507 research outputs found
On the motion of a classical charged particle
We show that the Lorentz-Dirac equation is not an unavoidable consequence of
energy-momentum conservation for a point charge. What follows solely from
conservation laws is a less restrictive equation already obtained by Honig and
Szamosi. The latter is not properly an equation of motion because, as it
contains an extra scalar variable, it does not determine the future evolution
of the charge. We show that a supplementary constitutive relation can be added
so that the motion is determined and free from the troubles that are customary
in Lorentz-Dirac equation, i. e. preacceleration and runaways
Hydrogen Epoch of Reionization Array (HERA)
The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to
measure 21 cm emission from the primordial intergalactic medium (IGM)
throughout cosmic reionization (), and to explore earlier epochs of our
Cosmic Dawn (). During these epochs, early stars and black holes
heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is
designed to characterize the evolution of the 21 cm power spectrum to constrain
the timing and morphology of reionization, the properties of the first
galaxies, the evolution of large-scale structure, and the early sources of
heating. The full HERA instrument will be a 350-element interferometer in South
Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz.
Currently, 19 dishes have been deployed on site and the next 18 are under
construction. HERA has been designated as an SKA Precursor instrument.
In this paper, we summarize HERA's scientific context and provide forecasts
for its key science results. After reviewing the current state of the art in
foreground mitigation, we use the delay-spectrum technique to motivate
high-level performance requirements for the HERA instrument. Next, we present
the HERA instrument design, along with the subsystem specifications that ensure
that HERA meets its performance requirements. Finally, we summarize the
schedule and status of the project. We conclude by suggesting that, given the
realities of foreground contamination, current-generation 21 cm instruments are
approaching their sensitivity limits. HERA is designed to bring both the
sensitivity and the precision to deliver its primary science on the basis of
proven foreground filtering techniques, while developing new subtraction
techniques to unlock new capabilities. The result will be a major step toward
realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table
What is evidence required for and who generates that evidence in the Finnish Educational System?
Peer reviewe
The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores
P2Y2 receptors, which are equally responsive to ATP and UTP, can trigger intracellular signaling events, such as intracellular calcium mobilization and mitogen-activated protein (MAP) kinase phosphorylation in polymorphonuclear leukocytes (PMN). Moreover, extracellular nucleotides have been shown to prime chemoattractant-induced superoxide production. The aim of our study was to investigate the mechanism responsible for the priming effect of extracellular nucleotides on reactive oxygen species (ROS) production induced in human neutrophils by two different chemoattractants: formyl-methionyl-leucyl-phenylalanine (fMLP) and interleukin-8 (IL-8). Nucleotide-induced priming of ROS production was concentration- and time-dependent. When UTP was added to neutrophil suspensions prior to chemoattractant, the increase of the response reached the maximum at 1 min of pre-incubation with the nucleotide. UTP potentiated the phosphorylation of p44/42 and p38 MAP kinases induced by chemoattractants, however the P2 receptor-mediated potentiation of ROS production was still detectable in the presence of a SB203580 or U0126, supporting the view that MAP kinases do not play a major role in regulating the nucleotide-induced effect. In the presence of thapsigargin, an inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca2+-ATPases in mammalian cells, the effect of fMLP was not affected, but UTP-induced priming was abolished, suggesting that the release of calcium from thapsigargin-sensitive intracellular stores is essential for nucleotide-induced priming in human neutrophils
The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage
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