Volatile oil composition and antioxidant activity of leaf of Chaerophyllum villosum Wall. ex DC from Uttrakhand, India

The genus Chaerophyllum, belonging to Apiaceae family, comprised of about 110 species which includes annual and perennial herbal plants widely distributed in temperate and sub temperate zones of Asia, Africa and Europe. Chaerophyllum villosum Wall. ex DC. was widely distributed in E. Asia Himalayas from India to Bhutan, Nepal and China and widely grows in moist shady places, road sides or open grassy places at elevations of 2100-3500 m. In high altitude tribes of Uttarakhand Himalaya (India) it was commonly known and sold in the name of ‘Ganjari’ widely used by people in food, spice and also as medicine. The volatile oil composition of leaf of Chaerophyllum villosum Wall. ex DC. (family: Apiaceae) were analyzed and compared using capillary GC and GC-MS. The leaf essential oil of C. villosum was dominated by monoterpene hydrocarbons (91.34%) represented by γ-terpinene (74.93%) as single major constituent followed by p-cymene (10.00%), terpinolene (2.93%) and β-pinene (2.54%), the antioxidant activity of leaf essential oil also evaluated. &nbsp

Composition of a new chemotype of Senecio chrysanthemoides DC.

1745-17481,10β-epoxy-6-oxo-furanoeremophilane 1 (21.8%) along with furanoligularenone 2, germacrene D 3, selin-11-en-4α-ol 4 and caryophyllene oxide 5 have been identified in Senecio chrysanthemoides DC. of the Garhwal region of Himalaya at an altitude of 3600 m. 1,10β-epoxy-6-oxo-furanoeremophilane 1 has not been reported in Senecio chrysanthemoides DC. but reported in the other species of the genus Senecio. Presence of compounds 1-5 and absence of previously reported β-thujone and 6-hydroxy-p-menth-4(5)-en-3-one makes it a new chemotype within the genus Senecio

Essential oil composition of valeriana jatamansi jones from himalayan regions of India

Valeriana jatamansi Jones germplasm collected from sub-temperate Himalayan region of Uttarakhand and North-East state of Meghalaya, India was evaluated under identical conditions at National Bureau of Plant Genetic Resources, Bhowali, India, to study germplasm diversity based on essential oil composition. Twenty one compounds were identified in V. jatamansi root oil by GC and GC-MS. The major compounds identified were patchouli alcohol (0.4-63.7%), maaliol (2.9-53.8%), seychellene (4.1-27.4%), calarene/ί-gurjunene (3.0-20.8%), α-santalene (0.6-12.0%). Other compounds present were bornyl acetate (0.6-1.5%), α-guaiene (0.7-2.3%), α-bulnesene/d-guaiene (0.7-6.3%), 7-epi-α-selinene (0.4-1.4%), kessane (2.1-3.3%), spathulenol (0.7-3.4%), viridiflorol (0.9-7.1%), α-patchoulene (0.8-6.6%), ί-patchoulene (0.4-0.8%). Two superior chemotypes identified in V. jatamansi oil from Uttarakhand were: patchouli alcohol rich (IC573221, 63.7%) and maaliol rich (IC573222, 53.8%; IC589096, 51.7%), while accession from north-east was patchouli alcohol rich chemotype (IC574522, 57.2%). These superior chemotypes with higher amounts of patchouli alcohol and maaliol could be used for promoting cultivation as well as for meeting need of pharmaceutical industries

<span style="font-size:10.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-US">Synthesis, characterization and <i style="mso-bidi-font-style:normal">in vitro</i> antibacterial activity of cinnamyl amine derivatives</span>

907-912A series of cinnamyl amine derivatives have been synthesized and characterized by their MS, 1H and 13C NMR spectral data. Antibacterial activity has been evaluated against three Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus aureus MTCC 96 and Staphylococcus epidermidis MTCC 435) and two Gram-negative (<i style="mso-bidi-font-style: normal">Escherichia coli MTCC 723 and Pseudomonas aeruginosa MTCC 741) bacteria. The Schiff base derivatives benzyl-(3-phenylallylidene)amine 3, phenyl-(3-phenylallylidene)amine 4 and amine derivatives 2-[benzyl-(3-phenylallyl)-amino]-1-(4-methoxyphenyl)ethanone 8c and 1-(4-bromophenyl)-2-[phenyl-(3-phenylallyl)-amino]ethanone <b style="mso-bidi-font-weight: normal">9c showed remarkable antibacterial activity against B. subtilis,<i style="mso-bidi-font-style: normal"> S. aureus and S. epidermidis bacterial strains even at low concentration and are close to the standard antibiotic streptomycin (MIC 3.3-7.0 μg mL-1). Furthermore, methoxy substitution at phenacyl nucleus increased the antibacterial activity as compared to the methyl and bromo substituents under identical conditions

Original scientific paper Constituents and antimicrobial activity of the essential oils

erecta Benth., were tested for their in vitro antimicrobial activity against six pathogenic bacterial and two fungal strains. The results showed that Pseudomonas aeruginosa was the most sensitive strain tested to the essential oils of Nepeta species. The essential oils of N. elliptica and N. erecta exhibited the highest activity against P. aeruginosa, followed by the essential oils of N. leucophylla and N. clarkei. The essential oils from N. elliptica and N. erecta were also found to be very effective against Serratia marcescens; while the essential oil from N. leucophylla displayed significant activity against Proteus vulgaris and Staphylococcus aureus. Other bacterial strains displayed variable degree of susceptibility against one or more of the tested essential oils. The essential oil from N. leucophylla also showed the highest antifungal activity against both tested fungal strains, viz. Candida albicans and Trichophyton rubrum, followed by the essential oils from N. clarkei, N. govaniana and N. erecta. Iridodial derivatives, viz. iridodial β-monoenol acetate (25.4 %), dihydroiridodial diacetate (18.2 %) and iridodial dienol diacetate (7.8 %) were identified as the majo