Severe local skin reaction after the application of ingenol mebutate gel treated by photodynamic therapy: A case report

Ingenol mebutate (IM) was recently introduced for the treatment of actinic keratosis (AK). It is considered a safe and effective treatment in spite of local reactions frequently reported. These reactions may consist of erythema, flaking, crusting, swelling, vesicles and erosions, and would usually spontaneously recede within 20–30 days. We reported a case of a patient affected by multiple actinic keratosis of the scalp treated with IM. The patient reported a severe reaction that was not solved in two months. We decided to treat the reaction with photodynamic therapy and aminolevulinic acid. This treatment was demonstrated to be effective in solving this severe side effect

Detecting the gravito-magnetic field of the dark halo of the Milky Way - the LaDaHaD mission concept

We propose to locate transponders and atomic clocks in at least three of the Lagrange points of the Sun-Earth pair, with the aim of exploiting the time of flight asymme- try between electromagnetic signals travelling in opposite directions along polygonal loops having the Lagrange points at their vertices. The asymmetry is due to the pres- ence of a gravito-magnetic field partly caused by the angular momentum of the Sun, partly originating from the angular momentum of the galactic dark halo in which the Milky Way is embedded. We list also various opportunities which could be associated with the main objective of this Lagrange Dark Halo Detector (LaDaHaD)

The IXPE Instrument Calibration Equipment

The Imaging X-ray Polarimetry Explorer is a mission dedicated to the measurement of X-ray polarization from tens of astrophysical sources belonging to different classes. Expected to be launched at the end of 2021, the payload comprises three mirrors and three focal plane imaging polarimeters, the latter being designed and built in Italy. While calibration is always an essential phase in the development of high-energy space missions, for IXPE it has been particularly extensive both to calibrate the response to polarization, which is peculiar to IXPE, and to achieve a statistical uncertainty below the expected sensitivity. In this paper we present the calibration equipment that was designed and built at INAF-IAPS in Rome, Italy, for the calibration of the polarization-sensitive focal plane detectors on-board IXPE. Equipment includes calibration sources, both polarized and unpolarized, stages to align and move the beam, test detectors and their mechanical assembly. While all these equipments were designed to fit the specific needs of the IXPE Instrument calibration, their versatility could also be used in the future for other projects

The Imaging X-ray Polarimetry Explorer (IXPE): Technical Overview

The Imaging X-ray Polarimetry Explorer (IXPE) will expand the information space for study of cosmic sources, by adding linear polarization to the properties (time, energy, and position) observed in x-ray astronomy. Selected in 2017 January as a NASA Astrophysics Small Explorer (SMEX) mission, IXPE will be launched into an equatorial orbit in 2021. The IXPE mission will provide scientifically meaningful measurements of the x-ray polarization of a few dozen sources in the 2-8 keV band, including polarization maps of several x-ray-bright extended sources and phase-resolved polarimetry of many bright pulsating x-ray sources

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe