Mixing in incompressible flows: transport, dissipation, and their interplay

In this survey, we address mixing from the point of view of partial differential equations, motivated by applications that arise in fluid dynamics. We give an account of optimal mixing, loss of regularity for transport equations, enhanced dissipation, and anomalous dissipation

Mixing in incompressible flows: transport, dissipation, and their interplay

In this survey, we address mixing from the point of view of partial differential equations, motivated by applications that arise in fluid dynamics. We give an account of optimal mixing, loss of regularity for transport equations, enhanced dissipation, and anomalous dissipation.Comment: Survey article, submitted to Notices of the AM

Discovery of Dust Emission Activity Emanating from Main-belt Asteroid 2015 FW412

We present the discovery of activity emanating from main-belt asteroid 2015 FW412, a finding stemming from the Citizen Science project Active Asteroids, a NASA Partner program. We identified a pronounced tail originating from 2015 FW412 and oriented in the anti-motion direction in archival Blanco 4-m (Cerro Tololo Inter-American Observatory, Chile) Dark Energy Camera (DECam) images from UT 2015 April 13, 18, 19, 21 and 22. Activity occurred near perihelion, consistent with the main-belt comets (MBCs), an active asteroid subset known for sublimation-driven activity in the main asteroid belt; thus 2015 FW412 is a candidate MBC. We did not detect activity on UT 2021 December 12 using the Inamori-Magellan Areal Camera and Spectrograph (IMACS) on the 6.5 m Baade telescope, when 2015 FW412 was near aphelion.Comment: 4 pages, 1 figur

Recommendations from the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL)

International audienceAbstractRare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important is the difficulty of making pricing and reimbursement (P&R) decisions in rare diseases. Until now, there has been little consensus on the most appropriate assessment criteria, perspective or appraisal process. This paper proposes nine principles to help improve the consistency of OMP P&R assessment in Europe and ensure that value assessment, pricing and funding processes reflect the specificities of rare diseases and contribute to both the sustainability of healthcare systems and the sustainability of innovation in this field. These recommendations are the output of the European Working Group for Value Assessment and Funding Processes in Rare Diseases (ORPH-VAL), a collaboration between rare disease experts, patient representatives, academics, health technology assessment (HTA) practitioners, politicians and industry representatives. ORPH-VAL reached its recommendations through careful consideration of existing OMP P&R literature and through a wide consultation with expert stakeholders, including payers, regulators and patients. The principles cover four areas: OMP decision criteria, OMP decision process, OMP sustainable funding systems and European co-ordination. This paper also presents a guide to the core elements of value relevant to OMPs that should be consistently considered in all OMP appraisals. The principles outlined in this paper may be helpful in drawing together an emerging consensus on this topic and identifying areas where consistency in payer approach could be achievable and beneficial. All stakeholders have an obligation to work together to ensure that the promise of OMP’s is realised

Discutindo a educação ambiental no cotidiano escolar: desenvolvimento de projetos na escola formação inicial e continuada de professores

A presente pesquisa buscou discutir como a Educação Ambiental (EA) vem sendo trabalhada, no Ensino Fundamental e como os docentes desta escola compreendem e vem inserindo a EA no cotidiano escolar., em uma escola estadual do município de Tangará da Serra/MT, Brasil. Para tanto, realizou-se entrevistas com os professores que fazem parte de um projeto interdisciplinar de EA na escola pesquisada. Verificou-se que o projeto da escola não vem conseguindo alcançar os objetivos propostos por: desconhecimento do mesmo, pelos professores; formação deficiente dos professores, não entendimento da EA como processo de ensino-aprendizagem, falta de recursos didáticos, planejamento inadequado das atividades. A partir dessa constatação, procurou-se debater a impossibilidade de tratar do tema fora do trabalho interdisciplinar, bem como, e principalmente, a importância de um estudo mais aprofundado de EA, vinculando teoria e prática, tanto na formação docente, como em projetos escolares, a fim de fugir do tradicional vínculo “EA e ecologia, lixo e horta”.Facultad de Humanidades y Ciencias de la Educació

Optimization of the air flow to the radiator of a racing MX motorbike

reservedQuesto lavoro di tesi ha lo scopo di indagare tramite software CFD quali sono le maggiori criticità che diminuiscono l'afflusso di aria al radiatore nella parte frontale della moto, ottimizzando le geometrie e creandone di nuove, con nuove proposte basate su simulazioni bidimensionaliThis thesis work aims to investigate through CFD software which are the major criticalities that decrease the airflow to the radiator in the front part of the bike, optimizing the geometries and creating new ones, with new proposals based on two-dimensional simulations

Sowing the seeds of the future: Policies for financing tomorrow's innovations

In this paper, we discuss the state of the art in research and policy making related to the dynamics of financing innovation, highlighting gaps in the literature and setting up the objectives of this Special Issue. We also provide a discussion of methodological issues and future directions for the stream of studies aiming at the evaluation of the effectiveness and impact of policies to finance innovation. Finally, we discuss how the articles in this collection contribute to improve our understanding of the financing of innovation along differen