106 research outputs found
Some protein tyrosine phosphatases target in part to lipid rafts and interact with caveolin-1
Observing Ultra High Energy Cosmic Particles from Space: SEUSO, the Super Extreme Universe Space Observatory Mission
The experimental search for ultra high energy cosmic messengers, from eV to beyond eV, at the very end of the known energy
spectrum, constitutes an extraordinary opportunity to explore a largely unknown
aspect of our universe. Key scientific goals are the identification of the
sources of ultra high energy particles, the measurement of their spectra and
the study of galactic and local intergalactic magnetic fields. Ultra high
energy particles might, also, carry evidence of unknown physics or of exotic
particles relics of the early universe. To meet this challenge a significant
increase in the integrated exposure is required. This implies a new class of
experiments with larger acceptances and good understanding of the systematic
uncertainties. Space based observatories can reach the instantaneous aperture
and the integrated exposure necessary to systematically explore the ultra high
energy universe. In this paper, after briefly summarising the science case of
the mission, we describe the scientific goals and requirements of the SEUSO
concept. We then introduce the SEUSO observational approach and describe the
main instrument and mission features. We conclude discussing the expected
performance of the mission
TTRV30M oligomeric aggregates inhibit proliferation of renal progenitor cells but maintain their capacity to differentiate into podocytes in vitro
Publicado em: The Proceedings of the XIIIth International Symposium on Amyloidosis,
May 6-10, 2012, Groningen, The NetherlandsIn Familial Amyloidotic Polyneuropathy, the amyloid deposition of mutant transthyretin TTR V30M can lead to renal complications. An unexplored mechanism is the toxicity of oligomeric TTR aggregates. A subset of renal progenitor cells (RPC) in the adult human kidney can induce regeneration of podocytes and tubular structures of the nephron, which can be critical for preventing irreversible renal failure. We assessed whether RPC are vulnerable, in vitro, to TTRV30M oligomers. RPC proliferation was reduced by 16.3±9.7% and 32.6±6.3% after 48 and 72 hours, respectively, in the presence of the oligomers. However, oligomers did not induce apoptosis or alterations in cell cycle to any significant extent, and did not influence RPC differentiation into podocytes. From this first attempt, we can say that TTRV30M oligomers inhibit RPC proliferation but do not influence their capacity to differentiate into mature podocytes, and thus should not compromise tissue regeneration.FC
Ultrathin Tropical Tropopause Clouds (UTTCs) : I. Cloud morphology and occurrence
Subvisible cirrus clouds (SVCs) may contribute to dehydration close to the tropical tropopause. The higher and colder SVCs and the larger their ice crystals, the more likely they represent the last efficient point of contact of the gas phase with the ice phase and, hence, the last dehydrating step, before the air enters the stratosphere. The first simultaneous in situ and remote sensing measurements of SVCs were taken during the APE-THESEO campaign in the western Indian ocean in February/March 1999. The observed clouds, termed Ultrathin Tropical Tropopause Clouds (UTTCs), belong to the geometrically and optically thinnest large-scale clouds in the Earth´s atmosphere. Individual UTTCs may exist for many hours as an only 200--300 m thick cloud layer just a few hundred meters below the tropical cold point tropopause, covering up to 105 km2. With temperatures as low as 181 K these clouds are prime representatives for defining the water mixing ratio of air entering the lower stratosphere
Differential expression of two isoforms of the chemokine receptor CXCR3 determines the ultimate effect of IP-10 on survival of human hepatic stellate cells (HSC)
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