Synthesis of an Ortho-Triazacyclophane: N,N\u27,N\u27\u27-Trimethyltribenzo-1,4,7-triazacyclononatriene

N,N\u27,N\u27\u27-Trimethyltribenzo-1,4,7-triazacyclononatriene has been synthesized via sequential palladium-catalyzed Buchwald-Hartwig N-arylation reactions affording the 9-membered triaza o-cyclophane in 35% overall yield. An X-ray crystal structure shows the new cyclophane to have a C(2)-symmetric saddle conformation, as compared to the crown conformation exhibited by the related carbocyclic cyclotriveratrylene (CTV)

Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials

Background Small-volume resuscitation can rapidly correct hypovolemia. Hyperoncotic albumin solutions, long in clinical use, are suitable for small-volume resuscitation; however, their clinical benefits remain uncertain. Methods Randomized clinical trials comparing hyperoncotic albumin with a control regimen for volume expansion were sought by multiple methods, including computer searches of bibliographic databases, perusal of reference lists, and manual searching. Major findings were qualitatively summarized. In addition, a quantitative meta-analysis was performed on available survival data. Results In all, 25 randomized clinical trials with a total of 1,485 patients were included. In surgery, hyperoncotic albumin preserved renal function and reduced intestinal edema compared with control fluids. In trauma and sepsis, cardiac index and oxygenation were higher after administration of hydroxyethyl starch than hyperoncotic albumin. Improved treatment response and renal function, shorter hospital stay and lower costs of care were reported in patients with liver disease receiving hyperoncotic albumin. Edema and morbidity were decreased in high-risk neonates after hyperoncotic albumin administration. Disability was reduced by therapy with hyperoncotic albumin in brain injury. There was no evidence of deleterious effects attributable to hyperoncotic albumin. Survival was unaffected by hyperoncotic albumin (pooled relative risk, 0.95; 95% confidence interval 0.78 to 1.17). Conclusion In some clinical indications, randomized trial evidence has suggested certain benefits of hyperoncotic albumin such as reductions in morbidity, renal impairment and edema. However, further clinical trials are needed, particularly in surgery, trauma and sepsis

Spin polarons in triangular antiferromagnets

The motion of a single hole in a 2D triangular antiferromagnet is investigated using the t-J model. The one-hole states are described by strings of spin deviations around the hole. Using projection technique the one-hole spectral function is calculated. For large J/t we find low-lying quasiparticle-like bands which are well separated from an incoherent background by a gap of order J. However, for small J/t this gap vanishes and the spectrum becomes broad over an energy range of several t. The results are compared with SCBA calculations and numerical data.Comment: 4 pages, 6 figs, to be publish in PR

Pair production in laser fields oscillating in space and time

The production of electron-positron pairs from vacuum by counterpropagating laser beams of linear polarization is calculated. In contrast to the usual approximate approach, the spatial dependence and magnetic component of the laser field are taken into account. We show that the latter strongly affects the creation process at high laser frequency: the production probability is reduced, the kinematics is fundamentally modified, the resonant Rabi-oscillation pattern is distorted and the resonance positions are shifted, multiplied and split.Comment: 5 pages, 5 figure

Robot-Assisted Epiretinal Membrane Peeling: A Prospective Assessment of Pre- and Intra-Operative Times and of Surgeons' Subjective Perceptions.

PURPOSE The Preceyes Surgical System (PSS) is a robotic assistive device that may enhance surgical precision. This study assessed pre- and intra-operative times and surgeons' perceptions of robot-assisted epiretinal membrane peeling (RA-MP). METHODS We analyzed the time requirement of three main tasks: the preparation of the PSS (I), patient preparation (II), and surgery (III). Following surgery, the surgeons were asked questions about their experience. RESULTS RA-MP was performed in nine eyes of nine patients. Task I required an average time of 12.3 min, initially taking 15 min but decreasing to 6 min in the last surgery. Task II showed a mean time of 47.2 (range of 36-65) min. Task III had a mean time of 72.4 (range of 57-100) min. A mean time of 27.9 (range of 9-46) min was necessary for RA-MP. The responses to the questionnaire revealed a trend towards increasing ease and reduced stress as familiarity with the PSS increased. CONCLUSIONS A substantial reduction in pre- and intra-operative times, decreasing to a total of 115 min, was demonstrated. RA-MP was positively anticipated by the surgeons and led to no hand or arm strain while being more complex than manual MP

Hole motion in an arbitrary spin background: Beyond the minimal spin-polaron approximation

The motion of a single hole in an arbitrary magnetic background is investigated for the 2D t-J model. The wavefunction of the hole is described within a generalized string picture which leads to a modified concept of spin polarons. We calculate the one-hole spectral function using a large string basis for the limits of a Neel ordered and a completely disordered background. In addition we use a simple approximation to interpolate between these cases. For the antiferromagnetic background we reproduce the well-known quasiparticle band. In the disordered case the shape of the spectral function is found to be strongly momentum-dependent, the quasiparticle weight vanishes for all hole momenta. Finally, we discuss the relevance of results for the lowest energy eigenvalue and its dispersion obtained from calculations using a polaron of minimal size as found in the literature.Comment: 13 pages, 8 figures, to appear in Phys. Rev.

Cumulant approach to weakly doped antiferromagnets

We present a new approach to static and dynamical properties of holes and spins in weakly doped antiferromagnets in two dimensions. The calculations are based on a recently introduced cumulant approach to ground--state properties of correlated electronic systems. The present method allows to evaluate hole and spin--wave dispersion relations by considering hole or spin excitations of the ground state. Usually, these dispersions are found from time--dependent correlation functions. To demonstrate the ability of the approach we first derive the dispersion relation for the lowest single hole excitation at half--filling. However, the main purpose of this paper is to focus on the mutual influence of mobile holes and spin waves in the weakly doped system. It is shown that low-energy spin excitations strongly admix to the ground--state. The coupling of spin waves and holes leads to a strong suppression of the staggered magnetization which can not be explained by a simple rigid--band picture for the hole quasiparticles. Also the experimentally observed doping dependence of the spin--wave excitation energies can be understood within our formalism.Comment: REVTEX, 25 pages, 7 figures (EPS), to be published in Phys. Rev.

Immundefekte bei chronischer Rhinosinusitis : eine bedeutende und oft unterschätzte Ursache

Background Chronic rhinosinusitis (CRS) is one of the most frequent chronic diseases. Among these patients the prevalence of immune defects is higher than in the healthy general population. Methods A selective review of the literature was carried out in PubMed and Medline covering the period between 2008 and 2019. Additionally, recent German publications in journals not listed in the abovementioned databases were analyzed. Results The diagnostic workflow with respect to the immunodeficiency consists of a detailed anamnesis and physical examination, laboratory tests and the antibody reaction to polysaccharide vaccines and antigens. Beside antibiotic treatment, vaccinations and immunoglobulin replacement are available. Notwithstanding the above, functional endoscopic surgery of the paranasal sinuses should be performed according to guideline recommendations. Conclusion Patients with CRS who do not sufficiently respond to conservative and surgical treatment should be checked for underlying immunodeficiencies

Protein Kinase CK2 Regulates Nerve/Glial Antigen (NG)2-Mediated Angiogenic Activity of Human Pericytes

Protein kinase CK2 is a crucial regulator of endothelial cell proliferation, migration and sprouting during angiogenesis. However, it is still unknown whether this kinase additionally affects the angiogenic activity of other vessel-associated cells. In this study, we investigated the effect of CK2 inhibition on primary human pericytes. We found that CK2 inhibition reduces the expression of nerve/glial antigen (NG)2, a crucial factor which is involved in angiogenic processes. Reporter gene assays revealed a 114 bp transcriptional active region of the human NG2 promoter, whose activity was decreased after CK2 inhibition. Functional analyses demonstrated that the pharmacological inhibition of CK2 by CX-4945 suppresses pericyte proliferation, migration, spheroid sprouting and the stabilization of endothelial tubes. Moreover, aortic rings of NG2−/− mice showed a significantly reduced vascular sprouting when compared to rings of NG2+/+ mice, indicating that NG2 is an important regulator of the angiogenic activity of pericytes. In vivo, implanted Matrigel plugs containing CX-4945-treated pericytes exhibited a lower microvessel density when compared to controls. These findings demonstrate that CK2 regulates the angiogenic activity of pericytes through NG2 gene expression. Hence, the inhibition of CK2 represents a promising anti-angiogenic strategy, because it does not only target endothelial cells, but also vessel-associated pericytes