Wp index: A new substorm index derived from high-resolution geomagnetic field data at low latitude

Geomagnetic field data with high time resolution (typically 1 s) have recently become more commonly acquired by ground stations. Such high time resolution data enable identifying Pi2 pulsations which have periods of 40–150 s and irregular (damped) waveforms. It is well-known that pulsations of this type are clearly observed at mid- and low-latitude ground stations on the nightside at substorm onset. Therefore, with 1-s data from multiple stations distributed in longitude around the Earth's circumference, substorm onset can be regularly monitored. In the present study we propose a new substorm index, the Wp index (Wave and planetary), which reflects Pi2 wave power at low-latitude, using geomagnetic field data from 11 ground stations. We compare the Wp index with the AE and ASY indices as well as the electron flux and magnetic field data at geosynchronous altitudes for 11 March 2010. We find that significant enhancements of the Wp index mostly coincide with those of the other data. Thus the Wp index can be considered a good indicator of substorm onset. The Wp index, other geomagnetic indices, and geosynchronous satellite data are plotted in a stack for quick and easy search of substorm onset. The stack plots and digital data of the Wp index are available at the Web site (http://s-cubed.info) for public use. These products would be useful to investigate and understand space weather events, because substorms cause injection of intense fluxes of energetic electrons into the inner magnetosphere and potentially have deleterious impacts on satellites by inducing surface charging

Search for the Θ+\Theta^{+} pentaquark via the π−p→K−X\pi^-p\to K^-X reaction at 1.92 GeV/cc

The $\Theta^+$ pentaquark baryon was searched for via the $\pi^-p\to K^-X$ reaction in a missing-mass resolution of 1.4 MeV/$c^2$(FWHM) at J-PARC. $\pi^-$ meson beams were incident on the liquid hydrogen target with the beam momentum of 1.92 GeV/$c$. No peak structure corresponding to the $\Theta^+$ mass was observed. The upper limit of the production cross section averaged over the scattering angle of 2$^{\circ}$ to 15$^{\circ}$ in the laboratory frame was obtained to be 0.26 $\mu$b/sr in the mass region of 1.51$-$1.55 GeV/$c^2$.The upper limit of the $\Theta^+$ decay width using the effective Lagrangian approach was obtained to be 0.72 MeV/$c^2$ and 3.1 MeV/$c^2$ for $J^P_{\Theta}=1/2^+$ and $J^P_{\Theta}=1/2^-$, respectively.Comment: 5 pages, 3 figures, 1 tabl

Hubble Space Telescope/Advanced Camera for Surveys Morphology of Lyα Emitters at Redshift 5.7 in the COSMOS Field

We present detailed morphological properties of Lyα emitters (LAEs) at z ≈ 5.7 in the COSMOS field based on Hubble Space Telescope Advanced Camera for Surveys (ACS) data. The ACS imaging in the F814W filter covered 85 LAEs of the 119 LAEs identified in the full two square degree field, and 47 LAEs of them are detected in the ACS images. Nearly half of them are spatially extended with a size larger than 0.15 arcsec (~0.88 kpc at z = 5.7) and up to 0.4 arcsec (~2.5 kpc at z = 5.7). The others are nearly unresolved compact objects. Two LAEs show double-component structures indicating interaction or merging of building components to form more massive galaxies. By stacking the ACS images of all the detected sources, we obtain a Sersic parameter of n ~ 0.7 with a half-light radius of 0.13 arcsec (0.76 kpc), suggesting that the majority of ACS detected LAEs have not spheroidal-like but disk-like or irregular light profiles. Comparing ACS F814W magnitudes (I _(814)) with Subaru/Suprime-Cam magnitudes in the NB816, i', and z' bands, we find that the ACS imaging in the F814W band mainly probes UV continuum rather than Lyα line emission. UV continuum sizes tend to be larger for LAEs with larger Lyα emission regions as traced by the NB816 imaging. The nondetection of 38 LAEs in the ACS images is likely due to the fact that their surface brightness is too low both in the UV continuum and Lyα emission. Estimating I_(814) for the ACS-undetected LAEs from the z' and NB816 magnitudes, we find that 16 of these are probably LAEs with a size larger than 0.15 arcsec in UV continuum. All these results suggest that our LAE sample contains systematically larger LAEs in UV continuum size than those previously studied at z ~ 6

HTLV-1 propels thymic human T cell development in “human immune system” Rag2-/- IL-2R γc-/- Mice

Alteration of early haematopoietic development is thought to be responsible for the onset of immature leukemias and lymphomas. We have previously demonstrated that TaxHTLV-1 interferes with ß-selection, an important checkpoint of early thymopoiesis, indicating that human T-cell leukemia virus type 1 (HTLV-1) infection has the potential to perturb thymic human αβ T-cell development. To verify that inference and to clarify the impact of HTLV-1 infection on human T-cell development, we investigated the in vivo effects of HTLV-1 infection in a “Human Immune System” (HIS) Rag2-/-γc-/- mouse model. These mice were infected with HTLV-1, at a time when the three main subpopulations of human thymocytes have been detected. In all but two inoculated mice, the HTLV-1 provirus was found integrated in thymocytes; the proviral load increased with the length of the infection period. In the HTLV-1-infected mice we observed alterations in human T-cell development, the extent of which correlated with the proviral load. Thus, in the thymus of HTLV-1-infected HIS Rag2-/-γc-/- mice, mature single-positive (SP) CD4+ and CD8+ cells were most numerous, at the expense of immature and double-positive (DP) thymocytes. These SP cells also accumulated in the spleen. Human lymphocytes from thymus and spleen were activated, as shown by the expression of CD25: this activation was correlated with the presence of tax mRNA and with increased expression of NF-kB dependent genes such as bfl-1, an anti-apoptotic gene, in thymocytes. Finally, hepato-splenomegaly, lymphadenopathy and lymphoma/thymoma, in which Tax was detected, were observed in HTLV-1-infected mice, several months after HTLV-1 infection. These results demonstrate the potential of the HIS Rag2-/-γc-/- animal model to elucidate the initial steps of the leukemogenic process induced by HTLV-1

Compatibility between high energy particle confinement and magnetohydrodynamic stability in the inward-shifted plasmas of the Large Helical Device

The experimentally optimized magnetic field configuration of the Large Helical Device [A. Iiyoshi et al., Nucl. Fusion 39, 1245 (1999)], where the magnetic axis is shifted inward by 15 cm from the early theoretical prediction, reveals 50% better global energy confinement than the prediction of the scaling law. This configuration has been investigated further from the viewpoints of high energy particle confinement and magnetohydrodynamic (MHD) stability. The confinement of high energy ions is improved as expected. The minority heating of ion cyclotron range of frequency was successful and the heating efficiency was improved by the inward shift. The confinement of passing particles by neutral beam injection was also improved under low magnetic field strength, and there could be obtained an almost steady high beta discharge up to 3% in volume average. This was a surprising result because the observed pressure gradient exceeded the Mercier unstable limit. The observed MHD activities became as high as beta but they did not grow enough to deteriorate the confinement of high energy ions or the performance of the bulk plasma, which was still 50% better than the scaling. According to these favorable results, better performance would be expected by increasing the heating power because the neoclassical transport can also be improved there

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains Differentially Modulates Src Kinase Activity in Brain Maturation

Src family kinases (SFK) control multiple processes during brain development and function. We show here that the phosphoprotein associated with glycosphigolipid-enriched microdomains (PAG)/Csk binding protein (Cbp) modulates SFK activity in the brain. The timing and localization of PAG expression overlap with Fyn and Src, both of which we find associated to PAG. We demonstrate in newborn (P1) mice that PAG negatively regulates Src family kinases (SFK). P1 Pag1-/- mouse brains show decreased recruitment of Csk into lipid rafts, reduced phosphorylation of the inhibitory tyrosines within SFKs, and an increase in SFK activity of >/ = 50%. While in brain of P1 mice, PAG and Csk are highly and ubiquitously expressed, little Csk is found in adult brain suggesting altered modes of SFK regulation. In adult brain Pag1-deficiency has no effect upon Csk-distribution or inhibitory tyrosine phosphorylation, but kinase activity is now reduced (−20–30%), pointing to the development of a compensatory mechanism that may involve PSD93. The distribution of the Csk-homologous kinase CHK is not altered. Importantly, since the activities of Fyn and Src are decreased in adult Pag1-/- mice, thus presenting the reversed phenotype of P1, this provides the first in vivo evidence for a Csk-independent positive regulatory function for PAG in the brain

Improved plasma performance on Large Helical Device

Since the start of the Large Helical Device (LHD) experiment, various attempts have been made to achieve improved plasma performance in LHD [A. Iiyoshi et al., Nucl. Fusion 39, 1245 (1999)]. Recently, an inward-shifted configuration with a magnetic axis position R_ax of 3.6 m has been found to exhibit much better plasma performance than the standard configuration with R_ax of 3.75 m. A factor of 1.6 enhancement of energy confinement time was achieved over the International Stellarator Scaling 95. This configuration has been predicted to have unfavorable magnetohydrodynamic (MHD) properties, based on linear theory, even though it has significantly better particle-orbit properties, and hence lower neoclassical transport loss. However, no serious confinement degradation due to the MHD activities was observed, resolving favorably the potential conflict between stability and confinement at least up to the realized volume-averaged beta of 2.4%. An improved radial profile of electron temperature was also achieved in the configuration with magnetic islands, minimized by an external perturbation coil system for the Local Island Divertor (LID). The LID has been proposed for remarkable improvement of plasma confinement like the high (H) mode in tokamaks, and the LID function was suggested in limiter experiments

Formation of electron internal transport barrier and achievement of high ion temperature in Large Helical Device

An internal transport barrier (ITB) was observed in the electron temperature profile in the Large Helical Device [O. Motojima et al., Phys. Plasmas 6, 1843 (1999)] with a centrally focused intense electron cyclotron resonance microwave heating. Inside the ITB the core electron transport was improved, and a high electron temperature, exceeding 10 keV in a low density, was achieved in a collisionless regime. The formation of the electron-ITB is correlated with the neoclassical electron root with a strong radial electric field determined by the neoclassical ambipolar flux. The direction of the tangentially injected beam-driven current has an influence on the electron-ITB formation. For the counter-injected target plasma, a steeper temperature gradient, than that for the co-injected one, was observed. As for the ion temperature, high-power NBI (neutral beam injection) heating of 9 MW has realized a central ion temperature of 5 keV with neon injection. By introducing neon gas, the NBI absorption power was increased in low-density plasmas and the direct ion heating power was much enhanced with a reduced number of ions, compared with hydrogen plasmas

Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas

Familial Non-Medullary Thyroid Carcinoma (fNMTC) represents 3–7% of all thyroid tumours and is associated with some of the highest familial risks among all cancers, with an inheritance pattern compatible with an autosomal dominant model with reduced penetrance. We previously mapped a predisposing locus, TCO (Thyroid tumour with Cell Oxyphilia) on chromosome 19p13.2, for a particular form of thyroid tumour characterised by cells with an abnormal proliferation of mitochondria (oxyphilic or oncocytic cells). In the present work, we report the systematic screening of 14 candidate genes mapping to the region of linkage in affected TCO members, that led us to identify two novel variants respectively in exon 9 and exon 13 of TIMM44, a mitochondrial inner membrane translocase for the import in the mitochondria of nuclear-encoded proteins. These variants were co-segregating with the TCO phenotype, were not present in a large group of controls and were predicted to negatively affect the protein (exon 9 change) or the transcript (exon 13 change). Functional analysis was performed in vitro for both changes and although no dramatic loss of function effects were identified for the mutant alleles, subtler effects might still be present that could alter Timm44 function and thus promote oncocytic tumour development. Thus we suggest that TIMM44 should be considered for further studies in independent samples of affected individuals with TCO