Accessible opera : overcoming linguistic and sensorial barriers

The desire to make media available for all has been rapidly accepted and implemented by most European countries. Opera, as one of the many audiovisual representations, also falls under the category of production which needs to be made accessible and this article aims to analyse how opera has gone through a complete transformation to become a cultural event for all, overcoming not only linguistic but also sensorial barriers. The first part of the article analyses the various forms of translation associated with opera and the main challenges they entail. The second presents different systems used to make opera accessible to the sensorially challenged, highlighting their main difficulties. Examples from research carried out at the Barcelona's Liceu opera house are presented to illustrate various modalities, especially audio description. All in all, it is our aim to show how translated-related processes have made it possible to open opera to a wider audience despite some initial reluctance

Terminological challenges in the translation of science documentaries: a case-study

This article aims to describe some of the main terminological problems audiovisual translators have to face when dealing with the translation of science documentaries, specifically in the English-Catalan combination. The first section of the article presents some theoretical concepts which underlie this research and which are taken, for the most part, from Cabré's Communicative Theory of Terminology. Then, specific terminological problems audiovisual translators have to solve are described using the data provided by a corpus of four science documentaries lasting approximately 50 minutes each. These challenges include identifying a term, understanding a term, finding the right equivalent, dealing with the absence of an adequate equivalent, solving denominative variations, choosing between in vivo and in vitro terminology, and overcoming mistranscriptions

Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment

Multiple myeloma (MM) is characterized by the clonal expansion of malignant plasma cells in the bone marrow (BM). MM remains an incurable disease, with the majority of patients experiencing multiple relapses from different drugs. The MM tumor microenvironment (TME) and in particular bone-marrow stromal cells (BMSCs) play a crucial role in the development of drug resistance. Metabolic reprogramming is emerging as a hallmark of cancer that can potentially be exploited for cancer treatment. Recent studies show that metabolism is further adjusted in MM cells during the development of drug resistance. However, little is known about the role of BMSCs in inducing metabolic changes that are associated with drug resistance. In this Perspective, we summarize current knowledge concerning the metabolic reprogramming of MM, with a focus on those changes associated with drug resistance to the proteasome inhibitor Bortezomib (BTZ). In addition, we present proof-of-concept fluxomics (glucose isotope-tracing) and Seahorse data to show that co-culture of MM cells with BMSCs skews the metabolic phenotype of MM cells towards a drug-resistant phenotype, with increased oxidative phosphorylation (OXPHOS), serine synthesis pathway (SSP), TCA cycle and glutathione (GSH) synthesis. Given the crucial role of BMSCs in conveying drug resistance, insights into the metabolic interaction between MM and BMSCs may ultimately aid in the identification of novel metabolic targets that can be exploited for therapy

Investigating potential planetary nebula/cluster pairs

Publisher's Version/PDFContext. Fundamental parameters characterizing the end-state of intermediate-mass stars may be constrained by discovering planetary nebulae (PNe) in open clusters (OCs). Cluster membership may be exploited to establish the distance, luminosity, age, and physical size for PNe, and the intrinsic luminosity and mass of its central star. Aims. Four potential PN-OC associations were investigated to assess the cluster membership for the PNe. Methods. Radial velocities were measured from intermediate-resolution optical spectra, complemented with previous estimates in the literature.When the radial velocity study supported the PN/OC association, we analyzed whether other parameters (e.g., age, distance, reddening, central star brightness) were consistent with this conclusion. Results. Our measurements imply that the PNe VBe 3 and HeFa 1 are not members of the OCs NGC5999 and NGC6067, respectively, and that they very likely belong to the background bulge population. Conversely, consistent radial velocities indicate that NGC2452/NGC 2453 could be associated, but our results are not conclusive so additional observations are warranted. Finally, we demonstrate that all the available information point to He 2-86 being a young, highly internally obscured PN member of NGC4463. New near-infrared photometry acquired via the Vista Variables in the Via Lactea ESO public survey was used in tandem with existing UBV photometry to measure the distance, reddening, and age of NGC4463, finding d = 1.55 ± 0.10 kpc, E(B − V) = 0.41 ± 0.02, and τ = 65 ± 10 Myr, respectively. The same values should be adopted for the PN if the proposed cluster membership is confirme

Deriving metallicities from calcium triplet spectroscopy\ud in combination with near-infrared photometry

Context. When they are established with sufficient precision, the ages, metallicities and kinematics of Galactic globular clusters\ud (GGCs) can shed much light on the dynamical and chemical evolution of the Galactic halo and bulge.While the most fundamental\ud way of determining GC abundances is by means of high-resolution spectroscopy, in practice this method is limited to only the brighter\ud stars in the nearest and less reddened objects. This restriction has, over the years, led to the development of a large number of techniques\ud that measure the overall abundance indirectly from parameters that correlate with overall metallicity. One of the most efficient\ud methods is measuring the equivalent width (EW) of the calcium II triplet (CaT) at λ ≈ 8500 Å in red giants, which are corrected for\ud the luminosity and temperature effects using the V magnitude differences from the horizontal branch (HB).\ud Aims. We establish a similar method in the near-infrared (NIR), by combining the power of the differential magnitudes technique with\ud the advantages of NIR photometry to minimize differential reddening effects.\ud Methods. We used the Ks magnitude difference between the star and the reddest part of the HB (RHB) or of the red clump (RC) to\ud generate reduced equivalent widths (rEW) from previously presented datasets. Then we calibrated these rEWagainst three previously\ud reported different metallicity scales; one of which we corrected using high-resolution spectroscopic metallicities.\ud Results. We calculated the calibration relations for the two datasets and the three metallicity scales and found that they are approximately\ud equivalent, with almost negligible differences. We compared our NIR calibrations with the corresponding optical ones, and\ud found them to be equivalent, which shows that the luminosity-corrected rEW using the Ks magnitude is compatible with the one\ud obtained from the V magnitude. We then used the metallicities obtained from the calibration to investigate the internal metallicity\ud distributions of the GCs.\ud Conclusions. We have established that the ([Fe/H]:rEW) relation is independent of the magnitude used for the luminosity correction\ud and find that the calibration relations change only slightly for different metallicity scales. The CaT technique using NIR photometry is\ud thus a powerful tool to derive metallicities. In particular, it can be used to study the internal metallicity spread of a GC.We confirm the\ud presence of at least two metallicity populations in NGC6656 and find that several other GCs present peculiar metallicity distributionsFONDECYT - project 3140177GEMINI-CONICYT 3210008GEMINI-CONICYT 32110005Chilean BASAL Centro de Excelencia en Astrofísica y Tecnologías Afines (CATA) - PFB 06/200

Investigating potential planetary nebula/cluster pairs

Fundamental parameters characterizing the end-state of intermediate-mass stars may be constrained by discovering planetary nebulae (PNe) in open clusters (OCs). Cluster membership may be exploited to establish the distance, luminosity, age, and physical size for PNe, and the intrinsic luminosity and mass of its central star. Four potential PN-OC associations were investigated, to assess the cluster membership for the PNe. Radial velocities were measured from intermediate-resolution optical spectra, complemented with previous estimates in the literature. When the radial velocity study supported the PN/OC association, we analyzed if other parameters (e.g., age, distance, reddening, central star brightness) were consistent with this conclusion. Our measurements imply that the PNe VBe3 and HeFa1 are not members of the OCs NGC5999 and NGC6067, respectively, and likely belong to the background bulge population. Conversely, consistent radial velocities indicate that NGC2452/NGC2453 could be associated, but our results are not conclusive and additional observations are warranted. Finally, we demonstrate that all the available information point to He2-86 being a young, highly internally obscured PN member of NGC4463. New near-infrared photometry acquired via the Vista Variables in the Via Lactea ESO public survey was used in tandem with existing UBV photometry to measure the distance, reddening, and age of NGC4463, finding d=1.55+-0.10 kpc, E(B-V)=0.41+-0.02, and tau=65+-10 Myr, respectively. The same values should be adopted for the PN if the proposed cluster membership will be confirmed.Comment: Accepted for publication in A&

Analysis of age-related left ventricular collagen remodeling in living donors: Implications in arrhythmogenesis

Age-related fibrosis in the left ventricle (LV) has been mainly studied in animals by assessing collagen content. Using second-harmonic generation microscopy and image processing, we evaluated amount, aggregation and spatial distribution of LV collagen in young to old pigs, and middle-age and elder living donors. All collagen features increased when comparing adult and old pigs with young ones, but not when comparing adult with old pigs or middle-age with elder individuals. Remarkably, all collagen parameters strongly correlated with lipofuscin, a biological age marker, in humans. By building patient-specific models of human ventricular tissue electrophysiology, we confirmed that amount and organization of fibrosis modulated arrhythmia vulnerability, and that distribution should be accounted for arrhythmia risk assessment. In conclusion, we characterize the age-associated changes in LV collagen and its potential implications for ventricular arrhythmia development. Consistency between pig and human results substantiate the pig as a relevant model of age-related LV collagen dynamics. © 2022 The Author(s

Comparing the Effect of Naturally Restored Forest and Grassland on Carbon Sequestration and Its Vertical Distribution in the Chinese Loess Plateau

Vegetation restoration has been conducted in the Chinese Loess Plateau (CLP) since the 1950s, and large areas of farmland have been converted to forest and grassland, which largely results in SOC change. However, there has been little comparative research on SOC sequestration and distribution between secondary forest and restored grassland. Therefore, we selected typical secondary forest (SF-1 and SF-2) and restored grassland (RG-1 and RG-2) sites and determined the SOC storage. Moreover, to illustrate the factors resulting in possible variance in SOC sequestration, we measured the soil δ13C value. The average SOC content was 6.8, 9.9, 17.9 and 20.4 g kg−1 at sites SF-1, SF-2, RG-1 and RG-2, respectively. Compared with 0–100 cm depth, the percentage of SOC content in the top 20 cm was 55.1%, 55.3%, 23.1%, and 30.6% at sites SF-1, SF-2, RG-1 and RG-2, suggesting a higher SOC content in shallow layers in secondary forest and in deeper layers in restored grassland. The variation of soil δ13C values with depth in this study might be attributed to the mixing of new and old carbon and kinetic fractionation during the decomposition of SOM by microbes, whereas the impact of the Suess effect (the decline of 13C atmospheric CO2 values with the burning of fossil fuel since the Industrial Revolution) was minimal. The soil δ13C value increased sharply in the top 20 cm, which then increased slightly in deeper layers in secondary forest, indicating a main carbon source of surface litter. However the soil δ13C values exhibited slow increases in the whole profile in the restored grasslands, suggesting that the contribution of roots to soil carbon in deeper layers played an important role. We suggest that naturally restored grassland would be a more effective vegetation type for SOC sequestration due to higher carbon input from roots in the CLP