Why Is Ethnocentrism More Common Than Humanitarianism?

A compelling agent-based computer simulation suggests that ethnocentrism, often thought to rely on complex social cognition and learning, may have arisen through biological evolution (Hammond & Axelrod, 2006). From a neutral start, ethnocentric strategies evolve to dominate other possible strategies (selfish, traitorous, and humanitarian) that differentiate patterns of cooperation with in-group and outgroup agents. We present new analyses and simulations to clarify and explain this outcome by formulating and testing two hypotheses for explaining how ethnocentrism eventually dominates its closest competitor, humanitarianism. Results indicate support for the direct hypothesis that ethnocentrics exploit humanitarian cooperation along the frontiers between ethnocentric and humanitarian groups as world population saturates. We find very little support for the contrasting freerider-suppression hypothesis that ethnocentrics are better than humanitarians at suppressing non-cooperating free riders, although both hypotheses correctly predict a close temporal relation between population saturation and ethnocentric dominance

Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation

We previously found that scavenger receptor cysteine-rich gp-340 (glycoprotein-340), isolated from lung or saliva, directly inhibits human IAVs (influenza A viruses). We now show that salivary gp-340 has broad antiviral activity against human, equine and porcine IAV strains. Although lung and salivary gp-340 are identical in protein sequence, salivary gp-340 from one donor had significantly greater antiviral activity against avian-like IAV strains which preferentially bind sialic acids in α(2,3) linkage. A greater density of α(2,3)-linked sialic acids was present on the salivary gp-340 from this donor as compared with salivary gp-340 from another donor or several preparations of lung gp-340. Hence, the specificity of sialic acid linkages on gp-340 is an important determinant of anti-IAV activity. Gp-340 binds to SP-D (surfactant protein D), and we previously showed that lung gp-340 has co-operative interactions with SP-D in viral neutralization and aggregation assays. We now report that salivary gp-340 can, in some cases, strongly antagonize certain antiviral activities of SP-D. This effect was associated with greater binding of salivary gp-340 to the carbohydrate recognition domain of SP-D as compared with the binding of lung gp-340. These findings may relate to inter-individual variations in innate defence against highly pathogenic IAV and to effects of aspiration of oral contents on SP-D-mediated lung functions