Running an open MOOC on learning in laboratories

CONTEXT Teaching in laboratories plays an integral role in education. This includes both proximal as well as remote laboratories. In many instances, learning activities are designed around equipment and traditional laboratory activities. Pedagogical aspects and instructional design are often not considered or are an afterthought. PURPOSE The aim of this project was to help to address this gap by designing, implementing and facilitating an open online course on the pedagogy of using laboratory experiences in the curriculum. APPROACH The MOOC for Enhancing Laboratory Learning Outcomes (MELLO) has been designed to assist educators at all levels, from schools to universities, to improve the quality of laboratory experiences in STEM (Science, Technology, Engineering, and Mathematics) education. Experienced educators seeking to review and revise current practices or beginning educators were all welcome to participate. Based on learning theory and research literature, online course has been developed that covers constructive alignment of practical activities with the wider curriculum, learning objectives, pedagogical approaches to laboratory learning, laboratory modalities and session planning. RESULTS 120 participants from Australia and around the world took part in the course. While the participants did not work on their own laboratory activity throughout the courses (as envisaged when designing the course), participants who actively took part in the course were positive about the value of the course. CONCLUSIONS The MOOC has been capable of supporting a large number of participants including university educators around the world who use laboratory experiences and will continue to do so through future iterations of the course. Moving forward, there is scope to adapt the pedagogical approach of the course to cater for the way the participants have engaged with the material

Current Solutions

Current is the first comprehensive safety solution that can, with the push of a button, dispatch police to a user’s GPS location, notify friends and family, alert the nearby community, and record audio and video. Current is a phone case and mobile app that integrates hardware and software, offering user safety, ease of access, and peace of mind. No other self-defense product integrates all four layers of safety and these products are rarely in a user\u27s hands when needed. Current’s mobile device case is equipped with external buttons that can quickly and easily activate in-app functionality, which Current has worked closely with its patent attorney, Tom Lebens, in order to develop and finalize. In addition, the Current case has an external safety switch which prevents accidental releases, and the case’s built-in battery supplies a user’s phone extra battery life. The fact is, everyone has smartphones. And everyone belongs to some kind of social network. Today, people still protect themselves with mace or a whistle; you do all these things by yourself. But now, we all carry these computers in our pocket, and we’re all connected to people. We have GPS, we have maps, we have notifications. It’s time for a new kind of safety—personal safety that leverages the connectedness of today\u27s world

Barriers and facilitators to the implementation of the advanced nurse practitioner role in primary care settings: a scoping review

Background: Workload and workforce issues in primary care are key drivers for the growing international trend to expand nursing roles. Advanced nurse practitioners are increasingly being appointed to take on activities and roles traditionally carried out by doctors. Successful implementation of any new role within multidisciplinary teams is complex and time-consuming, therefore it is important to understand the factors that may hinder or support implementation of the advanced nurse practitioner role in primary care settings. Objectives: To identify, appraise and synthesise the barriers and facilitators that impact implementation of advanced practitioner roles in primary care settings. Methods: A scoping review conducted using the Arksey and O’Malley (2005) framework and reported in accordance with PRISMA-ScR. Eight databases (Cochrane Library, Health Business Elite, Kings Fund Library, HMIC, Medline, CINAHL, SCOPUS and Web of Science) were searched to identify studies published in English between 2002 and 2017. Study selection and methodological assessment were conducted by two independent reviewers. A pre-piloted extraction form was used to extract the following data: study characteristics, context, participants and information describing the advanced nurse practitioner role. Deductive coding for barriers and facilitators was undertaken using a modified Yorkshire Contributory Framework. We used inductive coding for barriers or facilitators that could not be classified using pre-defined codes. Disagreements were addressed through discussion. Descriptive data was tabulated within evidence tables, and key findings for barriers and facilitators were brought together within a narrative synthesis based on the volume of evidence. Findings: Systematic searching identified 5976 potential records, 2852 abstracts were screened, and 122 full texts were retrieved. Fifty-four studies (reported across 76 publications) met the selection criteria. Half of the studies (n=27) were conducted in North America (n=27), and 25/54 employed a qualitative design. The advanced nurse practitioner role was diverse, working across the lifespan and with different patient groups. However, there was little agreement about the level of autonomy, or what constituted everyday activities. Team factors were the most frequently reported barrier and facilitator. Individual factors, lines of responsibility and ‘other’ factors (i.e. funding), were also frequently reported barriers. Facilitators included individual factors, supervision and leadership and ‘other’ factors (i.e. funding, planning for role integration). Conclusion: Building collaborative relationships with other healthcare professionals and negotiating the role are critical to the success of the implementation of the advanced nurse practitioner role. Team consensus about the role and how it integrates into the wider team is also essential

Care Café: a chronology and a protocol

Publisher PD

Molybdenum dioxide in carbon nanoreactors as a catalytic nanosponge for the efficient desulfurization of liquid fuels

The principle of a “catalytic nanosponge” that combines the catalysis of organosulfur oxidation and sequestration of the products from reaction mixtures is demonstrated. Group VI metal oxide nanoparticles (CrOx, MoOx, WOx) are embedded within hollow graphitized carbon nanofibers (GNFs), which act as nanoscale reaction vessels for oxidation reactions used in the decontamination of fuel. When immersed in a model liquid alkane fuel contaminated with organosulfur compounds (benzothiophene, dibenzothiophene, dimethyldibenzothiophene), it is found that MoO2@GNF nanoreactors, comprising 30 nm molybdenum dioxide nanoparticles grown within the channel of GNFs, show superior abilities toward oxidative desulfurization (ODS), affording over 98% sulfur removal at only 5.9 mol% catalyst loading. The role of the carbon nanoreactor in MoO2@GNF is to enhance the activity and stability of catalytic centers over at least 5 cycles. Surprisingly, the nanotube cavity can selectively absorb and remove the ODS products (sulfoxides and sulfones) from several model fuel systems. This effect is related to an adsorptive desulfurization (ADS) mechanism, which in combination with ODS within the same material, yields a “catalytic nanosponge” MoO2@GNF. This innovative ODS and ADS synergistic functionality negates the need for a solvent extraction step in fuel desulfurization and produces ultralow sulfur fuel

Recovery of consciousness and cognition after general anesthesia in humans

Understanding how the brain recovers from unconsciousness can inform neurobiological theories of consciousness and guide clinical investigation. To address this question, we conducted a multicenter study of 60 healthy humans, half of whom received general anesthesia for 3 hr and half of whom served as awake controls. We administered a battery of neurocognitive tests and recorded electroencephalography to assess cortical dynamics. We hypothesized that recovery of consciousness and cognition is an extended process, with differential recovery of cognitive functions that would commence with return of responsiveness and end with return of executive function, mediated by prefrontal cortex. We found that, just prior to the recovery of consciousness, frontal-parietal dynamics returned to baseline. Consistent with our hypothesis, cognitive reconstitution after anesthesia evolved over time. Contrary to our hypothesis, executive function returned first. Early engagement of prefrontal cortex in recovery of consciousness and cognition is consistent with global neuronal workspace theory

In vitro Natural Killer Cell Immunotherapy for Medulloblastoma

How the immune system attacks medulloblastoma (MB) tumors effectively is unclear, although natural killer (NK) cells play an important role in immune defense against tumor cells. Interactions between receptors on NK cells and ligands expressed by tumor cells are critical for tumor control by immunotherapy. In this study, we analyzed tumor samples from 54 MB patients for expression of major histocompatibility complex class I-related chains A (MICA) and UL16 binding protein (ULPB-2), which are ligands for the NK group 2 member D activatory receptor (NKG2D). The percentage of MICA and ULBP-2 positive cells was higher than 25% in 68% and 6% of MB patients, respectively. A moderate-high intensity of MICA cytoplasmic staining was observed in 46% MB patients and weak ULBP-2 staining was observed in 8% MB patients. No correlation between MICA/ULBP-2 expression and patient outcome was found. We observed that HTB-186, a MB cell line, was moderately resistant to NK cell cytotoxicity in vitro. Blocking MICA/ULBP-2 on HTB-186, and NKG2D receptor on NK cells increased resistance to NK cell lysis in vitro. However, HLA class I blocking on HTB-186 and overnight incubation with IL-15 stimulated NK cells efficiently killed tumor cells in vitro. We conclude that although NKG2D/MICA-ULBP-2 interactions have a role in NK cell cytotoxicity against MB, high expression of HLA class I can protect MB from NK cell cytotoxicity. Even so, our in vitro data indicate that if NK cells are appropriately stimulated, they may have the potential to target MB in vivo

A Design and Feasibility Study for the Detector Assembly of the Experiment for X-ray Characterization and Timing (EXACT ) CubeSat Project

The Experiment for X-ray Characterization and Timing (EXACT) is intended to be a proof of concept for the use of inexpensive small satellite technology to fill the need for long term solar Hard X-Ray monitoring with co-observation as a high energy counterpart to existing solar X-ray monitoring satellites (e.g. GOES), as well as provide precise timing measurements of solar HXR's. EXACT is a three-axis-stabilized, 3U CubeSat that makes use of an existing University of Minnesota Aerospace Department designed Gamma Ray Burst sensor that is intended for studies in deep space navigation using Gamma-ray burst timing for relative ranging of spacecraft. The high timing resolution of the GRB sensor, as well as the heritage of the pulse-read-out circuitry, makes it a good candidate for use on EXACT if it can be shown to suit the energy range and resolution requirements in the HXR regime. The GRB detector design incorporates square scintillators of Thallium-doped Cesium Iodide (CsI(Tl)), each connected to one Avalanche Photodiode (APD) for read-out to a pulse processing board. This paper will detail the design of the current GRB detector, report the results of the laboratory evaluation of that design, and make recommendations for modifications to the current design in order to fulfill the instrumentation requirements of EXACT