Robustness assessment approaches for steel framed structures under catastrophic events

The current study deals with the robustness assessment methods of steel framed buildings under catastrophic events. Two steel framed buildings, designed according to old and new seismic Italian codes, have been herein analysed, by considering the uncertainties of both the material strength and the applied loads, through two investigation methods. First, within the methodologies used for robustness assessment under seismic loads, a deterministic method, framed within the Performance Based Seismic Design (PBSD), has been applied. Later on, the robustness of studied structures under different column-removed conditions, related to different catastrophic events (blast, impact, fire and so on), has been assessed by means of two forcebased analysis techniques (a literature approach and a more advanced procedure) in order to estimate their resistance against progressive collapse. The application of the two methods has allowed to calculate the robustness index of examined structures, by taking into account the influence of both the catenary effect phenomenon and different beam-to-column joints, with the final aim to show their behavioural difference in terms of robustness

Calibration of a Bending Model for Cold-formed Sections

The calibration procedure of a numerical model based on the simulation of the moment-curvature relation for cold-formed steel beams is presented. The results of bending tests on beams with double-channel cross-section are used to assess the proper values to the parameters which quantify the model

Seismic analysis of a SFT solution for the Messina Strait crossing

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On the equivalence of the X-ray scattering retrieval with beam tracking and analyser-based imaging using a synchrotron source

X-ray phase contrast imaging (XPCI) methods give access to contrast mechanisms that are based on the refractive properties of matter on top of the absorption coefficient in conventional x-ray imaging. Ultra small angle x-ray scattering (USAXS) is a phase contrast mechanism that arises due to multiple refraction events caused by physical features of a scale below the physical resolution of the used imaging system. USAXS contrast can therefore give insight into subresolution structural information, which is an ongoing research topic in the vast field of different XPCI techniques. In this study, we quantitatively compare the USAXS signal retrieved by the beam tracking XPCI technique with the gold standard of the analyzer based imaging XPCI technique using a synchrotron x-ray source. We find that, provided certain conditions are met, the two methods measure the same quantity

A systematic risk assessment and meta-analysis on the use of oral β-alanine supplementation.

β-Alanine supplementation is one of the world's most commonly used sports supplements, and its use as a nutritional strategy in other populations is ever-increasing, due to evidence of pleiotropic ergogenic and therapeutic benefits. Despite its widespread use, there is only limited understanding of potential adverse effects. To address this, a systematic risk assessment and meta-analysis was undertaken. Four databases were searched using keywords and Medical Subject Headings. All human and animal studies that investigated an isolated, oral, β-alanine supplementation strategy were included. Data were extracted according to 5 main outcomes, including 1) side effects reported during longitudinal trials, 2) side effects reported during acute trials, 3) effect of supplementation on circulating health-related biomarkers, 4) effect of supplementation on skeletal muscle taurine and histidine concentration, and 5) outcomes from animal trials. Quality of evidence for outcomes was ascertained using the Grading of Recommendations Assessment Development and Evaluation (GRADE) framework, and all quantitative data were meta-analyzed using multilevel models grounded in Bayesian principles. In total, 101 human and 50 animal studies were included. Paraesthesia was the only reported side effect and had an estimated OR of 8.9 [95% credible interval (CrI): 2.2, 32.6] with supplementation relative to placebo. Participants in active treatment groups experienced similar dropout rates to those receiving the placebo treatment. β-Alanine supplementation caused a small increase in circulating alanine aminotransferase concentration (effect size, ES: 0.274, CrI: 0.04, 0.527), although mean data remained well within clinical reference ranges. Meta-analysis of human data showed no main effect of β-alanine supplementation on skeletal muscle taurine (ES: 0.156; 95% CrI: −0.38, 0.72) or histidine (ES: −0.15; 95% CrI: −0.64, 0.33) concentration. A main effect of β-alanine supplementation on taurine concentration was reported for murine models, but only when the daily dose was ≥3% β-alanine in drinking water. The results of this review indicate that β-alanine supplementation within the doses used in the available research designs, does not adversely affect those consuming it

Application of structural topology optimisation in aluminium cross-sectional design

Aluminium is lightweight and corrosion-resistant; however, its low Young's Modulus predisposes the need for better material distribution across its section to increase stiffness. This paper studies a holistic design optimisation approach with the power of structural topology optimisation aiming to develop novel structural aluminium beam and column profiles. The optimisation methodology includes forty standard loading combinations while the optimisation results were combined through an X-ray overlay technique. This design optimisation approach is referred here to as the Sectional Optimisation Method (SOM). SOM is supported by engineering intuition as well as the collaboration of 2D and 3D approaches with a focus on post-processing and manufacturability through a morphogenesis process. Ten optimised cross-sectional profiles for beams and columns are presented. The shape of one of the best performing optimised sections was simplified by providing cross-section elements with a uniform thickness and using curved elements of constant radius. A second level heuristic shape optimisation was done by creating new section shapes based on the original optimised design. The paper also carries out stub column tests using finite element analysis (FEA) to determine the loacl buckling behaviour of the above-optimised aluminium profiles under compression and to investigate the effectiveness of using the existing classification methods according to codified provisions of Eurocode 9. The herein presented work aims to integrate topology optimisation aspects in cross-sectional design of aluminium alloy element building applications, providing thus a new concept in design procedures of lightweight aluminium structures

Acute cardiometabolic effects of brief active breaks in sitting for patients with rheumatoid arthritis

Exercise is a treatment in rheumatoid arthritis, but participation in moderate-to-vigorous exercise is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. We compared the acute effects of active breaks in sitting with those of moderate-to-vigorous exercise on cardiometabolic risk markers in patients with rheumatoid arthritis. In a crossover fashion, 15 women with rheumatoid arthritis underwent three 8-h experimental conditions: prolonged sitting (SIT), 30-min bout of moderate-to-vigorous exercise followed by prolonged sitting (EX), and 3-min bouts of light-intensity walking every 30 min of sitting (BR). Postprandial glucose, insulin, c-peptide, triglycerides, cytokines, lipid classes/subclasses (lipidomics), and blood pressure responses were assessed. Muscle biopsies were collected following each session to assess targeted proteins/genes. Glucose [−28% in area under the curve (AUC), P = 0.036], insulin (−28% in AUC, P = 0.016), and c-peptide (−27% in AUC, P = 0.006) postprandial responses were attenuated in BR versus SIT, whereas only c-peptide was lower in EX versus SIT (−20% in AUC, P = 0.002). IL-1β decreased during BR, but increased during EX and SIT (P = 0.027 and P = 0.085, respectively). IL-1ra was increased during EX versus BR (P = 0.002). TNF-α concentrations decreased during BR versus EX (P = 0.022). EX, but not BR, reduced systolic blood pressure (P = 0.013). Lipidomic analysis showed that 7 of 36 lipid classes/subclasses were significantly different between conditions, with greater changes being observed in EX. No differences were observed for protein/gene expression. Brief active breaks in sitting can offset markers of cardiometabolic disturbance, which may be particularly useful for patients who may find it difficult to adhere to exercise. NEW & NOTEWORTHY Exercise is a treatment in rheumatoid arthritis but is challenging for some patients. Light-intensity breaks in sitting could be a promising alternative. Our findings show beneficial, but differential, cardiometabolic effects of active breaks in sitting and exercise in patients with rheumatoid arthritis. Breaks in sitting mainly improved glycemic and inflammatory markers, whereas exercise improved lipidomic and hypotensive responses. Breaks in sitting show promise in offsetting aspects of cardiometabolic disturbance associated with prolonged sitting in rheumatoid arthritis