مراقبة ملوثات الهواء المنبعثة من محطة توليد كهرباء مدينة غزة

Power plants are considered a major air pollution source, which emit to atmosphere many air pollutants such as particulate matter, carbon monoxide (CO), sulfur oxide, and nitrogen oxide. The aim of study is focusing on monitoring the air pollutants (PM2.5, CO, CO2), noise level, and health effects of air pollution on residents around power plant in Gaza City-Palestine. Gaza power plant site was monitored for four months during summer and winter seasons of 2012 by using air pollutant devices; 3-Channel handheld laser particle counter and Kanomax meter. A public health questionnaire was also distributed on residents around power plant to assess the impact of air pollution on their health status. The results showed that the concentration of particulate matter exceeded on WHO standard and the highest level was 79 mg/m3 and lowest level was 49mg/m3, while the concentration of carbon monoxide was less than WHO standards and the highest level was 2.18 ppm and lowest level was 0.1 ppm. The concentration of carbon dioxide oscillated from 254ppm to 514ppm. The public health questionnaire showed that 40% from population visited the hospital because of a disease that infect the respiratory tract. Other people suffered from a burning sensation in the eyes, short of breathing and rapid breathing, and feeling bronchial infection. The study concluded that the concentration of particulate matter and carbon dioxide were high, while the level of carbon monoxide and noise were low. The level of public awareness was good. The study recommended that periodic maintenance for power plant must be carried out and uses modern technology techniques to reduce the emission of air pollutants. The provision of modern devices to monitor air pollutants and train technical staff to carry out the monitoring process. Establishing a continuous monitoring program of pollutants emitted from plant, this program includes monitoring the health status of the population around the plant and the extent of affected by emitted pollutants and respondent by medical care and proper education. Sampling power plant stacks to be tested and find out their components and increase the public awareness about the risks of air pollutants on health and environment, finally provide financial support for scientific research in the air pollution field

Knowledge and Awareness of Diabetes Mellitus Disease among High School Students in King Abdulaziz Military City, Tabuk, Saudi Arabia

BACKGROUND: Saudi Arabia is considered to be one of the highest countries in the Middle East for the incidence of diabetes mellitus (DM). Data are lacking regarding knowledge and awareness about DM among school students in Saudi Arabia. AIM: The study aimed to assess the level of knowledge and awareness of DM among high school students within the military city, Tabuk, Saudi Arabia. METHODS: A descriptive type of cross-sectional study was conducted among 278 high school students applying a convenience sampling technique. The sample size was calculated using OpenEpi, Version 3. Self-administered questionnaires were distributed to the high school students (male and female) after official communication with the school’s dean. The level of knowledge and awareness was categorized into “adequate” and “inadequate” as per each topic/question, and also as per each response/answer. Data entry and analysis were carried out using the Statistical Package for the Social Sciences. Pearson’s Chi-square tests were performed to explore if there is any significant association between the knowledge and awareness level of the high school students and their (i) gender, (ii) age, and (iii) level of education. RESULTS: More than half of the high school students had adequate level of knowledge and awareness about DM in terms of symptoms (67.3%), complications (56.5%), monitoring method (62.6%), lifestyle modifications (63.7%), frequency of routine eye check-up (63.3%), important factors for blood sugar control (79.1%), treatment (56.5%), and management of hypoglycemia symptoms (57.6%). On the contrary, a large number of the students showed inadequate level of knowledge and awareness about the disease in terms of definition (80.6%), major causes (57.9%), effect of high blood pressure (51.8%), frequency of routine blood pressure check-up (55%), rationale of a regular urine test (58.3%), medication for DM (66.9%), and duration of medication (69.8%). However, no significant associations were found between the knowledge and awareness level of the high school students about the definition or major causes of DM and the (i) gender, (ii) age group, and (iii) level of education of the students. CONCLUSION: The level of knowledge and awareness of a considerable number of high school students regarding DM was inadequate, and some of them possessed various misconceptions about this particular chronic disease. Health authorities and school authorities in the region should offer special efforts to improve the level of knowledge and awareness of the students through regular health education campaigns

Routing game on the line: The case of multi-players

International audienceIn this paper, we study a sequential routing game networks where M users send traffic to a destination on a line. Each user arrives at time epoch with a given capacity. Then, he ships its demand over time on a shared resource. The state of a player evolves according to whether he decides to transmit or not. The decision of each user is thus spatio-temporal control. We provide explicit expression of the equilibrium of such systems and compare it to the global optimum case. In particular, we compute the price of anarchy of such scheme and identify a Braess-type paradox in the context of sequential routing game

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear understanding of the molecular mechanisms of action of phenolic compounds. Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. They inactivate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and modulate mitogen-activated protein Kinase (MAPk) and arachidonic acids pathways. Polyphenolic compounds inhibit phosphatidylinositide 3-kinases/protein kinase B (PI3K/AkT), inhibitor of kappa kinase/c-Jun amino-terminal kinases (IKK/JNK), mammalian target of rapamycin complex 1 (mTORC1) which is a protein complex that controls protein synthesis, and JAK/STAT. They can suppress toll-like receptor (TLR) and pro-inflammatory genes’ expression. Their antioxidant activity and ability to inhibit enzymes involved in the production of eicosanoids contribute as well to their anti-inflammation properties. They inhibit certain enzymes involved in reactive oxygen species ROS production like xanthine oxidase and NADPH oxidase (NOX) while they upregulate other endogenous antioxidant enzymes like superoxide dismutase (SOD), catalase, and glutathione (GSH) peroxidase (Px). Furthermore, they inhibit phospholipase A2 (PLA2), cyclooxygenase (COX) and lipoxygenase (LOX) leading to a reduction in the production of prostaglandins (PGs) and leukotrienes (LTs) and inflammation antagonism. The effects of these biologically active compounds on the immune system are associated with extended health benefits for different chronic inflammatory diseases. Studies of plant extracts and compounds show that polyphenols can play a beneficial role in the prevention and the progress of chronic diseases related to inflammation such as diabetes, obesity, neurodegeneration, cancers, and cardiovascular diseases, among other conditions

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension

Germline mutations involving small mothers against decapentaplegic-transforming growth factor-β (SMAD-TGF-β) signaling are an important but rare cause of pulmonary arterial hypertension (PAH), which is a disease characterized, in part, by vascular fibrosis and hyperaldosteronism (ALDO). We developed and analyzed a fibrosis protein-protein network (fibrosome) in silico, which predicted that the SMAD3 target neural precursor cell expressed developmentally down-regulated 9 (NEDD9) is a critical ALDO-regulated node underpinning pathogenic vascular fibrosis. Bioinformatics and microscale thermophoresis demonstrated that oxidation of Cys18 in the SMAD3 docking region of NEDD9 impairs SMAD3-NEDD9 protein-protein interactions in vitro. This effect was reproduced by ALDO-induced oxidant stress in cultured human pulmonary artery endothelial cells (HPAECs), resulting in impaired NEDD9 proteolytic degradation, increased NEDD9 complex formation with Nk2 homeobox 5 (NKX2-5), and increased NKX2-5 binding to COL3A1 Up-regulation of NEDD9-dependent collagen III expression corresponded to changes in cell stiffness measured by atomic force microscopy. HPAEC-derived exosomal signaling targeted NEDD9 to increase collagen I/III expression in human pulmonary artery smooth muscle cells, identifying a second endothelial mechanism regulating vascular fibrosis. ALDO-NEDD9 signaling was not affected by treatment with a TGF-β ligand trap and, thus, was not contingent on TGF-β signaling. Colocalization of NEDD9 with collagen III in HPAECs was observed in fibrotic pulmonary arterioles from PAH patients. Furthermore, NEDD9 ablation or inhibition prevented fibrotic vascular remodeling and pulmonary hypertension in animal models of PAH in vivo. These data identify a critical TGF-β-independent posttranslational modification that impairs SMAD3-NEDD9 binding in HPAECs to modulate vascular fibrosis and promote PAH

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension

Iron–sulfur (Fe-S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR-210-ISCU1/2 axis cause Fe-S deficiencies in vivo and promote PH. In pulmonary vascular cells and particularly endothelium, hypoxic induction of miR-210 and repression of the miR-210 targets ISCU1/2 down-regulated Fe-S levels. In mouse and human vascular and endothelial tissue affected by PH, miR-210 was elevated accompanied by decreased ISCU1/2 and Fe-S integrity. In mice, miR-210 repressed ISCU1/2 and promoted PH. Mice deficient in miR-210, via genetic/pharmacologic means or via an endothelial-specific manner, displayed increased ISCU1/2 and were resistant to Fe-S-dependent pathophenotypes and PH. Similar to hypoxia or miR-210 overexpression, ISCU1/2 knockdown also promoted PH. Finally, cardiopulmonary exercise testing of a woman with homozygous ISCU mutations revealed exercise-induced pulmonary vascular dysfunction. Thus, driven by acquired (hypoxia) or genetic causes, the miR-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing Fe-S deficiency and PH. These findings carry broad translational implications for defining the metabolic origins of PH and potentially other metabolic diseases sharing similar underpinnings