905 research outputs found
Magnetic and Transport Properties in (=00.4)
Magnetic and transport properties of () system have been investigated. A broad maximum in M(T) curve,
indicative of low-dimensional antiferromagnetic ordering originated from
layers, is observed in Ca-free sample. With increasing Ca
doping level up to 0.2, the M(T) curve remains almost unchanged, while
resistivity is reduced by three orders. Higher Ca doping level leads to a
drastic change of magnetic properties. In comparison with the samples with
, the temperature corresponding to the maximum of M(T) is much
lowered for the sample =0.3. The sample =0.4 shows a small kink instead
of a broad maximum and a weak ferromagnetic feature. The electrical transport
behavior is found to be closely related to magnetic properties for the sample
=0.2, 0.25, 0.3, 0.4. It suggests that layers are involved
in charge transport in addition to conducting planes to interpret the
correlation between magnetism and charge transport. X-ray photoelectron
spectroscopy studies give an additional evidence of the the transfer of the
holes into the charge reservoir
NMR study of the layered cobalt oxyphosphide Sr2Sc(Co1-xFex)PO3
We report the results of 31P-nuclear magnetic resonance (NMR) measurements on the layered cobalt oxyphosphide Sr2Sc(Co1−xFex)PO3 in order to investigate the magnetic properties at low temperatures from a microscopic view point. The 31P-Knight shifts measured at the resonance peak maximum of Sr2Sc(Co1−xFex)PO3 have positive values and are T-independent in an entire temperature range, and the absolute value decreases with increasing Fe content. Also, the nuclear spin-lattice relaxation rate 1/T1 is almost proportional to the temperature at low temperatures. The magnitude of 1/T1T decreases with increasing the Fe content, which suggests the decrease of the density of states around the Fermi level
Electronic structure of NiS_{1-x}Se_x
We investigate the electronic structure of the metallic NiSSe
system using various electron spectroscopic techniques. The band structure
results do not describe the details of the spectral features in the
experimental spectrum, even for this paramagnetic metallic phase. However, a
parameterized many-body multi-band model is found to be successful in
describing the Ni~2 core level and valence band, within the same model. The
asymmetric line shape as well as the weak intensity feature in the Ni~2 core
level spectrum has been ascribed to extrinsic loss processes in the system. The
presence of satellite features in the valence band spectrum shows the existence
of the lower Hubbard band, deep inside the metallic regime, consistent
with the predictions of the dynamical mean field theory.Comment: To be published in Physical Review B, 18 pages and 5 figure
Defining Developmental Potency and Cell Lineage Trajectories by Expression Profiling of Differentiating Mouse Embryonic Stem Cells
Biologists rely on morphology, function and specific markers to define the differentiation status of cells. Transcript profiling has expanded the repertoire of these markers by providing the snapshot of cellular status that reflects the activity of all genes. However, such data have been used only to assess relative similarities and differences of these cells. Here we show that principal component analysis of global gene expression profiles map cells in multidimensional transcript profile space and the positions of differentiating cells progress in a stepwise manner along trajectories starting from undifferentiated embryonic stem (ES) cells located in the apex. We present three ‘cell lineage trajectories’, which represent the differentiation of ES cells into the first three lineages in mammalian development: primitive endoderm, trophoblast and primitive ectoderm/neural ectoderm. The positions of the cells along these trajectories seem to reflect the developmental potency of cells and can be used as a scale for the potential of cells. Indeed, we show that embryonic germ cells and induced pluripotent cells are mapped near the origin of the trajectories, whereas mouse embryo fibroblast and fibroblast cell lines are mapped near the far end of the trajectories. We suggest that this method can be used as the non-operational semi-quantitative definition of cell differentiation status and developmental potency. Furthermore, the global expression profiles of cell lineages provide a framework for the future study of in vitro and in vivo cell differentiation
CANGAROO-III Observation of TeV Gamma Rays from the vicinity of PSR B1 706-44
Observation by the CANGAROO-III stereoscopic system of the Imaging Cherenkov
Telescope has detected extended emission of TeV gamma rays in the vicinity of
the pulsar PSR B170644. The strength of the signal observed as
gamma-ray-like events varies when we apply different ways of emulating
background events. The reason for such uncertainties is argued in relevance to
gamma-rays embedded in the "off-source data", that is, unknown sources and
diffuse emission in the Galactic plane, namely, the existence of a complex
structure of TeV gamma-ray emission around PSR B170644.Comment: 10 pages, 13 figures, to be published in Ap
CANGAROO-III observation of TeV gamma rays from the unidentified gamma-ray source HESS J1614-518
We report the detection, with the CANGAROO-III imaging atmospheric Cherenkov
telescope array, of a very high energy gamma-ray signal from the unidentified
gamma-ray source HESS J1614-518, which was discovered in the H.E.S.S. Galactic
plane survey. Diffuse gamma-ray emission was detected above 760 GeV at the 8.9
sigma level during an effective exposure of 54 hr from 2008 May to August. The
spectrum can be represented by a power-law:
8.2+-2.2_{stat}+-2.5_{sys}x10^{-12}x (E/1TeV)^{-Gamma} cm^{-2} s^{-1} TeV^{-1}
with a photon index Gamma of 2.4+-0.3_{stat}+-0.2_{sys}, which is compatible
with that of the H.E.S.S. observations. By combining our result with
multi-wavelength data, we discuss the possible counterparts for HESS J1614-518
and consider radiation mechanisms based on hadronic and leptonic processes for
a supernova remnant, stellar winds from massive stars, and a pulsar wind
nebula. Although a leptonic origin from a pulsar wind nebula driven by an
unknown pulsar remains possible, hadronic-origin emission from an unknown
supernova remnant is preferred.Comment: 9 pages, 7 figures, accepted for publication in Ap
From kesterite to stannite photovoltaics:Stability and band gaps of the Cu2 (Zn, Fe) SnS4 alloy
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene discovery efforts6-11. In sample sizes up to 1.2 million individuals, we discovered 566 genetic variants in 406 loci associated with multiple stages of tobacco use (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci evidencing pleiotropic association. Smoking phenotypes were positively genetically correlated with many health conditions, whereas alcohol use was negatively correlated with these conditions, such that increased genetic risk for alcohol use is associated with lower disease risk. We report evidence for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission. The results provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures
Amelioration of endotoxemia by a synthetic analog of Omega-3 epoxyeicosanoids
Sepsis, a systemic inflammatory response to pathogenic factors, is a difficult to treat life-threatening condition associated with cytokine and eicosanoid storms and multi-organ damage. Omega-3 polyunsaturated fatty acids, such as eicosapentaenoic (EPA) and docosahexaenoic acid, are the precursors of potent anti-inflammatory lipid mediators, including 17,18-epoxyeicosatetraenoic acid (17,18-EEQ), the main metabolite of EPA generated by cytochrome P450 epoxygenases. Searching for novel therapeutic or preventative agents in sepsis, we tested a metabolically robust synthetic analog of 17,18-EEQ (EEQ-A) for its ability to reduce mortality, organ damage, and pro-inflammatory cytokine transcript level in a mouse model of lipopolysaccharide (LPS)-induced endotoxemia, which is closely related to sepsis. Overall survival significantly improved following preventative EEQ-A administration along with decreased transcript level of pro-inflammatory cytokines. On the other hand, the therapeutic protocol was effective in improving survival at 48 hours but insignificant at 72 hours. Histopathological analyses showed significant reductions in hemorrhagic and necrotic damage and infiltration in the liver. In vitro studies with THP-1 and U937 cells showed EEQ-A mediated repression of LPS-induced M1 polarization and enhancement of IL-4-induced M2 polarization of macrophages. Moreover, EEQ-A attenuated the LPS-induced decline of mitochondrial function in THP-1 cells, as indicated by increased basal respiration and ATP production as well as reduction of the metabolic shift to glycolysis. Taken together, these data demonstrate that EEQ-A has potent anti-inflammatory and immunomodulatory properties that may support therapeutic strategies for ameliorating the endotoxemia
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