Evidence for the Permo-Triassic transtensional rifting in the Iberian Range (NE Spain) according to magnetic fabrics results

Anisotropy of magnetic susceptibility (AMS) techniques are applied to Permo-Triassic red beds from the Castilian Branch (Iberian Range, NE Spain) that were deposited in an extensional basin inverted during Cenozoic times. The main goal of this work is to characterize the tectonic evolution of the basinal stage by differentiating synsedimentary to early diagenetic magnetic fabrics from the secondary tectonic fabrics related to compression, which are scarcely developed because no penetrative structures related to compression have been recognized. Oblate magnetic fabrics, with kmin axes perpendicular to bedding ,are observed in most cases. Magnetic lineations are variable, showing a dominant ENE-WSW maximum, which fits with a dextral transtensional regime acting on NW-SE master faults during the Triassic. We propose that variations in the orientation of the magnetic lineation are associated with transfer faults which fragment the basin and trigger strain partitioning in different areas. Magnetic fabrics are locally modified by Cenozoic compression, with intermediate and minimum axes distributed along girdles perpendicular to fold axes. Comparing all these results with macrostructures and mesostructural kinematic indicators, we conclude that the fine-grained hematite-bearing rocks carry a consistent magnetic fabric which can be used to reconstruct the basin history.This study was financed by the research project CGL2009-08969 of the MICINN (Spanish Ministry of Science and Innovation). C. García-Lasanta also acknowledges the MICINN for the research grant BES-2010-037509.Peer reviewe

A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2)

The rate and the extent of drug dissolution and its absorption depend on the characteristics of the active pharmaceutical ingredient (API) as well as the dosage form properties. In this work dissolution profiles of furosemide tablets of nine commercial products marketed in Argentine were evaluated. All Brands fulfill the specifications of dissolution test of USP. Comparison of dissolution profiles were carried out by model-dependent and model independent approaches. The Weibull model provided the best kinetic curve adjustment. Brands IV, VI and IX had the best fitting, with the maximum determination coefficient and the smallest AIC values. Results obtained via model-independent approach show that there was not significative difference in Dissolution efficiency between the reference product and Brands II, III and IV and in Mean dissolution time between the reference product and Brands II, III, IV and V. Using fit factors, only Brands I and III were similar. It has been demonstrated in vivo bioequivalence of furosemide market products interchangeability with generics should be avoided.Fil: Han, Yong Ki. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Simionato, Laura Daniela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Calvo, Romina Giselle. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Mattei, M. Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; ArgentinaFil: Segall, Adriana Ines. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentin

Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease