PERSUASIVE MESSAGES: THE EFFECT OF PROFILING

In the present study, we investigate to which degree persuasion profiling can increase the effectiveness of adaptive persuasive systems. For this purpose, an experiment was conducted in which subjects were exposed to persuasive SMS messages under three experimental conditions. One group received messages that fit to their personality traits, a second group obtained messages that do not fit, and a third group was exposed to a random selection of messages. Comparing the degree to which the three experimental groups responded to the messages, we could show that well-fitting messages and randomly selected messages perform significantly better than non-fitting messages, whereas the difference between well-fitting and randomly selected messages was not significant

A CMOS TDI image sensor for Earth observation

Time Delay and Integration (TDI) is used to increase the Signal to Noise Ratio (SNR) in image sensors when imaging fast moving objects. One important TDI application is in Earth observation from space. In order to operate in the space radiation environment, the effect that radiation damage has on the performance of the image sensors must be understood. This work looks at prototype TDI sensor pixel designs, produced by e2v technologies. The sensor is a CCD-like charge transfer device, allowing in-pixel charge summation, produced on a CMOS process. The use of a CMOS process allows potential advantages such as lower power consumption, smaller pixels, higher line rate and extra on-chip functionality which can simplify system design. CMOS also allows a dedicated output amplifier per column allowing fewer charge transfers and helping to facilitate higher line rates than CCDs. In this work the effect on the pixels of radiation damage from high energy protons, at doses relevant to a low Earth orbit mission, is presented. This includes the resulting changes in Charge Transfer inefficiency (CTI) and dark signal

Auf lange Dauer gute Erträge in Bio

Die Erträge im Biolandbau sind auch für die wichtigen Kulturen Mais und Soja gut, das zeigt der DOK-Langzeitversuch

Bons rendements bio sur la durée

L’essai DOC montre que les rendements de l’agriculture bio sont aussi bons dans des cultures comme le maïs et le soja

A dot that went for a walk: People prefer lines drawn with human-like kinematics

A dominant theory of embodied aesthetic experience (Freedberg & Gallese, 2007) posits that the appreciation of visual art is linked to the artist’s movements when creating the artwork, yet a direct link between the kinematics of drawing actions and the aesthetics of drawing outcomes has not been experimentally demonstrated. Across four experiments we measured aesthetic responses of students from arts and non-arts backgrounds to drawing movements generated from computational models of human writing. Experiment 1 demonstrated that human-like drawing movements with bell-shaped velocity profiles (Sigma Lognormal (SL) and Minimum Jerk (MJ)) are perceived as more natural and pleasant than movements with a uniform profile, and in both Experiments 1 and 2 movements that were perceived as more natural were also preferred. Experiment 3 showed that this effect persists if lower-level dynamic stimulus features are fully matched across experimental and control conditions. Furthermore, aesthetic preference for human-like movements were associated with greater perceptual fluency in Experiment 3, evidenced by unbiased estimations of the duration of natural movements. In Experiment 4, line drawings with visual features consistent with the dynamics of natural, human-like movements were preferred, but only by art students. Our findings directly link the aesthetics of human action to the visual aesthetics of drawings, but highlight the importance of incorporating artistic expertise into embodied accounts of aesthetic experience

Full-Scale Application of in-situ Automated Fiber Placement for the Production of a Fuselage Skin Segment

The CleanSky II multi-functional fuselage demonstrator is the world’s largest known aviation structure made of thermoplastic composites. The Center for Lightweight Production Technology (ZLP) in Augsburg together with Premium Aerotec, supported by Aernnova and Airbus was responsible for the delivery of the 8 m long upper half shell. The first step in the upper shell production is the skin placement which is done by means of in-situ automated fiber placement (in-situ T-AFP). The process is a lean, single-stage additive manufacturing process for thermoplastic CFRPs. In order to ensure a sufficient quality in the laminate the ZLP has worked intensively on dedicated design principles for the process, material quality requirements and an optimization of process parameters. Major advancements on the way towards a full-scale fuselage have been displayed in the past by the manufacturing of a scaled demonstrator. This paper presents the evolution to the recently manufactured full-scale component with a total length of 8 m, a diameter of 4 m and a composite part design that includes reinforcements for the door cut-outs and two different welding interfaces. The latter will be leveraged for the joining of two half-shells by means of thermoplastic welding. In this work the methodology for a scale up to an actual airplane geometry and the associated challenges are emphasized. Critical aspects of the scale up and potential mitigation of future issues for in-situ process are discussed with regards to design, process and manufacturing. Finally, a way towards industrial, full-scale productions by means of in-situ AFP is proposed

Implementation of a mass canine rabies vaccination campaign in both rural and urban regions in southern Malawi

Rabies is a devastating zoonotic disease causing nearly 60,000 deaths globally each year. The disease causes Malawi an economic loss of 13 million USD and kills almost 500 people annually. Domestic dogs are the main reservoir for rabies and vaccinating over 70% of the dog population is the most efficient method to reduce its incidence in both humans and canines. However, achieving such coverages is often difficult and depend on many geospatial factors. Rural and pastoral regions are considered difficult to vaccinate efficiently due to low dog densities, and reports of campaigns spanning large areas containing vastly different communities are lacking. This study describes a mass canine vaccination campaign covering rural and urban regions in southern Malawi. The campaign achieved an average vaccination coverage of 83.4% across 3 districts, and vaccinated over 89,000 dogs through a combined static point and door-to-door effort. A dog population of 107,574 dogs was estimated (dog:human ratio of 1:23). The canine population was found to be almost completely owned (99.2%) and mostly kept for security purposes (82.7%). The dogs were mainly adults, males, and not neutered. Regression analysis identified education level and proportion of young dogs as the only factors influencing (positively and negatively, respectively) whether vaccination coverage over 70% was achieved in a region, independently of variables such as population density or poverty. A second regression analysis was performed predicting absolute vaccination coverage. While education level and the proportion of confined dogs were associated with positive vaccination coverage, higher proportions of young animals and female dogs were associated with a decrease in coverage. This study confirms the feasibility of homogeneously vaccinating over 70% of the dogs in a large area including rural and urban communities. These findings can inform the logistics of future campaigns and might be used as a template to facilitate high-number, high-coverage vaccination campaigns to other regions in sub-Saharan Africa

Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data

Molecular chaperones are essential elements of the protein quality control machinery that governs translocation and folding of nascent polypeptides, refolding and degradation of misfolded proteins, and activation of a wide range of client proteins. The prokaryotic heat-shock protein DnaK is the E. coli representative of the ubiquitous Hsp70 family, which specializes in the binding of exposed hydrophobic regions in unfolded polypeptides. Accurate prediction of DnaK binding sites in E. coli proteins is an essential prerequisite to understand the precise function of this chaperone and the properties of its substrate proteins. In order to map DnaK binding sites in protein sequences, we have developed an algorithm that combines sequence information from peptide binding experiments and structural parameters from homology modelling. We show that this combination significantly outperforms either single approach. The final predictor had a Matthews correlation coefficient (MCC) of 0.819 when assessed over the 144 tested peptide sequences to detect true positives and true negatives. To test the robustness of the learning set, we have conducted a simulated cross-validation, where we omit sequences from the learning sets and calculate the rate of repredicting them. This resulted in a surprisingly good MCC of 0.703. The algorithm was also able to perform equally well on a blind test set of binders and non-binders, of which there was no prior knowledge in the learning sets. The algorithm is freely available at http://limbo.vib.be

ROBUST ASSEMBLY - QUALITY ASSURED WELDING TECHNOLOGIES FOR FULL-SCALE APPLICATIONS

Thermoplastic welding technologies offer the possibility of producing an integral assembly out of two or more separate components, with an interface that is non-distinguishable to the component structure itself. However, institutional research on thermoplastic welding technologies is mostly focusing the technology readiness levels (TRL) one to three, demonstrating the validity of the functional principle in a reduced scale. Within the European Clean Sky 2 (CS 2) initiative, the Multifunctional Fuselage Demonstrator (MFFD) an eight-meter long, cylindrical aircraft fuselage barrel will be manufactured challenging different thermoplastic part manufacturing and welding technologies in full scale. Within this paper we are focusing to present the custom-made welding jigs and end-effectors for ultrasonic and resistance welding, developed for the MFFD upper shell assembly. To assure adequate integrated quality assurance the weld tools are equipped with various sensors for component positioning and process control. The accumulated data are validated and inline stored within a storage for heterogenous product and research data (shepard) to assure the robust process execution and safeguard traceability

Human Splicing Finder: an online bioinformatics tool to predict splicing signals

Thousands of mutations are identified yearly. Although many directly affect protein expression, an increasing proportion of mutations is now believed to influence mRNA splicing. They mostly affect existing splice sites, but synonymous, non-synonymous or nonsense mutations can also create or disrupt splice sites or auxiliary cis-splicing sequences. To facilitate the analysis of the different mutations, we designed Human Splicing Finder (HSF), a tool to predict the effects of mutations on splicing signals or to identify splicing motifs in any human sequence. It contains all available matrices for auxiliary sequence prediction as well as new ones for binding sites of the 9G8 and Tra2-β Serine-Arginine proteins and the hnRNP A1 ribonucleoprotein. We also developed new Position Weight Matrices to assess the strength of 5′ and 3′ splice sites and branch points. We evaluated HSF efficiency using a set of 83 intronic and 35 exonic mutations known to result in splicing defects. We showed that the mutation effect was correctly predicted in almost all cases. HSF could thus represent a valuable resource for research, diagnostic and therapeutic (e.g. therapeutic exon skipping) purposes as well as for global studies, such as the GEN2PHEN European Project or the Human Variome Project