Robot assisted stapedotomy ex vivo with an active handheld instrument

Micron is a fully handheld active micromanipulator that helps to improve position accuracy and precision in microsurgery by cancelling hand tremor. This work describes adaptation, tuning, and testing of the Micron system for stapedotomy, a microsurgical procedure performed in the middle ear to restore hearing that requires accurate manipulation in narrow spaces. Two end-effectors, a handle, and a brace (or rest) were designed and prototyped. The control system was adapted for the new hardware. The system was tested ex vivo in stapedotomy procedure comparing manually-performed and Micron-assisted surgical tasks. Tremor amplitude was found to be reduced significantly. Further testing is needed in order to obtain statistically significant results regarding other parameters dealing with regularity of the fenestra shap

Social Media Technologies' Use for the Competitive Information and Knowledge Sharing, and Its Effects on Industrial SMEs' Innovation

The effective use of technologies supporting decision making is essential to companies? survival. Recent studies analyzed social media technologies (SMT) in the context of small- and medium-sized enterprises (SMEs), contributing to the discussion on SMT benefits from the marketing perspective. This article focuses on the effects of SMT use on innovation. Our findings provide empirical evidence on the positive effects of SMT use for acquiring external information and for sharing knowledge and innovation performance

Enterprise 2.0: Research challenges and opportunities

© Springer International Publishing Switzerland 2015. Blending Web 2.0 technologies with enterprise information systems is setting up the stage for a new generation of information systems that will help enterprises open up new communication channels with their stakeholders. Contrary to traditional enterprises with top-down command flow and bottom-up feedback flow, the same flows in Enterprise 2.0 cross all levels and in all directions bringing people together in the development of creative and innovative ideas. The power of Web 2.0 technologies stems from their ability to capture real-world phenomena such as collaboration, competition, and partnership that can be converted into useful and structured information sources from which enterprises can draw information about markets’ trends, consumers’ habits, suppliers’ strategies, etc. This paper discusses the research efforts that our international research group has put into the topic of Enterprise 2.0 (aka Social Enterprise). In particular, our research group advocates that existing practices for managing enterprise information systems need to be re-visited in a way that permits to capture social relations that arise inside and outside the enterprise, to establish guidelines and techniques to assist IT practitioners integrate social relations into their design, development, and maintenance efforts of these information systems, and last but not least to identify and tackle challenges that prevent capturing social relations

Targeting quiescent leukemic stem cells using second generation autophagy inhibitors

In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs). In clinical studies hydroxychloroquine (HCQ), the only clinically approved autophagy inhibitor, does not consistently inhibit autophagy in cancer patients, so more potent autophagy inhibitors are needed. We generated a murine model of CML in which autophagic flux can be measured in bone marrow-located LSCs. In parallel, we use cell division tracing, phenotyping of primary CML cells, and a robust xenotransplantation model of human CML, to investigate the effect of Lys05, a highly potent lysosomotropic agent, and PIK-III, a selective inhibitor of VPS34, on the survival and function of LSCs. We demonstrate that long-term haematopoietic stem cells (LT-HSCs: Lin−Sca-1+c-kit+CD48−CD150+) isolated from leukemic mice have higher basal autophagy levels compared with non-leukemic LT-HSCs and more mature leukemic cells. Additionally, we present that while HCQ is ineffective, Lys05-mediated autophagy inhibition reduces LSCs quiescence and drives myeloid cell expansion. Furthermore, Lys05 and PIK-III reduced the number of primary CML LSCs and target xenografted LSCs when used in combination with TKI treatment, providing a strong rationale for clinical use of second generation autophagy inhibitors as a novel treatment for CML patients with LSC persistence

The history, evolution, and future of big data & analytics:A bibliometric analysis of its relationship to performance in organizations

Big data and analytics (BDA) are gaining momentum, particularly in the practitioner world. Research linking BDA to improved organizational performance seems scarce and widely dispersed though, with the majority focused on specific domains and/or macro-level relationships. In order to synthesize past research and advance knowledge of the potential organizational value of BDA, the authors obtained a data set of 327 primary studies and 1252 secondary cited papers. This paper reviews this body of research, using three bibliometric methods. First, it elucidates its intellectual foundations via co-citation analysis. Second, it visualizes the historical evolution of BDA and performance research and its substreams through algorithmic historiography. Third, it provides insights into the field's potential evolution via bibliographic coupling. The results reveal that the academic attention for the BDA-performance link has been increasing rapidly. The study uncovered ten research clusters that form the field's foundation. While research seems to have evolved following two main, isolated streams, the past decade has witnessed more cross-disciplinary collaborations. Moreover, the study identified several research topics undergoing focused development, including financial and customer risk management, text mining and evolutionary algorithms. The review concludes with a discussion of the implications for different functional management domains and the gaps for both research and practice.</p

Social Interactions vs Revisions, What is important for Promotion in Wikipedia?

In epistemic community, people are said to be selected on their knowledge contribution to the project (articles, codes, etc.) However, the socialization process is an important factor for inclusion, sustainability as a contributor, and promotion. Finally, what does matter to be promoted? being a good contributor? being a good animator? knowing the boss? We explore this question looking at the process of election for administrator in the English Wikipedia community. We modeled the candidates according to their revisions and/or social attributes. These attributes are used to construct a predictive model of promotion success, based on the candidates's past behavior, computed thanks to a random forest algorithm. Our model combining knowledge contribution variables and social networking variables successfully explain 78% of the results which is better than the former models. It also helps to refine the criterion for election. If the number of knowledge contributions is the most important element, social interactions come close second to explain the election. But being connected with the future peers (the admins) can make the difference between success and failure, making this epistemic community a very social community too

Arguably big biology: Sociology, spatiality and the knockout mouse project

© 2013 copyright Palgrave MacmillanThis is a post-peer-review, pre-copyedit version of an article published in BioSocieties. The definitive publisher-authenticated version BioSocieties, 2013, Vol. 8, pp. 417-431 is available online at: http://www.palgrave-journals.com/biosoc/journal/v8/n4/full/biosoc201325a.htmlFollowing the completion of the Human Genome Project (HGP), a critical challenge has been how to make biological sense of the amassed sequence data and translate this into clinical applications. A range of large biological research projects, as well as more distributed experimental collaborations, are seeking to realise this through translational research initiatives and postgenomic approaches. Drawing on interviews with key participants, this article explores the biological assumptions, sociological challenges and spatial imaginaries at play in arguments around one of these developments, which is using genetically altered mice to understand gene function. The knockout mouse project (KOMP) is a large-scale initiative in functional genomics, seeking to produce a ‘knockout mouse’ for each gene in the mouse’s genome, which can then be used to answer questions about gene function in mammals. KOMP is frequently framed as one successor to the HGP, emblematic of the ambitions of internationally coordinated biological research. However, the development of new technologies for generating and managing genetically altered mice, alongside the challenge of asking biologically meaningful questions of vast numbers of animals, is creating new frictions in this extension and intensification of biological research practices. This article introduces two separate approaches to the future of international research using mutant mice as stakeholders to negotiate the biological, sociological and spatial challenges of collaboration. The first centres on the directed research practices and sociological assumptions of KOMP, as individual researchers are reorganised around shared animals, databases and infrastructures. The second highlights an alternative vision of the future of biomedical research, using distributed management to enhance the sensitivities and efficiencies of existing experimental practices over space. These exemplify two different tactics in the organisation of an ‘arguably’ big biology. They also critically embody different sociological and spatial imaginaries for the collaborative practices of international translational research

ASTERIX and 2.0 Knowledge Management : exploring the appropriation of 2.0 KMS via the Myth of the Gaulish village

International audienceKnowledge Management Systems (KMS) in companies have profoundly changed in recent years. They have become KMS 2.0 that aim to transform the firm and are driven by a new relationship to knowledge in line with 2.0 organisations. These 2.0 KMS have implemented modes of organisation that disrupt those that previously guided firms’ performance. This can sometimes lead to paradoxical organizational dysfunctions as witnessed by the difficulties faced by some traditionally hierarchical French companies. Through a case study of Constructor and a theoretical background on IS appropriation in organizations and myths in management, we show how the Asterix myth contributes to understanding how 2.0. KMS are appropriated in such companies. We find evidence of similarities regarding knowledge and Knowledge Management between the Asterix’ myth and the behaviours and practices concerning knowledge management within Constructor. As a result, the Asterix’ myth may be a relevant perspective for understanding the obstacles, advantages and appropriations of 2.0. KMS within French organizations