Mobile Tower Exposure affects on memory and Motor Co-ordination on Mice

Mobile is now become as an integral part of our daily life and mobile users have been increasing day by day globally. In India, mobile base stations and their installation are irregular and unregulated. Result from STM (Short term memory) and LTM (Long term memory) test, sowed significant change in Mobile Tower Radiation Treated Mice (MTRTM) as compared with without MTR treated mice. The numbers of mistakes done by MTR-TM group of mice were higher than the control. After measuring the muscular strength by using rotating hanging wire test, the result revealed that calculated time of fall from wire and compare this time with control and radiated set of mouse. Three trials were done with same set of mouse at one week intervals. In all the three trials, the average difference between control and radiated mice for muscular strength was significant (p < 0.05). Path movement was more random in MTR-TM and also observed less activity than without treated control mice

Mobile Tower Exposure affects on memory and Motor Co-ordination on Mice

Mobile is now become as an integral part of our daily life and mobile users have been increasing day by day globally. In India, mobile base stations and their installation are irregular and unregulated. Result from STM (Short term memory) and LTM (Long term memory) test, sowed significant change in Mobile Tower Radiation Treated Mice (MTRTM) as compared with without MTR treated mice. The numbers of mistakes done by MTR-TM group of mice were higher than the control. After measuring the muscular strength by using rotating hanging wire test, the result revealed that calculated time of fall from wire and compare this time with control and radiated set of mouse. Three trials were done with same set of mouse at one week intervals. In all the three trials, the average difference between control and radiated mice for muscular strength was significant (p < 0.05). Path movement was more random in MTR-TM and also observed less activity than without treated control mice

A study of incidence and pattern of coronary artery anomalies in Western Rajasthan, India

Background: Coronary artery anomalies (CAAs) are a diverse group of congenital disorders whose manifestations and pathophysiological mechanisms are highly variable. Among patients undergoing coronary angiography, the incidence depends on the population studied and the criteria used to define an anomaly. This is the first ever study conducted in western Rajasthan to detect the incidence and pattern of coronary anomalies.Methods: We retrospectively studied 8500 coronary angiographies (CAG) done in the institution over a period of 12 years from 2004 to 2015 for detection of incidence and pattern of coronary anomalies. Patients with ischemic heart disease and valvular heart disease who underwent CAG were included in the study.Results: Out of the 8500 angiograms screened a total of 108 coronary anomalies were detected (incidence of 1.27%). Anomalies of origin and course was the most common anomaly (106 out of 108 patients) followed by anomalies of  coronary termination (fistulas) which was seen in just two patients. Most common anomaly was absent left main artery with separate origin of the left anterior descending (LAD) artery and left circumflex artery (LCx) (n=36, 33.3%), followed closely by anomalous origin of right coronary artery (RCA) from left sinus (n=34, 31.48%). Anomalous origin of LCx from right sinus/ RCA was the third most common anomaly (n=22, 20.37%). Other rare anomalies include anomalous origin of left coronary artery from right coronary sinus (n=6, 5.55%), RCA from posterior sinus (n=4, 3.7%). Single coronary artery, LAD from RCA and coronary artery fistula were seen in two patients each (n=2, 1.85%).Conclusions: In present study though the total incidence of coronary anomalies was similar to that in other studies, the pattern of coronary anomalies was slightly different from that reported from different parts of the world.

Medullary thyroid carcinoma spindle cell variant: a rare case report

Medullary thyroid carcinoma (MTC) accounts for only 4% of thyroid tumors and originates from parafollicular cells secreting calcitonin. However, it accounts for 13% of all thyroid cancer related death. We herein report a case of 50 years male who presented with a right neck swelling measuring 3×2×2 cm for 2 years, which was gradually increasing. Ultrasonography of the neck revealed a hypoechoic nodule in the right lobe of thyroid. There was no relevant family history. Patient was clinically euthyroid. Fine needle aspiration smears showed many dispersed spindle shaped cells and loosely cohesive clusters of cells. Nuclei of these cells are spindle shaped and showing moderate anisokaryosis. Clumps of hyaline material also seen. A provisional diagnosis of MTC spindle cell variant had been made, which was confirmed by histopathology. Early diagnosis of MTC is very important. Because if patient do not have metastatic disease usually cured by total thyroidectomy.

Coronary angiographic profile characteristics in young patients with acute coronary syndrome and comparison with older patients with acute coronary syndrome

Background: CAD is a major cause of death worldwide. Indians are prone as a community to CAD at much younger age. This study examined the coronary angiographic profile characteristic in young (60 year).Methods: 192 patients with ACS aged less than 40 year and 200 patients with ACS aged more than 60 year were included in this study. Coronary angiographic profile characteristics were evaluated in young ACS patients and compared with that in older patients.Results: Young ACS patients often had angiographically normal coronary arteries, nonobstructive disease and single vessel disease than older patients (p value<0.05).Conclusions: Angiographically normal coronary arteries, nonobstructive disease, single vessel disease are more frequent in younger patients

Pattern of neoplastic and non-neoplastic lesions of ovary: a five-year study in a tertiary care centre of rural india

Background: Most common ovarian lesions include benign non-neoplastic lesions including functional cysts and neoplastic lesions. While among cancers of female genital tract, the incidence of ovarian cancer ranks below only carcinoma of cervix and endometrium. The aim of this study was to observe and evaluate the frequency and morphological pattern of different ovarian pathologies encountered in this tertiary care centre of rural India.Methods: This was a retrospective five years observational study (2012-16) and conducted at Department of Pathology of UPUMS, Saifai. The study material included 264 histopathology specimens received in our department.Results: Total 264 cases of ovarian pathologies were studied, in which 147 cases were non-neoplastic while remaining 117 cases were neoplastic. The most common non-neoplastic lesion was follicular cyst (51.7%), followed by corpus luteal cyst (30.61%), endometriosis (15.64%). Among 117 neoplastic cases, 87 cases (74.35%) were benign, 5 cases (4.27%) were borderline tumours and 25 cases (21.36%) were diagnosed malignant. Serous cystadenoma was most common benign tumour with 53 cases (45.29%) followed by 20 cases (17.09%) of dermoid cyst and 12 cases (10.25%) of mucinous cystadenoma. While in malignant tumours, serous adenocarcinoma were most common (4.27%) followed by mucinous adenocarcinoma (2.56%).Conclusions: In our study, non-neoplastic ovarian lesions were more commonly seen than neoplastic lesions. Surface epithelial tumours were most common histologic type in all age groups. While serous adenocarcinoma was most common ovarian malignancy seen. Both non-neoplastic as well as neoplastic lesions of ovary often present with similar clinical and radiological features. So histopathological study is essential to diagnose ovarian tumours.

Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development

The hyperphosphorylation of tau protein and the overexpression of mTOR are considered to be the driving force behind Aβ plaques and Neurofibrillay Tangles (NFT's), hallmarks of Alzheimer's disease (AD). It is now evident that miscellaneous diseases such as Diabetes, Autoimmune diseases, Cancer, etc. are correlated with AD. Therefore, we reviewed the literature on the causes of AD and investigated the association of tau and mTOR with other diseases. We have discussed the role of insulin deficiency in diabetes, activated microglial cells, and dysfunction of blood-brain barrier (BBB) in Autoimmune diseases, Presenilin 1 in skin cancer, increased reactive species in mitochondrial dysfunction and deregulated Cyclins/CDKs in promoting AD pathogenesis. We have also discussed the possible therapeutics for AD such as GSK3 inactivation therapy, Rechaperoning therapy, Immunotherapy, Hormonal therapy, Metal chelators, Cell cycle therapy, γ-secretase modulators, and Cholinesterase and BACE 1-inhibitors which are thought to serve a major role in combating pathological changes coupled with AD. Recent research about the relationship between mTOR and aging and hepatic Aβ degradation offers possible targets to effectively target AD. Future prospects of AD aims at developing novel drugs and modulators that can potentially improve cell to cell signaling, prevent Aβ plaques formation, promote better release of neurotransmitters and prevent hyperphosphorylation of tau

Measurement of the Higgs boson production rate in association with top quarks in final states with electrons, muons, and hadronically decaying tau leptons at s√=13TeV

The rate for Higgs (H) bosons production in association with either one (tH) or two (tt¯H) top quarks is measured in final states containing multiple electrons, muons, or tau leptons decaying to hadrons and a neutrino, using proton–proton collisions recorded at a center-of-mass energy of 13TeV by the CMS experiment. The analyzed data correspond to an integrated luminosity of 137fb−1. The analysis is aimed at events that contain H→WW, H→ττ, or H→ZZ decays and each of the top quark(s) decays either to lepton+jets or all-jet channels. Sensitivity to signal is maximized by including ten signatures in the analysis, depending on the lepton multiplicity. The separation among tH, tt¯H, and the backgrounds is enhanced through machine-learning techniques and matrix-element methods. The measured production rates for the tt¯H and tH signals correspond to 0.92±0.19(stat)+0.17−0.13(syst) and 5.7±2.7(stat)±3.0(syst) of their respective standard model (SM) expectations. The corresponding observed (expected) significance amounts to 4.7 (5.2) standard deviations for tt¯H, and to 1.4 (0.3) for tH production. Assuming that the Higgs boson coupling to the tau lepton is equal in strength to its expectation in the SM, the coupling yt of the Higgs boson to the top quark divided by its SM expectation, κt=yt/ySMt, is constrained to be within −0.9<κt<−0.7 or 0.7<κt<1.1, at 95% confidence level. This result is the most sensitive measurement of the tt¯H production rate to date.SCOAP