902 research outputs found
Assessment of Spray Polyurethane Foam Worker Exposure to Organophosphate Flame Retardants Through Measures in Air, Hand Wipes, and Urine
Tris(1-chloro-2-propyl) phosphate (TCPP, also referenced as TCIPP), a flame retardant used in spray polyurethane foam insulation, increases cell toxicity and affects fetal development. Spray polyurethane foam workers have the potential to be exposed to TCPP during application. In this study, we determined exposure to TCPP and concentrations of the urinary biomarker bis(1-chloro-2-propyl) phosphate (BCPP) among 29 spray polyurethane foam workers over 2 work days. Work was conducted at residential or commercial facilities using both open-cell (low density) and closed-cell (high density) foam. Study participants provided two personal air samples (Day 1 and Day 2), two hand wipe samples (Pre-shift Day 2 and Post-shift Day 2), and two spot urine samples (Pre-shift Day 1 and Post-shift Day 2). Bulk samples of cured spray foam were also analyzed. Sprayers were found to have significantly higher TCPP geometric mean (GM) concentration in personal air samples (87.1 μg/m3), compared to helpers (30.2 μg/m3; p = 0.025). A statistically significant difference was observed between TCPP pre- and post-shift hand wipe GM concentrations (p = 0.004). Specifically, TCPP GM concentration in post-shift hand wipe samples of helpers (106,000 ng/sample) was significantly greater than pre-shift (27,300 ng/sample; p \u3c 0.001). The GM concentration of the urinary biomarker BCPP (23.8 μg/g creatinine) was notably higher than the adult male general population (0.159 μg/g creatinine, p \u3c 0.001). Urinary BCPP GM concentration increased significantly from Pre-shift Day 1 to Post-shift Day 2 for sprayers (p = 0.013) and helpers (p = 0.009). Among bulk samples, cured open-cell foam had a TCPP GM concentration of 9.23% by weight while closed-cell foam was 1.68%. Overall, post-shift BCPP urine concentrations were observed to be associated with TCPP air and hand wipe concentrations, as well as job position (sprayer vs. helper). Spray polyurethane foam workers should wear personal protective equipment including air-supplied respirators, coveralls, and gloves during application
Rapid planetesimal formation in turbulent circumstellar discs
The initial stages of planet formation in circumstellar gas discs proceed via
dust grains that collide and build up larger and larger bodies (Safronov 1969).
How this process continues from metre-sized boulders to kilometre-scale
planetesimals is a major unsolved problem (Dominik et al. 2007): boulders stick
together poorly (Benz 2000), and spiral into the protostar in a few hundred
orbits due to a head wind from the slower rotating gas (Weidenschilling 1977).
Gravitational collapse of the solid component has been suggested to overcome
this barrier (Safronov 1969, Goldreich & Ward 1973, Youdin & Shu 2002). Even
low levels of turbulence, however, inhibit sedimentation of solids to a
sufficiently dense midplane layer (Weidenschilling & Cuzzi 1993, Dominik et al.
2007), but turbulence must be present to explain observed gas accretion in
protostellar discs (Hartmann 1998). Here we report the discovery of efficient
gravitational collapse of boulders in locally overdense regions in the
midplane. The boulders concentrate initially in transient high pressures in the
turbulent gas (Johansen, Klahr, & Henning 2006), and these concentrations are
augmented a further order of magnitude by a streaming instability (Youdin &
Goodman 2005, Johansen, Henning, & Klahr 2006, Johansen & Youdin 2007) driven
by the relative flow of gas and solids. We find that gravitationally bound
clusters form with masses comparable to dwarf planets and containing a
distribution of boulder sizes. Gravitational collapse happens much faster than
radial drift, offering a possible path to planetesimal formation in accreting
circumstellar discs.Comment: To appear in Nature (30 August 2007 issue). 18 pages (in referee
mode), 3 figures. Supplementary Information can be found at 0708.389
Role of the general base Glu268 in nitroglycerin bioactivation and mechanism-based superoxide formation by aldehyde dehydrogenase-2
Spin qubits with electrically gated polyoxometalate molecules
Spin qubits offer one of the most promising routes to the implementation of
quantum computers. Very recent results in semiconductor quantum dots show that
electrically-controlled gating schemes are particularly well-suited for the
realization of a universal set of quantum logical gates. Scalability to a
larger number of qubits, however, remains an issue for such semiconductor
quantum dots. In contrast, a chemical bottom-up approach allows one to produce
identical units in which localized spins represent the qubits. Molecular
magnetism has produced a wide range of systems with tailored properties, but
molecules permitting electrical gating have been lacking. Here we propose to
use the polyoxometalate [PMo12O40(VO)2]q-, where two localized spins-1/2 can be
coupled through the electrons of the central core. Via electrical manipulation
of the molecular redox potential, the charge of the core can be changed. With
this setup, two-qubit gates and qubit readout can be implemented.Comment: 9 pages, 6 figures, to appear in Nature Nanotechnolog
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Influence of ground surface characteristics on the mean radiant temperature in urban areas
The effect of variations in land cover on mean radiant surface temperature (Tmrt) is explored through a simple scheme developed within the radiation model SOLWEIG. Outgoing longwave radiation is parameterised using surface temperature observations on a grass and an asphalt surface, whereas outgoing shortwave radiation is modelled through variations in albedo for the different surfaces. The influence of surface materials on Tmrt is small compared to the effects of shadowing. Nevertheless, altering ground surface materials could contribute to a reduction on Tmrt to reduce the radiant load during heat-wave episodes in locations where shadowing is not an option. Evaluation of the new scheme suggests that despite its simplicity it can simulate the outgoing fluxes well, especially during sunny conditions. However, it underestimates at night and in shadowed locations. One grass surface used to develop the parameterisation, with very different characteristics compared to an evaluation grass site, caused Tmrt to be underestimated. The implications of using high resolution (e.g. 15 minutes) temporal forcing data under partly cloudy conditions are demonstrated even for fairly proximal sites
Coordinated optimization of visual cortical maps (I) Symmetry-based analysis
In the primary visual cortex of primates and carnivores, functional
architecture can be characterized by maps of various stimulus features such as
orientation preference (OP), ocular dominance (OD), and spatial frequency. It
is a long-standing question in theoretical neuroscience whether the observed
maps should be interpreted as optima of a specific energy functional that
summarizes the design principles of cortical functional architecture. A
rigorous evaluation of this optimization hypothesis is particularly demanded by
recent evidence that the functional architecture of OP columns precisely
follows species invariant quantitative laws. Because it would be desirable to
infer the form of such an optimization principle from the biological data, the
optimization approach to explain cortical functional architecture raises the
following questions: i) What are the genuine ground states of candidate energy
functionals and how can they be calculated with precision and rigor? ii) How do
differences in candidate optimization principles impact on the predicted map
structure and conversely what can be learned about an hypothetical underlying
optimization principle from observations on map structure? iii) Is there a way
to analyze the coordinated organization of cortical maps predicted by
optimization principles in general? To answer these questions we developed a
general dynamical systems approach to the combined optimization of visual
cortical maps of OP and another scalar feature such as OD or spatial frequency
preference.Comment: 90 pages, 16 figure
Automatic versus manual forwarding in web surveys - A cognitive load perspective on satisficing responding.
Academic Performance and Behavioral Patterns
Identifying the factors that influence academic performance is an essential
part of educational research. Previous studies have documented the importance
of personality traits, class attendance, and social network structure. Because
most of these analyses were based on a single behavioral aspect and/or small
sample sizes, there is currently no quantification of the interplay of these
factors. Here, we study the academic performance among a cohort of 538
undergraduate students forming a single, densely connected social network. Our
work is based on data collected using smartphones, which the students used as
their primary phones for two years. The availability of multi-channel data from
a single population allows us to directly compare the explanatory power of
individual and social characteristics. We find that the most informative
indicators of performance are based on social ties and that network indicators
result in better model performance than individual characteristics (including
both personality and class attendance). We confirm earlier findings that class
attendance is the most important predictor among individual characteristics.
Finally, our results suggest the presence of strong homophily and/or peer
effects among university students
Acute cardiac injury after subarachnoid haemorrhage: two case reports
It is well known that cardiopulmonary complications are often associated to subarachnoid haemorrhage. For appropriate therapeutic managing it is very important to distinguish acute coronary syndrome from neurogenic myocardial injury, which is a reversible condition. Furthermore, because the hearts of brain dead patients may be utilized for therapeutic purpose, it has became of importance to rule out erroneous diagnosis of cardiac ischemia in order to avoid rejection of hearts potential suitable for transplantation
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