1,042 research outputs found
The Likelihood Ratio as a tool for Radio Continuum Surveys with SKA precursor telescopes
In this paper we investigate the performance of the likelihood ratio method
as a tool for identifying optical and infrared counterparts to proposed radio
continuum surveys with SKA precursor and pathfinder telescopes. We present a
comparison of the infrared counterparts identified by the likelihood ratio in
the VISTA Deep Extragalactic Observations (VIDEO) survey to radio observations
with 6, 10 and 15 arcsec resolution. We cross-match a deep radio catalogue
consisting of radio sources with peak flux density 60 Jy with deep
near-infrared data limited to 22.6. Comparing the
infrared counterparts from this procedure to those obtained when cross-matching
a set of simulated lower resolution radio catalogues indicates that degrading
the resolution from 6 arcsec to 10 and 15 arcsec decreases the completeness of
the cross-matched catalogue by approximately 3 and 7 percent respectively. When
matching against shallower infrared data, comparable to that achieved by the
VISTA Hemisphere Survey, the fraction of radio sources with reliably identified
counterparts drops from 89%, at 22.6, to 47% with
20.0. Decreasing the resolution at this shallower
infrared limit does not result in any further decrease in the completeness
produced by the likelihood ratio matching procedure. However, we note that
radio continuum surveys with the MeerKAT and eventually the SKA, will require
long baselines in order to ensure that the resulting maps are not limited by
instrumental confusion noise.Comment: 10 pages, 7 figures, accepted for publication in mnra
Inter-specific aggression generates ant mosaics in canopies of primary tropical rainforest
The ant mosaic is a concept of the non-random spatial distribution of individual ant species in trees built upon the assumption of interspecific behavioural associations. However, colony identity and environmental variance may also play a role in species distribution. Here we assess the presence of ant mosaics in a primary forest ecosystem and whether they are structured by species' aggressive behaviours or by habitat filtering.
We sampled arboreal ants from vertically stratified baits exposed in 225 canopy trees in a 9-ha plot of primary lowland forest in Papua New Guinea, the largest forest area surveyed to detect ant mosaics. We performed behavioural tests on conspecific ants from adjacent trees to determine the territories of individual colonies. We explored the environmental effects on the ant communities using information on the plot vegetation structure and topography. Furthermore, we created a novel statistical method to test for the community non-random spatial structure across the plot via spatial randomisation of individual colony territories. Finally, we linked spatial segregation among the four most common species to experimentally assessed rates of interspecies aggression.
The ant communities comprised 57 species of highly variable abundance and vertical stratification. Ant community composition was spatially dependent, but it was not affected by tree species composition or canopy connectivity. Only local elevation had a significant but rather small effect. Individual colony territories ranged from one tree to 0.7 ha. Species were significantly over-dispersed, with their territory overlap significantly reduced. The level of aggression between pairs of the four most common species was positively correlated with their spatial segregation. Our study demonstrates the presence of ant mosaics in tropical pristine forest, which are maintained by interspecific aggression rather than habitat filtering, with vegetation structure having a rather small and indirect effect, probably linked to microclimate variability.publishedVersio
Structure of laponite-styrene precursor dispersions for production of advanced polymer-clay nanocomposites
One method for production of polymer-clay nanocomposites involves dispersal of surface-modified clay in a polymerisable monomeric solvent, followed by fast in situ polymerisation. In order to tailor the properties of the final material we aim to control the dispersion state of the clay in the precursor solvent. Here, we study dispersions of surface-modified Laponite, a synthetic clay, in styrene via large-scale Monte-Carlo simulations and experimentally, using small angle X-ray and static light scattering. By tuning the effective interaction between simulated laponite particles we are able to reproduce the experimental scattering intensity patterns for this system, with good accuracy over a wide range of length scales. However, this agreement could only be obtained by introducing a permanent electrostatic dipole moment into the plane of each Laponite particle, which we explain in terms of the distribution of substituted metal atoms within each Laponite particle. This suggests that Laponite dispersions, and perhaps other clay suspensions, should display some of the structural characteristics of dipolar fluids. Our simulated structures show aggregation regimes ranging from networks of long chains to dense clusters of Laponite particles, and we also obtain some intriguing ‘globular’ clusters, similar to capsids. We see no indication of any ‘house-of-cards’ structures. The simulation that most closely matches experimental results indicates that gel-like networks are obtained in Laponite dispersions, which however appear optically clear and non-sedimenting over extended periods of time. This suggests it could be difficult to obtain truly isotropic equilibrium dispersion as a starting point for synthesis of advanced polymer-clay nanocomposites with controlled structures
Towards the fabrication of phosphorus qubits for a silicon quantum computer
The quest to build a quantum computer has been inspired by the recognition of
the formidable computational power such a device could offer. In particular
silicon-based proposals, using the nuclear or electron spin of dopants as
qubits, are attractive due to the long spin relaxation times involved, their
scalability, and the ease of integration with existing silicon technology.
Fabrication of such devices however requires atomic scale manipulation - an
immense technological challenge. We demonstrate that it is possible to
fabricate an atomically-precise linear array of single phosphorus bearing
molecules on a silicon surface with the required dimensions for the fabrication
of a silicon-based quantum computer. We also discuss strategies for the
encapsulation of these phosphorus atoms by subsequent silicon crystal growth.Comment: To Appear in Phys. Rev. B Rapid Comm. 5 pages, 5 color figure
It's not personal: can logbooks provide insights into engineering projects?
Engineering projects are often large, complex, high-value, high-risk, and distributed. As a result, it is vital to monitor and understand what is happening within each as it progresses, and highly challenging to do so. Without detailed understanding, management becomes difficult and falls back upon generic principles that are not always appropriate for each project context. To approach this issue, this paper studies the written logbooks of three engineers, and explores how the marks within can be analysed to generate project-level understanding, particularly that which informs engineering project management. This occurs through the study of three engineering logbooks using two detailed coding schemas, one classifying content and the other activity, creativity and novelty. By this analysis, this paper aims to understand and assess efficacy of studying logbooks given their time-consuming and difficult-to-code nature. From the results, feasibility is shown of developing detailed understanding of typical project progress, and the identification of specific events within a project upon which a manager may act. The efficacy of the study of logbooks for this purpose is then assessed
Transgressing the moral economy: Wheelerism and management of the nationalised coal industry in Scotland
This article illuminates the links between managerial style and political economy in post-1945 Britain, and explores the origins of the 1984–1985 miners' strike, by examining in longer historical context the abrasive attitudes and policies of Albert Wheeler, Scottish Area Director of the National Coal Board (NCB). Wheeler built on an earlier emphasis on production and economic criteria, and his micro-management reflected pre-existing centralising tendencies in the industries. But he was innovative in one crucial aspect, transgressing the moral economy of the Scottish coalfield, which emphasised the value of economic security and changes by joint industrial agreement
Joule-assisted silicidation for short-channel silicon nanowire devices
We report on a technique enabling electrical control of the contact
silicidation process in silicon nanowire devices. Undoped silicon nanowires
were contacted by pairs of nickel electrodes and each contact was selectively
silicided by means of the Joule effect. By a realtime monitoring of the
nanowire electrical resistance during the contact silicidation process we were
able to fabricate nickel-silicide/silicon/nickel- silicide devices with
controlled silicon channel length down to 8 nm.Comment: 6 pages, 4 figure
Single Spin Measurement using Single Electron Transistors to Probe Two Electron Systems
We present a method for measuring single spins embedded in a solid by probing
two electron systems with a single electron transistor (SET). Restrictions
imposed by the Pauli Principle on allowed two electron states mean that the
spin state of such systems has a profound impact on the orbital states
(positions) of the electrons, a parameter which SET's are extremely well suited
to measure. We focus on a particular system capable of being fabricated with
current technology: a Te double donor in Si adjacent to a Si/SiO2 interface and
lying directly beneath the SET island electrode, and we outline a measurement
strategy capable of resolving single electron and nuclear spins in this system.
We discuss the limitations of the measurement imposed by spin scattering
arising from fluctuations emanating from the SET and from lattice phonons. We
conclude that measurement of single spins, a necessary requirement for several
proposed quantum computer architectures, is feasible in Si using this strategy.Comment: 22 Pages, 8 Figures; revised version contains updated references and
small textual changes. Submitted to Phys. Rev.
BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis
BACKGROUND
BRCA1 methylation has been associated with homologous recombination deficiency, a biomarker of platinum sensitivity. Studies evaluating BRCA1-methylated tubal/ovarian cancer (OC) do not consistently support improved survival following platinum chemotherapy. We examine the characteristics of BRCA1-methylated OC in a meta-analysis of individual participant data.
METHODS
2636 participants' data across 15 studies were analyzed. BRCA1-methylated tumors were defined according to their original study. Associations between BRCA1 methylation and clinico-pathological characteristics were evaluated. The effects of methylation on overall survival (OS) and progression-free survival (PFS) were examined using mixed-effects models. All statistical tests were two-sided.
RESULTS
430 (16.3%) tumors were BRCA1-methylated. BRCA1 methylation was associated with younger age and advanced-stage high-grade serous OC. There were no survival differences between BRCA1-methylated and non-BRCA1-methylated OC (median PFS = 20.0 vs 18.5 months, HR = 1.01, 95% CI = 0.87-1.16, P=0.98; median OS = 46.6 vs 48.0 months, HR = 1.02, 95% CI = 0.87-1.18, P=0.96). Where BRCA1/2 mutations were evaluated (n = 1248), BRCA1 methylation displayed no survival advantage over BRCA1/2 intact (BRCA1/2 wild type non-BRCA1-methylated) OC. Studies used different methods to define BRCA1 methylation. Where BRCA1 methylation was determined using methylation-specific PCR and gel electrophoresis (n = 834), it was associated with improved survival (PFS: HR = 0.80, 95% CI = 0.66-0.97, P=0.02; OS: HR = 0.80, 95% CI = 0.63-1.00, P=0.05) on mixed-effects modelling.
CONCLUSION
BRCA1-methylated OC displays similar clinico-pathological features to BRCA1-mutated OC, but is not associated with survival. Heterogeneity within BRCA1 methylation assays influences associations. Refining these assays may better identify cases with silenced BRCA1 function and improved patient outcomes
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