary, potential protective factors against metabolic syndrome in dolphins may include young age, activity, and small meals fed throughout the day and night, and specific fish nutrients. These protective factors against insulin resistance and type 2 diabetes are similar to those reported in humans. Further studies may benefit humans and dolphins

Can a Code of Ethics Improve Manager Behavior and Investor Confidence? An Experimental Study

Policy makers and corporations have recently emphasized a code of ethics as an effective aspect of corporate governance. The corporate governance literature in accounting, however, provides little empirical or theoretical support for this emphasis. We address this gap between public policy and the literature by studying the effectiveness of a code of ethics in an experimental setting. Using Bicchieri\u27s (2006) model of social norm activation, we predict that a code of ethics will improve manager return behavior and investor confidence to the extent that it activates social norms that control opportunistic behavior. Further, we predict that adding a certification choice whereby the manager can publicly certify that he will adhere to the code will enhance the potential for the code of ethics to activate such norms. We find that a code of ethics only improves manager return behavior and investor confidence when the code incorporates a public certification choice by the manager. When the code is present but there is no certification choice, manager return behavior does not improve and investor confidence erodes over time because of increased expectations that are not met by managers. An analysis of individual return decisions and exit questionnaire responses supports the activation of social norms as the underlying mechanism behind our results