Tidal instability in a rotating and differentially heated ellipsoidal shell

The stability of a rotating flow in a triaxial ellipsoidal shell with an imposed temperature difference between inner and outer boundaries is studied numerically. We demonstrate that (i) a stable temperature field encourages the tidal instability, (ii) the tidal instability can grow on a convective flow, which confirms its relevance to geo- and astrophysical contexts and (iii) its growth rate decreases when the intensity of convection increases. Simple scaling laws characterizing the evolution of the heat flux based on a competition between viscous and thermal boundary layers are derived analytically and verified numerically. Our results confirm that thermal and tidal effects have to be simultaneously taken into account when studying geophysical and astrophysical flows

A systematic numerical study of the tidal instability in a rotating triaxial ellipsoid

The full non-linear evolution of the tidal instability is studied numerically in an ellipsoidal fluid domain relevant for planetary cores applications. Our numerical model, based on a finite element method, is first validated by reproducing some known analytical results. This model is then used to address open questions that were up to now inaccessible using theoretical and experimental approaches. Growth rates and mode selection of the instability are systematically studied as a function of the aspect ratio of the ellipsoid and as a function of the inclination of the rotation axis compared to the deformation plane. We also quantify the saturation amplitude of the flow driven by the instability and calculate the viscous dissipation that it causes. This tidal dissipation can be of major importance for some geophysical situations and we thus derive general scaling laws which are applied to typical planetary cores

ABO phenotypes and malaria related outcomes in mothers and babies in The Gambia: a role for histo-blood groups in placental malaria?

BACKGROUND: Host susceptibility to P.falciparum is critical for understanding malaria in pregnancy, its consequences for the mother and baby, and for improving malaria control in pregnant women. Yet host genetic factors which could influence placental malaria risk are little studied and there are no reports of the role of blood group polymorphisms on pregnancy outcomes in malaria endemic areas. This study analyses the association between ABO blood group phenotypes in relation to placental malaria pathology. METHODS: A total of 198 mother/child pairs delivering in Banjul and the Kombo-St Mary District (The Gambia) were analysed. ABO blood group was measured by agglutination. Placental malaria parasites wee enumerated and the presence of malaria pigment noted. Birth anthropometry was recorded and placental weight. Maternal and infant haemoglobin was measured. RESULTS: 89 (45%) subjects were primiparae and 110 (55%)multiparae. The ABO phenotype distribution was 38(A), 52(B), 6(AB) and 102(O). Placental histo-pathology showed active placental malaria in 74 (37%), past infection in 42 (21%) and no infection in 82 cases (41%). In primiparae blood group O was associated with a higher risk of active infection (OR = 2.99; 95% CI = 1.24–7.25), and a lower risk of past infection (OR = 0.31, 0.10–1.01, p < 0.05). In multiparae the O phenotype was associated with reduced prevalence of active or past placental infection (OR = 0.45; 95% CI 0.21–0.98). The mean feto-placental weight ratio was significantly higher in multiparae with group O women compared to non-O phenotypes (5.74 vs 5.36; p = 0.04). Among primiparae with active placental infection, mean birth weight was higher in children of mothers with the O phenotype (p = 0.04). CONCLUSION: These results indicate that blood group O was significantly associated with increased placental malaria infection in primiparae and reduced risk of infection in multiparae. This parity related susceptibility was not present with other ABO phenotypes. Cell surface glycans, such as ABO and related antigens have special relevance in reproductive biology and could modulate specific cell interactions as those associated with the pathogenesis of placental malaria

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases

Direct numerical simulations of bifurcations in an air-filled rotating baroclinic annulus

Three-dimensional direct numerical simulations (DNS) of the nonlinear dynamics and a route to chaos in a rotating fluid subjected to lateral heating are presented here and discussed in the context of laboratory experiments in the baroclinic annulus. Following two previous preliminary studies, the fluid used is air rather than a liquid as used in all other previous work. This study investigates a bifurcation sequence from the axisymmetric flow to a number of complex flows. The transition sequence, on increase of the rotation rate, from the axisymmetric solution via a steady fully developed baroclinic wave to chaotic flow, followed a variant of the classical quasi-periodic bifurcation route, starting with a subcritical Hopf and associated saddle-node bifurcation. This was followed by a sequence of two supercritical Hopf-type bifurcations, first to an amplitude vacillation, then to a three-frequency quasi-periodic modulated amplitude vacillation (MAV), and finally to a chaotic (MAV). In the context of the baroclinic annulus this sequence is unusual as the vacillation is usually found on decrease of the rotation rate from the steady wave flow. Further transitions of a steady wave with a higher wavenumber pointed to the possibility that a barotropic instability of the sidewall boundary layers and the subsequent breakdown of these barotropic vortices may play a role in the transition to structural vacillation and, ultimately, geostrophic turbulence. © 2006 Cambridge University Press

Direct numerical simulations of bifurcations in an air-filled rotating baroclinic annulus

Three-dimensional direct numerical simulations (DNS) of the nonlinear dynamics and a route to chaos in a rotating fluid subjected to lateral heating are presented here and discussed in the context of laboratory experiments in the baroclinic annulus. Following two previous preliminary studies, the fluid used is air rather than a liquid as used in all other previous work. This study investigates a bifurcation sequence from the axisymmetric flow to a number of complex flows. The transition sequence, on increase of the rotation rate, from the axisymmetric solution via a steady fully developed baroclinic wave to chaotic flow, followed a variant of the classical quasi-periodic bifurcation route, starting with a subcritical Hopf and associated saddle-node bifurcation. This was followed by a sequence of two supercritical Hopf-type bifurcations, first to an amplitude vacillation, then to a three-frequency quasi-periodic modulated amplitude vacillation (MAV), and finally to a chaotic (MAV). In the context of the baroclinic annulus this sequence is unusual as the vacillation is usually found on decrease of the rotation rate from the steady wave flow. Further transitions of a steady wave with a higher wavenumber pointed to the possibility that a barotropic instability of the sidewall boundary layers and the subsequent breakdown of these barotropic vortices may play a role in the transition to structural vacillation and, ultimately, geostrophic turbulence. © 2006 Cambridge University Press