A deep UVBRI CCD photometric study of open clusters Tr 1 and Be 11

We present deep $UBVRI$ CCD photometry for the young open star clusters Tr 1 and Be 11. The CCD data for Be 11 is obtained for the first time. The sample consists of $\sim$ 1500 stars reaching down to $V$ $\sim$ 21 mag. Analysis of the radial distribution of stellar surface density indicates that radius values for Tr 1 and Be 11 are 2.3 and 1.5 pc respectively. The interstellar extinction across the face of the imaged clusters region seems to be non-uniform with a mean value of $E(B-V)$ = 0.60$\pm$0.05 and 0.95$\pm$0.05 mag for Tr 1 and Be 11 respectively. A random positional variation of $E(B-V)$ is present in both the clusters. In the cluster Be 11, the reason of random positional variation may be apparent association of the HII region (S 213). The 2MASS $JHK$ data in combination with the optical data in the cluster Be 11 yields $E(J-K)$ = 0.40$\pm$0.20 mag and $E(V-K)$ = 2.20$\pm$0.20 mag. Colour excess diagrams indicate a normal interstellar extinction law in the direction of cluster Be 11. The distances of Tr 1 and Be 11 are estimated as 2.6$\pm$0.10 and 2.2$\pm$0.10 Kpc respectively, while the theoretical stellar evolutionary isochrones fitted to the bright cluster members indicate that the cluster Tr 1 and Be 11 are 40$\pm$10 and 110$\pm$10 Myr old. The mass functions corrected for both field star contamination and data incompleteness are derived for both the clusters. The slopes $1.50\pm0.40$ and $1.22\pm0.24$ for Tr 1 and Be 11 respectively are in agreement with the Salpeter's value. Observed mass segregations in both clusters may be due to the result of dynamical evolutions or imprint of star formation processes or both.Comment: 15 pages, 13 figures. Accepted for publication in MNRA

The Multiple Origin of Blue Straggler Stars: Theory vs. Observations

In this chapter we review the various suggested channels for the formation and evolution of blue straggler stars (BSSs) in different environments and their observational predictions. These include mass transfer during binary stellar evolution - case A/B/C and D (wind Roche-lobe overflow) mass transfer, stellar collisions during single and binary encounters in dense stellar cluster, and coupled dynamical and stellar evolution of triple systems. We also explore the importance of the BSS and binary dynamics in stellar clusters. We review the various observed properties of BSSs in different environments (halo and bulge BSSs, BSSs in globular clusters and BSSs in old open clusters), and compare the current observations with the theoretical predictions for BSS formation. We try to constrain the likely progenitors and processes that play a role in the formation of BSSs and their evolution. We find that multiple channels of BSS formation are likely to take part in producing the observed BSSs, and we point out the strengths and weaknesses of each the formation channel in respect to the observational constraints. Finally we point out directions to further explore the origin of BSS, and highlight eclipsing binary BSSs as important observational tool.Comment: Chapter 11, in Ecology of Blue Straggler Stars, H.M.J. Boffin, G. Carraro & G. Beccari (Eds), Astrophysics and Space Science Library, Springe

Stellar populations in NGC 5128 with the VLT: evidence for recent star formation

We resolve stars of the nearest giant elliptical galaxy NGC 5128 using VLT with FORS1 and ISAAC. We construct deep U, V and Ks color-magnitude and color-color diagrams in two different halo fields (in the halo and in the north-eastern diffuse shell). In the outer, shell field, at ~14 kpc from the center of the galaxy, there is a significant recent star formation with stars as young as 10 Myr, approximately aligned with the prominent radio and x-ray jet from the nucleus of the host AGN. Ionized gas filaments are evident in ultraviolet images near the area where neutral HI and CO molecular gas was previously observed. The underlying stellar population of the halo of the giant elliptical is predominantly old with a very broad metallicity distribution. The presence of an extended giant branch reaching M_bol=-5 mag suggests the existence of a significant intermediate-age AGB population in the halo of this galaxy.Comment: 18 pages, 18 figures; to be published in A&A; high res. version at http://www.eso.org/~mrejkuba/cenA_starsVLT.p

Genome-wide meta-analysis of common variant differences between men and women

The male-to-female sex ratio at birth is constant across world populations with an average of 1.06 (106 male to 100 female live births) for populations of European descent. The sex ratio is considered to be affected by numerous biological and environmental factors and to have a heritable component. The aim of this study was to investigate the presence of common allele modest effects at autosomal and chromosome X variants that could explain the observed sex ratio at birth. We conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency >0.05) single-nucleotide polymorphisms (SNPs). Allele frequencies were compared between men and women for directly-typed and imputed variants within each study. Forward-time simulations for unlinked, neutral, autosomal, common loci were performed under the demographic model for European populations with a fixed sex ratio and a random mating scheme to assess the probability of detecting significant allele frequency differences. We do not detect any genome-wide significant (P < 5 × 10−8) common SNP differences between men and women in this well-powered meta-analysis. The simulated data provided results entirely consistent with these findings. This large-scale investigation across ∼115 000 individuals shows no detectable contribution from common genetic variants to the observed skew in the sex ratio. The absence of sex-specific differences is useful in guiding genetic association study design, for example when using mixed controls for sex-biased trait

Utility-Based Mechanism for Structural Self-Organization in Service-Oriented MAS

Structural relations established among agents influence the performance of decentralized service discovery process in multiagent systems. Moreover, distributed systems should be able to adapt their structural relations to changes in environmental conditions. In this article, we present a service-oriented multiagent systems, where agents initially self-organize their structural relations based on the similarity of their services. During the service discovery process, agents integrate a mechanism that facilitates the self-organization of their structural relations to adapt the structure of the system to the service demand. This mechanism facilitates the task of decentralized service discovery and improves its performance. Each agent has local knowledge about its direct neighbors and the queries received during discovery processes. With this information, an agent is able to analyze its structural relations and decide when it is more appropriate to modify its direct neighbors and select the most suitable acquaintances to replace them. The experimental evaluation shows how this self-organization mechanism improves the overall performance of the service discovery process in the system when the service demand changesThis work is partially supported by the Spanish Ministry of Science and Innovation through grants CSD2007-0022 (CONSOLIDER-INGENIO 2010), TIN2012-36586-C03-01, TIN2012-36586-C03-01, TIN2012-36586-C03-02, PROMETEOII/2013/019, and FPU grant AP-2008-00601 awarded to E. Del Val.Del Val Noguera, E.; Rebollo Pedruelo, M.; Vasirani, M.; Fernández, A. (2014). Utility-Based Mechanism for Structural Self-Organization in Service-Oriented MAS. ACM Transactions on Autonomous and Adaptive Systems. 9(3):1-24. https://doi.org/10.1145/2651423S12493Sherief Abdallah and Victor Lesser. 2007. 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A search for spectroscopic binaries in the galactic globular cluster M4. Based on 5973 individual spectra collected at VLT

We present a large multi-epoch high resolution spectroscopic investigation for the search of binary candidates in the Galactic Globular Cluster (GGC) M4. The aim of our work is the identification of the binary candidates, and the determination of the binary fraction and of the binary radial distribution. We present a large multi-epoch high resolution spectroscopic investigation for the search of binary candidates in the Galactic Globular Cluster (GGC) M4. The aim of our work is the identification of the binary candidates, and the determination of the binary fraction and of the binary radial distribution. The average radial velocity of the observed cluster members is $70.29+/-0.07(+/-0.3)(+/-0.1)km/s. The search for variations in radial velocities among the stars with multi-epoch observations yielded 57 binary star candidates. Our radial velocity measurement accuracy allowed us to identify at a 3sigma level binaries with radial velocity variations larger than ~0.3km/s for the target stars with V<15, and larger than ~0.5km/s for the targets with V>15. We identified 4 binary star candidates out of 97 observed targets inside the core radius, and 53 candidates out of 2372 observed stars outside the core radius. Accounting for the incompleteness affecting our survey, the lower limit for the total binary fraction is f=3.0+/-0.3%. The lower limit for the binary fraction in the cluster core is f=5.1+/-2.3%, while outside the core it decreases to f=3.0+/-0.4%. Similarly, we found f=4.5+/-0.4% and f=1.8+/-0.6% for the binary fraction inside and outside the half mass radius.Comment: 13 pages, 12 figures, Accepted for publication in A&

Protocol per a la vigilància i el control de les arbovirosis transmeses per mosquits a Catalunya

Arbovirus; Mosquits; Malalties víriquesArboviruses; Mosquitoes; Viral diseasesArbovirus; Mosquitos; Enfermedades víricasThis protocol aims to provide a guide for the surveillance of the most likely arbovirosis transmitted by mosquito vectors in Catalonia (West Nile virus, dengue and chikungunya), establishing a set of surveillance activities for these diseases and control of the vectors, depending on the risk level of arbovirosisEste protocolo tiene como objetivo ofrecer una guía para la vigilancia de las arbovirosi más probables transmitidas por vectores mosquitos en Cataluña (virus del Nilo Occidental, dengue y chikungunya), estableciendo un conjunto de actividades de vigilancia de estas enfermedades y de control los vectores, según el nivel de riesgo de arbovirosiAquest protocol té com a objectiu oferir una guia per a la vigilància de les arbovirosis més probables transmeses per vectors mosquits a Catalunya (virus del Nil Occidental, dengue i chikungunya), establint un conjunt d’activitats de vigilància d’aquestes malalties i de control dels vectors, segons el nivell de risc d’arbovirosi

Protocol per a la vigilància i el control de les arbovirosis transmeses per mosquits a Catalunya

Arbovirus; Mosquits; Malalties víriquesArboviruses; Mosquitoes; Viral diseasesArbovirus; Mosquitos; Enfermedades víricasThis protocol aims to provide a guide for the surveillance of the most likely arbovirosis transmitted by mosquito vectors in Catalonia (West Nile virus, dengue and chikungunya), establishing a set of surveillance activities for these diseases and control of the vectors, depending on the risk level of arbovirosisEste protocolo tiene como objetivo ofrecer una guía para la vigilancia de las arbovirosi más probables transmitidas por vectores mosquitos en Cataluña (virus del Nilo Occidental, dengue y chikungunya), estableciendo un conjunto de actividades de vigilancia de estas enfermedades y de control los vectores, según el nivel de riesgo de arbovirosiAquest protocol té com a objectiu oferir una guia per a la vigilància de les arbovirosis més probables transmeses per vectors mosquits a Catalunya (virus del Nil Occidental, dengue i chikungunya), establint un conjunt d’activitats de vigilància d’aquestes malalties i de control dels vectors, segons el nivell de risc d’arbovirosi

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707